Standout Papers
Citation Impact
Citing Papers
Neurotoxic protein expression reveals connections between the circadian clock and mating behavior in Drosophila
2006 StandoutNobel
Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy
2001 StandoutScience
The PINK1/Parkin pathway regulates mitochondrial morphology
2008
TFEB Links Autophagy to Lysosomal Biogenesis
2011 StandoutScience
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
2008
A Gene Network Regulating Lysosomal Biogenesis and Function
2009 StandoutScience
Controlling Macromolecular Topology with Genetically Encoded SpyTag–SpyCatcher Chemistry
2013 StandoutNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP
2002
Parkinson-like syndrome induced by continuous MPTP infusion: Convergent roles of the ubiquitin-proteasome system and α-synuclein
2005 StandoutNobel
Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
2002 StandoutScience
Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125
2007
Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylation
2011
Analysis of the genome sequence of the flowering plant Arabidopsis thaliana
2000 StandoutNature
Effect of Wild-type or Mutant Parkin on Oxidative Damage, Nitric Oxide, Antioxidant Defenses, and the Proteasome
2002
Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin
2009
Proteasomal inhibition causes the formation of protein aggregates containing a wide range of proteins, including nitrated proteins
2003
Parkin Facilitates the Elimination of Expanded Polyglutamine Proteins and Leads to Preservation of Proteasome Function
2003
Inducible Expression of Tau Repeat Domain in Cell Models of Tauopathy
2005
Protein misfolding in Alzheimer’s and Parkinson’s disease: genetics and molecular mechanisms
2002
mTOR Signaling in Growth Control and Disease
2012 Standout
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity
2012
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
2010 Standout
Formation and Removal of α-Synuclein Aggregates in Cells Exposed to Mitochondrial Inhibitors
2002
Dysfunction of mitochondrial complex I and the proteasome: interactions between two biochemical deficits in a cellular model of Parkinson's disease
2003
The p38 subunit of the aminoacyl-tRNA synthetase complex is a Parkin substrate: linking protein biosynthesis and neurodegeneration
2003
Autophagic degradation of tau in primary neurons and its enhancement by trehalose
2011
Dopamine covalently modifies and functionally inactivates parkin
2005
An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH‐SY5Y cells
2003
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
2006
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
2008
Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson's disease
2003
The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
2001
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
2003
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease
2015 Standout
Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
2005
Localization of a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, PARK6, on Human Chromosome 1p35-p36
2001
CHIP Is Associated with Parkin, a Gene Responsible for Familial Parkinson's Disease, and Enhances Its Ubiquitin Ligase Activity
2002
An Unfolded Putative Transmembrane Polypeptide, which Can Lead to Endoplasmic Reticulum Stress, Is a Substrate of Parkin
2001
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
RING Finger Proteins
2000
Lipid Rafts Mediate the Synaptic Localization of α-Synuclein
2004
The Co-chaperone Carboxyl Terminus of Hsp70-interacting Protein (CHIP) Mediates α-Synuclein Degradation Decisions between Proteasomal and Lysosomal Pathways
2005
Pattern Recognition Receptors and Inflammation
2010 Standout
Proteasome inhibition by paired helical filament‐tau in brains of patients with Alzheimer's disease
2003
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
2009
A Precipitating Role for Truncated α-Synuclein and the Proteasome in α-Synuclein Aggregation
2005
Parkin Suppresses Dopaminergic Neuron-Selective Neurotoxicity Induced by Pael-R in Drosophila
2003
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria
2010
Part II: α-synuclein and its molecular pathophysiological role in neurodegenerative disease
2003
Small Ubiquitin-like Modifier (SUMO) Modification of Natively Unfolded Proteins Tau and α-Synuclein
2006
Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations
2003
Rare genetic mutations shed light on the pathogenesis of Parkinson disease
2003
Tau in physiology and pathology
2015 Standout
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
2003
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
2006 StandoutNature
What causes cell death in Parkinson's disease?
