Citation Impact
Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
The Anatomy and Taxonomy of Protein Structure
1981 Standout
Diffraction-unlimited all-optical imaging and writing with a photochromic GFP
2011 StandoutNatureNobel
Recombinant human pigment epithelium‐derived factor (PEDF): Characterization of PEDF overexpressed and secreted by eukaryotic cells
1996
Structural Mechanisms for Domain Movements in Proteins
1994
Structural aspects of serpin inhibition
1994 Nobel
Demonstration by NMR of folding domains in lysozyme
1991 StandoutNatureNobel
Pigment Epithelium-derived Factor Behaves Like a Noninhibitory Serpin
1995
Interaction of subtilisins with serpins
1996
Crystal structure of viral serpin crmA provides insights into its mechanism of cysteine proteinase inhibition
2000
Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates
1995
Organization of Serpin Gene-1 from Manduca sexta
1996
The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions
1994
Crystal structure of an uncleaved α1‐antitrypsin reveals the conformation of its inhibitory reactive loop
1995
Plasminogen‐activator inhibitor type 2 (PAI‐2) is a spontaneously polymerising SERPIN
1993
Analysis of the plasma elimination kinetics and conformational stabilities of native, proteinase-complexed and reactive site cleaved serpins: comparison of .alpha.1-proteinase inhibitor, .alpha.1-antichymotrypsin, antithrombin III, .alpha.2-antiplasmin, angiotensinogen, and ovalbumin
1991
Role of the Catalytic Serine in the Interactions of Serine Proteinases with Protein Inhibitors of the Serpin Family
1995
Loop-inserted and thermostabilized structure of P1-p1′ cleaved ovalbumin mutant R339T 1 1Edited by R. Huber
2002
Modeling of serpin-protease complexes: Antithrombin-thrombin, α1-antitrypsin (358Met→Arg)-thrombin, α1-antitrypsin (358Met→Arg)-trypsin, and antitrypsin-elastase
1996
Interaction between the P14 Residue and Strand 2 of β-Sheet B Is Critical for Reactive Center Loop Insertion in Plasminogen Activator Inhibitor-2
2001
The crystal structure of plasminogen activator inhibitor 2 at 2.0 Å resolution: implications for serpin function
1999
.alpha.1-Proteinase Inhibitor Variant T345R. Influence of P14 Residue on Substrate and Inhibitory Pathways
1994
The structure of active serpin 1K from Manduca sexta
1999
Opossum serum .alpha.1-proteinase inhibitor: Purification, linear sequence, and resistance to inactivation by rattlesnake venom metalloproteinase
1993
Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1
1995
Stopped Flow Fluorescence Energy Transfer Measurement of the Rate Constants Describing the Reversible Formation and the Irreversible Rearrangement of the Elastase-α1-Proteinase Inhibitor Complex
1998
Antichymotrypsin Interaction with Chymotrypsin
1998
Inhibition of coagulation factors by recombinant barley serpin BSZx
1996
S‐ovalbumin, an ovalbumin conformer with properties analogous to those of loop‐inserted serpins
1995
The pH Dependence of Serpin-Proteinase Complex Dissociation Reveals a Mechanism of Complex Stabilization Involving Inactive and Active Conformational States of the Proteinase Which Are Perturbable by Calcium
2001
Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation
2000
Kinetic Characterization of the Proteinase Binding Defect in a Reactive Site Variant of the Serpin, Antithrombin
1995
Understanding, improving and using green fluorescent proteins
1995 StandoutNobel
Evidence for the extent of insertion of the active site loop of intact .alpha.1 proteinase inhibitor in .beta.-sheet A
1992 Nobel
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Topology of the Stable Serpin-Protease Complexes Revealed by an Autoantibody That Fails to React with the Monomeric Conformers of Antithrombin
1999
Covalent inhibition revealed by the crystal structure of the caspase-8/p35 complex
2001 Nature
Cleaved antitrypsin polymers at atomic resolution
2000
Crystal structure of the apoptotic suppressor CrmA in its cleaved form
2000
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
A cryo-electron microscopic study of ribosome-bound termination factor RF2
2003 StandoutNatureNobel
Cloning and characterization of hurpin (protease inhibitor 13): a new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family
1999
