Standout Papers
Citation Impact
Citing Papers
S6K1 −/− / S6K2 −/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway
2004
Hypothalamic mTOR Signaling Regulates Food Intake
2006 Science
Suppression of Aging in Mice by the Hormone Klotho
2005 StandoutScience
mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs
2010 Science
Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens
2003 StandoutScienceNobel
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
2007
Long-Lived Drosophila with Overexpressed dFOXO in Adult Fat Body
2004 Science
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
Systematic Identification of Pathways That Couple Cell Growth and Division in Yeast
2002 Science
Biochemical and Functional Characterizations of Small GTPase Rheb and TSC2 GAP Activity
2004
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control
2005
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway
2002 Standout
TOR Signaling in Growth and Metabolism
2006 Standout
TOR complex 2 is needed for cell cycle progression and anchorage-independent growth of MCF7 and PC3 tumor cells
2008
Nutritional control of gene expression in Drosophila larvae via TOR, Myc and a novel cis-regulatory element
2010
The Spectrin cytoskeleton regulates the Hippo signalling pathway
2015
Hypoinsulinaemia, glucose intolerance and diminished β-cell size in S6K1-deficient mice
2000 Nature
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
2001 Standout
The Plasticity of Aging: Insights from Long-Lived Mutants
2005
Differential Membrane Localization of ERas and Rheb, Two Ras-related Proteins Involved in the Phosphatidylinositol 3-Kinase/mTOR Pathway
2005 StandoutNobel
The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity
2001
Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast
2005
Extending the lifespan of long-lived mice
2001 Nature
The Drosophila Tuberous Sclerosis Complex Gene Homologs Restrict Cell Growth and Cell Proliferation
2001
Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression
2000
The interaction between FOXO and SIRT1: tipping the balance towards survival
2004
PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis
2007
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
2002
MicroRNAs
2004 Standout
PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase
2007
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
2000
The Tuberous Sclerosis Complex
2006 Standout
Will mTOR inhibitors make it as cancer drugs?
2003
The tor pathway: a target for cancer therapy
2004 Standout
Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body
2004
TOR signalling in bugs, brain and brawn
2003
Inactivation of the Tuberous Sclerosis Complex-1 and -2 Gene Products Occurs by Phosphoinositide 3-Kinase/Akt-dependent and -independent Phosphorylation of Tuberin
2003
Rheb Binds Tuberous Sclerosis Complex 2 (TSC2) and Promotes S6 Kinase Activation in a Rapamycin- and Farnesylation-dependent Manner
2003
A systematic RNAi screen for longevity genes in C. elegans
2005 StandoutNobel
Tsc tumour suppressor proteins antagonize amino-acid–TOR signalling
2002
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
2003
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase
2005
Yap1 Acts Downstream of α-Catenin to Control Epidermal Proliferation
2011
Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
2002
Identification of S6 Kinase 1 as a Novel Mammalian Target of Rapamycin (mTOR)-phosphorylating Kinase
2005
The expanding TOR signaling network
2005
Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin
2000
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
2004
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway
1999
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
2002 Standout
High-resolution cryo-electron microscopy structure of the Trypanosoma brucei ribosome
2013 StandoutNatureNobel
Cell Cycle-regulated Phosphorylation of Hamartin, the Product of the Tuberous Sclerosis Complex 1 Gene, by Cyclin-dependent Kinase 1/Cyclin B
2003
Molecular medicine for the brain: silencing of disease genes with RNA interference
2004
Regulation of translation initiation by FRAP/mTOR
2001
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
2004 StandoutNobel
RAS and RHO GTPases in G1-phase cell-cycle regulation
2004
Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia
2001
Salt-inducible kinases regulate growth through the Hippo signalling pathway in Drosophila
2012
Dpp Gradient Formation in the Drosophila Wing Imaginal Disc
2000
Tuberin Regulates p70 S6 Kinase Activation and Ribosomal Protein S6 Phosphorylation
2002
Genetic analysis of insulin signaling in Drosophila
2002
The Drosophila Circadian Network Is a Seasonal Timer
2007 StandoutNobel
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body
2004 Nature
Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency
2005
Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner
2005
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
2002 Standout
TOR, a Central Controller of Cell Growth
2000 Standout
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Inactivation of Conserved C. elegans Genes Engages Pathogen- and Xenobiotic-Associated Defenses
2012 StandoutNobel
hippo Encodes a Ste-20 Family Protein Kinase that Restricts Cell Proliferation and Promotes Apoptosis in Conjunction with salvador and warts
