Citation Impact
Citing Papers
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
2012 StandoutScience
Argonaute2 Is the Catalytic Engine of Mammalian RNAi
2004 StandoutScience
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Transition in Specification of Embryonic Metazoan DNA Replication Origins
1995 StandoutScience
ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.
1996
Sequential MCM/P1 Subcomplex Assembly Is Required to Form a Heterohexamer with Replication Licensing Activity
2000
‘Green revolution’ genes encode mutant gibberellin response modulators
1999 StandoutNature
Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases
1994 StandoutNobel
Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures
2006
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Initiation of Eukaryotic DNA Replication
2000
Cell Cycle- and Chromatin Binding State-dependent Phosphorylation of Human MCM Heterohexameric Complexes
1998
Phosphorylation of mammalian CDC6 by Cyclin A/CDK2 regulates its subcellular localization
1999
Xenopus Cdc45-dependent loading of DNA polymerase alpha onto chromatin under the control of S-phase cdk
1998
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
G protein linked signal transduction pathways in development: Dictyostelium as an experimental system
1989
Interactions between Mcm10p and other replication factors are required for proper initiation and elongation of chromosomal DNA replication in Saccharomyces cerevisiae
2000
Mechanisms ensuring rapid and complete DNA replication despite random initiation in Xenopus early embryos
2000
Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs
1997
Replication fork barriers in the Xenopus rDNA
1994
Reconstitution of an ATM-Dependent Checkpoint that Inhibits Chromosomal DNA Replication following DNA Damage
2000
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Geminin, an Inhibitor of DNA Replication, Is Degraded during Mitosis
1998
Tandem repeats of the 5′ non-transcribed spacer ofTetrahymenarDNA function as high copy number autonomous replicons in the macronucleus but do not prevent rRNA gene dosage regulation
1995 StandoutNobel
Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication
2000
Xenopus Mcm10 Binds to Origins of DNA Replication after Mcm2-7 and Stimulates Origin Binding of Cdc45
2002
The Cdc7 protein kinase is required for origin firing during S phase
1998
The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts
1995
Turgor-responsive gene transcription and RNA levels increase rapidly when pea shoots are wilted. Sequence and expression of three inducible genes
1990
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
Courtship in S. cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal
1990 StandoutNobel
Gene Ontology: tool for the unification of biology
2000 Standout
The Nuclear Ubiquitin-Proteasome System Degrades MyoD
2001 StandoutNobel
Qualifying for the license to replicate
1995
A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast
1997
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
Loading of an Mcm Protein onto DNA Replication Origins Is Regulated by Cdc6p and CDKs
1997
Binding of Human Minichromosome Maintenance Proteins with Histone H3
1996
Isolation and Characterization of Various Complexes of the Minichromosome Maintenance Proteins of Schizosaccharomyces pombe
2000
SH2 Signaling in a Lower Eukaryote: A STAT Protein That Regulates Stalk Cell Differentiation in Dictyostelium
1997
Regulation of activity of calcium activated neutral protease
1988
An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast
1996 Nature
hCDC47, a Human Member of the MCM Family
1996
Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex
2000
The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts
1996
Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin
2001
The Intrinsic DNA Helicase Activity of Methanobacterium thermoautotrophicum ΔH Minichromosome Maintenance Protein
2000
Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells.
