Citation Impact
Citing Papers
Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells
2005
Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation
2009 Science
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
2008
Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes
2018 StandoutScience
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
2002 Science
TOR Signaling in Growth and Metabolism
2006 Standout
Regulation of phosphoinositide 3-kinase expression in health and disease
2009
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
PI3-kinase inhibition: a target for drug development?
2000
The Role of Phosphatases in Inositol Signaling Reactions
1999
Chromatin remodeling and transcription
1997
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
mTOR Signaling in Growth Control and Disease
2012 Standout
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
2000
A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells
2000
An emerging role for PtdIns(4,5)P2-mediated signalling in human disease
2005
Tissue-specific Alternative Splicing Generates Two Synaptojanin Isoforms with Differential Membrane Binding Properties
1996
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Class I Phosphoinositide 3-Kinase p110β Is Required for Apoptotic Cell and Fcγ Receptor-mediated Phagocytosis by Macrophages
2003
Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents
2003
Phosphoinositide phosphatases in cell biology and disease
2010
Novel Inositol Polyphosphate 5-Phosphatase Localizes at Membrane Ruffles
1999
Coupling of Coat Assembly and Vesicle Budding to Packaging of Putative Cargo Receptors
1999 StandoutNobel
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Class I PI3K in oncogenic cellular transformation
2008
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
RSC, an Essential, Abundant Chromatin-Remodeling Complex
1996 StandoutNobel
Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions
1995
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
2005
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
1997 StandoutNature
ISWI, a member of the SWl2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor
1995
Distinct Membrane and Cytosolic Forms of Inositol Polyphosphate 5-Phosphatase II
1998
BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription
1993 Nature
Targeting phosphoinositide 3-kinase—Moving towards therapy
2007
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment.
2001
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
Cell Lines from Kidney Proximal Tubules of a Patient with Lowe Syndrome Lack OCRL Inositol Polyphosphate 5-Phosphatase and Accumulate Phosphatidylinositol 4,5-Bisphosphate
1998
Phosphoinositide 3‐kinases in cell migration
2008
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
2008 Nature
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
Identification and Characterization of a Novel Inositol Polyphosphate 5-Phosphatase
2000
Related GAP domains in inositol polyphosphate 5-phosphatase and the p85 subunit of phosphatidylinositol 3-kinase
1993
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
2006 Nature
The forkhead transcription factor gene FKHL7 is responsible for glaucoma phenotypes which map to 6p25
1998
Histone Octamer Transfer by a Chromatin-Remodeling Complex
1999 StandoutNobel
Different forms of TFIIH for transcription and DNA repair: Holo-TFIIH and a nucleotide excision repairosome
1995 StandoutNobel
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
2001
Properties of Type II Inositol Polyphosphate 5-Phosphatase
1995
Signalling by PI3K isoforms: insights from gene-targeted mice
2005
Synaptojanin 2, a Novel Synaptojanin Isoform with a Distinct Targeting Domain and Expression Pattern
1997
Direct Targeting of Rab‐GTPase–Effector Interactions
2014
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
2001 StandoutNobel
Identification of a Second SH2-Domain-Containing Protein Closely Related to the Phosphatidylinositol Polyphosphate 5-Phosphatase SHIP
1997
Cell-permeant caged InsP3 ester shows that Ca2+ spike frequency can optimize gene expression
1998 StandoutNatureNobel
A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling
2006
A Null Mutation in Inositol Polyphosphate 4-Phosphatase Type I Causes Selective Neuronal Loss in Weeble Mutant Mice
2001
Inositol trisphosphate and calcium signalling
1993 StandoutNature
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
1994 StandoutNobel
Cloning and Characterization of a 72-kDa Inositol-polyphosphate 5-Phosphatase Localized to the Golgi Network
2000
SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation
2000
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
1998 StandoutNature
Pharbin, a Novel Inositol Polyphosphate 5-Phosphatase, Induces Dendritic Appearances in Fibroblasts
1999
A presynaptic inositol-5-phosphatase
1996 Nature
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKCλ/ζ
2006
Points of control in inflammation
2002 StandoutNature
Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis
2008 Nature
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx
1993 StandoutNatureNobel
Protein Family Classification Based on Searching a Database of Blocks
1994
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Molecular mechanisms and clinical applications of angiogenesis
2011 StandoutNature
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
2004
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
2006
Phosphoinositide 3-kinase signalling – which way to target?
