Standout Papers
Citation Impact
Citing Papers
Tissue-Specific Thyroid Hormone Deprivation and Excess in Monocarboxylate Transporter (Mct) 8-Deficient Mice
2006
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans
2009
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
2005 StandoutScience
Abnormal thyroid hormone metabolism in mice lacking the monocarboxylate transporter 8
2007
Whole-genome resequencing reveals loci under selection during chicken domestication
2010 StandoutNature
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Genetic determinants of hepatic steatosis in man
2011
β-Arrestin-dependent Constitutive Internalization of the Human Chemokine Decoy Receptor D6
2004 StandoutNobel
Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions
2012
Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells
2015
Benefits and limitations of genome-wide association studies
2019
lincRNAs: Genomics, Evolution, and Mechanisms
2013 Standout
Energy balance regulation by thyroid hormones at central level
2013
Regulation of V2 Vasopressin Receptor Degradation by Agonist-promoted Ubiquitination
2003 StandoutNobel
Constitutive Activity in Melanocortin-4 Receptor
2014
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
Anatomy and regulation of the central melanocortin system
2005 Standout
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 StandoutNature
Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors
2003
MC4R Agonists: Structural Overview on Antiobesity Therapeutics
2018 StandoutNobel
Central nervous system control of food intake and body weight
2006 StandoutNature
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
2001 StandoutNature
Structural requirements for V2 vasopressin receptor proteolytic cleavage
1999
Advances in the molecular genetics of obesity
1999
Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance
2006
Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay
2011
Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist
2009
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Multigenic control of thyroid hormone functions in the nervous system
2008
Melanocortin‐4 Receptor Gene Mutations in a Dutch Cohort of Obese Children
2010
The changing landscape of atherosclerosis
2021 StandoutNature
Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells
2012
Maternal and child undernutrition and overweight in low-income and middle-income countries
2013 Standout
The SLC16 gene family – Structure, role and regulation in health and disease
2013
Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin
1999
Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination
2007
The Rise and Fall of the Chemoattractant Receptor GPR33
2005 StandoutNobel
Suppression of lung adenocarcinoma progression by Nkx2-1
2011 Nature
The central melanocortin system affects the hypothalamo-pituitary thyroid axis and may mediate the effect of leptin
2000
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
2003
The Need to Feed
2002
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Establishment and Dysfunction of the Blood-Brain Barrier
2015
Wnt/β-Catenin Signaling and Disease
2012 Standout
The Ectodomain of the Luteinizing Hormone Receptor Interacts with Exoloop 2 to Constrain the Transmembrane Region
2002 StandoutNobel
Central nervous system control of food intake
2000 StandoutNature
Obesity and thyroid function
2009
Physiological roles of the melanocortin MC3 receptor
2011
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
The Melanocortin-1 Receptor
2001
Age-specific stabilization in obesity prevalence in German children: A cross-sectional study from 1999 to 2008
2010
Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transporters
2009
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
2007
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7
2000
Emerging Biological Principles of Metastasis
2017 Standout
Modern science versus the stigma of obesity
2004
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
2004
Activation of the Luteinizing Hormone Receptor Following Substitution of Ser-277 with Selective Hydrophobic Residues in the Ectodomain Hinge Region
2000 StandoutNobel
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
2000
Childhood obesity
2010
The hormone resistin links obesity to diabetes
2001 StandoutNature
Mice lacking melanin-concentrating hormone are hypophagic and lean
1998 Nature
Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion
2010
From Lesions to Leptin
1999
Obesity and the Regulation of Energy Balance
2001 Standout
The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior
2000 StandoutNobel
Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides
1999
Leptin and the regulation of body weight in mammals
1998 StandoutNature
Proteomic comparison of human and great ape blood plasma reveals conserved glycosylation and differences in thyroid hormone metabolism
2001
Obesity in children and young people: a crisis in public health
2004 Standout
Mutations in SECISBP2 result in abnormal thyroid hormone metabolism
2005
Melanocortin-4 receptor–regulated energy homeostasis
2016
The molecular neurobiology of depression
2008 StandoutNature
Activation of the Melanocortin-4 Receptor Mobilizes Intracellular Free Calcium in Immortalized Hypothalamic Neurons
2006
Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus
1999
Body weight is regulated by the brain: a link between feeding and emotion
2005
Mutations in the human melanocortin-4 receptor gene associated with severe familial obesity disrupts receptor function through multiple molecular mechanisms
2003
Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist
2016
Modeling Development and Disease with Organoids
2016 Standout
Genetics of body-weight regulation
2000 Nature
The Many Roles of Chemokines and Chemokine Receptors in Inflammation
2006 Standout
Mechanisms of thyroid hormone action
2012
Thyroid Hormone Transporters in Health and Disease
2005
Nephrogenic Diabetes Insipidus
2001
Regulation of Thyrotropin-Releasing Hormone-Expressing Neurons in Paraventricular Nucleus of the Hypothalamus by Signals of Adiposity
2010
A War on Obesity, Not the Obese
2003 Science
The Nuclear Receptor Corepressor (NCoR) Controls Thyroid Hormone Sensitivity and the Set Point of the Hypothalamic-Pituitary-Thyroid Axis
2011
Minireview: Human Obesity—Lessons from Monogenic Disorders
2003
Cellular and Molecular Basis of Deiodinase-Regulated Thyroid Hormone Signaling1
2008
Chapter 4 Melanocortin‐4 Receptor Mutations In Obesity
2009
The Central Melanocortin System and Energy Homeostasis
1999
Leptin Signaling in the Central Nervous System and the Periphery
2004
Genetics of obesity
2006
Activation of Orphan Receptors by the Hormone Relaxin
2002 StandoutScience
Hypothalamic localization of the feeding effect of agouti-related peptide and alpha-melanocyte-stimulating hormone.