1996
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
2000
NEW EMBO MEMBER'S REVIEW: Control of chromosomal DNA replication in the early Xenopus embryo
2001
Cyclin A‐dependent kinase activity affects chromatin binding of ORC, Cdc6, and MCM in egg extracts of Xenopus laevis
1999
Mcm2 is a target of regulation by Cdc7–Dbf4 during the initiation of DNA synthesis
1997
The drosophila gastrulation gene concertina encodes a Gα-like protein
1991 StandoutNobel
Regulating S Phase: CDKs, Licensing and Proteolysis
1996 StandoutNobel
Human Claspin Is a Ring-shaped DNA-binding Protein with High Affinity to Branched DNA Structures
2004 StandoutNobel
Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
1997
Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycle
2001
Characterization of the Yeast Cdc7p/Dbf4p Complex Purified from Insect Cells
2000
Phosphorylation of Mcm4 at Specific Sites by Cyclin-dependent Kinase Leads to Loss of Mcm4,6,7 Helicase Activity
2001
Cell Cycle Regulation of Human CDC6 Protein
1999
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
JAKs and STATs in invertebrate model organisms
1999
Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex
2004 StandoutNatureNobel
Stepwise Regulated Chromatin Assembly of MCM2–7 Proteins
2000
XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis
2000 Nature
Single molecule analysis of DNA replication
1999
Selective instability of Orc1 protein accounts for the absence of functional origin recognition complexes during the M-G1 transition in mammals
2000
Expression of Cdc18/Cdc6 and Cdt1 during G2 phase induces initiation of DNA replication
2001
Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts
2000
Modular sequence elements associated with origin regions in eukaryotic chromosomal DNA
1994
Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus
1996
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
The Orc4p and Orc5p Subunits of the Xenopus and Human Origin Recognition Complex Are Related to Orc1p and Cdc6p
1998 StandoutNobel
MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells
1995 Nature
Intergenic DNA and the sequence requirements for replication initiation in eukaryotes
1994
The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium
2012 Nature
Role for a Xenopus Orc2-related protein in controlling DNA replication
1996 Nature
A DNA Helicase Activity Is Associated with an MCM4, -6, and -7 Protein Complex
1997
APC/C and SCF: Controlling Each Other and the Cell Cycle
2004
Biochemical Analysis of the Intrinsic Mcm4-Mcm6-Mcm7 DNA Helicase Activity
1999
Study of the cell cycle-dependent assembly of the DNA pre-replication centres in Xenopus egg extracts.
1994
Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts
1996 StandoutNobel
The long and the short of long–term memory—a molecular framework
1986 StandoutNatureNobel
Mechanisms for Initiating Cellular DNA Replication
2013
Cyclin E Uses Cdc6 as a Chromatin-Associated Receptor Required for DNA Replication
2001
Replication origins in eukaroytes
1996
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Purification and characterization of human DNA damage checkpoint Rad complexes
2001 StandoutNobel
DNA polymerase ɛ is required for coordinated and efficient chromosomal DNA replication in Xenopus egg extracts
2001
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA
2007 StandoutNobel
Conserved features in the mode of replication of eukaryotic ribosomal RNA genes.
1993
Regulation of Replicon Size in Xenopus Egg Extracts
1997 Science
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
STATs and Gene Regulation
1997 StandoutScience
The role of MCM/P1 proteins in the licensing of DNA replication.
1996
Cell Cycle Control of Cdc7p Kinase Activity through Regulation of Dbf4p Stability
1999
Chromosomal replication initiates and terminates at random sequences but at regular intervals in the ribosomal DNA of Xenopus early embryos.
1993
Cell Cycle Control of DNA Replication
1996 Science
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Cancer Cell Cycles
1996 StandoutScience
Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family.
1991 StandoutNobel
MCM Proteins in DNA Replication
1999
A Lesion in the DNA Replication Initiation Factor Mcm10 Induces Pausing of Elongation Forks through Chromosomal Replication Origins in Saccharomyces cerevisiae
1997
Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication
1996
Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.
1996
Changes in association of the Xenopus origin recognition complex with chromatin on licensing of replication origins
1999
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Distinct Phosphoisoforms of the Xenopus Mcm4 Protein Regulate the Function of the Mcm Complex
2000
Controlling mRNA lifespan
1988 StandoutNatureNobel
Xenopus Cdc7 function is dependent on licensing but not on XORC, XCdc6, or CDK activity and is required for XCdc45 loading
2000
A quantitative model for the cdc2 control of S phase and mitosis in fission yeast
1996 StandoutNobel
A double-hexamer archaeal minichromosome maintenance protein is an ATP-dependent DNA helicase
2000
Eukaryotic Transcriptional Regulation and Chromatin-Associated Protein Phosphorylation by Cyclic AMP
1982 Science
The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization
1993 StandoutNobel
Cdc6p modulates the structure and DNA binding activity of the origin recognition complex in vitro
2000
The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.
