Standout Papers
Citation Impact
Citing Papers
Epigenetic Silencing of MicroRNA-34b/c and B-Cell Translocation Gene 4 Is Associated with CpG Island Methylation in Colorectal Cancer
2008
Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer
2005 StandoutNobel
Persistent epigenetic differences associated with prenatal exposure to famine in humans
2008 Standout
Aberrant Silencing of Cancer-Related Genes by CpG Hypermethylation Occurs Independently of Their Spatial Organization in the Nucleus
2010
Genetic Unmasking of an Epigenetically Silenced microRNA in Human Cancer Cells
2007
General Transcription Factor Binding at CpG Islands in Normal Cells Correlates with Resistance to De novo DNA Methylation in Cancer Cells
2010
The Melanoma-Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion
2011
The Human let-7a-3 Locus Contains an Epigenetically Regulated MicroRNA Gene with Oncogenic Function
2007
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
2010 StandoutScience
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
2012 StandoutNobel
Genetic Disruption of Cytosine DNA Methyltransferase Enzymes Induces Chromosomal Instability in Human Cancer Cells
2005
Conserved, developmentally regulated mechanism couples chromosomal looping and heterochromatin barrier activity at the homeobox gene A locus
2011
Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput sequencing
2010
Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing
2005
Epigenetics provides a new generation of oncogenes and tumour-suppressor genes
2006
Hallmarks of Cancer: The Next Generation
2011 Standout
Molecular studies of major depressive disorder: the epigenetic perspective
2007
Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences
2009
The lncRNA MIR31HG regulates p16INK4A expression to modulate senescence
2015
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Phenotypic plasticity and the epigenetics of human disease
2007 Nature
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming
2009
Increased methylation variation in epigenetic domains across cancer types
2011
Regulation of growth and metabolism by imprinted genes
2006
Association of In Vitro Fertilization with Beckwith-Wiedemann Syndrome and Epigenetic Alterations of LIT1 and H19
2003
Expression profile of LIT1/KCNQ1OT1 and epigenetic status at the KvDMR1 in colorectal cancers
2006
Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery
2004
Functions of DNA methylation: islands, start sites, gene bodies and beyond
2012 Standout
Epigenetic regulation of theINK4b-ARF-INK4alocus
2010
The Genetic Signatures of Noncoding RNAs
2009
Circular RNAs are a large class of animal RNAs with regulatory potency
2013 StandoutNature
CpG islands and the regulation of transcription
2011 Standout
Elevation of Highly Up-regulated in Liver Cancer (HULC) by Hepatitis B Virus X Protein Promotes Hepatoma Cell Proliferation via Down-regulating p18
2012
The history of cancer epigenetics
2004 Standout
The rise of regulatory RNA
2014
Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer
2007
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
Charting a dynamic DNA methylation landscape of the human genome
2013 Nature
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells
2013
Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer
2004
A polymorphism in the chromosome 9p21 ANRIL locus is associated to Philadelphia positive acute lymphoblastic leukemia
2011
Long Noncoding RNAs: Emerging Stars in Gene Regulation, Epigenetics and Human Disease
2014
Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer That Predict for Poor Prognosis
2008
Intra-individual Change Over Time in DNA Methylation With Familial Clustering
2008
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response
2011 Nature
Developmental programming of CpG island methylation profiles in the human genome
2009
Epigenetic therapy of cancer: past, present and future
2006
The emerging role of lncRNAs in cancer
2015 Standout
Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina–associated domains
2011
Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation
2009
The power and the promise of DNA methylation markers
2003
The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease
2003
Cisplatin and paclitaxel target significant long noncoding RNAs in laryngeal squamous cell carcinoma
2014
Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome
2004
Genomic Imprinting and Cancer
1999
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Long Noncoding RNAs in Cancer Pathways
2016 Standout
Toll-like receptors and cancer
2008
Epigenetic gene silencing in cancer: the DNA hypermethylome
2007
Long non-coding RNAs: A new frontier in the study of human diseases
2013
Chromosome arm 16q in Wilms tumors: Unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene
2002
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
Bidirectional Transcription Directs Both Transcriptional Gene Activation and Suppression in Human Cells
2008
Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue
2004
Nucleosomes Containing Methylated DNA Stabilize DNA Methyltransferases 3A/3B and Ensure Faithful Epigenetic Inheritance
2011
Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis
2010
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
2002
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans
2011
The multilayered complexity of ceRNA crosstalk and competition
2014 StandoutNature
CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer
2010
Long non-coding RNAs as regulators of the endocrine system
2015
BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration
2012
Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band
2006
Long noncoding RNA-HOTAIR affects chemoresistance by regulating HOXA1 methylation in small cell lung cancer cells
2015
Epigenetics in Cancer
2008 Standout
Long Noncoding RNAs in Cancer: From Function to Translation
2015
Epigenetics in cancer
2009 Standout
Global loss of imprinting leads to widespread tumorigenesis in adult mice
2005
DNA hypomethylation and human diseases
2006
NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia
2001
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells
2009
Uncoupling Antisense-Mediated Silencing and DNA Methylation in the Imprinted Gnas Cluster
2011
Maintenance of self‐renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b
2006
Targeting long non-coding RNA to therapeutically upregulate gene expression
2013
Post-weaning diet affects genomic imprinting at the insulin-like growth factor 2 (Igf2) locus
2006
Noncoding RNA in development
2008
Large non-coding RNAs: missing links in cancer?
