Citation Impact
Citing Papers
Confirmation of intersubunit connectivity and topology of designed protein complexes by native MS
2018 StandoutNobel
High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane
2018 Science
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Accurate computational design of multipass transmembrane proteins
2018 StandoutScienceNobel
Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities
2024 StandoutNobel
Activation of STING requires palmitoylation at the Golgi
2016
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
TMEM173 variants and potential importance to human biology and disease
2018
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
2013
Mechanisms of SARS-CoV-2 entry into cells
2021 Standout
Unravelling biological macromolecules with cryo-electron microscopy
2016 Nature
Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA
2013
Parkinson's disease
2021 Standout
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
2016 Standout
Species‐specific detection of the antiviral small‐molecule compound CMA by STING
2013
Familial chilblain lupus due to a gain-of-function mutation in STING
2016
Molecular mechanisms and cellular functions of cGAS–STING signalling
2020
Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme
2020 Nature
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies
2019 Standout
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
2019 Standout
The structural basis for the sensing and binding of cyclic di-GMP by STING
2012
Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity
2014 StandoutNobel
Cytosolic Sensing of Viruses
2013
Structural basis of coreceptor recognition by HIV-1 envelope spike
2018 Nature
Type I interferons in infectious disease
2015 Standout
STING and the innate immune response to nucleic acids in the cytosol
2012
Single Amino Acid Change in STING Leads to Constitutive Active Signaling
2015
Immunogenic cell death in cancer and infectious disease
2016 Standout
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
2014 Standout
Molecular Dynamics Simulation for All
2018 Standout
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
2012
Antiviral resistance of stem cells
2018 StandoutNobel
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 Standout
Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
2013
Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING
2014
Parkinson's disease in the Western Pacific Region
2019
Innate immune detection of microbial nucleic acids
2013
The cGAS-cGAMP-STING Pathway of Cytosolic DNA Sensing and Signaling
2014
Dynamics and functions of lipid droplets
2018 Standout
The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
2012
STING-dependent cytosolic DNA sensing pathways
2013
Immune Sensing of DNA
2013
Interferons and viruses: an evolutionary arms race of molecular interactions
2015 StandoutNobel
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
2013
DNA recognition in immunity and disease
2013
Mechanisms and Functions of Inflammasomes
2014 Standout
Regulation of type I interferon responses
2013 Standout
The biogenesis, biology and characterization of circular RNAs
2019 Standout
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Newly described pattern recognition receptors team up against intracellular pathogens
2013
Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment
2019 StandoutNobel
Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase
2013
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
2014
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING
2013
Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System
2017
Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
2012
Structural basis of MsbA-mediated lipopolysaccharide transport
2017 Nature
Toll-Like Receptor Signaling Pathways
2014 Standout
Innate Immune Receptors
2016
Control of adaptive immunity by the innate immune system
2015 Standout
ATP-Dependent Effector-like Functions of RIG-I-like Receptors
2015 StandoutNobel
Multidrug efflux pumps: structure, function and regulation
2018 Standout
Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
2013 StandoutNobel
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Structure of the mammalian TRPM7, a magnesium channel required during embryonic development
2018
Cyclic‐di‐GMP and cyclic‐di‐AMP activate the NLRP3 inflammasome
2013
eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation
2016 StandoutNatureNobel
Lipid Nanoparticles Delivering Constitutively Active STING mRNA to Stimulate Antitumor Immunity
2022 StandoutNobel
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
Microglia Function in the Central Nervous System During Health and Neurodegeneration
2017 Standout
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
Structure basis for RNA-guided DNA degradation by Cascade and Cas3
2018 Science
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
2013 Standout
Mouse, but not Human STING, Binds and Signals in Response to the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid
2013
MPYS/STING-Mediated TNF-α, Not Type I IFN, Is Essential for the Mucosal Adjuvant Activity of (3′–5′)-Cyclic-Di-Guanosine-Monophosphate In Vivo
2013
New tools for automated high-resolution cryo-EM structure determination in RELION-3
2018 Standout
Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining
2016
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Simultaneous precise editing of multiple genes in human cells
2019 StandoutNobel
Cryo–electron microscopy structure of the lipid droplet–formation protein seipin
2018
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
2014
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
2020 StandoutNobel
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection
2016
Works of Heng Ru being referenced
Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding
2012
Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures
2015
Crystal structure of the WD40 domain dimer of LRRK2
2019