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
The Conformational Activation of Antithrombin
2000
Serpin α1proteinase inhibitor probed by intrinsic tryptophan fluorescence spectroscopy
1996
On/off blinking and switching behaviour of single molecules of green fluorescent protein
1997 StandoutNatureNobel
Serpin tertiary structure transformation
1991
The native strains in the hydrophobic core and flexible reactive loop of a serine protease inhibitor: crystal structure of an uncleaved α1-antitrypsin at 2.7 å
1996
Effects of mutations in the hinge region of serpins
1993
Importance of the Hinge Region between α-Helix F and the Main Part of Serpins, Based upon Identification of the Epitope of Plasminogen Activator Inhibitor Type 1 Neutralizing Antibodies
2000
Identification of centerin: a novel human germinal center B cell-restricted serpin
2000
Chemical remodelling of cell surfaces in living animals
2004 StandoutNatureNobel
Inhibition of Acrosin by Serpins. A Suicide Substrate Mechanism
1995
Arginine substitutions in the hinge region of antichymotrypsin affect serpin β-sheet rearrangement
1996
Pathogenic α1-Antitrypsin Polymers Are Formed by Reactive Loop-β-Sheet A Linkage
2000
Partitioning of Serpin-Proteinase Reactions between Stable Inhibition and Substrate Cleavage Is Regulated by the Rate of Serpin Reactive Center Loop Insertion into β-Sheet A
2000
The immune response of Drosophila
2003 StandoutNatureNobel
Crystal structure of ovalbumin as a model for the reactive centre of serpins
1990 Nature
Structural basis of latency in plasminogen activator inhibitor-1
1992 Nature
Crystal structure of cleaved human α1-antichymotrypsin at 2.7 å resolution and its comparison with other serpins
1991 Nobel
Crystal structure of neuroserpin: a neuronal serpin involved in a conformational disease
2001
The structure of a Michaelis serpin-protease complex.
2001
Heterologous Expression of Three Plant Serpins with Distinct Inhibitory Specificities
1996
Crystal structure of cleaved equine leucocyte elastase inhibitor determined at 1·95Å resolution
1992
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
The structure of a serpin–protease complex revealed by intramolecular distance measurements using donor–donor energy migration and mapping of interaction sites
2000
Characterization of a Human α1-Antitrypsin Variant That Is as Stable as Ovalbumin
1998
Crystal structure of uncleaved ovalbumin at 1·95 Å resolution
1991
What do dysfunctional serpins tell us about molecular mobility and disease?
1995
Why ion pair reversal by protein engineering is unlikely to succeed
1988 StandoutNatureNobel
Inhibitory conformation of the reactive loop of α1-antitrypsin
1996
The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
1991 StandoutNatureNobel
Formation of the Covalent Chymotrypsin·Antichymotrypsin Complex Involves No Large-scale Movement of the Enzyme
2001
Natural protein proteinase inhibitors and their interaction with proteinases
1992 Nobel
Mapping the Serpin-Proteinase Complex Using Single Cysteine Variants of α1-Proteinase Inhibitor Pittsburgh
1998
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
A 2.6 å structure of a serpin polymer and implications for conformational disease 1 1Edited by R. Huber
1999
The molecular structure of green fluorescent protein
1996
Crystal structure of an uncleaved serpin reveals the conformation of an inhibitory reactive loop
1994
Apparent Formation of Sodium Dodecyl Sulfate-stable Complexes between Serpins and 3,4-Dichloroisocoumarin-inactivated Proteinases Is Due to Regeneration of Active Proteinase from the Inactivated Enzyme
1997
Significance of secondary structure predictions on the reactive center loop region of seprins: a model for the folding of serpins into a metastable state
1996
The charge-relay system of serine proteinases: Proton magnetic resonance titration studies of the four histidines of porcine trypsin
1976
Major proteinase movement upon stable serpin–proteinase complex formation
1997
The anticoagulant activation of antithrombin by heparin
1997
Structural patterns in globular proteins
1976 StandoutNatureNobel
Kinetic Studies on the Interaction of α1-Proteinase Inhibitor (Pittsburgh) with Trypsin-Like Serine Proteinases
1986
Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor.
