Standout Papers
- Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. (1997)
- p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. (1994)
Citation Impact
Citing Papers
A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
2005 StandoutNobel
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 StandoutScience
TOR Signaling in Growth and Metabolism
2006 Standout
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress
1995
Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
1995
Mdm2 promotes the rapid degradation of p53
1997 StandoutNature
Signal transduction and transcription factors in rheumatic disease
1999
β-Arrestin Is Crucial for Ubiquitination and Down-regulation of the Insulin-like Growth Factor-1 Receptor by Acting as Adaptor for the MDM2 E3 Ligase
2005 StandoutNobel
Ionization Rates in a Bose-Einstein Condensate of Metastable Helium
2002 StandoutNobel
Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
2005 StandoutNature
Mechanism of Action of Camptothecin
2000
Caenorhabditis elegans pathways that surveil and defend mitochondria
2014 StandoutNatureNobel
Molecular mechanisms of drug resistance
2005
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Cancer drug resistance: an evolving paradigm
2013 Standout
Regulation of DNA replication and repair proteins through interaction with the front side of proliferating cell nuclear antigen
1998
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
When Checkpoints Fail
1997 StandoutNobel
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
1996 StandoutNature
Combination of irinotecan (CPT11) and 5-fluorouracil with an analysis of cellular determinants of drug activity
1998
Gene expression patterns associated with p53 status in breast cancer
2006
Molecular mechanisms of cisplatin resistance
2011 Standout
Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen
1994 Science
Significant correlation of monocyte chemoattractant protein-1 expression with neovascularization and progression of breast carcinoma
2001
Regulation of angiogenesis by hypoxia: role of the HIF system
2003 StandoutNobel
Hypoxia Inhibits G1/S Transition through Regulation of p27 Expression
2001 StandoutNobel
Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
1997
The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage
1999 StandoutNatureNobel
A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines 1 1Edited by A. R. Fersht
2000
A model for p53-induced apoptosis
1997 StandoutNature
p53 gene mutations are associated with poor survival in low and low-intermediate risk diffuse large B-cell lymphomas
2002
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
2003 StandoutNature
Mechanisms of tolerance to DNA damaging therapeutic drugs
2001
Mechanism of Action of Camptothecin
1996
Metastatic colonization by circulating tumour cells
2016 StandoutNature
The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression
1996 StandoutNobel
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
1999 StandoutNature
Retinoids: present role and future potential
1999
Excision Repair in Mammalian Cells
1995 StandoutNobel
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
2011 StandoutNature
The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation
2005
Mechanisms of resistance to cisplatin
2001
The p66shc adaptor protein controls oxidative stress response and life span in mammals
1999 StandoutNature
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
bax -deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis
1997
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Spectra of Spontaneous and X-Ray-Induced Mutations at the hprt Locus in Related Human Lymphoblast Cell Lines That Express Wild-Type or Mutant p53
1995
Phosphorylated and unphosphorylated forms of human single-stranded DNA-binding protein are equally active in simian virus 40 DNA replication and in nucleotide excision repair.
1995
Karyotypic complexity of the NCI-60 drug-screening panel.
2003
The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.
1994
Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact.
2000
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
2011 Standout
p53 and Ceramide as Collaborators in the Stress Response
2013
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
Cancer Cell Cycles
1996 StandoutScience
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
2001
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
1998 StandoutScience
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
p53-dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cells
1998
Growth factor modulation of p53-mediated growth arrest versus apoptosis.
1995
Target-Oriented and Diversity-Oriented Organic Synthesis in Drug Discovery
2000 StandoutScience
Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis
2000 StandoutScience
Structure of P-Glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding
2009 StandoutScience
Phthalascidin, a synthetic antitumor agent with potency and mode of action comparable to ecteinascidin 743
1999
Response: Does the p53 Up-Regulated Gadd45 Protein Have a Role in Excision Repair?
1995 Science
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.
1994
Relationship of sequence-specific transactivation and p53-regulated apoptosis in interleukin 3-dependent hematopoietic cells.
1996
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
1998 StandoutScience
Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.
2001
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts
2004
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.
1995 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Cellular pharmacology of the combination of the DNA topoisomerase I inhibitor SN-38 and the diaminocyclohexane platinum derivative oxaliplatin.
1999
Cell Cycle Checkpoints: Preventing an Identity Crisis
1996 StandoutScience
A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.
1996
Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
2004 StandoutScience
Works of I Bae being referenced
Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.
1997 StandoutNobel
Topoisomerase I-related parameters and camptothecin activity in the colon carcinoma cell lines from the National Cancer Institute anticancer screen.
1995
p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents.
1994 StandoutNobel
Characterization of human Gadd45, a p53-regulated protein.
1994
The p53-dependent gamma-ray response of GADD45.
1994