Standout Papers
- Antibiotics LL-Z1272 identified as novel inhibitors discriminating bacterial and mitochondrial quinol oxidases (2008)
- Ascosteroside C, a new mitochondrial respiration inhibitor discovered by pesticidal screening using recombinant Saccharomyces cerevisiae (2015)
- Trichopolyn VI: a new peptaibol insecticidal compound discovered using a recombinant <i>Saccharomyces cerevisiae</i> screening system (2015)
- Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550 (2006)
- An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria (2000)
- Biochemical and Spectroscopic Properties of Cyanide-Insensitive Quinol Oxidase from Gluconobacter oxydans (2009)
- Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083 (2006)
Citation Impact
Citing Papers
The coupling mechanism of mammalian respiratory complex I
2020 Science
Protein structure determination using metagenome sequence data
2017 StandoutScienceNobel
Rates of Behavior and Aging Specified by Mitochondrial Function During Development
2002 Science
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
2005 StandoutNobel
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction
2010
Iron‐sulphur clusters and the problem with oxygen
2006
The Quinone Binding Site in Escherichia coli Succinate Dehydrogenase Is Required for Electron Transfer to the Heme b
2006
Inhibitors of NADH–ubiquinone reductase: an overview
1998
The Quinone-binding Site in Succinate-ubiquinone Reductase fromEscherichia coli
1998
Structure of photosystem II and molecular architecture of the oxygen-evolving centre
2004
Quinone-Annonaceous Acetogenins: Synthesis and Complex I Inhibition Studies of a New Class of Natural Product Hybrids
2001
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
The Saccharomyces cerevisiae succinate dehydrogenase does not require heme for ubiquinone reduction
2007
Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
1996
1,4‐Pentenyne as a Five‐Carbon Synthon for Efficient and Selective Syntheses of Natural Products Containing 2,4‐Dimethyl‐1‐penten‐1,5‐ylidene and Related Moieties by Means of Zr‐Catalyzed Carboalumination of Alkynes and Alkenes
2007 StandoutNobel
Physicochemical Profiling (Solubility, Permeability and Charge State)
2001
Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi
2002
Catalytic properties of the mitochondrial NADH–ubiquinone oxidoreductase (Complex I) and the pseudo-reversible active/inactive enzyme transition
1998
Tracing the tail of ubiquinone in mitochondrial complex I
2012
Kinetic Characterization of Mitochondrial Complex I Inhibitors Using Annonaceous Acetogenins
1999
Structure of mammalian respiratory complex I
2016 Nature
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
2006 StandoutNobel
Simple screening method for improving membrane protein thermostability
2011
A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans
2010
Recent advances in the stereoselective synthesis of tetrahydrofurans
2006
Mitochondrial cytochrome c oxidase and succinate dehydrogenase complexes contain plant specific subunits
2004
Cytochrome bd terminal oxidase1All amino acid numbering refers to the E. coli enzyme.1
1997
Light‐Controlled Tools
2012
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
2005 Standout
Reactive oxygen species (ROS) as pleiotropic physiological signalling agents
2020 Standout
Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling
2016
Gramicidin S identified as a potent inhibitor for cytochrome bd‐type quinol oxidase
2008 StandoutNobel
Human Complex I deficiency: Clinical spectrum and involvement of oxygen free radicals in the pathogenicity of the defect
1998
The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney
2007
Structural and Computational Analysis of the Quinone-binding Site of Complex II (Succinate-Ubiquinone Oxidoreductase)
2005
Prediction of transmembrane helix orientation in polytopic membrane proteins.