2003
mTOR, translational control and human disease
2005
IRS-2 pathways integrate female reproduction and energy homeostasis
2000 Nature
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
2007 Nature
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb
2003 Standout
Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2
2003
GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR
2003
A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
2003
The genetic control of organ growth: insights from Drosophila
2000
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Rapamycin‐sensitive phase of 3T3‐L1 preadipocyte differentiation after clonal expansion
2001
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
2002 StandoutNature
The Sterile 20-like Kinase Tao-1 Controls Tissue Growth by Regulating the Salvador-Warts-Hippo Pathway
2011
Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
2015 Standout
Lifespan Regulation by Evolutionarily Conserved Genes Essential for Viability
2007 StandoutNobel
Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner
2010
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling
2002
Rheb promotes cell growth as a component of the insulin/TOR signalling network
2003
Target of Rapamycin (TOR)-signaling and RAIP Motifs Play Distinct Roles in the Mammalian TOR-dependent Phosphorylation of Initiation Factor 4E-binding Protein 1
2003
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
2001
The Drosophila Cyclin D-Cdk4 complex promotes cellular growth
2000
Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype – phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex
2005
The conserved PI3′K/PTEN/Akt signaling pathway regulates both cell size and survival in Drosophila
2000
4E-BP Extends Lifespan upon Dietary Restriction by Enhancing Mitochondrial Activity in Drosophila
2009
MAP4K family kinases act in parallel to MST1/2 to activate LATS1/2 in the Hippo pathway
2015
Insulin and insulin-like growth factor signalling in neoplasia
2008 Standout
Mitochondria, Oxidants, and Aging
2005 Standout
The Caenorhabditis elegans Germ Line Regulates Distinct Signaling Pathways to Control Lifespan and Innate Immunity
2009
The Hippo Signaling Pathway in Development and Cancer
2010 Standout
Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster
2004
Upstream and downstream of mTOR
2004 Standout
Does the ribosome translate cancer?
2003
SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response
2003
The Farnesyl Transferase Inhibitor (FTI) SCH66336 (lonafarnib) Inhibits Rheb Farnesylation and mTOR Signaling
2005
MicroRNA Pathways in Flies and Worms
2003 StandoutNobel
Distinct effects of single amino-acid changes to tuberin on the function of the tuberin–hamartin complex
2004
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
2003 StandoutNobel
Insulin Receptor Substrate and p55 Orthologous Adaptor Proteins Function in the Caenorhabditis elegans daf-2/Insulin-like Signaling Pathway
2002 StandoutNobel
Chapter 1 Physiological Roles of Ribosomal Protein S6: One of Its Kind
2008
Regulation of PTEN Transcription by p53
2001
TOR Deficiency in C. elegans Causes Developmental Arrest and Intestinal Atrophy by Inhibition of mRNA Translation
2002
Phosphorylation and Functional Inactivation of TSC2 by Erk
2005 Standout
cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
2013
Ribosomal S6 Kinase Signaling and the Control of Translation
1999
Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase
2005
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Rheb Binds and Regulates the mTOR Kinase
2005
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
2006
The Hippo pathway: regulators and regulations
2013
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
2001 Standout
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Tsc2 is not a critical target of Akt during normal Drosophila development
2004
The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals
2010
Regulation of imaginal disc cell size, cell number and organ size by Drosophila class IA phosphoinositide 3-kinase and its adaptor
1999
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
2002 Standout
Stem cells, ageing and the quest for immortality
2006 StandoutNature
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
2006
The Rheb family of GTP-binding proteins
2004
Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development
2002 Nature
Akt regulates growth by directly phosphorylating Tsc2
2002 Standout
Stress and mTORture signaling
2006
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
2005
The Cell Adhesion Molecule Echinoid Functions as a Tumor Suppressor and Upstream Regulator of the Hippo Signaling Pathway
2012
Regulation of Lifespan in Drosophila by Modulation of Genes in the TOR Signaling Pathway
2004
Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies
2004
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB
1999
The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
2001
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
2008
Identification of Dominant Negative Mutants of Rheb GTPase and Their Use to Implicate the Involvement of Human Rheb in the Activation of p70S6K
2003
Drosophila PTEN Regulates Cell Growth and Proliferation through PI3K-Dependent and -Independent Pathways
2000
Nf2 /Merlin controls progenitor homeostasis and tumorigenesis in the liver
