Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
Induction of FOXP3 expression in naive human CD4+FOXP3− T cells by T-cell receptor stimulation is transforming growth factor-β–dependent but does not confer a regulatory phenotype
2007
Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells
2010
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells
2009 Science
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Cutting Edge: Foxp3-Mediated Induction of Pim 2 Allows Human T Regulatory Cells to Preferentially Expand in Rapamycin
2008
Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice
2009
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Transcription factor Foxp3 and its protein partners form a complex regulatory network
2012
The alarmin IL-33 promotes regulatory T-cell function in the intestine
2014 Nature
Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells
2008
Two modes of immune suppression by Foxp3+ regulatory T cells under inflammatory or non-inflammatory conditions
2011 StandoutNobel
Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases
2013
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
2009 StandoutNobel
Treg and CTLA-4: Two intertwining pathways to immune tolerance
2013
Function of a Foxp3 cis -Element in Protecting Regulatory T Cell Identity
2014
GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice
2011
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2
2012
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
2008
Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response
2013
Structure of a Domain-Swapped FOXP3 Dimer on DNA and Its Function in Regulatory T Cells
2011
Predicting and interpreting large-scale mutagenesis data using analyses of protein stability and conservation
2022
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
2010 Nature
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
2009
FOXP3 and scurfy: how it all began
2014 StandoutNobel
An N-Terminal Mutation of the Foxp3 Transcription Factor Alleviates Arthritis but Exacerbates Diabetes
2012
The regulation of immune tolerance by FOXP3
2017
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
2007
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cells
2011
Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
2010
T-Cell Hyperactivation and Paralysis in Severe COVID-19 Infection Revealed by Single-Cell Analysis
2020
The emerging roles of forkhead box (Fox) proteins in cancer
2007
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells
2007
miR‐142‐3p restricts cAMP production in CD4 + CD25 − T cells and CD4 + CD25 + T REG cells by targeting AC9 mRNA
2008
Regulatory T cells: how do they suppress immune responses?
2009 StandoutNobel
Regulatory T cells in cancer immunotherapy
2016 StandoutNobel
Analyses of a Mutant Foxp3 Allele Reveal BATF as a Critical Transcription Factor in the Differentiation and Accumulation of Tissue Regulatory T Cells
2017
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Biochemistry and therapeutic implications of mechanisms involved in FOXP3 activity in immune suppression
2007
Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity
2024 StandoutNobel
Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
2013
Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells
2009
Regulatory T cells – a brief history and perspective
2007 StandoutNobel
Regulatory T Cell-Specific Epigenomic Region Variants Are a Key Determinant of Susceptibility to Common Autoimmune Diseases
2020 StandoutNobel
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
2012
TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function
2008 StandoutNature
CLIP170-like tip1p Spatially Organizes Microtubular Dynamics in Fission Yeast
2000 StandoutNobel
Development and Maintenance of Regulatory T cells
2013 StandoutNobel
Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity
2010
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells
2010
Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer
2019 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Fission yeast cell morphogenesis: identification of new genes and analysis of their role during the cell cycle.
1995 StandoutNobel
Regulatory T Cells: Mechanisms of Differentiation and Function
2007 Standout
Genetic and epigenetic basis of Treg cell development and function: from a FoxP3‐centered view to an epigenome‐defined view of natural Treg cells
2014 StandoutNobel
CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells
2011
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans
2015 StandoutNobel
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Regulatory T Cells and Human Disease
2020 StandoutNobel
From IPEX syndrome to FOXP3 mutation: a lesson on immune dysregulation
2016
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production
2011
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations
2014
Treg functional stability and its responsiveness to the microenvironment
2014
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
The Biology of Interleukin-2
2007
Controversies concerning thymus‐derived regulatory T cells: fundamental issues and a new perspective
2015
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Basis of CTLA-4 function in regulatory and conventional CD4+ T cells
2012
CD4 T cells: fates, functions, and faults
2008
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
The Ets-1 transcription factor controls the development and function of natural regulatory T cells
2010
Conditional stability of T cells
2010 StandoutNatureNobel
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
2012
Runx proteins regulate Foxp3 expression
2009
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Fission yeast orb 6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle
1998 StandoutNobel
Microtubules mediate mitochondrial distribution in fission yeast.
1996 StandoutNobel
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Single dose of anti–CTLA-4 enhances CD8 + T-cell memory formation, function, and maintenance
2010 StandoutNobel
Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
2009
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers
2017 StandoutNobel
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
Identification of fission yeast nuclear markers using random polypeptide fusions with green fluorescent protein
1996 StandoutNobel
Works of Hiroko Yaguchi being referenced
Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T Cells
2009 StandoutNobel
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Menin Missense Mutants Associated with Multiple Endocrine Neoplasia Type 1 Are Rapidly Degraded via the Ubiquitin-Proteasome Pathway
2004
Fission yeast protein kinase C gene homologues are required for protoplast regeneration: a functional link between cell wall formation and cell shape control
1994