Citation Impact
Citing Papers
Glycolytic Enzymes Can Modulate Cellular Life Span
2005
Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence
2009
Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria
2005 StandoutScience
Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras -Induced Premature Senescence
2002
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Genome-wide Association of Hypoxia-inducible Factor (HIF)-1α and HIF-2α DNA Binding with Expression Profiling of Hypoxia-inducible Transcripts
2009 StandoutNobel
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Cellular senescence: unravelling complexity
2009
Angiogenesis inhibition: A review
1994
Rac1 Activity Is Required for the Activation of Hypoxia-inducible Factor 1
2001 StandoutNobel
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
2008
How Tumors Become Angiogenic
1996
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
1996 Standout
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
2013 StandoutNature
Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway
2003
Wound repair and regeneration
2008 StandoutNature
BRAFE600-associated senescence-like cell cycle arrest of human naevi
2005 StandoutNature
Tumor suppressors and oncogenes in cellular senescence☆
2000
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
Modulation of oxidative stress as an anticancer strategy
2013 Standout
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
2008
Putting the stress on senescence
2001
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Oxidant signals and oxidative stress
2003
Angiogenesis in cancer and other diseases
2000 StandoutNature
The Hallmarks of Cancer
2000 Standout
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
2002 StandoutNature
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
The Proteasome Is Involved in Angiogenesis
1998 StandoutNobel
NF-κB inhibition delays DNA damage–induced senescence and aging in mice
2012
Autophagy: Renovation of Cells and Tissues
2011 Standout
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
2011 StandoutNature
Mitochondria, Oxidants, and Aging
2005 Standout
p38MAPK in the Senescence of Human and Murine Fibroblasts
2010
Cellular senescence and chromatin structure
2007
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
2005
Mitogenic signalling and the p16INK4a–Rb pathway cooperate to enforce irreversible cellular senescence
2006
The essence of senescence: Figure 1.
2010 Standout
Stem cells, ageing and the quest for immortality
2006 StandoutNature
Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions
2016
Genome maintenance mechanisms for preventing cancer
2001 StandoutNature
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Regulation of cellular response to oncogenic and oxidative stress by Seladin-1
2004 Nature
Autophagy maintains stemness by preventing senescence
2016 Nature
Imaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
2004 StandoutNobel
Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis
2008
Atherosclerosis — An Inflammatory Disease
1999 Standout
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
2002
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
2005 StandoutNature
Mechanisms of Antineoplastic Action of Somatostatin Analogs
1998 Nobel
Cellular senescence and its effector programs
2014
Genes involved in senescence and immortalization
2000
The role of senescent cells in ageing
2014 StandoutNature
Tumor Stroma-Derived TGF-β Limits Myc-Driven Lymphomagenesis via Suv39h1-Dependent Senescence
2010
The Hallmarks of Aging
2013 Standout
Free radicals and senescence
2008
Homocysteinemia as a risk factor for atherosclerosis: a review
1997
Modulation of insulin-like growth factor (IGF) and IGF binding protein biosynthesis by hypoxia in cultured vascular endothelial cells
1998
Cellular mechanisms and physiological consequences of redox-dependent signalling
2014 Standout
Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
2000
Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells
2005
The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
2007
Cellular senescence: from physiology to pathology
2014 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Reactive Species-Mediated Regulation of Cell Signaling and the Cell Cycle: The Role of MAPK
2005
Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell
2000
DNA Damage Signaling and p53-dependent Senescence after Prolonged β-Interferon Stimulation
2006
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Glycated Collagen I Induces Premature Senescence-Like Phenotypic Changes in Endothelial Cells
2002
Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study
1998 StandoutScience
Mitochondrial Fission, Fusion, and Stress
2012 StandoutScience
Role for Mitochondrial Oxidants as Regulators of Cellular Metabolism
2000
Idiopathic Pulmonary Fibrosis: Prevailing and Evolving Hypotheses about Its Pathogenesis and Implications for Therapy
2001 Standout
Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
2012
Spermidine in health and disease
2018 StandoutScience
Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis
1999 StandoutScience
Aging‐induced proinflammatory shift in cytokine expression profile in rat coronary arteries
2003
Broken Limits to Life Expectancy
2002 StandoutScience
Normal Human Fibroblasts Are Resistant to RAS-Induced Senescence
2004
Metabolic reprogramming and cancer progression
2020 StandoutScience
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases
2002
The signals and pathways activating cellular senescence
2004
The Superoxide-Generating Oxidase Nox1 Is Functionally Required for Ras Oncogene Transformation
2004
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Homocysteine and Cardiovascular Disease
1998 Standout
Palladium‐Catalyzed Fluorosulfonylvinylation of Organic Iodides
2017 StandoutNobel
Ras‐dependent and ‐independent regulation of reactive oxygen species by mitogenic growth factors and TGF‐β1
2000
Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion‐induced necrosis and apoptosis in vivo
2000
Genes Expressed in Human Tumor Endothelium
2000 StandoutScience
Free Radicals in the Physiological Control of Cell Function
2002 Standout
IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine ‘Bystander senescence’
2012
Real-time in vivo imaging of p16Ink4a reveals cross talk with p53
2009
Influence of Induced Reactive Oxygen Species in p53-Mediated Cell Fate Decisions
2003
Murine Models of Life Span Extension
2004
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel
Works of Hideki Ito being referenced
Ras Proteins Induce Senescence by Altering the Intracellular Levels of Reactive Oxygen Species
1999
Interferon-β, an autocrine cytokine, suppresses human fetal skin fibroblast migration into a denuded area in a cell monolayer but is not involved in the age-related decline of cell migration
1996
Tumor necrosis factor reduces lifespan of human endothelial cells in vitro
1990
Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment
1993
Radicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis
1993
Stimulatory effects of insulin and insulin-like growth factor I on migration and tube formation by vascular endothelial cells
1992
Eicosapentaenoic acid inhibits tube formation of vascular endothelial cellsin vitro
1991