Citation Impact
Citing Papers
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
2001 StandoutScienceNobel
HIFα Targeted for VHL-Mediated Destruction by Proline Hydroxylation: Implications for O 2 Sensing
2001 StandoutScienceNobel
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels
1997
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
1998 StandoutScience
A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development
1997
Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway
1997
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
The Mouse Gene for Hypoxia‐Inducible Factor‐1α
1997
Induction of human neuronal cells by defined transcription factors
2011 StandoutNatureNobel
Zebrafish Dpr2 Inhibits Mesoderm Induction by Promoting Degradation of Nodal Receptors
2004 Science
Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse
2003
Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex
2002
Strategies and New Developments in the Generation of Patient-Specific Pluripotent Stem Cells
2007 StandoutNobel
SoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesis
2012
Structural basis for the recognition of hydroxyproline in HIF-1α by pVHL
2002 StandoutNatureNobel
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
Nas transgenic mouse line allows visualization of Notch pathway activity in vivo
2006
New type of POU domain in germ line-specific protein Oct-4
1990 Nature
Tandem repeats finder: a program to analyze DNA sequences
1999 Standout
Forces in Tissue Morphogenesis and Patterning
2013 Standout
Oct-3/4 and Sox2 Regulate Oct-3/4 Gene in Embryonic Stem Cells
2004
Notch activity acts as a sensor for extracellular calcium during vertebrate left–right determination
2004 Nature
New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2
1998
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
2004
UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells
1998
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Conserved and divergent paths that regulate self-renewal in mouse and human embryonic stem cells
2004
Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT
1997 Nature
Molecular motors
2003 Nature
Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
2000 Standout
Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation
1998
Dynamic molecular processes mediate cellular mechanotransduction
2011 Nature
Differential Roles for Sox15 and Sox2 in Transcriptional Control in Mouse Embryonic Stem Cells
2005 StandoutNobel
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway
2000 StandoutNobel
Fluid dynamics in zebrafish Kupffer's vesicle
2008
Octamania: The POU factors in murine development
1991
Nodal signaling and the evolution of deuterostome gastrulation
2005
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
TRP channels as cellular sensors
2003 StandoutNature
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
2008
Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4
1998 Standout
Morphogen gradient interpretation by a regulated trafficking step during ligand–receptor transduction
2005 StandoutNobel
Mechanism of Nodal Flow: A Conserved Symmetry Breaking Event in Left-Right Axis Determination
2005
Electrically driven directional motion of a four-wheeled molecule on a metal surface
2011 StandoutNatureNobel
The Effects of Hemodynamic Force on Embryonic Development
2010
Generation of germline-competent induced pluripotent stem cells
2007 StandoutNatureNobel
Conserved Patterns of Cell Movements during Vertebrate Gastrulation
2005
POU domain family values: flexibility, partnerships, and developmental codes.
1997
Silencing of the Gene for the β Subunit of Human Chorionic Gonadotropin by the Embryonic Transcription Factor Oct-3/4
1996
Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity
2011
A two-cilia model for vertebrate left-right axis specification: Figure 1.
2003
Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning
2010 Nature
Self-renewal of teratocarcinoma and embryonic stem cells
2004
Ciliar functions in the nephron
2009
A method for fast database search for allk-nucleotide repeats
1994
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 StandoutNatureNobel
Sequence Alignment with Tandem Duplication
1997
The basics of epithelial-mesenchymal transition
2009 Standout
Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein
1998 Standout
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1α
1998 StandoutNobel
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
2009 Standout
A nexus between Oct-4 and E1 A: Implications for gene regulation in embryonic stem cells
1991
A rapidly evolving region in the immunoglobulin heavy chain loci of rat and mouse: postulated role of (dC-dA)n · (dG-dT)n sequences
1988
Regulation of transcription and cell identity by POU domain proteins
1991 StandoutNobel
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo
1990 Nature
Nodal Flow and the Generation of Left-Right Asymmetry
2006
The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells
2003 StandoutNobel
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
2003 Standout
Suppression of induced pluripotent stem cell generation by the p53–p21 pathway
2009 StandoutNatureNobel
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants
2004 StandoutNobel
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
2009
Unusual DNA sequences associated with the ends of yeast chromosomes
1984 Nature
Embryo-Derived Stem Cells: Of Mice and Men
2001
Structure of two human beta-actin-related processed genes one of which is located next to a simple repetitive sequence.
