Standout Papers
- Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells (2003)
- Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4 (1998)
- Nanog Is the Gateway to the Pluripotent Ground State (2009)
- BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3 (2003)
Citation Impact
Citing Papers
Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer
2005 StandoutNobel
Generation of human induced pluripotent stem cells from dermal fibroblasts
2008
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
2007 StandoutScience
Self-renewal of embryonic stem cells by a small molecule
2006
Genome-wide gain-of-function screen identifies novel regulators of pluripotency
2010
Esrrb Is a Pivotal Target of the Gsk3/Tcf3 Axis Regulating Embryonic Stem Cell Self-Renewal
2012
Conserved POU Binding DNA Sites in the Sox2 Upstream Enhancer Regulate Gene Expression in Embryonic and Neural Stem Cells
2004
Transcriptional Regulation of Nanog by OCT4 and SOX2
2005
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Mesp1 Acts as a Master Regulator of Multipotent Cardiovascular Progenitor Specification
2008
Hallmarks of Cancer: The Next Generation
2011 Standout
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Dissecting self-renewal in stem cells with RNA interference
2006 Nature
Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex
2002
A protein interaction network for pluripotency of embryonic stem cells
2006 Nature
Genetic and Epigenetic Regulators of Pluripotency
2007
Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells
2007 StandoutNobel
Control of the Embryonic Stem Cell State
2011
Nodal inhibits differentiation of human embryonic stem cells along the neuroectodermal default pathway
2004
Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1
2011 StandoutNatureNobel
Oct-3/4 and Sox2 Regulate Oct-3/4 Gene in Embryonic Stem Cells
2004
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Direct cell reprogramming is a stochastic process amenable to acceleration
2009 Nature
Multipotent cell lineages in early mouse development depend on SOX2 function
2003 Standout
Chromatin Connections to Pluripotency and Cellular Reprogramming
2011
Capturing Pluripotency
2008
Changing potency by spontaneous fusion
2002 StandoutNature
Type I iodothyronine deiodinase is a selenocysteine-containing enzyme
1991 StandoutNature
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
2004
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
2008
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
2007 StandoutNobel
Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells
2004
The ground state of embryonic stem cell self-renewal
2008 StandoutNature
Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition
2008
22q11.21 Deletion Syndromes: A Review of Proximal, Central, and Distal Deletions and Their Associated Features
2015 Standout
An RNAi Screen of Chromatin Proteins Identifies Tip60-p400 as a Regulator of Embryonic Stem Cell Identity
2008
Variation in the safety of induced pluripotent stem cell lines
2009 StandoutNobel
Pax6 Is a Human Neuroectoderm Cell Fate Determinant
2010
Derivation of Embryonic Stem-Cell Lines from Human Blastocysts
2004
Single-Molecule Dynamics of Enhanceosome Assembly in Embryonic Stem Cells
2014 StandoutNobel
Forcing cells to change lineages
2009 Nature
Genome editing reveals a role for OCT4 in human embryogenesis
2017 Nature
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
2000 Standout
SetDB1 contributes to repression of genes encoding developmental regulators and maintenance of ES cell state
2009
Differential Roles for Sox15 and Sox2 in Transcriptional Control in Mouse Embryonic Stem Cells
2005 StandoutNobel
Coevolution of HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes
2001
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
2000 StandoutNobel
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal
2009
WNT/β-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells
2005
Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation
2001
Stem cells with multilineage potential derived from porcine skin
2004
Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst
2010
Evidence for specific selenium target tissues and new biologically important selenoproteins
1988
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
2008
Internal ribosome entry sites and dicistronic RNAs in mammalian transgenesis
1995
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
2013
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
2005
Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro
2000 Standout
Oct4 distribution and level in mouse clones: consequences for pluripotency
2002
A novel mechanism for regulating clonal propagation of mouse ES cells
2004
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
2012 Nature
A core Klf circuitry regulates self-renewal of embryonic stem cells
2008
Reprogramming towards pluripotency requires AID-dependent DNA demethylation
2009 Nature
Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo
2002
