Citation Impact
Citing Papers
Checkpoint Proteins Control Survival of the Postmitotic Cells in Caenorhabditis elegans
2006 Science
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Caveolin-1 Regulates the Antagonistic Pleiotropic Properties of Cellular Senescence through a Novel Mdm2/p53-Mediated Pathway
2009
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
2012 StandoutNobel
Loss of cryptochrome reduces cancer risk in p53 mutant mice
2009 StandoutNobel
p53 Regulates Mitochondrial Respiration
2006 Science
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Hallmarks of Cancer: The Next Generation
2011 Standout
The lac repressor
2005
Phenotypic plasticity and the epigenetics of human disease
2007 Nature
Cellular senescence: unravelling complexity
2009
Oncogenic forms of p53 inhibit p53-regulated gene expression
1992 Science
HMGA2 expression in white adipose tissue linking cellular senescence with diabetes
2013
Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
1992 StandoutNobel
The heat shock transcription factor Hsf1 is downregulated in DNA damage–associated senescence, contributing to the maintenance of senescence phenotype
2012
Mutational hot spot in the p53 gene in human hepatocellular carcinomas
1991 Nature
Tumor suppression and normal aging in mice with constitutively high p53 activity
2006
Deleted in breast cancer–1 regulates SIRT1 activity and contributes to high-fat diet–induced liver steatosis in mice
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
New tricks of an old molecule: lifespan regulation by p53
2006
Cellular senescence: when bad things happen to good cells
2007 Standout
Sirtuin 1 in lipid metabolism and obesity
2011
p53-Induced Adipose Tissue Inflammation Is Critically Involved in the Development of Insulin Resistance in Heart Failure
2012
A senescent cell bystander effect: senescence‐induced senescence
2012
p53 — a Jack of all trades but master of none
2009
Cellular senescence in aging and age-related disease: from mechanisms to therapy
2015 Standout
p53: new roles in metabolism
2007
Unleashing the power of p53: lessons from mice and men: Figure 1.
2006
Cellular Senescence in Cancer and Aging
2007 Standout
Genome imprinting, cellular mosaicism and carcinogenesis
1990
Increased p53 activity does not accelerate telomere‐driven ageing
2006
When Checkpoints Fail
1997 StandoutNobel
The role of p53 in tumour suppression: lessons from mouse models
1999
Reduced Life- and Healthspan in Mice Carrying a Mono-Allelic BubR1 MVA Mutation
2012
Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents
1992 StandoutNobel
p53: link to the past, bridge to the future
2005
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 Standout
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
2005 Nature
Tumor suppressor genes
1991 Standout
DNA Repair, Genome Stability, and Aging
2005
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
2006 Nature
A role for the Drosophila neurogenic genes in mesoderm differentiation
1991 StandoutNobel
Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome
1990 StandoutNature
Cellular senescence and DNA repair
2006
How stem cells age and why this makes us grow old
2007
Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function
2004 StandoutNobel
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
The p53 tumour suppressor gene
1991 StandoutNature
Multiplexed and Programmable Regulation of Gene Networks with an Integrated RNA and CRISPR/Cas Toolkit in Human Cells
2014
Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
2009
Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
1998
p63 deficiency activates a program of cellular senescence and leads to accelerated aging
2005
p53 isoforms can regulate p53 transcriptional activity
2005
Stems Cells and the Pathways to Aging and Cancer
2008
p53 in health and disease
2007 Standout
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
2012
Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells
1991
The common biology of cancer and ageing
2007 Nature
Development and applications of a molecular genetic linkage map of the mouse genome
1991
Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging
2004
p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress
2006
Two faces of p53: aging and tumor suppression
2007
Molecular themes in oncogenesis
1991 StandoutNobel
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Evidence implicating heterozygous deletion of chromosome 7 in the pathogenesis of familial leukemia associated with monosomy 7
1992
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
2007
Reassessing the role of p53 in cancer and ageing from an evolutionary perspective
2007
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1
2010
Delayed ageing through damage protection by the Arf/p53 pathway
2007 Nature
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
Genetic Alterations during Colorectal-Tumor Development
1988 Standout
Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis
2007
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
DNA damage response and cellular senescence in tissues of aging mice
2009
Disruption of the circadian clock due to theClockmutation has discrete effects on aging and carcinogenesis
2008
Sirtuin Catalysis and Regulation
2012
JNK1 Phosphorylates SIRT1 and Promotes Its Enzymatic Activity
2009
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
Reduced Expression of the Caenorhabditis elegans p53 Ortholog cep-1 Results in Increased Longevity
2007
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
1992
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
2010
Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span
2005
SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
2010
Low frequency of the p53 gene mutations in neuroblastoma
1994
Age-Associated Increase in Cytokine Production During Systemic Inflammation—II: The Role of IL-1β in Age-Dependent IL-6 Upregulation in Adipose Tissue
2014
p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
2013
A gene for the mouse pink-eyed dilution locus and for human type II oculocutaneous albinism
1993 Nature
Cellular senescence: from physiology to pathology
2014 Standout
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 StandoutNobel
Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.
