Standout Papers
Citation Impact
Citing Papers
Cardiac Hypertrophy: The Good, the Bad, and the Ugly
2003 Standout
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
The emerging biology of RNA post-transcriptional modifications
2016
Macrophage JAK2 deficiency protects against high-fat diet-induced inflammation
2017
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
2010
Hallmarks of Cancer: The Next Generation
2011 Standout
An association study of the m6A genes with major depressive disorder in Chinese Han population
2015
Islet inflammation in type 2 diabetes
2019
PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
2016
Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia
2007
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice
2014
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
2008
Mesp1 Coordinately Regulates Cardiovascular Fate Restriction and Epithelial-Mesenchymal Transition in Differentiating ESCs
2008
Adipose tissue, adipokines, and inflammation
2005 Standout
Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites
2014
Regulation and function of mTOR signalling in T cell fate decisions
2012
Angiopoietin-like protein 4: health effects, modulating agents and structure–function relationships
2012
Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization in Adipose Tissue and Improves Systemic Glucose Tolerance via Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity
2012
Enhanced angiogenesis in obesity and in response to PPARγ activators through adipocyte VEGF and ANGPTL4 production
2008
Vascular-Targeted Overexpression of G Protein-Coupled Receptor Kinase-2 in Transgenic Mice Attenuates β-Adrenergic Receptor Signaling and Increases Resting Blood Pressure
2002
Gene expression regulation mediated through reversible m6A RNA methylation
2014
Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling
2015
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation
2007
N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
2016
Inflammatory links between obesity and metabolic disease
2011 Standout
Obesity, inflammation, and liver cancer
2011
Innate Immune Receptors: Key Regulators of Metabolic Disease Progression
2013
m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells
2014 Standout
Coordination of m 6 A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming
2015
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
Elevated resistin levels in chronic kidney disease are associated with decreased glomerular filtration rate and inflammation, but not with insulin resistance
2006
Molecular mechanisms of epithelial–mesenchymal transition
2014 Standout
T‐Cell Recruitment and Th1 Polarization in Adipose Tissue During Diet‐Induced Obesity in C57BL/6 Mice
2010
YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
2016
C-type lectins in immunity and homeostasis
2018
The spectrum of T cell metabolism in health and disease
2017
Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice
2006
N6-Methylated Adenosine in RNA: From Bacteria to Humans
2015
Post-transcriptional gene regulation by mRNA modifications
2016 Standout
RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance
2014
Inflammation and Lipid Signaling in the Etiology of Insulin Resistance
2012
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
2011 Standout
Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance
2016
Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity
2019
Sodium–hydrogen exchange inhibition attenuates glycoside-induced hypertrophy in rat ventricular myocytes
2009
Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity
2018
Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance
2015
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
2016
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
2013 Standout
Dynamics of Human and Viral RNA Methylation during Zika Virus Infection
2016
Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes
2014
Magnesium Replacement Improves the Metabolic Profile in Obese and Pre-Diabetic Patients with Mild-to-Moderate Chronic Kidney Disease: A 3-Month, Randomised, Double-Blind, Placebo-Controlled Study
2017 Standout
Differentiation and function of Foxp3+ effector regulatory T cells
2012
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression
2010
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury
2009
Transcriptome-wide high-throughput deep m6A-seq reveals unique differential m6A methylation patterns between three organs in Arabidopsis thaliana
2015
Inflammatory lipid mediators in adipocyte function and obesity
2010
Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
2020
Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients
2014
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
2013
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
2015
The IL-1 Pathway in Type 2 Diabetes and Cardiovascular Complications
2015
Innate Immune Control of Adipose Tissue Homeostasis
2019
Adipokines in inflammation and metabolic disease
2011 Standout
β Cell-Specific Deletion of the IL-1 Receptor Antagonist Impairs β Cell Proliferation and Insulin Secretion
2018
N6-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding
2015
Epigenetic Regulation of Kupffer Cell Function in Health and Disease
2021
E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer
2009
Diet–microbiota interactions as moderators of human metabolism
2016 StandoutNature
Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
2010 Standout
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
NF-κB, Inflammation, and Metabolic Disease
2011 Standout
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
2008
An Integrated View of Immunometabolism
2018
Insulin Resistance is Associated with MCP1-Mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans
2014
Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase
2012
Molecular regulation of angiogenesis and lymphangiogenesis
2007 Standout
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Adipocyte-Specific IKKβ Signaling Suppresses Adipose Tissue Inflammation through an IL-13-Dependent Paracrine Feedback Pathway
2014
Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells
2011 Standout