2010
Regulation of mammalian translation factors by nutrients
2002
A Nutrient Sensor Mechanism Controls Drosophila Growth
2003
bantam Encodes a Developmentally Regulated microRNA that Controls Cell Proliferation and Regulates the Proapoptotic Gene hid in Drosophila
2003 Standout
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
2009
Neurogenesis and the Cell Cycle
2003
Insulin/IGF signalling and ageing: seeing the bigger picture
2001
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in Drosophila
2003
Growth regulation by oncogenes — new insights from model organisms
2001
Efficacy of a rapamycin analog (CCI‐779) and IFN‐γ in tuberous sclerosis mouse models
2004
Akt Activates the Mammalian Target of Rapamycin by Regulating Cellular ATP Level and AMPK Activity
2005
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size
2004
Insulin signaling pathways in cortical dysplasia and TSC‐tubers: Tissue microarray analysis
2004
Drosophila myc Regulates Cellular Growth during Development
1999
Revealing the world of RNA interference
2004 StandoutNatureNobel
The LKB1 tumor suppressor negatively regulates mTOR signaling
2004
The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
2013
The role of autophagy during the early neonatal starvation period
2004 StandoutNatureNobel
Control of growth and organ size in Drosophila
2002
Regulation of cellular growth by the Drosophila target of rapamycin dTOR
2000
Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
2001
Regulation of B-Raf Kinase Activity by Tuberin and Rheb Is Mammalian Target of Rapamycin (mTOR)-independent
2004
A Conserved Regulatory System for Aging
2001
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
Tao-1 Phosphorylates Hippo/MST Kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway
2011
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Temporal Control of Differentiation by the Insulin Receptor/Tor Pathway in Drosophila
2004
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
2012
p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling
2008
Growth Signaling: TSC Takes Its Place
2002
Mitogen‐activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
2006
Regulation of mTORC1 by amino acids
2014
Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E
2002 Nature
Autophagy regulation by nutrient signaling
2013
Rapamycin passes the torch: a new generation of mTOR inhibitors
2011
Insulin/IGF signaling drives cell proliferation in part via Yorkie/YAP
2012
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
2004
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans
2003 StandoutNature
An encore for ribosome biogenesis in the control of cell proliferation
2000
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
The functions of animal microRNAs
2004 StandoutNatureNobel
Ras1 Promotes Cellular Growth in the Drosophila Wing
2000
Tsc1+ and tsc2+ Regulate Arginine Uptake and Metabolism in Schizosaccharomyces pombe
2004
Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice
2001
The mTOR Inhibitor RAD001 Sensitizes Tumor Cells to DNA-Damaged Induced Apoptosis through Inhibition of p21 Translation
2005
Rheb fills a GAP between TSC and TOR
2003
Inactivation of Merlin in malignant mesothelioma cells and the Hippo signaling cascade dysregulation
2011
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
2004 Standout
Drosophila Tsc1 Functions with Tsc2 to Antagonize Insulin Signaling in Regulating Cell Growth, Cell Proliferation, and Organ Size
2001
Lost in translation
2004
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
2004 Standout
Dietary Restriction in Long-Lived Dwarf Flies
2002 Science
Signaling from Akt to FRAP/TOR Targets both 4E-BP and S6K in Drosophila melanogaster
2003
A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function
2001 Science
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
2005
Differential Requirement of mTOR in Postmitotic Tissues and Tumorigenesis
2009
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster
2010
Serotonin Activates S6 Kinase in a Rapamycin-Sensitive Manner inAplysiaSynaptosomes
2001
mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells
2004 StandoutNobel
Ras/Erk Signaling Is Essential for Activation of Protein Synthesis by Gq Protein-Coupled Receptor Agonists in Adult Cardiomyocytes
2002
Synthesis and Function of 3-Phosphorylated Inositol Lipids
2001 Standout
TSC2: filling the GAP in the mTOR signaling pathway
2003
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
Role of MicroRNAs in Plant and Animal Development
2003 StandoutScienceNobel
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Spectrin regulates Hippo signaling by modulating cortical actomyosin activity
2015
Shar-pei mediates cell proliferation arrest during imaginal disc growth inDrosophila
2002
mTOR Controls Cell Cycle Progression through Its Cell Growth Effectors S6K1 and 4E-BP1/Eukaryotic Translation Initiation Factor 4E
2003
FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse
2001
Hippo Pathway Regulation of Gastrointestinal Tissues
2014
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
Mutations prolong life in flies; implications for aging in mammals
2001
The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
2004
Multiple genes at 17q23 undergo amplification and overexpression in breast cancer.
