Citation Impact
Citing Papers
Phosphoinositide 3–kinase γ participates in T cell receptor–induced T cell activation
2007
Akt1 and Akt2 promote peripheral B-cell maturation and survival
2009
CD18-dependent activation of the neutrophil NADPH oxidase during phagocytosis of Escherichia coli or Staphylococcus aureus is regulated by class III but not class I or II PI3Ks
2008
Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells
2005
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
2008
Talin determines the nanoscale architecture of focal adhesions
2015
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Idelalisib given front-line for treatment of chronic lymphocytic leukemia causes frequent immune-mediated hepatotoxicity
2016
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Conformational disruption of PI3Kδ regulation by immunodeficiency mutations in PIK3CD and PIK3R1
2017
PTEN-deficient cancers depend on PIK3CB
2008
The p110δ Isoform of Phosphoinositide 3-Kinase Controls Clonal Expansion and Differentiation of Th Cells
2006
Regulation of phosphoinositide 3-kinase expression in health and disease
2009
MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells
2009
The PI3K/AKT Pathway as a Target for Cancer Treatment
2015
Opportunities and challenges in the development of kinase inhibitor therapy for cancer
2003
Modulation of Integrin Activation by an Entropic Spring in the β-Knee
2010 StandoutNobel
EGFR Antagonists in Cancer Treatment
2008 Standout
Transgenic Enrichment of Cardiomyocytes From Human Embryonic Stem Cells
2007
Role of the phosphoinositide 3‐kinase p110δ in generation of type 2 cytokine responses and allergic airway inflammation
2007
PI3Kδ and primary immunodeficiencies
2016
A role for phosphoinositol 3–kinase δ in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease
2010
The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
2005 StandoutNobel
Akt and mTOR in B Cell Activation and Differentiation
2012
PI3K signalling in inflammation
2014
CASK and Protein 4.1 Support F-actin Nucleation on Neurexins
2001 StandoutNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Class I Phosphoinositide 3-Kinase p110β Is Required for Apoptotic Cell and Fcγ Receptor-mediated Phagocytosis by Macrophages
2003
Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents
2003
The cancer glycocalyx mechanically primes integrin-mediated growth and survival
2014 StandoutNatureNobel
Blockade of PI3Kγ suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
2005
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
The glycans of stem cells
2007
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Class I PI3K in oncogenic cellular transformation
2008
The class II phosphoinositide 3‐kinase PI3K‐C2β regulates cell migration by a PtdIns(3)P dependent mechanism
2005
Synergy in activating class I PI3Ks
2015
Recruitment and regulation of phosphatidylinositol phosphate kinase type 1γ by the FERM domain of talin
2002 Nature
Principles and challenges of genome-wide DNA methylation analysis
2010
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Genes that Distinguish Physiological and Pathological Angiogenesis
2007
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
PI3K in lymphocyte development, differentiation and activation
2003
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Quantifying cellular adhesion to extracellular matrix components by single-cell force spectroscopy
2010
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin
2003 Nature
Genetic Analyses of Integrin Signaling
2010
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
2005
Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells
2009
A Vinculin Binding Domain from the Talin Rod Unfolds to Form a Complex with the Vinculin Head
2005
Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development
2008
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Targeting phosphoinositide 3-kinase—Moving towards therapy
2007
Immunogenicity of induced pluripotent stem cells
2011 StandoutNature
Exploiting the PI3K/AKT Pathway for Cancer Drug Discovery
2005 Standout
Targeting the phosphoinositide 3-kinase pathway in cancer
2009 Standout
Phosphoinositide 3‐kinases in cell migration
2008
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
2008 Nature
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
PI3Kγ inhibition: towards an 'aspirin of the 21st century'?
2006
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
2014 Nature
Testicular germ-cell tumours in a broader perspective
2005 Standout
Four-and-a-Half LIM Domain Proteins Inhibit Transactivation by Hypoxia-inducible Factor 1
2012 StandoutNobel
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation
1999
Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia
2005
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
2004 Nature
Focal adhesions – the cytoskeletal connection
2000
Cancer-specific mutations in phosphatidylinositol 3-kinase
2007
Reproducible, Ultra High-Throughput Formation of Multicellular Organization from Single Cell Suspension-Derived Human Embryonic Stem Cell Aggregates
2008
Regulation of Class-Switch Recombination and Plasma Cell Differentiation by Phosphatidylinositol 3-Kinase Signaling
2006
The phosphoinositide-3 kinase γ–Akt pathway mediates renal tubular injury in cisplatin nephrotoxicity
2007
p110γ and p110δ Phosphoinositide 3-Kinase Signaling Pathways Synergize to Control Development and Functions of Murine NK Cells
2007
Signalling by PI3K isoforms: insights from gene-targeted mice
2005
Talin Is Essential for Integrin Function in Drosophila
2002
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
2004 Standout
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Talin depletion reveals independence of initial cell spreading from integrin activation and traction
2008
Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling
2000
Origin and physiological roles of inflammation
2008 StandoutNature
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting
2014
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function
2003
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
AKT/PKB Signaling: Navigating the Network
2017 Standout
Clonal evolution in cancer
2012 StandoutNature
Genetic and epigenetic stability of human pluripotent stem cells
2012
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold
2004
Points of control in inflammation
2002 StandoutNature
PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model
2014
The PI3K Pathway in Human Disease
2017 Standout
Calpain Cleavage Promotes Talin Binding to the β3Integrin Cytoplasmic Domain
2001
A Putative Src Homology 3 Domain Binding Motif but Not the C-terminal Dystrophin WW Domain Binding Motif Is Required for Dystroglycan Function in Cellular Polarity in Drosophila
2007 StandoutNobel
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
2009 Standout
Integrins
2002 Standout
Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice
2007 StandoutNobel
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
2004
The talin–tail interaction places integrin activation on FERM ground
2004
A selective inhibitor of the p110δ isoform of PI 3-kinase inhibits AML cell proliferation and survival and increases the cytotoxic effects of VP16
2006
Phosphoinositide 3-kinase signalling – which way to target?
