Standout Papers
- Dispersed localization of D segments in the human immunoglobulin heavy-chain locus. (1988)
- Molecular analysis of a chromosomal translocation, t(9;14)(p13;q32), in a diffuse large-cell lymphoma cell line expressing the Ki-1 antigen. (1990)
- Phenotypic conversion of T lymphoblastic lymphoma to acute biphenotypic leukemia composed of lymphoblasts and myeloblasts. Molecular genetic evidence of the same clonal origin. (1988)
- Establishment of a peripheral T-cell lymphoma cell line showing amplification of the c-myc oncogene. (1988)
Citation Impact
Citing Papers
Identification and characterization of essential genes in the human genome
2015 Science
The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors.
1993
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
1993
PRAD1/lCyclin D1 proto‐oncogene: Genomic organization, 5′ dna sequence, and sequence of a tumor‐specific rearrangement breakpoint
1993
TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
1991
Mutations in the NF-κB signaling pathway: implications for human disease
2006
Regulation of progression through the Gl phase of the cell cycle by the rum1+ gene
1994 StandoutNatureNobel
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Expression analysis of a Notch homologue in the mouse embryo
1992
DNA synthesis control in yeast: An evolutionarily conserved mechanism for regulating DNA synthesis genes?
1992
IκB-β regulates the persistent response in a biphasic activation of NF-κB
1995
Diverse Effects of BCL3 Phosphorylation on Its Modulation of NF-κB p52 Homodimer Binding to DNA
1997
extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
1993 StandoutNobel
Cloning of a mitogen-inducible gene encoding a κB DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs
1990 Nature
NF-κB in cancer: from innocent bystander to major culprit
2002 Standout
Mechanisms of chromosomal translocations in B cell lymphomas
2001
Human Immunoglobulin Heavy-Chain Variable Region Genes: Organization, Polymorphism, and Expression
1991
Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus
1993 StandoutNobel
Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA
1999
NF-κB, the first quarter-century: remarkable progress and outstanding questions
2012 Standout
Sct1 functions in partnership with Cdc10 in a transcription complex that activates cell cycle START and inhibits differentiation
1993
BCL-3 and NF-κB p50 Attenuate Lipopolysaccharide-induced Inflammatory Responses in Macrophages
2004
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
IκBγ, a 70 kd protein identical to the C-terminal half of p110 NF-κB: A new member of the IκB family
1992
Selective activation of NF-κB subunits in human breast cancer: potential roles for NF-κB2/p52 and for Bcl-3
2000
Physical linkage of a variable region segment and the joining region segment of the human immunoglobulin heavy chain locus
1988 StandoutNobel
The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults
1996 StandoutNobel
The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
1994 StandoutNobel
A role for the Drosophila neurogenic genes in mesoderm differentiation
1991 StandoutNobel
Activation-induced Cytosine Deaminase (AID) Is Actively Exported out of the Nucleus but Retained by the Induction of DNA Breaks
2004
Translocations, master genes, and differences between the origins of acute and chronic leukemias
1991
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
The oncoprotein Bcl-3 directly transactivates through κB motifs via association with DNA-binding p50B homodimers
1993
Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas
1995
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
1990
The candidate oncoprotein Bcl-3 is an antagonist of pSO/NF-κB-mediated inhibition
1992 Nature
Physical map of the 3′ region of the human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments in one haplotype.