1983
Identification of the Cystic Fibrosis Gene: Chromosome Walking and Jumping
1989 StandoutScience
Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related.
1989 StandoutNobel
Rex-1, a Gene Encoding a Transcription Factor Expressed in the Early Embryo, Is Regulated via Oct-3/4 and Oct-6 Binding to an Octamer Site and a Novel Protein, Rox-1, Binding to an Adjacent Site
1998
Genome organization and transactivation of the human immunodeficiency virus type 2
1987 StandoutNatureNobel
Fluid flows and forces in development: functions, features and biophysical principles
2012
Synergistic Activation of the Fibroblast Growth Factor 4 Enhancer by Sox2 and Oct-3 Depends on Protein-Protein Interactions Facilitated by a Specific Spatial Arrangement of Factor Binding Sites
1997
Nucleotide sequences in Xenopus 5S DNA required for transcription termination
1981
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
Targeted mutations in the Caenorhabditis elegans POU homeo box gene ceh-18 cause defects in oocyte cell cycle arrest, gonad migration, and epidermal differentiation.
1994 StandoutNobel
Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region.
1994
Generation of Transgene-Free Lung Disease-Specific Human Induced Pluripotent Stem Cells Using a Single Excisable Lentiviral Stem Cell Cassette
2010
Patched1 Regulates Hedgehog Signaling at the Primary Cilium
2007 StandoutScience
Is there left-handed DNA at the ends of yeast chromosomes?
1983 StandoutNatureNobel
Nucleotide sequence analysis of the delta beta-globin gene region in humans.
1983
FGF-induced vesicular release of Sonic hedgehog and retinoic acid in leftward nodal flow is critical for left–right determination
2005 Nature
Coordinated Transcriptional Regulation of theunc-25Glutamic Acid Decarboxylase and theunc-47GABA Vesicular Transporter by theCaenorhabditis elegansUNC-30 Homeodomain Protein
1999 StandoutNobel
Oct-4: a germline-specific transcription factor mapping to the mouse t-complex.
1990
Phenotypic Complementation Establishes Requirements for Specific POU Domain and Generic Transactivation Function of Oct-3/4 in Embryonic Stem Cells
2002
Pivotal roles for eomesodermin during axis formation,epithelium-to-mesenchyme transition and endoderm specification in the mouse
2008
Class-C SOX Transcription Factors Control GnRH Gene Expression via the Intronic Transcriptional Enhancer
2011
Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development
2016 StandoutNobel
HTLV-1 p27rex stabilizes human interleukin-2 receptor alpha chain mRNA.
1990 StandoutNobel
Timing of endogenous activin-like signals and regional specification of theXenopusembryo
2001
The Gene for the Embryonic Stem Cell Coactivator UTF1 Carries a Regulatory Element Which Selectively Interacts with a Complex Composed of Oct-3/4 and Sox-2
1999
Principles of planar polarity in animal development
2011
Selective suppression of human papillomavirus transcription in non-tumorigenic cells by 5-azacytidine.
1988 StandoutNobel
The oct-1 homeo domain contacts only part of the octamer sequence and full oct-1 DNA-binding activity requires the POU-specific domain.
1990
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Oct2 Transactivation from a Remote Enhancer Position Requires a B-Cell-Restricted Activity
1992
Mechanisms of Mechanotransduction
2006
Fbx15 Is a Novel Target of Oct3/4 but Is Dispensable for Embryonic Stem Cell Self-Renewal and Mouse Development
2003 StandoutNobel
Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression.
1994
Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1
1999 StandoutNobel
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
1997
The Murine Sim-2 Gene Product Inhibits Transcription by Active Repression and Functional Interference
1997
Expression and Activity of the POU Transcription Factor SCIP
1990 Science
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3
1998
In line with our ancestors: Oct-4 and the mammalian germ
1998
Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.
1989 Standout
POU-domain transcription factors: pou-er-ful developmental regulators.
1991
(dC-dA)n.(dG-dT)n sequences have evolutionarily conserved chromosomal locations in Drosophila with implications for roles in chromosome structure and function.
1987
A Molecular Elevator
2004 StandoutScienceNobel
Transcriptional regulation of the murine k-FGF gene in embryonic cell lines
1992
Structure and function of telomeres
1991 StandoutNatureNobel
Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirus.