1996 StandoutNobel
The Role of Nucleotide Binding and Hydrolysis in the Function of the Fission Yeast cdc18+ Gene Product
1999
Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein
1992 StandoutScienceNobel
Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin.
1984
A Role for Cdk2 Kinase in Negatively Regulating DNA Replication during S Phase of the Cell Cycle
1997
Replication Origins in XenopusEgg Extract Are 5–15 Kilobases Apart and Are Activated in Clusters That Fire at Different Times
2001
Schizosaccharomyces pombe cdc 20 + encodes DNA polymerase ɛ and is required for chromosomal replication but not for the S phase checkpoint
1997 StandoutNobel
The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum ΔH contains DNA helicase activity
1999
Regulation of Chromosome Replication
2000
Identification of a Preinitiation Step in DNA Replication That Is Independent of Origin Recognition Complex and cdc6, but Dependent on cdk2
1998
Site-Specific Initiation of DNA Replication in Xenopus Egg Extract Requires Nuclear Structure
1995
The role of MCM/P1 proteins in the licensing of DNA replication
1996
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
1997
Cell cycle control of replication initiation in eukaryotes
1996
CDC45, a Novel Yeast Gene That Functions with the Origin Recognition Complex and Mcm Proteins in Initiation of DNA Replication
1997
Constitutive expression of a complement-like protein in Toll and JAK gain-of-function mutants ofDrosophila
2000 StandoutNobel
Translational control during early dictyostelium development: Possible involvement of poly(A) sequences
1984
ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae.
1996
A Distinct G 1 Step Required to Specify the Chinese Hamster DHFR Replication Origin
1996 Science
The Molecular Biology of Axon Guidance
1996 StandoutScience
DNA Replication in Eukaryotic Cells
2002 Standout
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Initiating DNA synthesis: from recruiting to activating the MCM complex
2001
Cell-cell interactions in Dictyostelium development
1989
INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS
1997
Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.
1996
THE UBIQUITIN SYSTEM
1998 StandoutNobel
mcm5/cdc46-bob1 bypasses the requirement for the S phase activator Cdc7p
1997
Preferential binding of ATR protein to UV-damaged DNA
2002 StandoutNobel
Cell cycle control of eukaryotic DNA replication
1996
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin
1996
Physical Interactions among Mcm Proteins and Effects of Mcm Dosage on DNA Replication in Saccharomyces cerevisiae
1996
Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle.
1996
Identification of an Origin of Bidirectional DNA Replication in the Ubiquitously Expressed Mammalian CAD Gene
1995
Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
1992 StandoutScienceNobel
Works of Hiro Mahbubani being referenced
Characterization of two highly diverged but developmentally co-regulated cysteine proteinase genes inDictyostelium discoideum
1985
Characterization of the Xenopus replication licensing system
1997
Mammalian Cdh1/Fzr mediates its own degradation
2004
Positively and negatively acting signals regulating stalk cell and anterior-like cell differentiation in dictyostelium
1991
Purification of an MCM-containing complex as a component of the DNA replication licensing system
1995 Nature
Cell Cycle-Regulated Recognition of the Destruction Box of Cyclin B by the APC/C in Xenopus Egg Extracts
2004 Nobel
DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts
1992
The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin
1999
A developmentally regulated cysteine proteinase in Dictyostelium discoideum.
1985
Cell Cycle Regulation of the Replication Licensing System: Involvement of a Cdk-dependent Inhibitor
1997
Cell-type-specific actin mRNA populations in Dictyostelium discoideum
1982
A change in the rate of transcription of a eukaryotic gene in response to cyclic AMP.
1980
Direct induction of dictyostelium prestalk gene expression by DIF provides evidence that DIF is a morphogen
1987