2003
Roles of Non-catalytic Subunits in Gβγ-induced Activation of Class I Phosphoinositide 3-Kinase Isoforms β and γ
1999
The SNF/SWI family of global transcriptional activators
1994
Phosphoinositide 3-Kinases and Their FYVE Domain-containing Effectors as Regulators of Vacuolar/Lysosomal Membrane Trafficking Pathways
1999
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3
2001 StandoutNobel
Structural organization of yeast and mammalian mediator complexes
2000 StandoutNobel
ATP-Dependent Chromatin-Remodeling Complexes
2000
Structure, function, and biology of SHIP proteins
2000
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Identification and characterization of a TFIID-like multiprotein complex from Saccharomyces cerevisiae.
1995 StandoutNobel
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase.
1995
Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases
2000
Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio
2003
PIK3CA as an oncogene in cervical cancer
2000
Transcriptional Coactivator Complexes
2001
TFG3/TAF30/ANC1, a Component of the Yeast SWI/SNF Complex That Is Similar to the Leukemogenic Proteins ENL and AF-9
1996 StandoutNobel
Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex
2002
Phosphoinositide 3-Kinase Catalytic Subunit Deletion and Regulatory Subunit Deletion Have Opposite Effects on Insulin Sensitivity in Mice
2005
A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation
2002
A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain.
1993
The yeast SNF2/SWI2 protein has DNA-stimulated ATPase activity required for transcriptional activation.
1993
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
1999
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Diversity and specialization of mammalian SWI/SNF complexes.
1996
Purification and biochemical heterogeneity of the mammalian SWI-SNF complex.
1996
New Responsibilities for the PI3K Regulatory Subunit p85α
2001
Evidence for a mediator cycle at the initiation of transcription
1997 StandoutNobel
The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
2006
Identification and characterization of Drosophila relatives of the yeast transcriptional activator SNF2/SWI2.
1994
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
2007
Metabolic reprogramming and cancer progression
2020 StandoutScience
PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target
2006
SNF11, a New Component of the Yeast SNF-SWI Complex That Interacts with a Conserved Region of SNF2
1995
Co-expression in vertebrate tissues and cell lines of multiple inositol 1,4,5-trisphosphate (InsP3) receptors with distinct affinities for InsP3.
1994 StandoutNobel
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Translating the Histone Code
2001 StandoutScience
Roles of SWI1, SWI2, and SWI3 Proteins for Transcriptional Enhancement by Steroid Receptors
1992 Science
Phosphoinositides as Regulators in Membrane Traffic
1996 Science
Deletion of the phosphoinositide 3-kinase p110γ gene attenuates murine atherosclerosis
2007
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
2000 StandoutNobel
Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex.
1996
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.
2003
A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.
1993
Human DNA Repair Genes
2001 StandoutScienceNobel
Calcium - a life and death signal
1998 StandoutNature
The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
2008
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway
2005
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer
2018
A multisubunit complex containing the SWI1/ADR6,SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated fromyeast.
1994 StandoutNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Association of the Mediator complex with enhancers of active genes
2003 StandoutNobel
Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase
1994
Works of Ichiro Okabe being referenced
The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase
1992 Nature
Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase
1999
Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase
2002
Cloning of human and bovine homologs of SNF2/SWI2: a global activator of transcription in yeastS.cerevisiae
1992
Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase
2002