1992
High resolution nuclear magnetic resonance studies of the active site of chymotrypsin
1974
The biosynthesis of oncovirus proteins
1978
Nucleotide Sequence of Yellow Fever Virus: Implications for Flavivirus Gene Expression and Evolution
1985 StandoutScienceNobel
Quantitation of Transcription and Clonal Selection of Single Living Cells with β-Lactamase as Reporter
1998 StandoutScienceNobel
A hinge region mutation in C1-inhibitor (Ala436–>Thr) results in nonsubstrate-like behavior and in polymerization of the molecule.
1993
Protein Structure Determination in Solution by Nuclear Magnetic Resonance Spectroscopy
1989 StandoutScienceNobel
Two-Angstrom Crystal Structure of Oxidized Chromatium High Potential Iron Protein
1974
Serpin Structure, Mechanism, and Function
2002 Standout
Tertiary structural differences between microbial serine proteases and pancreatic serine enzymes
1975 Nature
THE GREEN FLUORESCENT PROTEIN
1998 StandoutNobel
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function
2000
Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum
1984 StandoutNatureNobel
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
1991 StandoutScienceNobel
Release of a Two‐Chain Form of Antithrombin from the Antithrombin‐Thrombin Complex
1979
Chemical Glycobiology
2001 StandoutScienceNobel
Structural basis of the activation and action of trypsin
1978 StandoutNobel
The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.
1991
Adenylyl Cyclase Amino Acid Sequence: Possible Channel- or Transporter-Like Structure
1989 StandoutScienceNobel
The protein products of the myc and myb oncogenes and adenovirus E1a are structurally related
1983 StandoutNatureNobel
Crystal Structure of the Aequorea victoria Green Fluorescent Protein
1996 StandoutScienceNobel
THE STRUCTURE OF OXIDIZED CYTOCHROME $C=2= OF RHODOSPIRILLUM RUBRUM
1973
Selective alteration of substrate specificity by replacement of aspartic acid-189 with lysine in the binding pocket of trypsin
1987
Cell Surface Engineering by a Modified Staudinger Reaction
2000 StandoutScienceNobel
Neuroserpin, an axonally secreted serine protease inhibitor.
1996
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product
1980 StandoutNatureNobel
Disulfide bond-modified trypsinogen. Role of disulfide 179-203 on the specificity characteristics of bovine trypsin toward synthetic substrates.
1976
Structure of a serpin–protease complex shows inhibition by deformation
2000 Nature
Biological implications of a 3 å structure of dimeric antithrombin
1994
The refined crystal structure of bovine β-trypsin at 1·8 Å resolution
1975
Single amino acid substitutions of alpha 1-antitrypsin that confer enhancement in thermal stability
1994
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
A simple method for displaying the hydropathic character of a protein
1982 Standout
The serpin superfamily of proteinase inhibitors: structure, function, and regulation.
1994
Structure of bovine trypsinogen at 1.9 Å resolution
1977
Structure and mechanism of chymotrypsin
1976
Crystal Structure of DNA Photolyase from Escherichia coli
1995 StandoutScienceNobel
The charge relay system in chymotrypsin and chymotrypsinogen
1973
Kinetic characterization of the substrate reaction between a complex of antithrombin with a synthetic reactive-bond loop tetradecapeptide and four target proteinases of the inhibitor.
