Standout Papers
Citation Impact
Citing Papers
Identification of factors required for m 6 A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI
2017
N6-Methyladenosine Modulates Nonsense-Mediated mRNA Decay in Human Glioblastoma
2019
Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II–associated methyltransferase
2018 Science
RNA modifications modulate gene expression during development
2018 Science
The emerging biology of RNA post-transcriptional modifications
2016
METTL3-mediated m 6 A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance
2019
Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA
2014
Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1
2019
N 6 ‐Methyladenosine‐Sensitive RNA‐Cleaving Deoxyribozymes
2018
The RNA m 6 A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence
2017
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
2019
The Role of m6A/m-RNA Methylation in Stress Response Regulation
2018
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cells
2019
MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein
2017
How do cells cope with RNA damage and its consequences?
2019
Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo
2019
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets
2018
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal
2018
METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma
2019
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein–RNA Interactome
2017
Dynamic m 6 A modification and its emerging regulatory role in mRNA splicing
2015
S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1
2017
The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway
2019
The role of m6A RNA methylation in human cancer
2019 Standout
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression
2018
N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription
2020 Science
N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer
2019
YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma
2019
Identifying sequence features that drive ribosomal association for lncRNA
2018
Engineering precision nanoparticles for drug delivery
2020 Standout
Lipid-nanoparticle-encapsulated mRNA vaccines induce protective memory CD8 T cells against a lethal viral infection
2021 StandoutNobel
Coronavirus biology and replication: implications for SARS-CoV-2
2020 Standout
Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase
2018
Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis
2017
The Biogenesis, Functions, and Challenges of Circular RNAs
2018 Standout
m6A modification controls the innate immune response to infection by targeting type I interferons
2018
Extensive translation of circular RNAs driven by N6-methyladenosine
2017
The m6A reader protein YTHDC2 interacts with the small ribosomal subunit and the 5′–3′ exoribonuclease XRN1
2018
N6-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics
2016
Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm
2018
N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
2017
Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance
2017
N6-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
2016
Posttranscriptional m6A Editing of HIV-1 mRNAs Enhances Viral Gene Expression
2016
mRNA vaccines — a new era in vaccinology
2018 StandoutNobel
EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis
2019
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation
2017
Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins
2015
A brave new world of RNA-binding proteins
2018
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesis
2019
Lipid nanoparticles for mRNA delivery
2021 Standout
YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex
2016
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPG
2019
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation
2018 Nature
Enantioselective Synthesis of Allylboronates and Allylic Alcohols by Copper‐Catalyzed 1,6‐Boration
2014
Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery
2021 StandoutNobel
Cracking the epitranscriptome
2016
PECAM-1 directed re-targeting of exogenous mRNA providing two orders of magnitude enhancement of vascular delivery and expression in lungs independent of apolipoprotein E-mediated uptake
2018 StandoutNobel
A dynamic N6-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitors
2018
N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection
2016
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
2016
Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
2016
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3
2019
METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
2019
RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding
2017
The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
2016
Dynamics of Human and Viral RNA Methylation during Zika Virus Infection
2016
m6A-LAIC-seq reveals the census and complexity of the m6A epitranscriptome
2016
Interactions, localization, and phosphorylation of the m6A generating METTL3–METTL14–WTAP complex
2018
Programmable RNA-Guided RNA Effector Proteins Built from Human Parts
2019
Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex
2019
Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation
2017
Asymmetric Diboration of Terminal Alkenes with a Rhodium Catalyst and Subsequent Oxidation: Enantioselective Synthesis of Optically Active 1,2‐Diols
2013
Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain
2018 StandoutNobel
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
2017
Recent advances in mRNA vaccine technology
2020 StandoutNobel
Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism
2018 Standout
Epitranscriptomic influences on development and disease
2017
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cells
2019 Nature
Pre-mRNA processing includes N6 methylation of adenosine residues that are retained in mRNA exons and the fallacy of “RNA epigenetics”
2017
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery
2021 StandoutNobel
m 6 A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program
2017
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
m6A modulates haematopoietic stem and progenitor cell specification
2017 Nature
Delivery technologies for cancer immunotherapy
2019 Standout
Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation
2017
Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates
2019 Standout
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation
2015
Structural and molecular mechanisms for the control of eukaryotic 5′–3′ mRNA decay
2018
RNA structure maps across mammalian cellular compartments
2019
Exploring in vitro expression and immune potency in mice using mRNA encoding the Plasmodium falciparum malaria antigen, CelTOS
2022 StandoutNobel
N6-Methyladenosine Modification in a Long Noncoding RNA Hairpin Predisposes Its Conformation to Protein Binding
2015
m6A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination
2016 Nature
Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts
2018
<p>RNA m<sup>6</sup>A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway</p>
