Standout Papers
Citation Impact
Citing Papers
Highly Active ppm Level Organic Copper Catalyzed Photo‐Induced ICAR ATRP of Methyl Methacrylate
2014
Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways
2011
Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization
2004 StandoutScienceNobel
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Dynamin at actin tails
2002
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure
2003 Science
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Spinophilin Blocks Arrestin Actions in Vitro and in Vivo at G Protein-Coupled Receptors
2004 StandoutScienceNobel
SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
2001 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Functional Genomic Analysis of RNA Interference in C. elegans
2005 StandoutScienceNobel
Colocalization of synapsin and actin during synaptic vesicle recycling
2003
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Medicinal strategies in the treatment of obesity
2000 Nature
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes
2013 Standout
Distinct Targeting and Fusion Functions of the PX and SNARE Domains of Yeast Vacuolar Vam7p
2007
Synaptojanin Forms Two Separate Complexes in the Nerve Terminal
1997
Cargo Selection in Vesicular Transport: The Making and Breaking of a Coat
2002
Decision-making in structure solution using Bayesian estimates of map quality: thePHENIX AutoSolwizard
2009
Intersectin, a Novel Adaptor Protein with Two Eps15 Homology and Five Src Homology 3 Domains
1998
Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination
2003 StandoutNobel
Endocytosis without clathrin coats
2001
Absence of Soluble Leptin Receptor in Plasma fromdbPas/dbPas and Otherdb/db Mice
1998
Receptor downregulation and multivesicular-body sorting
2002
Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles
1997
The dephosphins: dephosphorylation by calcineurin triggers synaptic vesicle endocytosis
2001
Differential Nucleocytoplasmic Shuttling of β-Arrestins
2002
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Accessory factors in clathrin-dependent synaptic vesicle endocytosis
2000
Multiple Cargo Binding Sites on the COPII Subunit Sec24p Ensure Capture of Diverse Membrane Proteins into Transport Vesicles
2003 StandoutNobel
Amphiphysins: Raising the BAR for Synaptic Vesicle Recycling and Membrane Dynamics
2002
Dynamin and its partners: a progress report
1998
EHSH1/Intersectin, a Protein That Contains EH and SH3 Domains and Binds to Dynamin and SNAP-25
1999 StandoutNobel
Dap160, a Neural-specific Eps15 Homology and Multiple SH3 Domain-containing Protein That Interacts with DrosophilaDynamin
1998
The unfolded protein response: controlling cell fate decisions under ER stress and beyond
2012 Standout
Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice
1996
Localization of leptin receptor mRNA and the long form splice variant (Ob‐Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
1996
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and ß-arrestin proteins
2002
Alternative RNA splicing in the nervous system
2001
The Leptin Receptor
1997
SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation
1999
IRS-2 pathways integrate female reproduction and energy homeostasis
2000 Nature
Synaptic vesicle endocytosis
1997
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α
2009
Endocytosis at the synaptic terminal
2003
Modulating stress responses by the UPRosome: A matter of life and death
2011
Regulated portals of entry into the cell
2003 StandoutNature
Ubiquitination of β-Arrestin Links Seven-transmembrane Receptor Endocytosis and ERK Activation
2007 StandoutNobel
Generation of Coated Intermediates of Clathrin-Mediated Endocytosis on Protein-Free Liposomes
1998
Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice
1997 Standout
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction
2010
Functional partnership between amphiphysin and dynamin in clathrin-mediated endocytosis
1999
Leptin Receptor (OB-R) Signaling
1997
A human leptin mutant induces weight gain in normal mice
1997
Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats
2011 StandoutNatureNobel
Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15
1997
The amphiphysin family of proteins and their role in endocytosis at the synapse
1998
Pathophysiological Significance of theObeseGene Product, Leptin, in Ventromedial Hypothalamus (VMH)-Lesioned Rats: Evidence for Loss of Its Satiety Effect in VMH-Lesioned Rats1
1997
Disabled‐2 Colocalizes with the LDLR in Clathrin‐Coated Pits and Interacts with AP‐2
2001
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Endoplasmic reticulum stress-sensing mechanisms in yeast and mammalian cells
