Citation Impact
Citing Papers
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Targeting of Cyclic AMP Degradation to β 2 -Adrenergic Receptors by β-Arrestins
2002 StandoutScienceNobel
PDE4 cAMP-specific phosphodiesterases
2001
Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes
2004
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4
2008 StandoutNobel
Phosphodiesterase 4D and Protein Kinase A Type II Constitute a Signaling Unit in the Centrosomal Area
2001
AMP-activated protein kinase: also regulated by ADP?
2011
Phosphodiesterase regulation of nitric oxide signaling
2007
β-arrestins: traffic cops of cell signaling
2004 StandoutNobel
β-Adrenergic- and muscarinic receptor-induced changes in cAMP activity in adult cardiac myocytes detected with FRET-based biosensor
2005
Merkel Cells Activate Sensory Neural Pathways through Adrenergic Synapses
2018 StandoutNobel
Single L-type Ca2+ channel regulation by cGMP-dependent protein kinase type I in adult cardiomyocytes from PKG I transgenic mice
2003
Identification and characterization of a new human type 9 cGMP-specific phosphodiesterase splice variant (PDE9A5)
2003
β-Arrestin Scaffolding of Phosphatidylinositol 4-Phosphate 5-Kinase Iα Promotes Agonist-stimulated Sequestration of the β2-Adrenergic Receptor
2008 StandoutNobel
Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination
2003 StandoutNobel
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
Atrial natriuretic peptide administered just prior to reperfusion limits infarction in rabbit hearts
2006
Nitric oxide signaling and the regulation of myocardial function
2008
CDK5RAP2 Regulates Centriole Engagement and Cohesion in Mice
2010
Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
2005 Standout
The role of autophagy in neurodegenerative disease
2013 Standout
Cyclic nucleotide phosphodiesterases and their role in endocrine cell signaling
2002
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
2006 Standout
Cyclic Nucleotide Phosphodiesterase Activity, Expression, and Targeting in Cells of the Cardiovascular System
2003
Subcellular Localization of Cyclic Nucleotide Phosphodiesterase Type 10A Variants, and Alteration of the Localization by cAMP-dependent Protein Kinase-dependent Phosphorylation
2004
PDE7A1, a cAMP-specific Phosphodiesterase, Inhibits cAMP-dependent Protein Kinase by a Direct Interaction with C
2006
AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
2010
New insights into nNOS regulation of vascular homeostasis
2005 StandoutNobel
cGMP in the Vasculature
2008
β2‐Adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels
1999 StandoutNobel
Arrestin Development: Emerging Roles for β-arrestins in Developmental Signaling Pathways
2009 StandoutNobel
Sustained Soluble Guanylate Cyclase Stimulation Offsets Nitric-Oxide Synthase Inhibition to Restore Acute Cardiac Modulation by Sildenafil
2008
cGMP-Phosphodiesterase Activity Is Up-regulated in Response to Pressure Overload of Rat Ventricles
2003
Paracrine and autocrine effects of nitric oxide on myocardial function
2000
Dimerization of the Type 4 cAMP-specific Phosphodiesterases Is Mediated by the Upstream Conserved Regions (UCRs)
2002
Nitric Oxide and Peroxynitrite in Health and Disease
2007 Standout
mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module
2001
Mitochondria: In Sickness and in Health
2012 Standout
Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels
2005
Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases
2012
cGMP Regulated Protein Kinases (cGK)
2008
Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions
2008
cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action
2010 Standout
Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias
2005
Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions
2010 StandoutNobel
Inhibitors of cyclic nucleotide phosphodiesterase 3 and 5 as therapeutic agents in heart failure
2006
β-Arrestin1 Mediates Insulin-like Growth Factor 1 (IGF-1) Activation of Phosphatidylinositol 3-Kinase (PI3K) and Anti-apoptosis
2003 StandoutNobel
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways
2005 Nature
Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)
2005
Neurobiology of Depression
2002 Standout
Teaching old receptors new tricks: biasing seven-transmembrane receptors
2010 StandoutNobel
Free radicals and antioxidants in normal physiological functions and human disease
2006 Standout
Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes
2008
Functional expression and regulation of the hyperpolarization activated non‐selective cation current in embryonic stem cell‐derived cardiomyocytes
2000
The Physiology of Glucagon-like Peptide 1
2007 Standout
Myocardial Reperfusion Injury
2007 Standout
Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes
2009
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
2011 Standout
Cerebral organoids model human brain development and microcephaly
2013 StandoutNature
Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following 2-adrenergic stimulation of ICa,L in frog ventricular myocytes
2003
Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling
2009
TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid
2002
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics
2009
AMPK: a nutrient and energy sensor that maintains energy homeostasis
2012 Standout
Cytoskeletal genes regulating brain size
2005
cGMP-Hydrolytic Activity and Its Inhibition by Sildenafil in Normal and Failing Human and Mouse Myocardium