2000
The Genetics of Aging
2001 StandoutNobel
Functional Studies of Shaggy/Glycogen Synthase Kinase 3 Phosphorylation Sites in Drosophila melanogaster
2004
Extended Longevity in Mice Lacking the Insulin Receptor in Adipose Tissue
2003 Science
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
2001
The Hippo pathway regulates intestinal stem cell proliferation duringDrosophilaadult midgut regeneration
2010
The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
2010
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Drosophila Melted Modulates FOXO and TOR Activity
2005
A characterization of the effects of Dpp signaling on cell growth and proliferation in theDrosophilawing
2002
Pam and Its Ortholog Highwire Interact with and May Negatively Regulate the TSC1·TSC2 Complex
2004
Phosphorylation of Tuberin as a Novel Mechanism for Somatic Inactivation of the Tuberous Sclerosis Complex Proteins in Brain Lesions
2004
Islet β cell expression of constitutively active Akt1/PKBα induces striking hypertrophy, hyperplasia, and hyperinsulinemia
2001
The NF1 tumor suppressor critically regulates TSC2 and mTOR
2005
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
2009 Standout
Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes.
2001
Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies
2003
The bantam Gene Regulates Drosophila Growth
2002
Drosophila Target of Rapamycin Kinase Functions as a Multimer
2005
Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development
2004
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase
2003
mTOR: a pharmacologic target for autophagy regulation
2015 Standout
Spinophilin regulates the formation and function of dendritic spines
2000
Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice
2002
Transduction of Growth or Mitogenic Signals into Translational Activation of TOP mRNAs Is Fully Reliant on the Phosphatidylinositol 3-Kinase-Mediated Pathway but Requires neither S6K1 nor rpS6 Phosphorylation
2002
Distinct Signaling Events Downstream of mTOR Cooperate To Mediate the Effects of Amino Acids and Insulin on Initiation Factor 4E-Binding Proteins
2005 StandoutNobel
DrosophilaRheb GTPase is required for cell cycle progression and cell growth
2003
TOR Signaling
2003
mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF†
2003
Dysregulation of the TSC-mTOR pathway in human disease
2004 Standout
Timing Requirements for Insulin/IGF-1 Signaling in C. elegans
2002 Science
Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
2013
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
The Endocrine Regulation of Aging by Insulin-like Signals
2003 Science
The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila
2010
Tuberous sclerosis complex tumor suppressor–mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
2002
Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning
2006
Hippo signaling: growth control and beyond
2010
The PI3K–PDK1 connection: more than just a road to PKB
2000
Morphogen gradient interpretation
2001 StandoutNatureNobel
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity inPten+/−mice
2001
Works of Hugo Stocker being referenced
Drosophila Pez Acts in Hippo Signaling to Restrict Intestinal Stem Cell Proliferation
2012
Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome
2011
Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4
1999
Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2
2003 Standout
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
2003
An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
2001
Genetic control of cell size
2000
The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila
2010
The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling
2003
Diet-Dependent Effects of the Drosophila Mnk1/Mnk2 Homolog Lk6 on Growth via eIF4E
2005
How Are the Sizes of Cells, Organs, and Bodies Controlled?
2003
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1
2002
Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity
2001
Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB
2002 Science
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
2001 Science
Drosophila S6 Kinase: A Regulator of Cell Size
1999 Science
Genetic control of size inDrosophila
2000
TheDrosophilainsulin/IGF receptor controls growth and size by modulating PtdInsP3 levels
2002
PDK1 regulates growth through Akt and S6K in Drosophila
2001