Citation Impact
Citing Papers
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex
2005 StandoutScience
The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling
2004
Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a
2009 Science
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
2004 StandoutScience
The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization
2008
Regulation of Cell Migration by the C2 Domain of the Tumor Suppressor PTEN
2004 Science
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
2002 Standout
DJ-1, a novel regulator of the tumor suppressor PTEN
2005
Hallmarks of Cancer: The Next Generation
2011 Standout
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling
2001
Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
2000
PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy
2002
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Inflammation and cancer
2002 StandoutNature
Analysis of the genome to personalize therapy for melanoma
2010
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
1999
Apoptosis in cancer
2000 Standout
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
2000
Regulation of PTEN by Rho small GTPases
2005
PTEN, a unique tumor suppressor gene.
2000
PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells is mediated by p27kip1
2000
Reversible Inactivation of the Tumor Suppressor PTEN by H2O2
2002
Oncogenic kinase signalling
2001 StandoutNature
Mutational Spectra of PTEN/MMAC1 Gene: a Tumor Suppressor With Lipid Phosphatase Activity
1999
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
1999
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Wound repair and regeneration
2008 StandoutNature
Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function
2001 StandoutNobel
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling
2006
Tenets of PTEN Tumor Suppression
2008
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Cellular survival: a play in three Akts
1999 Standout
Regulated portals of entry into the cell
2003 StandoutNature
The Hallmarks of Cancer
2000 Standout
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
PTEN: One Gene, Many Syndromes
2003
Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity
2009
The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB
1999
PTEN Interactions with Focal Adhesion Kinase and Suppression of the Extracellular Matrix-dependent Phosphatidylinositol 3-Kinase/Akt Cell Survival Pathway
1999
Ten years of protein kinase B signalling: a hard Akt to follow
2001
SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
1999
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
2001 StandoutNobel
PTEN, more than the AKT pathway
2007
Protein‐Reactive Natural Products
2005
The Multiple Roles of PTEN in Tumor Suppression
2000
Functional roles of Akt signaling in mouse skin tumorigenesis
2002
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Human PIR1 of the Protein-tyrosine Phosphatase Superfamily Has RNA 5′-Triphosphatase and Diphosphatase Activities
1999
Identification of PTEN mutations in metastatic melanoma specimens
2000
PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease
2002
Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN
1999
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Epigenetic PTEN Silencing in Malignant Melanomas without PTEN Mutation
2000
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
2001
Modulation of cellular apoptotic potential: contributions to oncogenesis
1999
Regulation of Glycogen Synthase in Rat Hepatocytes
1999
EMT, the cytoskeleton, and cancer cell invasion
2009
Transcriptional activation of p21WAF1by PTEN/MMAC1 tumr suppressor
2000
PTEN: Life as a Tumor Suppressor
2001
Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine
2000
Expression Cloning of Protein Targets for 3-Phosphorylated Phosphoinositides
1999
Mutations of the human PTEN gene
2000
Inflammation and the development of pancreatic cancer
2002
Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent Pathways
2000
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Shank-interacting protein–like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells
2010
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation
2000
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
The functions and regulation of the PTEN tumour suppressor
2012 Standout
WWP2 is an E3 ubiquitin ligase for PTEN
2011
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling
2000
Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients
2002
α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells
2011
Role of Cyclin G-associated Kinase in Uncoating Clathrin-coated Vesicles from Non-neuronal Cells
2000
Signalling through phosphoinositide 3-kinases: the lipids take centre stage
1999
Germline PTEN Promoter Mutations and Deletions in Cowden/Bannayan-Riley-Ruvalcaba Syndrome Result in Aberrant PTEN Protein and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway
2003
The Tumor Suppressor PTEN Negatively Regulates Insulin Signaling in 3T3-L1 Adipocytes
2000
Up-regulation of Akt3 in Estrogen Receptor-deficient Breast Cancers and Androgen-independent Prostate Cancer Lines
1999 Standout
The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells
1999
T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance
2001 StandoutNobel
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
2003 StandoutNobel
β1-Integrin and PTEN control the phosphorylation of protein kinase C
2000
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1999 Standout
Interaction of the Tumor Suppressor PTEN/MMAC with a PDZ Domain of MAGI3, a Novel Membrane-associated Guanylate Kinase
2000 Standout
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Cutting Edge: T Cell Requirement for CD28 Costimulation Is Due to Negative Regulation of TCR Signals by PTEN
2006
Adenovirus-mediated gene transfer of MMAC1/PTEN to glioblastoma cells inhibits S phase entry by the recruitment of p27Kip1 into cyclin E/CDK2 complexes.
1999
AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation
1999
Iterative in Situ Click Chemistry Assembles a Branched Capture Agent and Allosteric Inhibitor for Akt1
2011 StandoutNobel
Deficiency of PTEN in Jurkat T Cells Causes Constitutive Localization of Itk to the Plasma Membrane and Hyperresponsiveness to CD3 Stimulation
2000
Impaired Fas Response and Autoimmunity in Pten +/− Mice
1999 Science
Ribosomal Synthesis of Dehydroalanine-Containing Peptides
2006 StandoutNobel
Integrin Signaling
1999 StandoutScience
Shc and Fak Differentially Regulate Cell Motility and Directionality Modulated by Pten
1999
Crystal Structure of the PTEN Tumor Suppressor
1999
Phosphorylation of the PTEN Tail Regulates Protein Stability and Function
2000
5′ Phospholipid Phosphatase SHIP-2 Causes Protein Kinase B Inactivation and Cell Cycle Arrest in Glioblastoma Cells
2000
The NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope
2015 StandoutNobel
Inositol-lipid binding motifs: signal integrators through protein-lipid and protein-protein interactions
2005
The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway
1999
β1-Integrin and PTEN control the phosphorylation of protein kinase C
2000
Surfing the p53 network
2000 StandoutNature
E-Syts, a family of membranous Ca 2+ -sensor proteins with multiple C 2 domains
2007 StandoutNobel
Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
2000
Specific Inhibition of PTEN Expression Reverses Hyperglycemia in Diabetic Mice
2002
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis
2002
Physiological Functions of Pten in Mouse Tissues.
2003 StandoutNobel
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
The Developmental Biology of Brain Tumors
2001
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
1999
TEP1 , the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation
2000
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Mutation ofPten/Mmac1in mice causes neoplasia in multiple organ systems
1999
Protein Kinases as Mediators of Phosphoinositide 3-Kinase Signaling
2000
Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN
2000
Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding Proteins
2005 StandoutNobel
Regulation of G1progression by thePTENtumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
1999
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
2000
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development
1999
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
Antiapoptotic Role of PPARβ in Keratinocytes via Transcriptional Control of the Akt1 Signaling Pathway
2002
A Role for Nuclear PTEN in Neuronal Differentiation
2000
PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death.
1999
Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis
2001
Filamentous Phage Display in the New Millennium
2005
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
The PI3K–PDK1 connection: more than just a road to PKB
2000
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression
2006
Works of Ian Pass being referenced
Tumor suppressor and anti-inflammatory actions of PPARγ agonists are mediated via upregulation of PTEN
2001
The Adaptor Protein Fish Associates with Members of the ADAMs Family and Localizes to Podosomes of Src-transformed Cells
2003
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions
2001
The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells
2005
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
2000
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
1998
Antagonism of PI 3-kinase-dependent signalling pathways by the tumour suppressor protein, PTEN
2001
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions
2001
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
2000
Interfacial kinetic analysis of the tumour suppressor phosphatase, PTEN: evidence for activation by anionic phospholipids
2003