2006
Mitochondrial fumarate reductase as a target of chemotherapy: From parasites to cancer cells
2011
SDH mutations in cancer
2011
Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli
2012
Enantioselective total synthesis of atpenin A5
2009 StandoutNobel
Natural Product Hybrids as New Leads for Drug Discovery
2003 Standout
Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
2019 StandoutNobel
Uncoupling: new approaches to an old problem of bioenergetics
1998
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Comparison of Catalytic Activity and Inhibitors of Quinone Reactions of Succinate Dehydrogenase (Succinate–Ubiquinone Oxidoreductase) and Fumarate Reductase (Menaquinol–Fumarate Oxidoreductase) from Escherichia coli
1999
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Pathological mechanisms and parent-of-origin effects in hereditary paraganglioma/pheochromocytoma (PGL/PCC)
2011
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Binding of the Respiratory Chain Inhibitor Antimycin to the Mitochondrial bc1 Complex: A New Crystal Structure Reveals an Altered Intramolecular Hydrogen-bonding Pattern
2005
Rational design of photosynthetic reaction center protein maquettes
2022
SMK-1, an Essential Regulator of DAF-16-Mediated Longevity
2006
The Hallmarks of Aging
2013 Standout
The natural product capsaicin inhibits photosynthetic electron transport at the reducing side of photosystem II and purple bacterial reaction center: structural details of capsaicin binding
2000
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase
2003
Mitochondrial ROS-induced ROS release: An update and review
2006
Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II
2005
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The Ubiquinone-binding Site of the Saccharomyces cerevisiae Succinate-Ubiquinone Oxidoreductase Is a Source of Superoxide
2003
The NADH‐fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments
2010
Catalyst‐Directed Diastereo‐ and Site‐Selectivity in Successive Nucleophilic and Electrophilic Allylations of Chiral 1,3‐Diols: Protecting‐Group‐Free Synthesis of Substituted Pyrans
2014
Ivermectin: 25 years and still going strong
2007 StandoutNobel
Novel Mitochondrial Complex II Isolated from Trypanosoma cruzi Is Composed of 12 Peptides Including a Heterodimeric Ip Subunit
2009 StandoutNobel
Long-chain fatty acids act as protonophoric uncouplers of oxidative phosphorylation in rat liver mitochondria
1989
Mitochondrial Electron Transport Is a Key Determinant of Life Span in Caenorhabditis elegans
2001
Electron-transfer complexes in Ascaris mitochondria
2002
Clues from cell metabolism
2010 StandoutNatureNobel
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
2005 Standout
Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases
2016 ScienceNobel
Total synthesis of nafuredin-γ, a γ-lactone related to nafuredin with selective inhibitory activity against NADH-fumarate reductase
2003 StandoutNobel
Peroxidase Activity of Myoglobin Is Enhanced by Chemical Mutation of Heme-Propionates
1999 StandoutNobel
Complexation of Polyoxometalates with Cyclodextrins
2015 StandoutNobel
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp. FKI-3389
2011 StandoutNobel
Photoswitchable Intramolecular H-Stacking of Perylenebisimide
2010 StandoutNobel
Dialogue between E. coli free radical pathways and the mitochondria of C. elegans
2015 StandoutNobel
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles
2004 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
3-Nitropropionic Acid is a Suicide Inhibitor of Mitochondrial Respiration that, Upon \nOxidation by Complex II, Forms a Covalent Adduct With a Catalytic Base Arginine in the Active Site \nof the Enzyme
2005
Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release
2014 Standout
ROS-based lethality of Caenorhabditis elegans mitochondrial electron transport mutants grown on Escherichia coli siderophore iron release mutants
2019 StandoutNobel
Cell-based screening strategy in the search for bioactive microbial secondary metabolites
2004 Nobel
Microbial metabolites: 45 years of wandering, wondering and discovering
2011 StandoutNobel
EglN3 hydroxylase stabilizes BIM-EL linking VHL type 2C mutations to pheochromocytoma pathogenesis and chemotherapy resistance
2019 StandoutNobel
Discovery, chemistry, and chemical biology of microbial products
2007 StandoutNobel
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
The total synthesis and biological evaluation of nafuredin-γ and its analogues
2008 StandoutNobel
Emergent properties arising from the assembly of amphiphiles. Artificial vesicle membranes as reaction promoters and regulators
2014
Nafuredin, a Novel Inhibitor of NADH-fumarate Reductase, Produced by Aspergillus niger FT-0554.