The cellular and signaling networks linking the immune system and metabolism in disease
2012
Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity
2020
The immunomodulating role of exercise in metabolic disease
2014
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
A majority of m6A residues are in the last exons, allowing the potential for 3′ UTR regulation
2015
Chronic tissue inflammation and metabolic disease
2021
Innate Lymphoid Cells in the Induction of Obesity
2019
Local proliferation of macrophages in adipose tissue during obesity-induced inflammation
2013
The dynamic epitranscriptome: N6-methyladenosine and gene expression control
2014
Adipocyte differentiation from the inside out
2006 Standout
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
2014
Increased Serum Resistin in Nonalcoholic Fatty Liver Disease Is Related to Liver Disease Severity and Not to Insulin Resistance
2006
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Adipose tissue remodeling and obesity
2011
Dietary Regulation of Immunity
2020
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
2011
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
TGF-β-induced epithelial to mesenchymal transition
2009 Standout
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Macrophage-mediated inflammation in metabolic disease
2011
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
2006 Standout
Associations Among Adipose Tissue Immunology, Inflammation, Exosomes and Insulin Sensitivity in People With Obesity and Nonalcoholic Fatty Liver Disease
2021
Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-γ in inflammation in human adipose tissue
2009
Molecular Regulation of Vascular Smooth Muscle Cell Differentiation in Development and Disease
2004 Standout
Inflammation in obesity, diabetes, and related disorders
2022 Standout
Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells
2016
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
NK cells link obesity-induced adipose stress to inflammation and insulin resistance
2015
Adipose Natural Killer Cells Regulate Adipose Tissue Macrophages to Promote Insulin Resistance in Obesity
2016
Resistin is secreted from macrophages in atheromas and promotes atherosclerosis
2005
N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions
2015 StandoutNature
Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype
2009
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
2010
Digoxin inhibits development of hypoxic pulmonary hypertension in mice
2012 StandoutNobel
Role of resistin in obesity, insulin resistance and Type II diabetes
2005
Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis
2013 Science
Fibrosis, not cell size, delineates β-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo
2006 StandoutNobel
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na + channels
2004 StandoutNobel
B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile
2013
Restricted inactivation of serum response factor to the cardiovascular system
2004
Tissue Tregs
2016
Adipose invariant natural killer T cells
2014
Zeb1 links epithelial-mesenchymal transition and cellular senescence
2008
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
2010
Adipose tissue B2 cells promote insulin resistance through leukotriene LTB4/LTB4R1 signaling
2017
Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes
2008
G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation
2003
Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease
2015
Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet–Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis
2011
Characterizing 5-methylcytosine in the mammalian epitranscriptome
2013
The role of Krüppel-like factors in the reprogramming of somatic cells to induced pluripotent stem cells.
2009
TGF-β regulates isoform switching of FGF receptors and epithelial-mesenchymal transition
2011
Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis
2011 Science
Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene
2004 StandoutNobel
Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes
2014
Immune Regulation in Obesity-Associated Adipose Inflammation
2013
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction
2010
Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice
2009
Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain
2014
Reduced Adipose Tissue Oxygenation in Human Obesity
2008
Macrophage Proliferation Sustains Adipose Tissue Inflammation in Formerly Obese Mice
2016
Inflammasomes and Metabolic Disease
2013
Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance
2010
CD40-Mediated Maintenance of Immune Homeostasis in the Adipose Tissue Microenvironment
2014
A Systems Biology Approach Identifies Inflammatory Abnormalities Between Mouse Strains Prior to Development of Metabolic Disease
2010
Dynamic, M2-Like Remodeling Phenotypes of CD11c+ Adipose Tissue Macrophages During High-Fat Diet–Induced Obesity in Mice
2010
Emerging Roles of RNA Modification: m6A and U-Tail
2014
Inflammatory Mechanisms in Obesity
2011 Standout
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Regulation of metabolism by the innate immune system
2015
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells
2010 StandoutNobel
New therapeutic approaches for the treatment of obesity
2016
Role of innate and adaptive immunity in obesity-associated metabolic disease
2017
Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
2010
Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation
2014
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Monocytes from patients with rheumatoid arthritis and type 2 diabetes mellitus display an increased production of interleukin (IL)-1βvia the nucleotide-binding domain and leucine-rich repeat containing family pyrin 3(NLRP3)-inflammasome activation: a possible implication for therapeutic decision in these patients
2015
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Molecular Mechanisms of Myocardial Remodeling
1999 Standout
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
Macrophages, Inflammation, and Insulin Resistance
2010 Standout
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.
