Standout Papers
- Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings. Taxonomy, production and enzyme inhibition. (1986)
- Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. (1991)
- Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings. (1986)
- Structures of jietacines: Unique .ALPHA.,.BETA.-unsaturated azoxy antibiotics. (1989)
- Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I Production, isolation, and physico-chemical and biological properties. (1986)
- Adechlorin, a new adenosine deaminase inhibitor containing chlorine. Production, isolation and properties. (1985)
Citation Impact
Citing Papers
Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**
2021 StandoutNobel
Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer
2020
pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells
1992
Graphene-based composites
2011 Standout
Structure Determination and Total Synthesis of Bottromycin A2: A Potent Antibiotic against MRSA and VRE
2008 StandoutNobel
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases
1993 StandoutNature
A pH‐sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate
2008
3D superhydrophobic electrospun meshes as reinforcement materials for sustained local drug delivery against colorectal cancer cells
2012
Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer
2004 Standout
Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer
2009 Standout
Phase II trial of irinotecan in patients with metastatic colorectal carcinoma.
1997
Differential Stabilization of Eukaryotic DNA Topoisomerase I Cleavable Complexes by Camptothecin Derivatives
1995 StandoutNobel
Chemical remodelling of cell surfaces in living animals
2004 StandoutNatureNobel
Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity
2002
Signal transduction by lymphocyte antigen receptors
1994 Standout
Novel Human Topoisomerase I Inhibitors, Topopyrones A, B, C and D. I. Producing Strain, Fermentation, Isolation, Physico-chemical Properties and Biological Activity.
2000
Progress of drug-loaded polymeric micelles into clinical studies
2014
Topoisomerase I inhibitors: topotecan and irenotecan
1994
The chemistry of graphene oxide
2009 Standout
Synthesis and nematocidal activities of jietacin a and its analogs.
1991 StandoutNobel
Gastric cancer
2020 Standout
Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer
2000 Standout
Direct Exfoliation of Graphite to Graphene in Aqueous Media with Diazaperopyrenium Dications
2013 StandoutNobel
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial
2000 Standout
Anticancer drug design based on plant-derived natural products
1999
Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group.
1993
Evaluation of folate conjugated pegylated thermosensitive magnetic nanocomposites for tumor imaging and therapy
2010
Development of HPMA copolymer–anticancer conjugates: Clinical experience and lessons learnt
2009
Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I
1997 StandoutNobel
Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
2004 Standout
A multicenter, Phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
1999
Atroposelective Total Synthesis of Axially Chiral Biaryl Natural Products
2010 Standout
Camptothecins: from bench research to hospital wards.
1994
Emerging DNA topoisomerase inhibitors as anticancer drugs
2004
Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications
2019 Standout
Noncovalent Functionalization of Graphene and Graphene Oxide for Energy Materials, Biosensing, Catalytic, and Biomedical Applications
2016 Standout
Enhanced Photoresponsive Ultrathin Graphitic-Phase C3N4Nanosheets for Bioimaging
2012 Standout
Fas ligand mediates activation-induced cell death in human T lymphocytes.
1995 StandoutNobel
FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer
2011 Standout
Irinotecan is an active agent in untreated patients with metastatic colorectal cancer.
1996
Functionalization of Graphene: Covalent and Non-Covalent Approaches, Derivatives and Applications
2012 Standout
Chemical Glycobiology
2001 StandoutScienceNobel
Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method
2005 StandoutNobel
Indolizine: a biologically active moiety
2014
Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves
2010 StandoutNobel
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
1992 StandoutScienceNobel
Interaction of an alkylating camptothecin derivative with a DNA base at topoisomerase I-DNA cleavage sites.
1995 StandoutNobel
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Total Synthesis of Camptothecin and Related Natural Products by a Flexible Strategy
2016
Selective anergy of V beta 8+ T cells in human immunodeficiency virus-infected individuals.