2019
WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
2019
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
2018
N6-Methyladenosine Guides mRNA Alternative Translation during Integrated Stress Response
2018
Critical Enzymatic Functions of FTO in Obesity and Cancer
2018
Gene Architecture and Sequence Composition Underpin Selective Dependency of Nuclear Export of Long RNAs on NXF1 and the TREX Complex
2020
Role of N6-methyladenosine modification in cancer
2017
Atlas of Subcellular RNA Localization Revealed by APEX-Seq
2019
Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs
2017
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
2018
An N-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells
2018
ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1
2019
mRNA vaccine with unmodified uridine induces robust type I interferon-dependent anti-tumor immunity in a melanoma model
2022 StandoutNobel
Materials for non-viral intracellular delivery of messenger RNA therapeutics
2015
mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis
2018 Nature
N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis
2017
RNA m6A methylation regulates the ultraviolet-induced DNA damage response
2017 Nature
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
2019 Standout
Direct RNA nanopore sequencing of full-length coronavirus genomes provides novel insights into structural variants and enables modification analysis
2019
Ythdf2-mediated m6A mRNA clearance modulates neural development in mice
2018
MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62
2019
5′ UTR m6A Promotes Cap-Independent Translation
2015 Standout
Dynamic m6A mRNA methylation directs translational control of heat shock response
2015 Nature
Dynamic m6A modification regulates local translation of mRNA in axons
2017
RNA N6-methyladenosine modification in cancers: current status and perspectives
2018
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover
2017
Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis
2017 Standout
N6-Methyladenosine Modification Controls Circular RNA Immunity
2019
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
2017 Nature
m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
2020 Standout
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
2019
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor
2018
The biogenesis, biology and characterization of circular RNAs
2019 Standout
An RNA-centric dissection of host complexes controlling flavivirus infection
2019 StandoutNobel
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA
2017
Catalytic Asymmetric Synthesis of Phosphine Boronates
2015 StandoutNobel
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β
2018
The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA
2016 Nature
Biomedical applications of mRNA nanomedicine
2018
Regulation of m6A Transcripts by the 3ʹ→5ʹ RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline
2017
YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma
2018
Reading, writing and erasing mRNA methylation
2019 Standout
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
2019
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma
2019
DART-seq: an antibody-free method for global m6A detection
2019
RNA N 6-Methyladenosine Modification in Normal and Malignant Hematopoiesis
2019
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
2017
N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice
2015
Structural basis of N6-adenosine methylation by the METTL3–METTL14 complex
2016 Nature
m6A RNA methylation promotes XIST-mediated transcriptional repression
2016 Nature
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
2019
The Biogenesis and Precise Control of RNA m6A Methylation
2019
Reading m6A in the Transcriptome: m6A-Binding Proteins
2017
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis
2017
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition
2018
Transient N-6-Methyladenosine Transcriptome Sequencing Reveals a Regulatory Role of m6A in Splicing Efficiency
2018
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells
2016
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
N 6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein
2017
Human METTL16 is a N 6 ‐methyladenosine (m 6 A) methyltransferase that targets pre‐mRNAs and various non‐coding RNAs
2017
Rational design of anti‐inflammatory lipid nanoparticles for mRNA delivery
2022 StandoutNobel
Monofluorination of Organic Compounds: 10 Years of Innovation
2015 Standout
Iron Catalysis in Organic Synthesis
2015 Standout
Pseudouridinylation of mRNA coding sequences alters translation
2019
3d Transition Metals for C–H Activation
2018 Standout
Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy
2023 StandoutNobel
m6A: Signaling for mRNA splicing
2016
Identification of a selective DNA ligase for accurate recognition and ultrasensitive quantification of N6-methyladenosine in RNA at one-nucleotide resolution
2018
An Elongation‐ and Ligation‐Based qPCR Amplification Method for the Radiolabeling‐Free Detection of Locus‐Specific N6‐Methyladenosine Modification
2018
Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta
2023 StandoutNobel
Resolution of Diols via Catalytic Asymmetric Acetalization
2015 StandoutNobel
N6-methyladenosine modification and METTL3 modulate enterovirus 71 replication
2018
N6-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression
2018
Stereochemical Control via Chirality Pairing: Stereodivergent Syntheses of Enantioenriched Homoallylic Alcohols
2021
Rethinking m6A Readers, Writers, and Erasers
2017
Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer
2017
Structural insights into FTO’s catalytic mechanism for the demethylation of multiple RNA substrates
2019
Detection ofN6-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease
2017
Advances in Biomaterials for Drug Delivery
2018
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Enantioselective Synthesis of Anti Homoallylic Alcohols from Terminal Alkynes and Aldehydes Based on Concomitant Use of a Cationic Iridium Complex and a Chiral Phosphoric Acid
2013
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3′-UTR mRNAs in male germ cells
2017
Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution
2017
Dysregulated N6‐methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer
2019
Stronger together for in-cell translation: natural and unnatural base modified mRNA
2022
ANKLE1 N6‐Methyladenosine‐related variant is associated with colorectal cancer risk by maintaining the genomic stability
2019
Engineering of a DNA Polymerase for Direct m6A Sequencing
2017
Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell Carcinoma
2020
Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization and IL-17 expression
2019 StandoutNobel
Sustainable Conversion of Carbon Dioxide: An Integrated Review of Catalysis and Life Cycle Assessment
2017 Standout
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
2018
Long noncoding RNA GAS5-AS1 suppresses growth and metastasis of cervical cancer by increasing GAS5 stability.