2010
Sustained expression of Hif‐1α in the diabetic environment promotes angiogenesis and cutaneous wound repair
2007
Feeding and body-weight regulation by hypothalamic neuropeptides—mediation of the actions of leptin
1999
Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor
2002
Membrane Fusion
2003 StandoutNobel
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Inhibition of receptor-mediated endocytosis by the amphiphysin SH3 domain
1997
Signaling on the Endocytic Pathway
2001
Phosphoinositides, key molecules for regulation of actin cytoskeletal organization and membrane traffic from the plasma membrane
2001
Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid
1999 Nature
Differential Interactions of the Growth Factor Receptor-bound Protein 2 N-SH3 Domain with Son of Sevenless and Dynamin
1998
Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation
2003
Binding of AP2 to Sorting Signals Is Modulated by AP2 Phosphorylation
2001
Cerebrospinal Fluid Leptin in Anorexia Nervosa: Correlation with Nutritional Status and Potential Role in Resistance to Weight Gain1
1997
Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle
2005 StandoutNobel
Automated Structure Solution with the PHENIX Suite
2008
Adipogenesis and Obesity: Rounding Out the Big Picture
1996
Life without white fat: a transgenic mouse
1998
Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p
2006
Interactions with Aromatic Rings in Chemical and Biological Recognition
2003 Standout
Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity
2000
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
The biology of leptin: a review.
1998
Ligand-independent Dimerization of the Extracellular Domain of the Leptin Receptor and Determination of the Stoichiometry of Leptin Binding
1997
Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD
2000
From Lesions to Leptin
1999
Obesity and the Regulation of Energy Balance
2001 Standout
Dynamin Undergoes a GTP-Dependent Conformational Change Causing Vesiculation
1998
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
1997 Nature
When cell biology meets development: endocytic regulation of signaling pathways
2002
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Genes Required for Systemic RNA Interference in Caenorhabditis elegans
2004
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
1996
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
2009
Nucleotide-dependent conformational changes in dynamin: evidence for a mechanochemical molecular spring
1999
Control of Three‐Dimensional Cell Adhesion by the Chirality of Nanofibers in Hydrogels
2014
Leptin Inhibits Bone Formation through a Hypothalamic Relay
2000 Standout
Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice
2000
Genetics of body-weight regulation
2000 Nature
Curvature of clathrin-coated pits driven by epsin
2002 Nature
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
Amyotrophic Lateral Sclerosis Pathogenesis: A Journey Through the Secretory Pathway
2010
Tyrosine Phosphorylation of Eps15 Is Required for Ligand-Regulated, but Not Constitutive, Endocytosis
2000
BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY
1997
The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
2016 Standout
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Mutations in Synaptojanin Disrupt Synaptic Vesicle Recycling
2000 StandoutNobel
A fluorescent light-up probe with “AIE + ESIPT” characteristics for specific detection of lysosomal esterase
2014
Dynamin and Its Role in Membrane Fission
2000
Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts
2014 Standout
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis
2002
The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α
2011
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
1998
Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release
2003
Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor
1997
Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials
2015 Standout
The Role of SOCS-3 in Leptin Signaling and Leptin Resistance
1999
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Synthesis of PVP-functionalized ultra-small MoS2 nanoparticles with intrinsic peroxidase-like activity for H2O2 and glucose detection
2016
Proteasome-Independent Functions of Ubiquitin in Endocytosis and Signaling
2007 Science
Involvement of Long Chain Fatty Acid Elongation in the Trafficking of Secretory Vesicles in Yeast
1998
Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks
2018
Simultaneous Binding of PtdIns(4,5)P 2 and Clathrin by AP180 in the Nucleation of Clathrin Lattices on Membranes
2001 Science
Defective STAT signaling by the leptin receptor in diabetic mice.