2009
RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO
2002 StandoutNature
Complex relationship between Parkin mutations and Parkinson disease
2002
Enrichment and Site Mapping of O-Linked N-Acetylglucosamine by a Combination of Chemical/Enzymatic Tagging, Photochemical Cleavage, and Electron Transfer Dissociation Mass Spectrometry
2009
Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin–protein ligase with monoubiquitylation capacity
2006
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress
2004
Regulation of β-Adrenergic Receptor Signaling by S-Nitrosylation of G-Protein-Coupled Receptor Kinase 2
2007 StandoutNobel
Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity
2000
Ubiquitin: structures, functions, mechanisms
2004
Protein degradation and protection against misfolded or damaged proteins
2003 StandoutNature
Aggregated and Monomeric α-Synuclein Bind to the S6′ Proteasomal Protein and Inhibit Proteasomal Function
2003
Protein folding and misfolding
2003 StandoutNature
Parkin and Parkinsonʼs disease
2001
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Pathogenesis of parkinson's disease: dopamine, vesicles and α-synuclein
2002
Themes and variations on ubiquitylation
2001
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
The roles of intracellular protein-degradation pathways in neurodegeneration
2006 Nature
Parkin Protects against the Toxicity Associated with Mutant α-Synuclein
2002
Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
2001
The Effects of Hemodynamic Force on Embryonic Development
2010
α-Synuclein is phosphorylated in synucleinopathy lesions
2002 Standout
From endoplasmic-reticulum stress to the inflammatory response
2008 StandoutNature
α-Synuclein Is Degraded by Both Autophagy and the Proteasome
2003
Part I: Parkin-associated proteins and Parkinson's disease
2003
Parkin ubiquitinates the α-synuclein–interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
2001
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
2004
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
2007
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons
2003
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
2010
A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery
2011
Methamphetamine produces neuronal inclusions in the nigrostriatal system and in PC12 cells
2003
Loss of autophagy in the central nervous system causes neurodegeneration in mice
2006 StandoutNature
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Alpha-synuclein and neurodegenerative diseases
2001
Selective Insolubility of α-Synuclein in Human Lewy Body Diseases Is Recapitulated in a Transgenic Mouse Model
2001
Diverse Effects of Pathogenic Mutations of Parkin That Catalyze Multiple Monoubiquitylation in Vitro
2005
Dopamine-dependent neurotoxicity of α-synuclein: A mechanism for selective neurodegeneration in Parkinson disease
2002
Are Ubiquitination Pathways Central to Parkinson's Disease?
2003
Neuroinflammatory mechanisms in Parkinson's disease: Potential environmental triggers, pathways, and targets for early therapeutic intervention
2007
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
Novel Monoclonal Antibodies Demonstrate Biochemical Variation of Brain Parkin with Age
2003
Altered Proteasomal Function in Sporadic Parkinson's Disease
2002
A block of autophagy in lysosomal storage disorders
2007
Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity
2003
Proteasomal degradation of tau protein
2002
Genetics of Parkinson's disease and biochemical studies of implicated gene products: Commentary
2002
CHOP/GADD153 is a mediator of apoptotic death in substantia nigra dopamine neurons in an in vivo neurotoxin model of parkinsonism
2005
Genetics of Parkinson's disease and biochemical studies of implicated gene products
2002
Expanding insights of mitochondrial dysfunction in Parkinson's disease
2006
Aggresomes Formed by α-Synuclein and Synphilin-1 Are Cytoprotective
2004
Dorfin Localizes to the Ubiquitylated Inclusions in Parkinson's Disease, Dementia with Lewy Bodies, Multiple System Atrophy, and Amyotrophic Lateral Sclerosis
2003
Biochemistry and Cell Biology of Tau Protein in Neurofibrillary Degeneration
2012
Pink1, Parkin, DJ-1 and mitochondrial dysfunction in Parkinson's disease
2007
The Pathobiology of Vascular Dementia
2013 Standout
L166P Mutant DJ-1, Causative for Recessive Parkinson's Disease, Is Degraded through the Ubiquitin-Proteasome System
2003
Parkin enhances mitochondrial biogenesis in proliferating cells
2006
Certain Pairs of Ubiquitin-conjugating Enzymes (E2s) and Ubiquitin-Protein Ligases (E3s) Synthesize Nondegradable Forked Ubiquitin Chains Containing All Possible Isopeptide Linkages
2007
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
2015 StandoutNature
Parkin and CASK/LIN-2 Associate via a PDZ-mediated Interaction and Are Co-localized in Lipid Rafts and Postsynaptic Densities in Brain
2002
A potential proteasome-interacting motif within the ubiquitin-like domain of parkin and other proteins
2003
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
2004
Genetics of Parkinson's disease and parkinsonism
2006
Two motifs within the tau microtubule‐binding domain mediate its association with the hsc70 molecular chaperone
2008
Parkinson's Disease
2003 Standout
Dorfin Ubiquitylates Mutant SOD1 and Prevents Mutant SOD1-mediated Neurotoxicity
2002
The autosomal recessive juvenile Parkinson disease gene product, parkin, interacts with and ubiquitinates synaptotagmin XI
2003
Ubiquitin–proteasome system dysfunction in Parkinson’s disease: current evidence and controversies
2007
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin‐like domain
2003
Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Cycle or a Double-Edged Sword?