2009
Sildenafil Stops Progressive Chamber, Cellular, and Molecular Remodeling and Improves Calcium Handling and Function in Hearts With Pre-Existing Advanced Hypertrophy Caused by Pressure Overload
2009
Transport, stability, and biological activity of resveratrol
2011
Cyclic AMP-specific PDE4 Phosphodiesterases as Critical Components of Cyclic AMP Signaling
2003
Pressure-overload magnitude-dependence of the anti-hypertrophic efficacy of PDE5A inhibition
2008
New Roles for β-Arrestins in Cell Signaling: Not Just for Seven-Transmembrane Receptors
2006 StandoutNobel
Cardiac excitation–contraction coupling
2002 StandoutNature
Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation
2012
Cyclic GMP-Hydrolyzing Phosphodiesterases
2008
Physiology and Pathophysiology of Vascular Signaling Controlled by Cyclic Guanosine 3′,5′-Cyclic Monophosphate–Dependent Protein Kinase
2003
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
2003
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering
2001 StandoutNobel
Cardiovascular and renal control in NOS-deficient mouse models
2003
Glucagon-Like Peptide-1 Increases cAMP but Fails to Augment Contraction in Adult Rat Cardiac Myocytes
2001
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions
2008
A Specific Pattern of Phosphodiesterases Controls the cAMP Signals Generated by Different G s -Coupled Receptors in Adult Rat Ventricular Myocytes
2006
Differential Expression of the Cyclic GMP-stimulated Phosphodiesterase PDE2A in Human Venous and Capillary Endothelial Cells
1999
Properties of Resveratrol:In VitroandIn VivoStudies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans
2015 Standout
Diversity of cAMP-Dependent Protein Kinase Isoforms and Their Anchoring Proteins in Mouse Ventricular Tissue
2007
Microplastics and Nanoplastics in Aquatic Environments: Aggregation, Deposition, and Enhanced Contaminant Transport
2017 Standout
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding
2002
Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases
2004
Tumor necrosis factor-α–dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability
2005
Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors
2010
Spermidine in health and disease
2018 StandoutScience
Role of Phosphodiesterase 3 in NO/cGMP-Mediated Antiinflammatory Effects in Vascular Smooth Muscle Cells
2003
Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes
2005 StandoutNobel
Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells
2006 StandoutNobel
Compartmentalization of Cardiac β-Adrenergic Inotropy Modulation by Phosphodiesterase Type 5
2007
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
2005 Standout
Nitric Oxide and Cardiac Function
2003
β-Arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of β2-adrenoceptor signalling to activation of ERK
2005
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation
2014 Standout
Compartmentation of Cyclic Nucleotide Signaling in the Heart
2006
Physiology and pathophysiology of vascular signaling controlled by guanosine 3',5'-cyclic monophosphate-dependent protein kinase.
2004
Multifaceted roles of β-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling
2003 StandoutNobel
Plastic and Human Health: A Micro Issue?
2017 Standout
Cyclic AMP compartmentation due to increased cAMP‐phosphodiesterase activity in transgenic mice with a cardiac‐directed expression of the human adenylyl cyclase type 8 (AC8)
2003
Compartmentalized Phosphodiesterase-2 Activity Blunts β-Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway
2005
Stimulated Emission Depletion Live-Cell Super-Resolution Imaging Shows Proliferative Remodeling of T-Tubule Membrane Structures After Myocardial Infarction
2012 StandoutNobel
Differential Regulation of Endothelial Cell Permeability by cGMP via Phosphodiesterases 2 and 3
2007
Phosphodiesterase Type 5
2007
Cyclic nucleotide phosphodiesterase-mediated integration of cGMP and cAMP signaling in cells of the cardiovascular system
2005
Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes
2003
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
2009 StandoutNobel
The PDZ-binding motif of the β 2 -adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes
2003 StandoutNobel
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
2007 Standout
Organization of β-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes
2007 StandoutNobel
cGMP Catabolism by Phosphodiesterase 5A Regulates Cardiac Adrenergic Stimulation by NOS3-Dependent Mechanism
2004
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency
2008
Works of Ignácio Verde being referenced
Myomegalin Is a Novel Protein of the Golgi/Centrosome That Interacts with a Cyclic Nucleotide Phosphodiesterase
2001
Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L‐type Ca2+ current in rat ventricular myocytes
1999
Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes
2007
Cyclic GMP regulation of the L‐type Ca2+ channel current in human atrial myocytes
2001
The effects of phthalates in the cardiovascular and reproductive systems: A review
2016
Muscarinic and β-adrenergic regulation of heart rate, force of contraction and calcium current is preserved in mice lacking endothelial nitric oxide synthase
1999
cGMP-stimulated cyclic nucleotide phosphodiesterase regulates the basal calcium current in human atrial myocytes.
1997
Cyclic Guanosine Monophosphate Compartmentation in Rat Cardiac Myocytes
2006