2003
Distinct signaling mechanisms activate the target of rapamycin in response to different B‐cell stimuli
2007
Does the PI3K pathway promote or antagonize regulatory T cell development and function?
2012
Effect of In Utero and Early-Life Conditions on Adult Health and Disease
2008 Standout
Role of YAP/TAZ in mechanotransduction
2011 StandoutNature
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock
2012
Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement
2003
A Case for Regulatory B Cells
2006
Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation
2007
Gene Targeting in a HUES Line of Human Embryonic Stem Cells Via Electroporation
2009
CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer
2007
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
The PI3K Isoforms p110α and p110δ Are Essential for Pre–B Cell Receptor Signaling and B Cell Development
2010
Type Iγ phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration
2007
Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio
2003
PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances
2012
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans
2010
Tissue Cells Feel and Respond to the Stiffness of Their Substrate
2005 StandoutScience
Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex
2002
Essential role of PI3Kδ and PI3Kγ in thymocyte survival
2005
Integrin activation takes shape
2002
Phosphoinositide 3-Kinase Activity in T Cells Regulates the Magnitude of the Germinal Center Reaction
2010
Recent Stem Cell Advances: Induced Pluripotent Stem Cells for Disease Modeling and Stem Cell–Based Regeneration
2010 StandoutNobel
Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination
2003 StandoutNobel
Therapeutic potential of phosphoinositide 3-kinase inhibitors
2004
Germinal Centers
2012
DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
2007
The p110α isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation
2006
Talin1 is critical for force-dependent reinforcement of initial integrin–cytoskeleton bonds but not tyrosine kinase activation
2003
The p110delta catalytic isoform of PI3K is a key player in NK-cell development and cytokine secretion
2007
Metabolic reprogramming and cancer progression
2020 StandoutScience
PI3 Kinases in Cancer: From Oncogene Artifact to Leading Cancer Target
2006
Physiological Functions of Pten in Mouse Tissues.
2003 StandoutNobel
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
2013
The Tail of Integrins, Talin, and Kindlins
2009 Science
Phosphoinositide 3-Kinase : Diverse Roles in Immune Cell Activation
2004
Fhl-1, a New Key Protein in Pulmonary Hypertension
2008
Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy
2016
Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag
2011 StandoutNobel
Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.
2003
Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells
2006
Structural basis for Zika envelope domain III recognition by a germline version of a recurrent neutralizing antibody
2020 StandoutNobel
The p110δ of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
2008
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells
2016
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
Integrin cytoplasmic domain-binding proteins
2000
Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer
2018
Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
2004 StandoutNobel
The Pten/PI3K pathway governs the homeostasis of Vα14iNKT cells
2006 StandoutNobel
Cutting Edge: T Cell Development Requires the Combined Activities of the p110γ and p110δ Catalytic Isoforms of Phosphatidylinositol 3-Kinase
2005
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
2004 StandoutNobel
Works of Helen Priddle being referenced
Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
2002 Science
Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR–/– embryos at 12.5 to 14.5 days of gestation
2004
Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome
2007
Common culture conditions for maintenance and cardiomyocyte differentiation of the human embryonic stem cell lines, BG01 and HUES-7
2005
Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines
2007
Stem-cell consequences of embryo epigenetic defects
2004
Disruption of thetalin gene arrests mouse development at the gastrulation stage
2000
Human embryonic stem cell methyl cycle enzyme expression: modelling epigenetic programming in assisted reproduction?
2005
Hematopoiesis from Human Embryonic Stem Cells: Overcoming the Immune Barrier in Stem Cell Therapies
2005
Disruption of the Talin Gene Compromises Focal Adhesion Assembly in Undifferentiated but Not Differentiated Embryonic Stem Cells
1998
Improved Human Embryonic Stem Cell Embryoid Body Homogeneity and Cardiomyocyte Differentiation from a Novel V-96 Plate Aggregation System Highlights Interline Variability
2006
Ablation of Undifferentiated Human Embryonic Stem Cells: Exploiting Innate Immunity Against the Gal α1-3Galβ1-4GlcNAc-R (α-Gal) Epitope
2006