2001 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Energy Converting NADH: Quinone Oxidoreductase (Complex I)
2006
Confined acids catalyze asymmetric single aldolizations of acetaldehyde enolates
2018 StandoutScienceNobel
A New Class of Rigid Multi(azobenzene) Switches Featuring Electronic Decoupling: Unravelling the Isomerization in Individual Photochromes
2019 StandoutNobel
Molecular modelling of electron transfer systems by noncovalently linked porphyrin–acceptor pairing
1997
Absolute configuration of nafuredin, a new specific NADH-fumarate reductase inhibitor
2001 StandoutNobel
Lewis-acid catalyzed formation of dihydropyrans
2011
Cell Biology of the Mitochondrion
2017
Heme Protein Assemblies
2004
Prediction of membrane protein structures with complex topologies using limited constraints
2009 StandoutNobel
Substitutions of Conserved Aromatic Amino Acid Residues in Subunit I Perturb the Metal Centers of the Escherichia coli bo-Type Ubiquinol Oxidase
1998
Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions
2017 StandoutNobel
Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q
2002 Science
Hybridnaturstoffe: Design, Synthese und biologische Untersuchung von Chinon-Annonin-Acetogeninen
2000
Mitochondrial Complex I
2013
Respiratory chain complex II as general sensor for apoptosis
2012
Analogues of cytotoxic squamocin using reliable reactions: new insights into the reactivity and role of the α,β-unsaturated lactone of the annonaceous acetogenins
2006
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Photopharmacology: Beyond Proof of Principle
2014 StandoutNobel
Escherichia coli succinate dehydrogenase variant lacking the heme b
2007
Unraveling the Photoswitching Mechanism in Donor–Acceptor Stenhouse Adducts
2016 StandoutNobel
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Control of Surface Wettability Using Tripodal Light-Activated Molecular Motors
2014 StandoutNobel
A Mutation in the SDHC Gene of Complex II Increases Oxidative Stress, Resulting in Apoptosis and Tumorigenesis
2005
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Electronic Decoupling in C3-Symmetrical Light-Responsive Tris(Azobenzene) Scaffolds: Self-Assembly and Multiphotochromism
2018 StandoutNobel
Function and Structure of Complex II of the Respiratory Chain
2003
Catalytic Asymmetric Vinylogous Prins Cyclization: A Highly Diastereo- and Enantioselective Entry to Tetrahydrofurans
2016 StandoutNobel
In Situ Formation of an Oxygen-Evolving Catalyst in Neutral Water Containing Phosphate and Co 2+
2008 StandoutScience
Works of Hideto Miyoshi being referenced
Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation
2003 Science
Oversized ubiquinones as molecular probes for structural dynamics of the ubiquinone reaction site in mitochondrial respiratory complex I
2020
Quantitative analyses of uncoupling activity of SF6847 (2,6-di-t-butyl-4-(2,2-dicyanovinyl)phenol) and its analogs with spinach chloroplasts
1987
Current topics on inhibitors of respiratory complex I
2015
Essential structural factors of annonaceous acetogenins as potent inhibitors of mitochondrial complex I
1998
Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH-ubiquinone oxidoreductases
1996
Probing the Ubiquinone Reduction Site of Mitochondrial Complex I Using Novel Cationic Inhibitors
1997
Role of a bound ubiquinone on reactions of the Escherichia coli cytochrome bo with ubiquinol and dioxygen
1999
Synthesis and inhibitory activity of ubiquinone–acetogenin hybrid inhibitor with bovine mitochondrial complex I
2003
A model of antimycin A binding based on structure-activity studies of synthetic antimycin A analogues
1995
Quinones in long‐lived clk‐1 mutants of Caenorhabditis elegans
2002
Essential structural factors of acetogenins, potent inhibitors of mitochondrial complex I
2002
Stabilization of a semiquinone radical at the high‐affinity quinone‐binding site (QH) of the Escherichia coli bo‐type ubiquinol oxidase
1995
Structure–activity relationships of some complex I inhibitors
1998
A γ-Lactone Form Nafuredin, Nafuredin-γ, also Inhibits Helminth Complex I
2005
Rhodoquinone reaction site of mitochondrial complex I, in parasitic helminth, Ascaris suum
2003
Probing Substrate Binding Site of the Escherichia coli Quinol Oxidases Using Synthetic Ubiquinol Analogues
1996
Structural factors of antimycin A molecule required for inhibitory action
1994
Defining the mechanism of action of S1QELs, specific suppressors of superoxide production in the quinone-reaction site in mitochondrial complex I
2019
Quantitative analyses of the uncoupling activity of substituted phenols with mitochondria from flight muscles of house flies
1988
Specificity of Pyridinium Inhibitors of the Ubiquinone Reduction Sites in Mitochondrial Complex I
1998
Inhibitor Probes of the Quinone Binding Sites of Mammalian Complex II and Escherichia coli Fumarate Reductase
1996
Comparison of the Inhibitory Action of Natural Rotenone and its Stereoisomers with Various NADH‐ubiquinone Reductases
1994
Inhibition of electron transport of rat-liver mitochondria by synthesized antimycin A analogs
1993
Contribution of the FAD and quinone binding sites to the production of reactive oxygen species from Ascaris suum mitochondrial complex II
2009
Comparison of the Structural Features of Ubiquinone Reduction Sites Between Glucose Dehydrogenase in Escherichia coli and Bovine Heart Mitochondrial Complex I
1996
Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550
2006 StandoutNobel
Altered Quinone Biosynthesis in the Long-lived clk-1Mutants of Caenorhabditis elegans
2001
Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083
2006 StandoutNobel
Comparison of the structures of the quinone-binding sites in beef heart mitochondria.