2000
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
A Thyroid Hormone Analog with Reduced Dependence on the Monocarboxylate Transporter 8 for Tissue Transport
2009
Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine
2002 StandoutNobel
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
Expression of Thyroid Hormone Transporters in the Human Hypothalamus
2011
Thyroid Hormone Regulation of Metabolism
2014 Standout
MCT8: From gene to disease and therapeutic approach
2011
Intra- and Interspecific Variation in Primate Gene Expression Patterns
2002 StandoutScienceNobel
Thyroid Hormones and the Metabolic Syndrome
2013
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans
2004
Structure-Function of the G Protein–Coupled Receptor Superfamily
2012
Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine
2002 StandoutNobel
Aquaporin water channels: atomic structure molecular dynamics meet clinical medicine
2002 StandoutNobel
A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH2 versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH2: A Bivalent Advantage
2017
Different causes of Reduced Sensitivity to Thyroid Hormone: Diagnosis and Clinical management
2013
Pathophysiological Importance of Thyroid Hormone Transporters
2009
The gut microbiota as an environmental factor that regulates fat storage
2004 Standout
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology
2010
Melanocortin receptors: their functions and regulation by physiological agonists and antagonists
2001
Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns
2010
The Function of Leptin in Nutrition, Weight, and Physiology
2002
Developmental and Cell-Specific Expression of Thyroid Hormone Transporters in the Mouse Cochlea
2011
Diiodothyropropionic Acid (DITPA) in the Treatment of MCT8 Deficiency
2012
Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus
2000
Gut hormone PYY3-36 physiologically inhibits food intake
2002 StandoutNature
Obesity: global epidemiology and pathogenesis
2019 Standout
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Prevalence of Childhood and Adult Obesity in the United States, 2011-2012
2014 Standout
Interactions Between the Melanocortin System and Leptin in Control of Sympathetic Nerve Traffic
1999
Obesity and the Environment: Where Do We Go from Here?
2003 StandoutScience
Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin
2003
Works of Heike Biebermann being referenced
Mutant G-protein-coupled receptors as a cause of human diseases
2004
Extended clinical phenotype, endocrine investigations and functional studies of a loss-of-function mutation A150V in the thyroid hormone specific transporter MCT8
2005
Increased constraints on MC4R during primate and human evolution
2008
Plasma Bile Acids Are Associated with Energy Expenditure and Thyroid Function in Humans
2011
Mutations in the Human Proopiomelanocortin Gene
2003
V2 vasopressin receptor dysfunction in nephrogenic diabetes insipidus caused by different molecular mechanisms
1998
Congenital hyperthyroidism
2009
A role for β-melanocyte-stimulating hormone in human body-weight regulation
2006
Prevalence, Spectrum, and Functional Characterization of Melanocortin-4 Receptor Gene Mutations in a Representative Population-Based Sample and Obese Adults from Germany
2006
Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
2004
A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population
2007
Inhibition of melanocortin-4 receptor dimerization by substitutions in intracellular loop 2
2013
Type 2 diabetes and impaired glucose tolerance in European children and adolescents with obesity -- a problem that is no longer restricted to minority groups
2004
Severe Congenital Hyperthyroidism Caused by a Germ-LineneoMutation in the Extracellular Portion of the Thyrotropin Receptor1
1998
A novel melanocortin-4 receptor gene mutation in a female patient with severe childhood obesity
2009
Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency
2002
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
1998 Standout
Mutationally Induced Disulfide Bond Formation within the Third Extracellular Loop Causes Melanocortin 4 Receptor Inactivation in Patients with Obesity
2003
Obesity Due to Proopiomelanocortin Deficiency: Three New Cases and Treatment Trials with Thyroid Hormone and ACTH4–10
2003
Mutation screen and association studies in the Diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13
2007
Lifestyle Intervention in Obese Children With Variations in the Melanocortin 4 Receptor Gene
2008
Surface translocation and tri-iodothyronine uptake of mutant MCT8 proteins are cell type-dependent
2009
MC4R oligomerizes independently of extracellular cysteine residues
2005
MC4R Dimerization in the Paraventricular Nucleus and GHSR/MC3R Heterodimerization in the Arcuate Nucleus: Is There Relevance for Body Weight Regulation?
2012
Melanocortin-4 Receptor Gene Variant I103 Is Negatively Associated with Obesity
2004
A Novel Non-Synonymous Mutation in the Melanocortin-4 Receptor Gene (MC4R) in a 2-Year-Old Austrian Girl with Extreme Obesity
2007
Autosomal-Dominant Mode of Inheritance of a Melanocortin-4 Receptor Mutation in a Patient with Severe Early-Onset Obesity Is Due to a Dominant-Negative Effect Caused by Receptor Dimerization
2003
Evolutionary Aspects in Evaluating Mutations in the Melanocortin 4 Receptor
2007
A conserved tyrosine residue (Y601) in transmembrane domain 5 of the human thyrotropin receptor serves as a molecular switch to determine G‐protein coupling
1998
Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency
2002
Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus
2010