2007
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
Metabolic cross-talk allows labeling of O-linked β- N -acetylglucosamine-modified proteins via the N -acetylgalactosamine salvage pathway
2011 StandoutNobel
Rare genetic mutations shed light on the pathogenesis of Parkinson disease
2003
Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System
2002
Parkin-proven disease
2003
PROTOFIBRILS , PORES , FIBRILS, AND NEURODEGENERATION : Separating the Responsible Protein Aggregates from The Innocent Bystanders
2003
Alterations in the common fragile site gene Parkin in ovarian and other cancers
2003
Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia
2001
Does Impairment of the Ubiquitin-Proteasome System or the Autophagy-Lysosome Pathway Predispose Individuals to Neurodegenerative Disorders such as Parkinson's Disease?
2010
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Mitochondrial-Nuclear Communications
2007
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Mussel-Inspired Surface Chemistry for Multifunctional Coatings
2007 StandoutScience
The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disorders
2001
Degradation of tau protein by autophagy and proteasomal pathways
2012
Double-knockout mice for α- and β-synucleins: Effect on synaptic functions
2004 StandoutNobel
Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death
2001
Mechanisms Underlying Ubiquitination
2001 Standout
Piezo1, a mechanically activated ion channel, is required for vascular development in mice
2014 StandoutNobel
Kinetic Stabilization of the α-Synuclein Protofibril by a Dopamine-α-Synuclein Adduct
2001 Science
Toxic Proteins in Neurodegenerative Disease
2002 Science
Fine Structure and Biochemical Mechanisms Underlying Nigrostriatal Inclusions and Cell Death after Proteasome Inhibition
2003
Alpha-synuclein: between synaptic function and dysfunction.
2003
Selective loss of 20S proteasome α-subunits in the substantia nigra pars compacta in Parkinson's disease
2002
Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model
2007
The β-Propensity of Tau Determines Aggregation and Synaptic Loss in Inducible Mouse Models of Tauopathy
2007
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity
2014
Evaluation of 50 probands with early-onset Parkinson’s disease for Parkin mutations
2002
Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants
2003
Mitochondrial Dysfunction and Oxidative Damage in parkin-deficient Mice
2004
Recent advances in the genetics and pathogenesis of Parkinson disease
2002
Increased glutathione S -transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease
2005
MOLECULAR PATHOPHYSIOLOGY OF PARKINSON'S DISEASE
2005
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system.
2002
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Parkin functions as an E2-dependent ubiquitin– protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1
2000
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
2010 Standout
Parkin is associated with actin filaments in neuronal and nonneural cells
2000
Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism
2003 StandoutScience
Chaperoning brain degeneration
2002
DIVERSE FUNCTIONS OF IL-2, IL-15, AND IL-7 IN LYMPHOID HOMEOSTASIS
2006
Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners
2012 StandoutNobel
Chemical Glycoproteomics
2016 StandoutNobel
Emerging Role for Autophagy in the Removal of Aggresomes in Schwann Cells
2003
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
2008 Standout
Drosophila parkinmutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
2004
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
S -Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function
2004 Science
Works of Hideki Shimura being referenced
Parkin Localizes to the Lewy Bodies of Parkinson Disease and Dementia with Lewy Bodies
2002
Parkin is associated with cellular vesicles
2001
Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion
2009
Phosphorylated tau and the neurodegenerative foldopathies
2004
Progress in the clinical and molecular genetics of familial parkinsonism
2000
Immunohistochemical and subcellular localization of parkin protein: Absence of protein in autosomal recessive juvenile parkinsonism patients
1999
CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival
2004
Parkin is linked to the ubiquitin pathway
2001
Importance of familial Parkinson’s disease and parkinsonism to the understanding of nigral degeneration in sporadic Parkinson’s disease
2000
Binding of Tau to Heat Shock Protein 27 Leads to Decreased Concentration of Hyperphosphorylated Tau and Enhanced Cell Survival
2004
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
2000 Standout
Familial Parkinson's disease. Alpha-synuclein and parkin.
2001
Phosphodiesterase III Inhibition Promotes Differentiation and Survival of Oligodendrocyte Progenitors and Enhances Regeneration of Ischemic White Matter Lesions in the Adult Mammalian Brain
2009
Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor β-Chain-Deficient Mice
2002
Ubiquitination of a New Form of α-Synuclein by Parkin from Human Brain: Implications for Parkinson's Disease
2001 Science