1993
Synthesis of 13C-Labeled Ubiquinone-Acetogenin Hybrid Inhibitors of Mitochondrial Complex I
2004
Light Control of Mitochondrial Complex I Activity by a Photoresponsive Inhibitor
2006
Identification of a novel quinone-binding site in the cytochrome bo complex from Escherichia coli.
1994
Complex II from phototrophic purple bacterium Rhodoferax fermentans displays rhodoquinol‐fumarate reductase activity
2003
Synthesis of Pyranicin and Its Inhibitory Action with Bovine Heart Mitochondrial Complex I
2008
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase)
2003
Exploring Interactions between the 49 kDa and ND1 Subunits in Mitochondrial NADH-Ubiquinone Oxidoreductase (Complex I) by Photoaffinity Labeling
2011
An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria
2000 StandoutNobel
Quantitative relationship between protonophoric and uncoupling activities of substituted phenols
1987
Role of the Isoprenyl Tail of Ubiquinone in Reaction with Respiratory Enzymes: Studies with Bovine Heart Mitochondrial Complex I and Escherichia coli bo-Type Ubiquinol Oxidase
1998
Probing the Ubiquinol-Binding Site in Cytochromebdby Site-Directed Mutagenesis
2006
Characterization of the Ubiquinone Reduction Site of Mitochondrial Complex I Using Bulky Synthetic Ubiquinones
1998
Glutamates 99 and 107 in Transmembrane Helix III of Subunit I of Cytochrome bd Are Critical for Binding of the Heme b595-d Binuclear Center and Enzyme Activity
2006
Anaerobic NADH-Fumarate Reductase System Is Predominant in the Respiratory Chain of Echinococcus multilocularis , Providing a Novel Target for the Chemotherapy of Alveolar Echinococcosis
2007
Glutamate 107 in Subunit I of the Cytochrome bd Quinol Oxidase from Escherichia coli Is Protonated and near the Heme d/Heme b595 Binuclear Center
2007
Quantitative Analysis of Partition Behavior of Substituted Phenols from Aqueous Phase into Liposomes Made of Lecithin and Various Lipids
1987
Synthesis and Inhibition Mechanism of Δlac-Acetogenins, a Novel Type of Inhibitor of Bovine Heart Mitochondrial Complex I
2004
Phytotoxic Compounds Cochlioquinones Are Inhibitors of Mitochondrial NADH-Ubiquinone Reductase
1996
Synthesis of (4R,15R,16R,21S)- and (4R,15S,16S,21S)-rollicosin
2005
Inhibition of electron transport of rat liver mitochondria by unnatural (‐)‐antimycin A3
1991
Molecular Mechanisms for the Induction of Peroxidase Activity of the Cytochrome c–Cardiolipin Complex
2011
The Biochemical Mode of Action of the Novel Selective Fungicide Cyazofamid: Specific Inhibition of Mitochondrial Complex III in Phythium spinosum
2001