1992
Illuminating Single Molecules in Condensed Matter
1999 StandoutScienceNobel
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Signal Sequence Trap: a Cloning Strategy for Secreted Proteins and Type I Membrane Proteins
1993 StandoutScienceNobel
Structural domains in proteins and their role in the dynamics of protein function
1983
Structure-function studies of the SERPIN plasminogen activator inhibitor type 1. Analysis of chimeric strained loop mutants
1990
Ligand binding: proteinase-protein inhibitor interactions
1991 Nobel
The necrotic Gene in Drosophila Corresponds to One of a Cluster of Three Serpin Transcripts Mapping at 43A1.2
2000
Crystal structure of bovine trypsinogen at 1.8 Å resolution. I. Data collection, application of Patterson search techniques and preliminary structural interpretation
1976 StandoutNobel
Comparison of predicted and experimentally determined secondary structure of adenyl kinase
1974 StandoutNatureNobel
Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A
1999
The Serpins Are an Expanding Superfamily of Structurally Similar but Functionally Diverse Proteins
2001
Thromboembolic disease due to thermolabile conformational changes of antithrombin Rouen-VI (187 Asn-->Asp)
1994
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
Stability and specificity of protein-protein interactions: The case of the trypsin-trypsin inhibitor complexes
1976
Engineering an Anion-Binding Cavity in Antichymotrypsin Modulates the “Spring-Loaded” Serpin−Protease Interaction
1998
Crystallographic structure studies of an IgG molecule and an Fc fragment
1976 StandoutNatureNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Studies on reactivity of human leukocyte elastase, cathepsin G, and porcine pancreatic elastase toward peptides including sequences related to the reactive site of .alpha.1-protease inhibitor (.alpha.1-antitrypsin)
1980
Isolation of Components of the Chloroplast Protein Import Machinery
1994 StandoutScienceNobel
Molecular recognition
1991
Catalysis by serine proteases and their zymogens. Study of acyl intermediates by circular dichroism
1975
Crystal structure of Escherichia coli methionyl-tRNA synthetase at 2.5 Å resolution
1982
Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.
1990
Ovalbumin and angiotensinogen lack serpin S–R conformational change
1989
Logical analysis of the mechanism of protein folding
1973
Neurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin
1992 StandoutScienceNobel
Structure of E. coli Glutaminyl-tRNA Synthetase Complexed with tRNA Gln and ATP at 2.8 Å Resolution
1989 StandoutScienceNobel
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
1984 StandoutNatureNobel
The structure of bovine trypsin : Electron density maps of the inhibited enzyme at 5 Å and at 2·7 Å resolution
1974
The SEC receptor recognizes a pentapeptide neodomain of alpha 1-antitrypsin-protease complexes
1991
Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor
1973 StandoutNobel
Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells
1998 StandoutScienceNobel
The structure of protein-protein recognition sites.
1990
Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26
2000
Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis
1997 StandoutScienceNobel
Fluorescent probes and the conformation of proteins
1968 StandoutNobel
Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor
1974 StandoutNobel
Works of H.T. Wright being referenced
Proteolytically cleaved mutant antithrombin‐Hamilton has high stability to denaturation characteristic of wild type inhibitor serpins
1994
Nonenzymatic Deamidation of Asparaginyl and Glutaminyl Residues in Protein
1991
Structural basis for serpin inhibitor activity
1995
The structural puzzle of how serpin serine proteinase inhibitors work
1996
Modeling the intact form of the α1-proteinase inhibitor
1990 Nobel
Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of alzheimer's disease
1999
Crystal structure of plakalbumin, a proteolytically nicked form of ovalbumin
1990
Alzheimer's Peptide Aβ1–42 Binds to Two β-Sheets of α1-Antichymotrypsin and Transforms It from Inhibitor to Substrate
1998
Introns and higher-order structure in the evolution of serpins
1993
Comparison of the crystal structures of chymotrypsinogen-A and α-chymotrypsin
1973
The intersubunit disulfide bridge of ricin is essential for cytotoxicity
1987
Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution
1974
Comparison of the π-, δ- and γ-chymotrypsin family with α-chymotrypsin
1968
A new mechanism for the hydrolytic editing function of aminoacyl‐tRNA synthetases
1980
Ovalbumin is an elastase substrate.
1984
Pi-, delta-, and gamma-chymotrypsin: three-dimensional electron-density and difference maps at 5 A resolution, and comparison with chymotrypsinogen.
1967
Chymotrypsinogen: 2,5-Å crystal structure, comparison with α-chymotrypsin, and implications for zymogen activation
1970
Activation of chymotrypsinogen-A
1973