1991 StandoutNobel
NF-κB-inducible BCL-3 Expression Is an Autoregulatory Loop Controlling Nuclear p50/NF-κB1 Residence
2001
Chromosomal translocations in human cancer
1994 Nature
Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling
2006
Nopp 140 shuttles on tracks between nucleolus and cytoplasm
1992 StandoutNobel
Immunological adjuvants promote activated T cell survival via induction of Bcl-3
2001
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
1995 Standout
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
1996 StandoutNobel
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB
1992 Nature
Segmental expression of Hoxb-1 is controlled by a highly conserved autoregulatory loop dependent upon exd/pbx
1995 StandoutNobel
A light-entrainment mechanism for the Drosophila circadian clock
1996 StandoutNatureNobel
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
1992
NF-κB and related proteins: Rel/dorsal homologies meet ankyrin-like repeats
1992
A VH gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes
1988
Sequence of the human immunoglobulin diversity (D) segment locus: a systematic analysis provides no evidence for the use of DIR segments, inverted D segments, “minor” D segments or D-D recombination 1 1Edited By J. Karn
1997 StandoutNobel
Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias
1990
The fission yeast cdc18+ gene product couples S phase to START and mitosis
1993 StandoutNobel
The repertoire of human germline vH sequences reveals about fifty groups of VH segments with different hypervariable loops
1992 StandoutNobel
Structural repertoire of the human VH segments
1992 StandoutNobel
The inhibitory ankyrin and activator Rel proteins
1992 Nobel
Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray
2003 Standout
The novel Notch homologue mouse Notch 3 lacks specific epidermal growth factor-repeats and is expressed in proliferating neuroepithelium
1994
BCL3 is induced by IL-6 via Stat3 binding to intronic enhancer HS4 and represses its own transcription
2006
Homeodomain-DNA recognition
1994 StandoutNobel
The Bcl-3 oncoprotein acts as a bridging factor between NF-κB/Rel and nuclear co-regulators
1999
Non-canonical NF-κB signaling pathway
2010
Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity
1992 StandoutNobel
Cancer-related inflammation
2008 StandoutNature
Cloning of a Differentially Expressed IκB-related Protein
1995
Function and Activation of NF-kappaB in the Immune System
1994 Standout
Critical Roles for the Bcl-3 Oncoprotein in T Cell–Mediated Immunity, Splenic Microarchitecture, and Germinal Center Reactions
1997
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
1994 StandoutNobel
B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-κB p50
1991
cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IκB gene family of vertebrates
1992 StandoutNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
REL proto-oncogene is frequently amplified in extranodal diffuse large cell lymphoma
1996
The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner.
1993 Nobel
Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB
1995
Bcl-3 Expression Promotes Cell Survival following Interleukin-4 Deprivation and Is Controlled by AP1 and AP1-Like Transcription Factors
2000
The role of clonal selection in the pathogenesis of an autoreactive human B cell lymphoma.
1991
AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas.
1992
A Novel NF-κB Complex Containing p65 Homodimers: Implications for Transcriptional Control at the Level of Subunit Dimerization
1993
Common structural constituents confer I kappa B activity to NF-kappa B p105 and I kappa B/MAD-3.
1993
Characterization of the Human Ig Heavy Chain Antigen Binding Complementarity Determining Region 3 Using a Newly Developed Software Algorithm, JOINSOLVER
2004
Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development
1992
A map of the human immunoglobulin VH locus completed by analysis of the telomeric region of chromosome 14q
1994 StandoutNobel
Genomic organization of IgH gene compared with the expression of Bcl-2 gene in t(14;18)-positive lymphoma
1991 StandoutNobel
Functional Role for IκBNS in T Cell Cytokine Regulation As Revealed by Targeted Gene Disruption
2007
Notch1 is essential for postimplantation development in mice.
1994
NF-κB RegulatesBCL3Transcription in T Lymphocytes Through an Intronic Enhancer
2003
Convergence of Ets- and Notch-Related Structural Motifs in a Heteromeric DNA Binding Complex
1991 Science
A hallmark of active class switch recombination: Transcripts directed by I promoters on looped-out circular DNAs
2001 StandoutNobel
Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2/lyt-10 gene in lymphoid malignancies
1994
Neurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.
1993 StandoutNobel
Constitutive Activation of Toll-Mediated Antifungal Defense in Serpin-Deficient Drosophila
1999 StandoutScienceNobel
BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins.
1994
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
Molecular characterization of five human anti-human immunodeficiency virus type 1 antibody heavy chains reveals extensive somatic mutation typical of an antigen-driven immune response.
1991
Bcl3 Interacts Cooperatively with Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) Coactivator 1α To Coactivate Nuclear Receptors Estrogen-Related Receptor α and PPARα
2009
NF-κB and Rel Proteins in Innate Immunity
1995
Xotch , the Xenopus Homolog of Drosophila Notch
1990 Science
The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.
1993 Nobel
Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines.
1994
NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule
1993
The ankyrin repeat domains of the NF-kappa B precursor p105 and the protooncogene bcl-3 act as specific inhibitors of NF-kappa B DNA binding.
1992
The physical organization of the human immunoglobulin heavy chain gene complex.
1990
Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments.
1990 StandoutNobel
yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.
1986
The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.
1993
Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members
2001 StandoutNobel
Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements.
1989
Regulation of cell cycle-dependent gene expression in yeast.
1990
Molecular analysis of cutaneous B- and T-cell lymphomas
1995
Differential interactions of Rel-NF-kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF-kappa B activity.