1998 Standout
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
2007
Snail is required for TGFβ-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells
2008
Therapeutic Modulation of Microbiota-Host Metabolic Interactions
2012
Hypoxia-inducible factor 1 transcriptional activity in endothelial cells is required for acute phase cardioprotection induced by ischemic preconditioning
2012 StandoutNobel
Alternative Macrophage Activation and Metabolism
2011
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Ichiro Manabe being referenced
Adipose tissue inflammation in obesity and metabolic syndrome.
2009
Lnk regulates integrin αIIbβ3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo
2009
SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ
2008
Adipose Natural Regulatory B Cells Negatively Control Adipose Tissue Inflammation
2013
Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation
2012
RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
2013
Isolation of the Embryonic Form of Smooth Muscle Myosin Heavy Chain (SMemb/NMHC-B) Gene and Characterization of Its 5′-Flanking Region
1997
Thrombomodulin Is a Clock-controlled Gene in Vascular Endothelial Cells
2007
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
2008
Significance of the transcription factor KLF5 in cardiovascular remodeling
2005
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
2009 Standout
SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism
2016
Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine–endothelial cell interactions
2004
The Smooth Muscle Myosin Heavy Chain Gene Exhibits Smooth Muscle Subtype-selective Modular Regulation in Vivo
2001
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation
2005
Jagged1-selective Notch Signaling Induces Smooth Muscle Differentiation via a RBP-Jκ-dependent Pathway
2006
Macrophage-inducible C-type lectin underlies obesity-induced adipose tissue fibrosis
2014
Activation of Na+-H+ Antiporter (NHE-1) gene expression during growth, hypertrophy and proliferation of the rabbit cardiovascular system
1995
CArG elements control smooth muscle subtype–specific expression of smooth muscle myosin in vivo
2001
δEF1 Mediates TGF-β Signaling in Vascular Smooth Muscle Cell Differentiation
2006
Smooth Muscle–Specific Expression of the Smooth Muscle Myosin Heavy Chain Gene in Transgenic Mice Requires 5′-Flanking and First Intronic DNA Sequence
1998
Endothelial PAS Domain Protein 1 Gene Promotes Angiogenesis Through the Transactivation of Both Vascular Endothelial Growth Factor and Its Receptor, Flt-1
2004
Klf5 is involved in self-renewal of mouse embryonic stem cells
2008
Adipogenesis in Obesity Requires Close Interplay Between Differentiating Adipocytes, Stromal Cells, and Blood Vessels
2007
Redifferentiation of Smooth Muscle Cells After Coronary Angioplasty Determined via Myosin Heavy Chain Expression
1997
Development of a Smooth Muscle–Targeted Cre Recombinase Mouse Reveals Novel Insights Regarding Smooth Muscle Myosin Heavy Chain Promoter Regulation
2000
Macrophages and islet inflammation in type 2 diabetes
2013
BTEB2, a Kruppel-Like Transcription Factor, Regulates Expression of the SMemb/Nonmuscle Myosin Heavy Chain B (SMemb/NMHC-B) Gene
1999
Recruitment of Serum Response Factor and Hyperacetylation of Histones at Smooth Muscle–Specific Regulatory Regions During Differentiation of a Novel P19-Derived In Vitro Smooth Muscle Differentiation System
2001