1989
The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein.
1992
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
2010 StandoutNobel
p53 Mutations in Human Cancers
1991 StandoutScience
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
The myoD Gene Family: Nodal Point During Specification of the Muscle Cell Lineage
1991 Science
Aging, Cellular Senescence, and Cancer
2012 Standout
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
Telomere length is paternally inherited and is associated with parental lifespan
2007 StandoutNobel
Tumor Suppressor Genes
1991 Science
Loss of allelic heterozygosity at a second locus on chromosome 11 in sporadic Wilms' tumor cells.
1989
The rate of telomere sequence loss in human leukocytes varies with age
1998 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Tumor-specific loss of 11p15.5 alleles in del11p13 Wilms tumor and in familial adrenocortical carcinoma.
1989
Molecular mechanisms of oncogenesis.
1989
Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
1990 StandoutScience
Mitotic recombination of chromosome 17 in astrocytomas.
1989
Nutrient Availability Regulates SIRT1 Through a Forkhead-Dependent Pathway
2004 Science
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Four faces of cellular senescence
2011 Standout
Viruses in Human Cancers
1991 StandoutScienceNobel
Identification of p53 as a Sequence-Specific DNA-Binding Protein
1991 Science
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
2008 Standout
p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.
1991
Aging increases CCN1 expression leading to muscle senescence
2013
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.
1990
Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
2011 StandoutNobel
Promotion of direct reprogramming by transformation-deficient Myc
2010 StandoutNobel
YACs to the rescue
1993 StandoutNatureNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
The Arf/p53 Pathway in Cancer and Aging
2008
Works of Heidi Scrable being referenced
Say when: reversible control of gene expression in the mouse by lac
2002
Immunity and cognition: what do age-related dementia, HIV-dementia and ‘chemo-brain’ have in common?
2008
Fat tissue, aging, and cellular senescence
2010
Progressive loss of SIRT1 with cell cycle withdrawal
2006
Molecular differential pathology of rhabdomyosarcoma
1989
The lac operator-repressor system is functional in the mouse
2001
Antagonistic pleiotropy and p53
2008
Phosphorylation Regulates SIRT1 Function
2008
Genetic and Epigenetic Losses of Heterozygosity in Cancer Predisposition and Progression
1990
Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping
1987 Nature
ΔNp53 or p44: priming the p53 pump
2005
Modulation of mammalian life span by the short isoform of p53
2004
Regenerative capacity of neural precursors in the adult mammalian brain is under the control of p53
2007
Hbo1 Links p53-Dependent Stress Signaling to DNA Replication Licensing
2007
A model for embryonal rhabdomyosarcoma tumorigenesis that involves genome imprinting.
1989
Muscle-specific gene expression in rhabdomyosarcomas and stages of human fetal skeletal muscle development.
1991
Mechanisms of p53 loss in human sarcomas.
1990
Rhabdomyosarcoma-associated locus and MYOD1 are syntenic but separate loci on the short arm of human chromosome 11.
1990