1994
A homolog of Drosophila Notch expressed during mammalian development
1991
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
An analysis of vertebrate mRNA sequences: intimations of translational control.
1991 Standout
Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.
1993
The Proto-Oncogene Bcl3, Induced by Tax, Represses Tax-Mediated Transcription via p300 Displacement from the Human T-Cell Leukemia Virus Type 1 Promoter
2008
p53 Represses Cyclin D1 Transcription through Down Regulation of Bcl-3 and Inducing Increased Association of the p52 NF-κB Subunit with Histone Deacetylase 1
2003
REL/NF-κB/IκB Story
1995
Immunological defects in mice with a targeted disruption in Bcl-3.
1997
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
1998 Standout
The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation.
1989
Constitutive Expression of Bcl-3 in Thymocytes Increases the DNA Binding of NF-κB1 (p50) Homodimers In Vivo
1996
Isolation, sequence, and chromosomal localisation of the human IκBR gene (NFKBIL2)
2000
Human rheumatoid B-1a (CD5+ B) cells make somatically hypermutated high affinity IgM rheumatoid factors.
1993
Chromosome Aberrations and Cancer
1991 Science
Dissociation of the dorsal-cactus complex and phosphorylation of the dorsal protein correlate with the nuclear localization of dorsal.
1993
A new cdc gene required for S phase entry of Schizosaccharomyces pombe encodes a protein similar to the cdc 10+ and SWI4 gene products.
1992
NF-κB Controls Expression of Inhibitor IκBα: Evidence for an Inducible Autoregulatory Pathway
1993 Science
p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction.
1993
The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B.
1993
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation
1994 Nobel
Constitutive activation of NF-kappa B is essential for transformation of rat fibroblasts by the human T-cell leukemia virus type I Tax protein.
1996
Diverse molecular mechanisms of inhibition of NF-kappa B/DNA binding complexes by I kappa B proteins.
1993
Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis
2003 StandoutNobel
The Putative Oncoprotein Bcl-3 Induces Cyclin D1 To Stimulate G1 Transition
2001
Cytoskeletal and DNA structure abnormalities result from bypass of requirement for the cdc10 start gene in the fission yeast Schizosaccharomyces pombe
1992
Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
1992 StandoutScienceNobel
Works of Hitoshi Ohno being referenced
Characterization and comparison of two newly established epstein-barr virus-negative lymphoma B-cell lines: Surface markers, growth characteristics, cytogenetics, and transplantability
1988
Identification of a transcriptional unit adjacent to the breakpoint in the 14;19 translocation of chronic lymphocytic leukemia
1990
Reappraisal of BCL3 as a Molecular Marker of Anaplastic Large Cell Lymphoma
2005
The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control
1990
Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor‐κB p52, which is associated with hyperphosphorylated Bcl‐3
2005
Genomic Structure of the Candidate Proto-oncogene BCL3
1994
Activation-induced cytidine deaminase expression in follicular lymphoma: association between AID expression and ongoing mutation in FL
2004
Bcl-3/IgH translocation (14;19)(q32;q13) in Non-Hodgkin's Lymphomas
2002
Molecular characterization of the t(14;19)(q32;q13) translocation in chronic lymphocytic leukemia.
1993
c‐yes and bc1‐2 genes located on 18q21.3 in a follicular lymphoma cell line carrying a t(14;18) chromosomal translocation
1987
Involvement of the BCL3 gene in two patients with chronic lymphocytic leukemia.
1994
Nonimmunoglobulin (non-Ig)/BCL6gene fusion in diffuse large B-cell lymphoma results in worse prognosis than Ig/BCL6
2000
Lymphoma cell line (FL-18) and Epstein-Barr virus-carrying cell line (FL-18-EB) obtained from a patient with follicular lymphoma: monoclonal derivation and different properties
1987
The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene
1996
Nonimmunoglobulin (non-Ig)/BCL6gene fusion in diffuse large B-cell lymphoma results in worse prognosis than Ig/BCL6
2000
The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene
1996
A newly established human lymphoma cell line, FL-18, carrying a 14;18 translocation.
1985
High-level expression of BCL3 differentiates t(2;5)(p23;q35)-positive anaplastic large cell lymphoma from Hodgkin disease
2003
Dispersed localization of D segments in the human immunoglobulin heavy-chain locus.
1988 StandoutNobel
BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: A molecular and cytogenetic study
1997