1996
A fluorescent light-up nanoparticle probe with aggregation-induced emission characteristics and tumor-acidity responsiveness for targeted imaging and selective suppression of cancer cells
2014
Transmembrane Collagen Receptors
2011
Activating transcription factor 4
2007
2014
Clathrin Assembly Lymphoid Myeloid Leukemia (CALM) Protein: Localization in Endocytic-coated Pits, Interactions with Clathrin, and the Impact of Overexpression on Clathrin-mediated Traffic
1999
Engineering the pH‐Responsive Catalytic Behavior of AuNPs by DNA
2013
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
1997
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Role of Phosphorylation in Regulation of the Assembly of Endocytic Coat Complexes
1998 Science
Cu(0)-Mediated Living Radical Polymerization: A Versatile Tool for Materials Synthesis
2015
Transforming Growth Factor-β Receptors Interact with AP2 by Direct Binding to β2 Subunit
2002
Molecular Receptors for Adenine and Guanine Employing Metal Coordination, Hydrogen‐Bonding and π‐Stacking Interactions
1997
Adaptors for Clathrin-Mediated Traffic
1999
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.
1996
Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor
1998
ADAPTORS FOR CLATHRIN COATS: Structure and Function
2004
Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)
2018 Standout
Bruchpilot Promotes Active Zone Assembly, Ca 2+ Channel Clustering, and Vesicle Release
2006 StandoutScienceNobel
Mechanisms of membrane deformation
2003
Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y
1996 Science
The β 2 -adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis
1999
Photoinduced Electron Transfer Reactions for Macromolecular Syntheses
2016
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Light-Controlled Radical Polymerization: Mechanisms, Methods, and Applications
2016 Standout
A Cell-Mimicking Structure Converting Analog Volume Changes to Digital Colorimetric Output with Molecular Selectivity
2017
Surface-initiated controlled polymerization as a convenient method for designing functional polymer brushes: From self-assembled monolayers to patterned surfaces
2011
Surface Chemoselective Phototransformation of C–H Bonds on Organic Polymeric Materials and Related High-Tech Applications
2013
Dynamin 2 Is Required for Phagocytosis in Macrophages
1999
Inhibition of clathrin-coated pit assembly by an Eps15 mutant
1999
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Catalase-like and Peroxidase-like Catalytic Activities of Silicon Nanowire Arrays
2012
The SH3p4/Sh3p8/SH3p13 protein family: Binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain
1997
Fine Structure of the Murine Leptin Receptor Gene: Splice Site Suppression Is Required to Form Two Alternatively Spliced Transcripts
1997
An aggregation-induced emission based “turn-on” fluorescent chemodosimeter for the selective detection of Pb2+ ions
2014
Fabricating a Cycloolefin Polymer Immunoassay Platform with a Dual-Function Polymer Brush via a Surface-Initiated Photoiniferter-Mediated Polymerization Strategy
2014
Biological Basket Weaving: Formation and Function of Clathrin-Coated Vesicles
2001
Leptin Receptor Immunoreactivity in Chemically Defined Target Neurons of the Hypothalamus
1998
Biosensing by luminogens with aggregation-induced emission characteristics
2014
Dynamin GTPase Domain Mutants Block Endocytic Vesicle Formation at Morphologically Distinct Stages
2001
Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues
1997
Geometrical optimisation of 1,1′-binaphthalene receptors for enantioselective molecular recognition of excitatory amino acid derivatives
1998
The Structural Era of Endocytosis
1999 Science
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Generation of high curvature membranes mediated by direct endophilin bilayer interactions
2001
