Citation Impact
Citing Papers
Role of UEV-1, an Inactive Variant of the E2 UbiquitinConjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells
1998 StandoutNobel
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
Circulating CD21 low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells
2009
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
2009 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Atypical Memory B Cells Are Greatly Expanded in Individuals Living in a Malaria-Endemic Area
2009
Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis
2023 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation
2014
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Subcellular localization of the von Hippel-Lindau disease gene product is cell cycle-dependent
1998
Bone marrow-derived mesenchymal stem cells and the tumor microenvironment
2010
Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy
2014
Pathogenesis of IgG4-related disease
2010
Analysis of von Hippel—Lindau mutations with comparative genomic hybridization in sporadic and hereditary hemangioblastomas: possible genetic heterogeneity
2002
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
Direct Interaction of the β-Domain of VHL Tumor Suppressor Protein with the Regulatory Domain of Atypical PKC Isotypes
1999
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues
1997 StandoutNobel
TH17 cells in development: an updated view of their molecular identity and genetic programming
2008
Comprehensive mutational analysis of the VHL gene in sporadic renal cell carcinoma: Relationship to clinicopathological parameters
2002
Molecular basis of the VHL hereditary cancer syndrome
2002 StandoutNobel
Delirium as a Predictor of Mortality in Mechanically Ventilated Patients in the Intensive Care Unit
2004 Standout
Renal Tumors in the Birt-Hogg-Dubé Syndrome
2002
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
1999 StandoutNatureNobel
Ubiquitination of a Novel Deubiquitinating Enzyme Requires Direct Binding to von Hippel-Lindau Tumor Suppressor Protein
2002
Molecular Genetic Analysis of the von Hippel-Lindau Disease Tumor Suppressor Gene in Familial and Sporadic Cerebellar Hemangioblastomas
1997
von Hippel-Lindau Disease
1997 StandoutNobel
HIF-1, O2, and the 3 PHDs
2001 StandoutNobel
IgG4-Related Disease
2012 Standout
Mutations of the VHL gene in sporadic renal cell carcinoma: Definition of a risk factor for VHL patients to develop an RCC
1999
Inhibition of Transcription Elongation by the VHL Tumor Suppressor Protein
1995 Science
Germline and Somatic Mutations in von Hippel-Lindau Disease Gene and Its Significance in the Development of Kidney Cancer
1999
Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
2011
A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations
2008 StandoutNobel
Trichloroethylene Exposure and Specific Somatic Mutations in Patients With Renal Cell Carcinoma
1999
HIF hydroxylation and the mammalian oxygen-sensing pathway
2003 StandoutNobel
Serologic issues in IgG4-related systemic disease and autoimmune pancreatitis
2010
Antigen-specific therapeutic approaches for autoimmunity
2019
Autoimmune pancreatitis and IgG4-related sclerosing disease
2010
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Isolation and characterization of the full-length 3′ untranslated region of the human von Hippel-Lindau tumor suppressor gene
1996
Glycosylation in health and disease
2019
Efficient tumour formation by single human melanoma cells
2008 Nature
General Transcription Factors for RNA Polymerase II1
1997
Activation-Induced Cytidine Deaminase Expression in CD4+ T Cells is Associated with a Unique IL-10-Producing Subset that Increases with Age
2011 StandoutNobel
Atherosclerosis — An Inflammatory Disease
1999 Standout
Transcription of the Sodium/myo-Inositol Cotransporter Gene Is Regulated by Multiple Tonicity-responsive Enhancers Spread over 50 Kilobase Pairs in the 5′-Flanking Region
1998
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Recent Advances in Autoimmune Pancreatitis
2015
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
2009 StandoutNature
De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease
2014
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
2003 Standout
Formation of the VHL–Elongin BC Tumor Suppressor Complex Is Mediated by the Chaperonin TRiC
1999
IgG4-related disease
2014 Standout
Mucin Granule Intraluminal Organization in Living Mucous/Goblet Cells
2005 StandoutNobel
Signaling to NF-κB
2004 Standout
Clonal evolution in cancer
2012 StandoutNature
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
2002 StandoutNobel
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
2007
A Novel Immunoglobulin-Immunoglobulin Interaction in Autoimmunity
2008
Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel–Lindau tumor suppressor
2002
Vascular endothelial growth factor overexpression is correlated with von Hippel‐Lindau tumor suppressor gene inactivation in patients with sporadic renal cell carcinoma
2002
The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1alpha transcriptional activity
2003
Differential Genetic Alterations in von Hippel-Lindau Syndrome-Associated and Sporadic Pheochromocytomas1
2000
Molecular genetic analysis of the von Hippel-Lindau disease (VHl) tumour suppressor gene in gonadal tumours
1995
HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression
2008 Standout
Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma
1996
MUTATION OF THEVHL GENE IS ASSOCIATED EXCLUSIVELY WITH THE DEVELOPMENT OF NON-PAPILLARY RENAL CELL CARCINOMAS
1996
A Novel IκB Protein, IκB-ζ, Induced by Proinflammatory Stimuli, Negatively Regulates Nuclear Factor-κB in the Nuclei
2001
Hypertonic Induction of Aquaporin-5 Expression through an ERK-dependent Pathway
2000 StandoutNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Identification of a Novel Antibody Associated with Autoimmune Pancreatitis
2009
Software and database for the analysis of mutations in the VHL gene
1998
Carboxy-terminal domain of AID required for its mRNA complex formation in vivo
2009 StandoutNobel
Inactivation of the von Hippel–Lindau ( VHL ) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL ‐independent pathway in clear cell renal tumourigenesis
1998
Transcription-Dependent Nuclear-Cytoplasmic Trafficking Is Required for the Function of the von Hippel-Lindau Tumor Suppressor Protein
1999
Post-transcriptional regulation of vascular endothelial growth factor mRNA by the product of the VHL tumor suppressor gene.
