Citation Impact
Citing Papers
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
2017
RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition
2014
Innovative scattering analysis shows that hydrophobic disordered proteins are expanded in water
2017 StandoutScienceNobel
Pertactin β-helix folding mechanism suggests common themes for the secretion and folding of autotransporter proteins
2006
De novo design of transmembrane β barrels
2021 StandoutScienceNobel
Strategy for Dual-Analyte Luciferin Imaging: In Vivo Bioluminescence Detection of Hydrogen Peroxide and Caspase Activity in a Murine Model of Acute Inflammation
2013 StandoutNobel
Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis
2014
Sculpting conducting nanopore size and shape through de novo protein design
2024 StandoutScienceNobel
Pyroptosis versus necroptosis: similarities, differences, and crosstalk
2018
A RIPK3–Caspase 8 Complex Mediates Atypical Pro–IL-1β Processing
2015
Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP 3 inflammasome assembly
2019
Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists
2024 StandoutScienceNobel
MLKL and FADD Are Critical for Suppressing Progressive Lymphoproliferative Disease and Activating the NLRP3 Inflammasome
2016
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
2018
Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
2012
BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1β Maturation in Macrophages
2018
Mitochondrial import and the twin-pore translocase
2004
Cell death in chronic inflammation: breaking the cycle to treat rheumatic disease
2020
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
A Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins
2009
Membrane protein architects: the role of the BAM complex in outer membrane protein assembly
2009
Structure of the BamC Two-Domain Protein Obtained by Rosetta with a Limited NMR Data Set
2011 StandoutNobel
3-Mercaptopropionic acid-mediated synthesis of peptide and protein thioesters
2008 StandoutNobel
Imaging beyond the proteome
2012 StandoutNobel
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
Importing Mitochondrial Proteins: Machineries and Mechanisms
2009
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
2013
Protein ligation: an enabling technology for the biophysical analysis of proteins
2006
Necroptosis and its role in inflammation
2015 StandoutNature
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
Mechanisms of NOD-like Receptor-Associated Inflammasome Activation
2013
Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs
2006
Chronic inflammation in the etiology of disease across the life span
2019 Standout
Bacterial Exotoxins and the Inflammasome
2015
Cofactor-dependent maturation of mammalian sulfite oxidase links two mitochondrial import pathways
2012
Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis
2014
Death by TNF: a road to inflammation
2022
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
TNFR1‐induced activation of the classical NF‐κB pathway
2011
IAP-targeted therapies for cancer
2008
Virus Inhibition of RIP3-Dependent Necrosis
2010
Hallmarks of aging: An expanding universe
2023 Standout
IAPs: from caspase inhibitors to modulators of NF-κB, inflammation and cancer
2010
Activation and regulation of the inflammasomes
2013 Standout
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
Necroptosis in the Pathophysiology of Disease
2019
TRAF2 Sets a Threshold for Extrinsic Apoptosis by Tagging Caspase-8 with a Ubiquitin Shutoff Timer
2012
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
2014 Nature
Transmembrane β-barrels: Evolution, folding and energetics
2017
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling
2015
Protective Roles for Caspase-8 and cFLIP in Adult Homeostasis
2013
Comparing the effects of different cell death programs in tumor progression and immunotherapy
2018
Evolving Strategies for Protein Synthesis Converge on Native Chemical Ligation
2006 StandoutNobel
Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase
2012 Standout
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape
2019 StandoutNobel
RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
2011
Mitochondria: In Sickness and in Health
2012 Standout
Identification of a Multicomponent Complex Required for Outer Membrane Biogenesis in Escherichia coli
2005
The Protein Import Machinery of Mitochondria
2004
Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance
2013
Identification of Putative Target Genes of the Transcription Factor RUNX2
2013 StandoutNobel
Fluorescent and colorimetric probes for detection of thiols
2010 Standout
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition
2013
Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α
2013
Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome
2012
Cell death is not essential for caspase-1-mediated interleukin-1β activation and secretion
2016
Site-specific N-terminal labelling of proteinsin vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry
2007
Crystal Structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 Complexes: Affinity, Specificity, and Regulation
2010
RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis
2014 Nature
Chemoselective Ligation and Modification Strategies for Peptides and Proteins
2008
Spherical nanosized focal spot unravels the interior of cells
2008 StandoutNobel
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Regulation of tumour necrosis factor signalling: live or let die
2015
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways
2011
RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway
2014
Regulated necrosis: the expanding network of non-apoptotic cell death pathways
2014
Mitochondrial protein import: from proteomics to functional mechanisms
2010
RIPK1 Blocks Early Postnatal Lethality Mediated by Caspase-8 and RIPK3
2014
Molecular mechanisms of necroptosis: an ordered cellular explosion
2010 Standout
Necroptosis in development, inflammation and disease