2019
The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies
2021 Standout
Ionizable lipid nanoparticles for in utero mRNA delivery
2021 StandoutNobel
RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview
2018
RNA N6‐methyladenosine methyltransferase‐like 3 promotes liver cancer progression through YTHDF2‐dependent posttranscriptional silencing of SOCS2
2017
Enantioselective Synthesis of Allylboronates and Allylic Alcohols by Copper‐Catalyzed 1,6‐Boration
2014
N6‐Methyladenosine‐Sensitive RNA‐Cleaving Deoxyribozymes
2018
Regioselective Copper-Catalyzed Carboxylation of Allylboronates with Carbon Dioxide
2013
ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2
2018
Structure and Thermodynamics of N6-Methyladenosine in RNA: A Spring-Loaded Base Modification
2015
A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA
2022 StandoutNobel
m6ASNP: a tool for annotating genetic variants by m6A function
2018
Kaposi's Sarcoma-Associated Herpesvirus Utilizes and Manipulates RNA N 6 -Adenosine Methylation To Promote Lytic Replication
2017
m6A modulates neuronal functions and sex determination in Drosophila
2016 Nature
Chiral Phosphoric Acid Catalyzed Conversion of Epoxides into Thiiranes: Mechanism, Stereochemical Model, and New Catalyst Design
2021 StandoutNobel
RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2
2019
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
Xio is a component of the Drosophila sex determination pathway and RNA N 6 -methyladenosine methyltransferase complex
2018
METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N 6‐methyladenosine‐dependent primary MicroRNA processing
2016
Tandem Reactions Involving 1-Silyl-3-Boryl-2-Alkenes. New Access to (Z)-1-Fluoro-1-Alkenes, Allyl Fluorides, and Diversely α-Substituted Allylboronates
2013
Stereochemical Control via Chirality Pairing: Stereodivergent Syntheses of Enantioenriched Homoallylic Alcohols
2021
SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function
2018
Structural insights into the molecular mechanism of the m6A writer complex
2016
Precise Antibody-Independent m6A Identification via 4SedTTP-Involved and FTO-Assisted Strategy at Single-Nucleotide Resolution
2018
Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma
2018
Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs
2018
Copper-Catalyzed Enantioselective Coupling between Allylboronates and Phosphates Using a Phenol–Carbene Chiral Ligand: Asymmetric Synthesis of Chiral Branched 1,5-Dienes
2018
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
2020 StandoutNobel
The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline
2017
“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates
2017 StandoutNobel
Detecting RNA modifications in the epitranscriptome: predict and validate
2017
N6-methyladenosine–encoded epitranscriptomics
2016
Works of Ian A. Roundtree being referenced
Single-base mapping of m 6 A by an antibody-independent method
2019
RNA epigenetics — chemical messages for posttranscriptional gene regulation
2015
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
2015 Standout
Post-transcriptional gene regulation by mRNA modifications
2016 Standout
Dynamic RNA Modifications in Gene Expression Regulation
2017 Standout
Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain
2014
A Catalytic Enantioselective Tandem Allylation Strategy for Rapid Terpene Construction: Application to the Synthesis of Pumilaside Aglycon
2013
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs
2017
Ni- and Pd-Catalyzed Synthesis of Substituted and Functionalized Allylic Boronates
2012