Standout Papers
Citation Impact
Citing Papers
CRISPR–Cas9 Structures and Mechanisms
2017 StandoutNobel
Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality
2020 StandoutNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
Origin of Antibiotics and Antibiotic Resistance, and Their Impacts on Drug Development: A Narrative Review
2023 Standout
Staphylococcus aureus virulence attenuation and immune clearance mediated by a phage lysin‐derived protein
2018
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
In Vitro and In Vivo Synergistic Therapeutic Effect of Cisplatin with Human Papillomavirus16 E6/E7 CRISPR/Cas9 on Cervical Cancer Cell Line
2016
Targeted glycan degradation potentiates the anticancer immune response in vivo
2020 StandoutNobel
CRISPR/Cas9-Derived Mutations Both Inhibit HIV-1 Replication and Accelerate Viral Escape
2016
Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme
2017 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Targeting microbial biofilms: current and prospective therapeutic strategies
2017 Standout
The ratio of CD8 + lymphocytes to tumor-infiltrating suppressive FOXP3 + effector regulatory T cells is associated with treatment response in invasive breast cancer
2022 StandoutNobel
Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review
2019 Standout
LncRNA-RMRP Acts as an Oncogene in Lung Cancer
2016
Delivery systems of CRISPR/Cas9-based cancer gene therapy
2018
Antibiotic resistance: a rundown of a global crisis
2018 Standout
Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
2020 Standout
Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications
2017
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
Prevention and treatment ofStaphylococcus aureusbiofilms
2015
A CRISPR toolbox to study virus–host interactions
2017
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
2016 StandoutNobel
Hypoxia-inducible factors in cancer stem cells and inflammation
2015
The up-regulation of long non-coding RNA CCAT2 indicates a poor prognosis for prostate cancer and promotes metastasis by affecting epithelial-mesenchymal transition
2016
ANRIL: A lncRNA at the CDKN2A/B Locus With Roles in Cancer and Metabolic Disease
2018
Effects of Linezolid on Suppressing In Vivo Production of Staphylococcal Toxins and Improving Survival Outcomes in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia
2013
Role of Antibodies in Protection Elicited by Active Vaccination with Genetically Inactivated Alpha Hemolysin in a Mouse Model of Staphylococcus aureus Skin and Soft Tissue Infections
2014
Skeletal infections: microbial pathogenesis, immunity and clinical management
2022 Standout
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
2017 StandoutNobel
Inflammation and tumor progression: signaling pathways and targeted intervention
2021 Standout
Next generation of immune checkpoint therapy in cancer: new developments and challenges
2018
The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
2021 StandoutNobel
The CRISPR-Cas immune system: Biology, mechanisms and applications
2015
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
2020 Standout
Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches
2020 StandoutNobel
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
2023 Standout
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Inhibition of HBV Expression in HBV Transgenic Mice Using AAV-Delivered CRISPR-SaCas9
2018
Animal models of obesity and diabetes mellitus
2018
Long noncoding RNA CCAT2 promotes breast tumor growth by regulating the Wnt signaling pathway
2015
<p>Antimicrobial Resistance: Implications and Costs</p>
2019 Standout
Regulatory T cells in cancer immunosuppression — implications for anticancer therapy
2019
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
A guide to cancer immunotherapy: from T cell basic science to clinical practice
2020 Standout
Synthesis of Heterobifunctional Protein Fusions Using Copper‐Free Click Chemistry and the Aldehyde Tag
2012 StandoutNobel
Vaccine review: “Staphyloccocus aureus vaccines: Problems and prospects”
2013
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
The human skin microbiome
2018 Standout
Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy
2023 StandoutNobel
Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management
2015 Standout
2016
In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges
2017
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Regulatory T Cells and Human Disease
2020 StandoutNobel
Long Noncoding RNA and Cancer: A New Paradigm
2017 Standout
Targeting Treg cells in cancer immunotherapy
2019 StandoutNobel
Conditional Recruitment to a DNA-Bound CRISPR–Cas Complex Using a Colocalization-Dependent Protein Switch
2020 StandoutNobel
Antibodies toStaphylococcus aureuscapsular polysaccharides 5 and 8 perform similarlyin vitrobut are functionally distinctin vivo
2016
CRISPR-Cas: biology, mechanisms and relevance
2016 StandoutNobel
CRISPR therapeutic tools for complex genetic disorders and cancer (Review)
2018
Synthesis of Heterobifunctional Protein Fusions Using Copper‐Free Click Chemistry and the Aldehyde Tag
2012 StandoutNobel
Bacterial Antibiotic Resistance: The Most Critical Pathogens
2021 Standout
Antibody–Enzyme Fusion Proteins for Cancer Therapy
2011
2016
Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic Targets?
2015
Staphylococcus aureus α-Toxin: Nearly a Century of Intrigue
2013
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy
2018
Regulatory T cells: a potential target in cancer immunotherapy
2018
Passive immunization with anti-glucosaminidase monoclonal antibodies protects mice from implant-associated osteomyelitis by mediating opsonophagocytosis ofStaphylococcus aureusmegaclusters
2014
Computational Design of Cyclic Peptide Inhibitors of a Bacterial Membrane Lipoprotein Peptidase
2024 StandoutNobel
Multimechanistic Monoclonal Antibody Combination Targeting Key Staphylococcus aureus Virulence Determinants in a Rabbit Model of Prosthetic Joint Infection
2021
Co-Stimulatory Receptors in Cancers and Their Implications for Cancer Immunotherapy
2020
CRISPR-Cas in Streptococcus pyogenes
2019 StandoutNobel
Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy
2020 StandoutNobel
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Hua Long being referenced
ICOS Promotes the Function of CD4+ Effector T Cells during Anti-OX40–Mediated Tumor Rejection
2016 StandoutNobel
Expression of MDR1, HIF-1α and MRP1 in sacral chordoma and chordoma cell line CM-319
2010
A Caspase-6 and Anti-HER2 Antibody Chimeric Tumor-Targeted Proapoptotic Molecule Decreased Metastasis of Human Osteosarcoma
2009
Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus
2015
Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency
2012
Appetite Enhancement and Weight Gain by Peripheral Administration of TrkB Agonists in Non-Human Primates
2008
First in human (FIH) study of an OX40 agonist monoclonal antibody (mAb) PF-04518600 (PF-8600) in adult patients (pts) with select advanced solid tumors: Preliminary safety and pharmacokinetic (PK)/pharmacodynamic results.
2016
Assessment of an Anti-Alpha-Toxin Monoclonal Antibody for Prevention and Treatment of Staphylococcus aureus-Induced Pneumonia
2013
High expression of long non-coding RNA ANRIL is associated with poor prognosis in hepatocellular carcinoma.
2015
Long non-coding RNA CCAT2 is up-regulated in gastric cancer and associated with poor prognosis.
2015
MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model
2015