Citation Impact
Citing Papers
NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
2008
Containment of Tumor-Colonizing Bacteria by Host Neutrophils
2008
Multiplex Genome Engineering Using CRISPR/Cas Systems
2013 StandoutScience
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
PIK3CA Cooperates with Other Phosphatidylinositol 3′-Kinase Pathway Mutations to Effect Oncogenic Transformation
2008
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
2011
TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization
2010
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
2007 StandoutScience
Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia
2006
The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations
2007 Science
Pancreatic cancer regression by intratumoural injection of live Streptococcus pyogenes in a syngeneic mouse model
2007
Optimized Clostridium -Directed Enzyme Prodrug Therapy Improves the Antitumor Activity of the Novel DNA Cross-Linking Agent PR-104
2008
The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells
2005
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
PTEN-deficient cancers depend on PIK3CB
2008
Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
2008
Mutational landscape and significance across 12 major cancer types
2013 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo
2006
Genome Engineering Using Adeno-Associated Virus (AAV)
2014
A Eukaryotic-like Ser/Thr Kinase Signals Bacteria to Exit Dormancy in Response to Peptidoglycan Fragments
2008
E1-L2 Activates Both Ubiquitin and FAT10
2007
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
2008 StandoutNature
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
2006 Standout
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
2012 Standout
Discovery of Drug-Resistant and Drug-Sensitizing Mutations in the Oncogenic PI3K Isoform p110α
2008
Targeting hypoxia cell signaling for cancer therapy
2007
Oral delivery of tumor‐targeting Salmonella exhibits promising therapeutic efficacy and low toxicity
2009
The genetics of ageing
2010 StandoutNature
Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF
2013
Genetic knockouts and knockins in human somatic cells
2007
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
PI3K pathway alterations in cancer: variations on a theme
2008
Otto Warburg's contributions to current concepts of cancer metabolism
2011 Standout
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Engineering the perfect (bacterial) cancer therapy
2010 Standout
Environmentally Controlled Invasion of Cancer Cells by Engineered Bacteria
2005
Oncogenic PI3K and its role in cancer
2005
Strategies for in vivo imaging of enzyme activity: an overview and recent advances
2011
Targeting phosphoinositide 3-kinase—Moving towards therapy
2007
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer
2006
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
2009
Comprehensive analysis of oncogenic effects of PIK3CA mutations in human mammary epithelial cells
2007
Targeting cancer with small molecule kinase inhibitors
2008 Standout
Tumor-specific colonization, tissue distribution, and gene induction by probiotic Escherichia coli Nissle 1917 in live mice
2007
Quantitative bioluminescence imaging of tumor-targeting bacteria in living animals
2008
Tumor suppressors and cell metabolism: a recipe for cancer growth
2009
Oral delivery of tumor‐targeting Salmonella for cancer therapy in murine tumor models
2007
Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium
2009
Immunity, Inflammation, and Cancer
2010 Standout
In vivo genome editing using Staphylococcus aureus Cas9
2015 StandoutNature
Precise hit: adeno-associated virus in gene targeting
2005
Tumor-targeting prodrug-activating bacteria for cancer therapy
2008
Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimurium
2009
Tumor Invasion of Salmonella enterica Serovar Typhimurium Is Accompanied by Strong Hemorrhage Promoted by TNF-α
2009
Potent anti-tumor activity of systemically-administered IL2-expressing Salmonella correlates with decreased angiogenesis and enhanced tumor apoptosis
2008
Colonization of experimental murine breast tumours by Escherichia coli K-12 significantly alters the tumour microenvironment
2008
Anti-tumor effects of the bacterium caulobacter crescentus in murine tumor models
2006
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Defining the Role of mTOR in Cancer
2007 Standout
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion
2007 StandoutNobel
Salmonella typhimurium specifically chemotax and proliferate in heterogeneous tumor tissue in vitro
2006
Amplicon profiles in ovarian serous carcinomas
2007
AAV-mediated gene targeting methods for human cells
2011
Ubiquitin and ubiquitin-like proteins as multifunctional signals
2005
Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain ofSalmonella typhymurium
2009
Inhibition of Tumor Growth and Metastasis by a Combination of Escherichia coli–mediated Cytolytic Therapy and Radiotherapy
2010
Bacterial therapies: completing the cancer treatment toolbox
2008
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
2008
Functional antibodies produced by oncolytic clostridia
2007
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Tumours with PI3K activation are resistant to dietary restriction
2009 Nature
Discovery and saturation analysis of cancer genes across 21 tumour types
2014 StandoutNature
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
Genome engineering
2009
Drug Resistance and the Solid Tumor Microenvironment
2007 Standout
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer
2007
Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma
2007
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
PIK3CA Gene Mutations in Pediatric and Adult Glioblastoma Multiforme
2006
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
2006
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
2011 Standout
Targeted Therapy with aSalmonella TyphimuriumLeucine-Arginine Auxotroph Cures Orthotopic Human Breast Tumors in Nude Mice
2006
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Breast Cancer–Associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells
2005
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Diabetes and Cancer
2010 Standout
Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation
2020
Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice.
2009
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
2014
Cancer-specific mutations in PIK3CA are oncogenic in vivo
2006
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Metabolic reprogramming and cancer progression
2020 StandoutScience
PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target
2006
Cancer Genome Landscapes
2013 StandoutScience
Hypoxia-inducible factor 1-dependent expression of platelet-derived growth factor B promotes lymphatic metastasis of hypoxic breast cancer cells
2012 StandoutNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Class 1A PI3K regulates vessel integrity during development and tumorigenesis
2008
Use and Abuse of RNAi to Study Mammalian Gene Function
2012 StandoutScienceNobel
Genetics and biology of pancreatic ductal adenocarcinoma
2016
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Escherichia coli Nissle 1917 Facilitates Tumor Detection by Positron Emission Tomography and Optical Imaging
2008
Engineered bidirectional communication mediates a consensus in a microbial biofilm consortium
2007 StandoutNobel
Akt Signaling and Cancer: Surviving but not Moving On
2006
Works of Ian Cheong being referenced
Genetic inactivation of AKT1 , AKT2 , and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation
2010
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
2009 Science
A Bacterial Protein Enhances the Release and Efficacy of Liposomal Cancer Drugs
2006 Science
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
2005
Targeting Vascular and Avascular Compartments of Tumors withC. novyi-NTand Anti-microtubule Agents
2004
Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers
2003
The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT
2006
A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane
2009
Imaging bacterial infections with radiolabeled 1-(2′-deoxy-2′-fluoro-β-D-arabinofuranosyl)-5-iodouracil
2005
Targeting Cancer with Bugs and Liposomes: Ready, Aim, Fire
2007
Bacteriolytic therapy can generate a potent immune response against experimental tumors
2004
Overcoming the hypoxic barrier to radiation therapy with anaerobic bacteria
2003