2016
Mechanisms and Functions of Inflammasomes
2014 Standout
Structural Basis of Outer Membrane Protein Biogenesis in Bacteria
2011
Expanding TRAF function: TRAF3 as a tri-faced immune regulator
2011
Mitochondria as multifaceted regulators of cell death
2019 Standout
Cytoplasmic DNA: sources, sensing, and role in aging and disease
2021
Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction
2009
Ferroptosis: mechanisms, biology and role in disease
2021 Standout
The Ripoptosome, a Signaling Platform that Assembles in Response to Genotoxic Stress and Loss of IAPs
2011
β-Barrel Proteins That Reside in the Escherichia coli Outer Membrane in Vivo Demonstrate Varied Folding Behavior in Vitro
2008
Allosteric Regulation of the Ubiquitin:NIK and Ubiquitin:TRAF3 E3 Ligases by the Lymphotoxin-β Receptor
2010
Ferroptosis and Necroptosis in the Kidney
2020
Building Better Barrels – β-barrel Biogenesis and Insertion in Bacteria and Mitochondria
2021
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair
2014
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease
2015 Standout
NEMO and RIP1 Control Cell Fate in Response to Extensive DNA Damage via TNF-α Feedforward Signaling
2011
The amyloid state and its association with protein misfolding diseases
2014 Standout
Human Monocytes Engage an Alternative Inflammasome Pathway
2016
Tumor Necrosis Factor Inhibits Spread of Hepatitis C Virus Among Liver Cells, Independent From Interferons
2017 StandoutNobel
Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis
2021 StandoutNobel
Mitochondrial apoptosis is dispensable for NLRP 3 inflammasome activation but non‐apoptotic caspase‐8 is required for inflammasome priming
2014
Assembly of theβ-Barrel Outer Membrane Proteins in Gram-Negative Bacteria, Mitochondria, and Chloroplasts
2012
Control of Life-or-Death Decisions by RIP1 Kinase
2013
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
2014
Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1β and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner
2012
Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient
2011 StandoutNobel
Caspase‐8 functions as a key mediator of inflammation and pro‐IL‐1β processing via both canonical and non‐canonical pathways
2015
Cellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitment
2009
Mitochondria—Striking a balance between host and endosymbiont
2019 Science
Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins
2019 StandoutNobel
Cytokine Storm
2020 Standout
WNT-Inflammasome Signaling Mediates NOD2-Induced Development of Acute Arthritis in Mice
2015
cFLIP Regulates Skin Homeostasis and Protects against TNF-Induced Keratinocyte Apoptosis
2013
Bacterial machineries for the assembly of membrane-embedded β-barrel proteins
2018
Versatile Peptide C-Terminal Functionalization via a Computationally Engineered Peptide Amidase
2016 StandoutNobel
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Translocation of Proteins into Mitochondria
2007
Genetically Encoded 1,2-Aminothiols Facilitate Rapid and Site-Specific Protein Labeling via a Bio-orthogonal Cyanobenzothiazole Condensation
2011
Caspase-8 Modulates Dectin-1 and Complement Receptor 3–Driven IL-1β Production in Response to β-Glucans and the Fungal Pathogen, Candida albicans
2014
Site-Specific Traceless Coupling of Potent Cytotoxic Drugs to Recombinant Antibodies for Pharmacodelivery
2012
A Bioorthogonal Quadricyclane Ligation
2011 StandoutNobel
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
2019
Ferroptosis as a target for protection against cardiomyopathy
2019 Standout
MLKL Activation Triggers NLRP3-Mediated Processing and Release of IL-1β Independently of Gasdermin-D
2017
TRAF2 Ser-11 Phosphorylation Promotes Cytosolic Translocation of the CD40 Complex To Regulate Downstream Signaling Pathways
2020
Chemoselektive Ligations‐ und Modifikationsstrategien für Peptide und Proteine
2008
Characterization of Six Lipoproteins in the σERegulon
2005
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
The Mononuclear Molybdenum Enzymes
2014 Standout
Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response
2011
The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis
2010
Detection of Homocysteine and Cysteine
2005
Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling
2014
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8 + T cells
2015 Science
Proapoptotic Chemotherapeutic Drugs Induce Noncanonical Processing and Release of IL-1β via Caspase-8 in Dendritic Cells
2013
Rapid access to Asp/Glu sidechain hydrazides as thioester precursors for peptide cyclization and glycosylation
2021 StandoutNobel
Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis
2018 StandoutNobel
Design Strategies for Water-Soluble Small Molecular Chromogenic and Fluorogenic Probes
2013 Standout
YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli
2006
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Works of Ian E. Gentle being referenced
The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria
2003
In TNF-stimulated Cells, RIPK1 Promotes Cell Survival by Stabilizing TRAF2 and cIAP1, which Limits Induction of Non-canonical NF-κB and Activation of Caspase-8
2011
Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins
2016
RIPK1 is not essential for TNFR1-induced activation of NF-κB
2009
Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
2012
TRAF2 Must Bind to Cellular Inhibitors of Apoptosis for Tumor Necrosis Factor (TNF) to Efficiently Activate NF-κB and to Prevent TNF-induced Apoptosis
2009
Conserved substrate binding by chaperones in the bacterial periplasm and the mitochondrial intermembrane space
2007
Molecular architecture and function of the Omp85 family of proteins
2005
Mature DIABLO/Smac Is Produced by the IMP Protease Complex on the Mitochondrial Inner Membrane
2005
Direct Production of Proteins with N-Terminal Cysteine for Site-Specific Conjugation
2004
A non‐death function of the mitochondrial apoptosis apparatus in immunity
2019