1994 StandoutNobel
Functional Nanomaterials for Phototherapies of Cancer
2014 Standout
Rescuing impairment of long-term potentiation in fyn-deficient mice by introducing Fyn transgene
1997 StandoutNobel
Microbial metabolites: 45 years of wandering, wondering and discovering
2011 StandoutNobel
Topoisomerase I-Mediated Antiproliferative Activity of Enantiomerically Pure Fluorinated Homocamptothecins
2000
Aryl−Aryl Bond Formation by Transition-Metal-Catalyzed Direct Arylation
2007 Standout
Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer
2003 Standout
Total Synthesis of the Azoxy Antibiotic Jietacin A
1989
PEGylated Nanographene Oxide for Delivery of Water-Insoluble Cancer Drugs
2008 Standout
Regioselective oxidation of β-hydroxyazo compounds to β-hydroxyazoxy compounds and its application to syntheses of maniwamycins A and B
1993
Carbon Nanomaterials for Biological Imaging and Nanomedicinal Therapy
2015 Standout
Lustromycin, a new antibiotic produced by Streptomyces sp.
1986 StandoutNobel
Irinotecan Plus Oxaliplatin and Leucovorin-Modulated Fluorouracil in Advanced Pancreatic Cancer—A Groupe Tumeurs Digestives of the Fédération Nationale des Centres de Lutte Contre le Cancer Study
2005
Maintenance of in Vivo Tolerance by Persistence of Antigen
1992 StandoutScienceNobel
Focal adhesion kinase in the brain: novel subcellular localization and specific regulation by Fyn tyrosine kinase in mutant mice.
1995 StandoutNobel
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Broad Family of Carbon Nanoallotropes: Classification, Chemistry, and Applications of Fullerenes, Carbon Dots, Nanotubes, Graphene, Nanodiamonds, and Combined Superstructures
2015 Standout
Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice.
1990
Magnetic Nanoparticles: Design and Characterization, Toxicity and Biocompatibility, Pharmaceutical and Biomedical Applications
2012 Standout
Recent Advances in Ultrathin Two-Dimensional Nanomaterials
2017 Standout
Phase I and pharmacokinetic trial of weekly CPT-11.
1993
Synthesis of the oxa-bridged octalin system of two anti-anaerobe antibiotics, luminamicin and lustromycin
2007 StandoutNobel
Multiple event activation of a generic prodrug trigger by antibody catalysis
1999 StandoutNobel
Structural Basis of Type II Topoisomerase Inhibition by the Anticancer Drug Etoposide
2011 StandoutScience
Jietacins with potent nematocidal activity; efficient isolation of novel analogs and divergent total synthesis of jietacin A, B, C, and D
2015 StandoutNobel
Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase.
2000
Philosophy of new drug discovery
1986 StandoutNobel
Catalytic Asymmetric Conjugate Addition of Indolizines to α,β‐Unsaturated Ketones
2017 StandoutNobel
Synthesis and Biological Activity of Natural Aminocyclopentitol Glycosidase Inhibitors: Mannostatins, Trehazolin, Allosamidins, and Their Analogues
1999
Works of Hiroshi Kuga being referenced
Stimulation of all T cells bearing Vβ1, Vβ3, Vβ11 and Vβ12 by staphylococcal enterotoxin A
1990
Camptothecin analog (CPT-11)-sensitive human pancreatic tumor cell line QGP-1N shows resistance to SN-38, an active metabolite of CPT-11
1992
DX-8951F, a water-soluble camptothecin analog, exhibits potent antitumor activity against a human lung cancer cell line and its SN-38-resistant variant
1997
Structures of jietacines: Unique .ALPHA.,.BETA.-unsaturated azoxy antibiotics.
1989 StandoutNobel
A possible mechanism for the long-lasting antitumor effect of the macromolecular conjugate DE-310: mediation by cellular uptake and drug release of its active camptothecin analog DX-8951
2004
Hyperthermia-enhanced tumor accumulation and antitumor efficacy of a doxorubicin-conjugate with a novel macromolecular carrier system in mice with non-small cell lung cancer
2007
Adecypenol, a unique adenosine deaminase inhibitor containing homopurine and cyclopentene rings.
1986 StandoutNobel
Adechlorin, a new adenosine deaminase inhibitor containing chlorine. Production, isolation and properties.
1985 StandoutNobel
Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I Production, isolation, and physico-chemical and biological properties.
1986 StandoutNobel
Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.
1991 Standout
Relationship between Drug Release of DE-310, Macromolecular Prodrug of DX-8951f, and Cathepsins Activity in Several Tumors
2007