2010
Transgenerational Stability of the Arabidopsis Epigenome Is Coordinated by CG Methylation
2007
Natural RNA circles function as efficient microRNA sponges
2013 StandoutNature
Aberrant Methylation of the Maspin Promoter Is an Early Event in Human Breast Cancer
2004
UBE3A/E6-AP mutations cause Angelman syndrome
1997
Association of H19 Promoter Methylation with the Expression of H19 and IGF-II Genes in Adrenocortical Tumors
2002
Immunity, Inflammation, and Cancer
2010 Standout
Cancer epigenetics reaches mainstream oncology
2011
Long noncoding RNAs and prostate carcinogenesis: the missing ‘linc’?
2014
The epigenetic progenitor origin of human cancer
2005
Dynamics of DNA Methylation in Recent Human and Great Ape Evolution
2013
Gene Silencing in Cancer in Association with Promoter Hypermethylation
2003 Standout
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
2009
Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells
2007
Loss of Imprinting of Insulin-Like Growth Factor-II (IGF2) Gene in Distinguishing Specific Biologic Subtypes of Wilms Tumor
2001
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
2003 Standout
The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing
2010
Non-coding RNAs in human disease
2011 Standout
Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis
2008 Standout
The Reality of Pervasive Transcription
2011
The novel BORIS + CTCF gene family is uniquely involved in the epigenetics of normal biology and cancer
2002
Junk DNA and the long non-coding RNA twist in cancer genetics
2015
Functions and Mechanisms of Long Noncoding RNAs in Ovarian Cancer
2015
Molecular Interplay of the Noncoding RNA ANRIL and Methylated Histone H3 Lysine 27 by Polycomb CBX7 in Transcriptional Silencing of INK4a
2010
Epigenetic variation during the adult lifespan: cross‐sectional and longitudinal data on monozygotic twin pairs
2012
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Differential DNA Methylation Correlates with Differential Expression of Angiogenic Factors in Human Heart Failure
2010
Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1
2008
Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation
2008
Long noncoding RNAs during normal and malignant hematopoiesis
2014
Charting histone modifications and the functional organization of mammalian genomes
2010
Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus
2007
Epigenetic modifications as therapeutic targets
2010
The Polycomb group protein EZH2 directly controls DNA methylation
2005 StandoutNature
Familial aggregation of abnormal methylation of parental alleles at the IGF2/H19 and IGF2R differentially methylated regions
2003
The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila
2009
Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine
2012
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
Rethinking how DNA methylation patterns are maintained
2009
Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression
2000
Characterization of HULC, a Novel Gene With Striking Up-Regulation in Hepatocellular Carcinoma, as Noncoding RNA
2006
Genetic and epigenetic stability of human pluripotent stem cells
2012
Epigenetic modifications and human disease
2010 Standout
Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry
2010
The role of MET1 in RNA-directed de novoand maintenance methylation of CG dinucleotides
2004
The Hallmarks of Aging
2013 Standout
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
DNA-binding factors shape the mouse methylome at distal regulatory regions
2011 Nature
A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
2007
Androgen‐responsive long noncoding RNA CTBP1‐AS promotes prostate cancer
2013
Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression
2010
Chromatin modification and epigenetic reprogramming in mammalian development
2002
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
Topological domains in mammalian genomes identified by analysis of chromatin interactions
2012 StandoutNature
Human DNA methylomes at base resolution show widespread epigenomic differences
2009 StandoutNature
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells
2007
Orphan CpG Islands Identify Numerous Conserved Promoters in the Mammalian Genome
2010
Targeting long non-coding RNAs in cancers: Progress and prospects
2013
The molecular neurobiology of depression
2008 StandoutNature
The fundamental role of epigenetic events in cancer
2002 Standout
Long noncoding RNAs: functional surprises from the RNA world
2009 Standout
miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA
2011
Long non-coding RNAs: insights into functions
2009 Standout
Environmental epigenomics and disease susceptibility
2007 Standout
Comprehensive methylome map of lineage commitment from haematopoietic progenitors
2010 Nature
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
Epigenetic Alterations of H19 and LIT1 Distinguish Patients with Beckwith-Wiedemann Syndrome with Cancer and Birth Defects
2002
DNA methylation and human disease
2005 Standout