1996
VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation.
2000
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Coexpression of transforming growth factor-alpha and épidermal growth factor receptor in capillary hemangioblastomas of the central nervous system.
1995
Clonal B cells in patients with hepatitis C virus–associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset
2011 StandoutNobel
Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.
1995
Comprehensive allelotyping of human renal cell carcinomas using microsatellite DNA probes.
1995
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
1997
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product.
1996
2015
What mediates progressive glomerulosclerosis? The glomerular endothelium comes of age.
1997
Cellular proteins that bind the von Hippel-Lindau disease gene product: mapping of binding domains and the effect of missense mutations.
1995
MUTATION OF THE VON HIPPEL-LINDAU TUMOUR SUPPRESSOR GENE IN CAPILLARY HAEMANGIOBLASTOMAS OF THE CENTRAL NERVOUS SYSTEM
1996
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.
1994
Complement receptor 2/CD21− human naive B cells contain mostly autoreactive unresponsive clones
2010
pVHL 19 is a biologically active product of the von Hippel–Lindau gene arising from internal translation initiation
1998 StandoutNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
IκB-ζ, a new anti-inflammatory nuclear protein induced by lipopolysaccharide, is a negative regulator for nuclear factor-κB
2003
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
2003 Standout
The Peritoneal Cavity Provides a Protective Niche for B1 and Conventional B Lymphocytes during Anti-CD20 Immunotherapy in Mice
2005
Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density.
1996
Amylase α-2A Autoantibodies
2008
Conditional stability of T cells
2010 StandoutNatureNobel
Structure of an HIF-1α-pVHL Complex: Hydroxyproline Recognition in Signaling
2002 StandoutScienceNobel
Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity
1999
IgG4-Related Disease
2013
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages
2003
Regulation of Hypoxia-Inducible mRNAs by the von Hippel-Lindau Tumor Suppressor Protein Requires Binding to Complexes Containing Elongins B/C and Cul2
1998 StandoutNobel
HIF-1 and human disease: one highly involved factor
2000 StandoutNobel
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Role ofVHLGene Mutation in Human Cancer
2004 StandoutNobel
BIALLELIC INACTIVATION OF THE VON HIPPEL-LINDAU TUMOR SUPPRESSOR GENE IN SPORADIC RENAL CELL CARCINOMA
2002
Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals
2008
The Molecular Basis of Von Hippel-Lindau Disease
1997 StandoutNobel
Works of Hiroshi Kitamura being referenced
Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes
2015
Effects of specific anti‐B and/or anti‐plasma cell immunotherapy on antibody production in baboons: depletion of CD20‐ and CD22‐positive B cells does not result in significantly decreased production of
anti‐αGal antibody
2001
Role of heat shock protein 47 in intestinal fibrosis of experimental colitis
2010
Alteration in mucin gene expression and biological properties of HT29 colon cancer cell subpopulations
1996
Mechanism of decrease in levels of hepatic P450 isozymes induced by intracerebral endotoxin: independence from sympathetic nervous and adrenocortical systems
1999
Mixed chimerism and tolerance without whole body irradiation in a large animal model
2000
Inhibition of myo-inositol transport causes acute renal failure with selective medullary injury in the rat
1998
Differential alterations in levels of hepatic microsomal cytochrome P450 isozymes following intracerebroventricular injection of bacterial lipopolysaccharide in rats
1998
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
2007
Requirement for Lymphoid Tissue-Inducer Cells in Isolated Follicle Formation and T Cell-Independent Immunoglobulin A Generation in the Gut
2008
MAIL, a novel nuclear IκB protein that potentiates LPS‐induced IL‐6 production
2000
The Sensing of Environmental Stimuli by Follicular Dendritic Cells Promotes Immunoglobulin A Generation in the Gut
2010
Peritubular Capillary Regression during the Progression of Experimental Obstructive Nephropathy
2002
Expression of betaine transporter mRNA: Its unique localization and rapid regulation in rat kidney
1996
Galactosialidosis associated with IgA nephropathy: Morphological study of renal biopsy
2008
Vascular Endothelial Growth Factor Enhances Glomerular Capillary Repair and Accelerates Resolution of Experimentally Induced Glomerulonephritis
2001
Identification of a Novel Autoantibody Against Pancreatic Secretory Trypsin Inhibitor in Patients with Autoimmune Pancreatitis
2006
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells
2011
Endothelial regeneration during the repair process following Habu-snake venom induced glomerular injury
1995
Discriminating gene expression profiles of memory B cell subpopulations
2008
Role of neutrophil elastase in the development of renal necrotizing vasculitis.
1996
Rare glomerular capillary regeneration and subsequent capillary regression with endothelial cell apoptosis in progressive glomerulonephritis.
1997
IL-21–induced Bε cell apoptosis mediated by natural killer T cells suppresses IgE responses
2006
Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas.
1994