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
The transcriptional and signalling networks of pluripotency
2011
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc
2007
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
2013 StandoutNature
Defining Molecular Cornerstones during Fibroblast to iPS Cell Reprogramming in Mouse
2008
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
2005 Standout
TGFβ in Cancer
2008 Standout
Derivation of pluripotent epiblast stem cells from mammalian embryos
2007 StandoutNature
Dnmt2 is not required for de novo and maintenance methylation of viral DNA in embryonic stem cells
1998
Ronin Is Essential for Embryogenesis and the Pluripotency of Mouse Embryonic Stem Cells
2008
Notch signalling regulates stem cell numbers in vitro and in vivo
2006 Nature
New cell lines from mouse epiblast share defining features with human embryonic stem cells
2007 StandoutNature
Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming
2010
DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development
1999 Standout
Stem Cells and Cancer
2004 Standout
Derivation and Manipulation of Murine Embryonic Stem Cells
2008
Functional Redundancy of GSK-3α and GSK-3β in Wnt/β-Catenin Signaling Shown by Using an Allelic Series of Embryonic Stem Cell Lines
2007
Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
2008
Revealing the world of RNA interference
2004 StandoutNatureNobel
Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human
2004
PU.1 Activates Transcription of SHP-1 Gene in Hematopoietic Cells
2007
Nuclear reprogramming and pluripotency
2006 Nature
Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells
2015 Standout
Chromatin signatures of pluripotent cell lines
2006
Histone arginine methylation regulates pluripotency in the early mouse embryo
2007 Nature
Interaction between Oct3/4 and Cdx2 Determines Trophectoderm Differentiation
2005
Molecular signature of human embryonic stem cells and its comparison with the mouse
2003
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
2010 StandoutNature
A Shift from Reversible to Irreversible X Inactivation Is Triggered during ES Cell Differentiation
2000
Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells
2006
Signalling, cell cycle and pluripotency in embryonic stem cells
2002
Defined Conditions for Neural Commitment and Differentiation
2003
Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming
2012
Embryonic stem cell differentiation: emergence of a new era in biology and medicine
2005
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Eomesodermin is required for mouse trophoblast development and mesoderm formation
2000 StandoutNatureNobel
Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
2002 StandoutNature
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
2003 Standout
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
2003 Standout
Directly Reprogrammed Fibroblasts Show Global Epigenetic Remodeling and Widespread Tissue Contribution
2007
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
1999
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells
2009
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
2013 Standout
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development
2003
Assessing Self-Renewal and Differentiation in Human Embryonic Stem Cell Lines
2005
Embryo-Derived Stem Cells: Of Mice and Men
2001
Oct-4 Knockdown Induces Similar Patterns of Endoderm and Trophoblast Differentiation Markers in Human and Mouse Embryonic Stem Cells
2004
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst
2005
High‐Efficiency RNA Interference in Human Embryonic Stem Cells
2005
Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons
2007
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells
2008 StandoutNobel
Oct‐4 : Gatekeeper in the Beginnings of Mammalian Development
2001
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification
2007
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
2007
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells
2006
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
1998 StandoutNobel
Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4
2004
Regulated expression of P210 Bcr-Abl during embryonic stem cell differentiation stimulates multipotential progenitor expansion and myeloid cell fate
2000
Selenocysteine tRNA[Ser]Sec gene is ubiquitous within the animal kingdom.
1990
Reactivation of the Paternal X Chromosome in Early Mouse Embryos
2004 StandoutScienceNobel
The Gene for the Embryonic Stem Cell Coactivator UTF1 Carries a Regulatory Element Which Selectively Interacts with a Complex Composed of Oct-3/4 and Sox-2
1999
LIF/STAT3 Signaling Fails to Maintain Self‐Renewal of Human Embryonic Stem Cells
2004
The Histone Demethylase KDM5b/JARID1b Plays a Role in Cell Fate Decisions by Blocking Terminal Differentiation
2008
Formation of a primitive ectoderm like cell population, EPL cells, from ES cells in response to biologically derived factors
1999
Molecular Mechanism to Maintain Stem Cell Renewal of ES Cells.