A long nuclear‐retained non‐coding RNA regulates synaptogenesis by modulating gene expression
2010
Non-coding RNAs and new opportunities for the private sector
2009
The evolution of gene expression levels in mammalian organs
2011 StandoutNatureNobel
Relationship between Gene Body DNA Methylation and Intragenic H3K9me3 and H3K36me3 Chromatin Marks
2011
Dynamic changes in the human methylome during differentiation
2010
CpG islands – ‘A rough guide’
2009
Genome-Wide Profiling of DNA Methylation Reveals a Class of Normally Methylated CpG Island Promoters
2007
LncRNA: A link between RNA and cancer
2014
Relaxation of imprinting in carcinogenesis
1996
Chromatin structure and the inheritance of epigenetic information
2010
Histone modifications and silencing prior to DNA methylation of a tumor suppressor gene
2003
Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression
2011
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
MYC regulates the non-coding transcriptome
2014
Long Noncoding RNA and Cancer: A New Paradigm
2017 Standout
Loss of Imprinting of Igf2 Alters Intestinal Maturation and Tumorigenesis in Mice
2005 Science
OCT4 establishes and maintains nucleosome-depleted regions that provide additional layers of epigenetic regulation of its target genes
2011
GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer
2003
Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction.
1999
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis
2005
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Loss of Imprinting ofIGF2: A Common Epigenetic Modifier of Intestinal Tumor Risk
2005
Use of H19 Gene Regulatory Sequences in DNA-Based Therapy for Pancreatic Cancer
2010
Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b
2003
Loss of imprinting of the insulin-like growth factor II gene occurs by biallelic methylation in a core region of H19 -associated CTCF-binding sites in colorectal cancer
2000
Development of targeted therapy for a broad spectrum of cancers (pancreatic cancer, ovarian cancer, glioblastoma and HCC) mediated by a double promoter plasmid expressing diphtheria toxin under the control of H19 and IGF2-P4 regulatory sequences.
2012
BSmooth: from whole genome bisulfite sequencing reads to differentially methylated regions
2012
Large Intervening Non-Coding RNA HOTAIR is Associated with Hepatocellular Carcinoma Progression
2011
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
2003
Cancer Genome Landscapes
2013 StandoutScience
Frequent loss of imprinting of PEG1/MEST in invasive breast cancer.
1999
The Eukaryotic Genome as an RNA Machine
2008 Science
Long Intergenic Noncoding RNAs: New Links in Cancer Progression
2011
Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth
2014 StandoutNobel
Epigenetic Epidemiology of the Developmental Origins Hypothesis
2007
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Selective Anchoring of DNA Methyltransferases 3A and 3B to Nucleosomes Containing Methylated DNA
2009
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Long noncoding RNAs in prostate cancer: mechanisms and applications
2014
H19-Promoter-Targeted Therapy Combined with Gemcitabine in the Treatment of Pancreatic Cancer
2012
CpG Methylation of Human Papillomavirus Type 16 DNA in Cervical Cancer Cell Lines and in Clinical Specimens: Genomic Hypomethylation Correlates with Carcinogenic Progression
2003
Epigenetic reprogramming in mammalian nuclear transfer
2003
Works of Hengmi Cui being referenced
Loss of IGF2 Imprinting: A Potential Marker of Colorectal Cancer Risk
2003 Science
Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition☆
2004
Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability
1998
DNA methylation and genomic imprinting: insights from cancer into epigenetic mechanisms
2002
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
2008 Nature
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
2002 Nature
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach
2004
The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
2009 Standout
Mosaic allelic insulin-like growth factor 2 expression patterns reveal a link between Wilms' tumorigenesis and epigenetic heterogeneity.
1999
Loss of Imprinting in Disease Progression in Chronic Myelogenous Leukemia
1998
Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.
2002
Loss of Imprinting in Disease Progression in Chronic Myelogenous Leukemia
1998
Papillomavirus-Like Particles Stimulate Murine Bone Marrow-Derived Dendritic Cells To Produce Alpha Interferon and Th1 Immune Responses via MyD88
2004
Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages
2002
Expression, promoter usage and parental imprinting status of insulin-like growth factor II (IGF2) in human hepatoblastoma: uncoupling of IGF2 and H19 imprinting.
1995
Promoter-specific IGF2 imprinting status and its plasticity during human liver development
1995
Loss of imprinting of insulin-like growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site.
2001
Inactivation of H19, an imprinted and putative tumor repressor gene, is a preneoplastic event during Wilms' tumorigenesis.
1997