1986
Structure and transcription of human papillomavirus sequences in cervical carcinoma cells
1985 StandoutNatureNobel
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
1985 StandoutNatureNobel
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1.
1992 StandoutNobel
Interstitial Flow and Its Effects in Soft Tissues
2007
Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells
1996
A novel type of aberrant recombination in immunoglobulin genes and its implications for V–J joining mechanism
1983 Nature
Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3.
1995
Retinoic Acid Represses Oct-3/4 Gene Expression through Several Retinoic Acid-Responsive Elements Located in the Promoter-Enhancer Region
1994
Works of Hiroshi Hamada being referenced
Generation of Robust Left-Right Asymmetry in the Mouse Embryo Requires a Self-Enhancement and Lateral-Inhibition System
2006
lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal
1998
cDNA Cloning of a Murine Homologue ofDrosophilaSingle-Minded, Its mRNA Expression in Mouse Development, and Chromosome Localization
1996
Two New Members of the Murine Sim Gene Family Are Transcriptional Repressors and Show Different Expression Patterns during Mouse Embryogenesis
1996
Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation
1999
Abnormal Nodal Flow Precedes Situs Inversus in iv and inv mice
1999
Planar polarization of node cells determines the rotational axis of node cilia
2010
Pitx2, a Bicoid-Type Homeobox Gene, Is Involved in a Lefty-Signaling Pathway in Determination of Left-Right Asymmetry
1998
The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
2001
Left–Right Asymmetric Expression of lefty2 and nodal Is Induced by a Signaling Pathway that Includes the Transcription Factor FAST2
2000
A CNS-specific POU transcription factor, Brn-2, is required for establishing mammalian neural cell lineages
1993
Determination of left–right patterning of the mouse embryo by artificial nodal flow
2002 Nature
Establishment of vertebrate left–right asymmetry
2002
Stringent integrity requirements for bothtrans-activation and DNA-binding in atrans-activator, Oct3
1991
Notch signaling regulates left–right asymmetry determination by inducingNodalexpression
2003
Cloning of inv, a gene that controls left/right asymmetry and kidney development
1998 Nature
Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch
2007 Nature
Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo
2004
Nodal Antagonists in the Anterior Visceral Endoderm Prevent the Formation of Multiple Primitive Streaks
2002
Identification of putative downstream genes of Oct‐3, a pluripotent cell‐specific transcription factor
1996
Origin of body axes in the mouse embryo
2007
A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells
1990
Inhibition of Nodal signalling by Lefty mediated through interaction with common receptors and efficient diffusion
2002
Identification of a novel left–right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily
2004
Left–right asymmetric expression of the TGFβ-family member lefty in mouse embryos
1996 Nature
Two closely‐related left‐right asymmetrically expressed genes, lefty‐1 and lefty‐2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos
1997
De Novo Formation of Left–Right Asymmetry by Posterior Tilt of Nodal Cilia
2005
The left-right axis in the mouse: from origin to morphology
2006
Characterization of genomic poly(dT-dG).poly(dC-dA) sequences: structure, organization, and conformation.
1984
The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia
2003
Enhanced gene expression by the poly(dT-dG).poly(dC-dA) sequence.
1984
Regulation of striatal D1A dopamine receptor gene transcription by Brn-4.
1996
Activin/Nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1
2000
The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse.
1995
In vitro synthesis of a 5S RNA precursor by isolated nuclei of rat liver and HeLa cells
1979
A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.
1982
Molecular structure and evolutionary origin of human cardiac muscle actin gene.
1982
Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential.
1993
Mutated beta-actin gene: coexpression with an unmutated allele in a chemically transformed human fibroblast cell line.
1981
Interplay of SOX and POU Factors in Regulation of the Nestin Gene in Neural Primordial Cells
2004
Functional cloning of mouse chromosomal loci specifically active in embryonal carcinoma stem cells.
1988
The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer.
1991
Characterization of a cell type-specific enhancer found in the human papilloma virus type 18 genome.
1987
Potential Z-DNA forming sequences are highly dispersed in the human genome
1982 Nature
Left–right patterning of the mouse lateral plate requires nodal produced in the node
2003
Molecular structure of the human cytoplasmic beta-actin gene: interspecies homology of sequences in the introns.
1985
cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix-Loop-Helix/PAS Factor (Arnt2) with Close Sequence Similarity to the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt)
1996