Well-Defined Protein/Peptide–Polymer Conjugates by Aqueous Cu-LRP: Synthesis and Controlled Self-Assembly
2015
Works of Hong Chen being referenced
Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity
2014
The Epsins Define a Family of Proteins That Interact with Components of the Clathrin Coat and Contain a New Protein Module
1999
A theranostic prodrug delivery system based on Pt(IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug
2015
The ENTH domain
2002
Sensitive sandwich ELISA based on a gold nanoparticle layer for cancer detection
2012
AIP1 Is Critical in Transducing IRE1-mediated Endoplasmic Reticulum Stress Response
2008
Poly(N‐vinylpyrrolidone)‐Modified Surfaces for Biomedical Applications
2012
Cell adhesion on chiral surface: The role of protein adsorption
2011
Incorporation of tyrosine phosphate into tetraphenylethylene affords an amphiphilic molecule for alkaline phosphatase detection, hydrogelation and calcium mineralization
2013
ATF4 Is a Mediator of the Nutrient-sensing Response Pathway That Activates the Human Asparagine Synthetase Gene
2002
A Fluorogenic Probe with Aggregation‐Induced Emission Characteristics for Carboxylesterase Assay through Formation of Supramolecular Microfibers
2014
Fibrinolytic Poly(dimethyl siloxane) Surfaces
2008
A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins
2002 Nature
Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis
1998 Nature
Functional Characterization of a Mammalian Sac1 and Mutants Exhibiting Substrate-specific Defects in Phosphoinositide Phosphatase Activity
2000
Anti-fouling bioactive surfaces
2010
The Interaction of Epsin and Eps15 with the Clathrin Adaptor AP-2 Is Inhibited by Mitotic Phosphorylation and Enhanced by Stimulation-dependent Dephosphorylation in Nerve Terminals
1999
Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice
1996 Standout
A Versatile, Fast, and Efficient Method of Visible-Light-Induced Surface Grafting Polymerization
2014
“Nano-catalyst” for DNA transformation
2011
Control the Wettability of Poly(N-isopropylacrylamide-co-1-adamantan-1-ylmethyl acrylate) Modified Surfaces: The More Ada, the Bigger Impact?
2013
Reciprocal Signaling by Integrin and Nonintegrin Receptors during Collagen Activation of Platelets
2003
Salt-Responsive Zwitterionic Polymer Brushes with Tunable Friction and Antifouling Properties
2015
Step-wise control of protein adsorption and bacterial attachment on a nanowire array surface: tuning surface wettability by salt concentration
2011
Bioorganometallic Chemistry. 8. The Molecular Recognition of Aromatic and Aliphatic Amino Acids and Substituted Aromatic and Aliphatic Carboxylic Acid Guests with Supramolecular (η5-Pentamethylcyclopentadienyl)rhodium−Nucleobase, Nucleoside, and Nucleotide Cyclic Trimer Hosts via Non-Covalent π−π and Hydrophobic Interactions in Water: Steric, Electronic, and Conformational Parameters
1996
Vertical SiNWAs for biomedical and biotechnology applications
2014
Visible light induced fast synthesis of protein–polymer conjugates: controllable polymerization and protein activity
2014
Gold Nanoparticle Layer: A Promising Platform for Ultra-Sensitive Cancer Detection
2011
Atom transfer radical polymerization of methyl methacrylate with a thermo-responsive ligand: construction of thermoregulated phase-transfer catalysis in an aqueous–organic biphasic system
2013
Synaptic Vesicle Endocytosis Impaired by Disruption of Dynamin-SH3 Domain Interactions
1997 Science
Fast and Green Synthesis of a Smart Glyco‐surface via Aqueous Single Electron Transfer‐Living Radical Polymerization
2014
Protein Adsorption and Cell Adhesion/Detachment Behavior on Dual-Responsive Silicon Surfaces Modified with Poly(N-isopropylacrylamide)-block-polystyrene Copolymer
2010
A facile approach to modify poly(dimethylsiloxane) surfaces via visible light-induced grafting polymerization
2014
Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf)
2000