2001
Nuclear reprogramming in heterokaryons is rapid, extensive, and bidirectional
2009
Histone Code Modifications on Pluripotential Nuclei of Reprogrammed Somatic Cells
2004
Human embryonic stem cells: prospects for development
2004
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
2007
Selenocysteine tRNA[Ser]Sec Gene Is Ubiquitous within the Animal Kingdom
1990
Derivation of germ-line-competent embryonic stem cell lines from preblastocyst mouse embryos
2005
Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning
2006
The Polycomb Group Protein Suz12 Is Required for Embryonic Stem Cell Differentiation
2007
Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells
2005 Science
Fbx15 Is a Novel Target of Oct3/4 but Is Dispensable for Embryonic Stem Cell Self-Renewal and Mouse Development
2003 StandoutNobel
Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development.
2002
Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression
2005
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules
2010
Activin/Nodal and FGF pathways cooperate to maintain pluripotency of human embryonic stem cells
2005
LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism
2005
TGFβ/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells
2005
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Spatiotemporal Recapitulation of Central Nervous System Development by Murine Embryonic Stem Cell-Derived Neural Stem/Progenitor Cells
2008
Klf4 Cooperates with Oct3/4 and Sox2 To Activate the Lefty1 Core Promoter in Embryonic Stem Cells
2006
Transcriptome Profiling of Human and Murine ESCs Identifies Divergent Paths Required to Maintain the Stem Cell State
2005
Defining a Developmental Path to Neural Fate by Global Expression Profiling of Mouse Embryonic Stem Cells and Adult Neural Stem/Progenitor Cells
2005
Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2
1999 StandoutNobel
Promotion of Trophoblast Stem Cell Proliferation by FGF4
1998 Science
Genesis of embryonic stem cells
2003
Brd4 Is Required for Recovery from Antimicrotubule Drug-induced Mitotic Arrest: Preservation of Acetylated Chromatin
2005
Incomplete reactivation ofOct4-related genes in mouse embryos cloned from somatic nuclei
2003
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
Nuclear Cloning and Epigenetic Reprogramming of the Genome
2001 Science
Works of Ian Chambers being referenced
Molecular Coupling of Xist Regulation and Pluripotency
2008 Science
The Molecular Basis of Pluripotency in Mouse Embryonic Stem Cells
2004
Paracrine induction of stem cell renewal by LIF-deficient cells
1998
An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells
2010
Nanog Is the Gateway to the Pluripotent Ground State
2009 StandoutNobel
Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells
2012
Molecular coupling of Tsix regulation and pluripotency
2010 Nature
Derivation of Germline Competent Embryonic Stem Cells with a Combination of Interleukin-6 and Soluble Interleukin-6 Receptor
1994
Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis
1996
Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory Pathway
1998
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
1998 Standout
Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation
2002
BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3
2003 Standout
Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells
2003 Standout
Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways
1994
Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells
1999
Nanog safeguards pluripotency and mediates germline development
2007 Nature
The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells
2011
Self-renewal of teratocarcinoma and embryonic stem cells
2004
Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles
2003
Nanog promotes transfer of pluripotency after cell fusion
2006 Nature
Signaling Mechanisms Regulating Self-Renewal and Differentiation of Pluripotent Embryonic Stem Cells
1999
The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the ‘termination’ codon, TGA.
1986
Estrogen-Related Receptor Beta Interacts with Oct4 To Positively Regulate Nanog Gene Expression
2008
Phenotypic Complementation Establishes Requirements for Specific POU Domain and Generic Transactivation Function of Oct-3/4 in Embryonic Stem Cells
2002
The transcriptional foundation of pluripotency
2009
Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines
2001
Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3' enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors.
1993
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
1994
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
1998
Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage
2014