Standout Papers
- Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis (2006)
- The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog (1996)
- Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo (1993)
Citation Impact
Citing Papers
Identification of noninvasive imaging surrogates for brain tumor gene-expression modules
2008
Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist
2004 StandoutNobel
Pten Haploinsufficiency Accelerates Formation of High-Grade Astrocytomas
2008
CD133+ and CD133− Glioblastoma-Derived Cancer Stem Cells Show Differential Growth Characteristics and Molecular Profiles
2007
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Marked Genomic Differences Characterize Primary and Secondary Glioblastoma Subtypes and Identify Two Distinct Molecular and Clinical Secondary Glioblastoma Entities
2006
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
1990 StandoutNature
Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer
2004 Standout
The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system
1998
Activating Smoothened mutations in sporadic basal-cell carcinoma
1998 StandoutNature
Anaplastic oligodendrogliomas with 1p19q codeletion have a proneural gene expression profile
2008
The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
1999 StandoutNature
Hallmarks of Cancer: The Next Generation
2011 Standout
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
2000
Heterogeneity of the Tumor Vasculature
2010
Effects of truncations of the cytoplasmic tail of the luteinizing hormone/chorionic gonadotropin receptor on receptor-mediated hormone internalization.
1992
Response Assessment Criteria for Glioblastoma: Practical Adaptation and Implementation in Clinical Trials of Antiangiogenic Therapy
2013
GDNF prevents degeneration and promotes the phenotype of brain noradrenergic neurons in vivo
1995
Pathways mediating VEGF-independent tumor angiogenesis
2009
Inhibition of renal cell carcinoma angiogenesis and growth by antisense oligonucleotides targeting vascular endothelial growth factor
2002
Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured fab in complex with antigen 1 1Edited by I. A. Wilson
1999
Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis.
1993
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
2001 Standout
Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein
1999 StandoutNature
Making a tumour's bed: glioblastoma stem cells and the vascular niche
2007
IDH1andIDH2Mutations in Gliomas
2009 Standout
Quantitative immunohistological analysis of the microvasculature in untreated human glioblastoma multiforme
1994
K‐252 Compounds: Modulators of Neurotrophin Signal Transduction
1992
Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP)
2017
Regulation of Neuropeptides in Adult Rat Forebrain by the Neurotrophins BDNF and NGF
1994
The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule
1995
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
1993 Standout
Activity‐dependent and hormonal regulation of neurotrophin mRNA levels in brain–implications for neuronal plasticity
1994
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
2006 Standout
GFRα1-Deficient Mice Have Deficits in the Enteric Nervous System and Kidneys
1998
Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells
1994
Hedgehog Elicits Signal Transduction by Means of a Large Complex Containing the Kinesin-Related Protein Costal2
1997 Nobel
Hedgehog and Patched in Neural Development and Disease
1998
How Tumors Become Angiogenic
1996
Interaction of Human α-Synuclein and Parkinson's Disease Variants with Phospholipids
2000
Brain-derived neurotrophic factor expression after long-term potentiation
1993
A Local Action of Neurotrophin-3 Prevents the Death of Proliferating Sensory Neuron Precursor Cells
1996
Transducing the Hedgehog Signal
2000
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
1999
Brain-derived neurotrophic factor messenger RNA is expressed in the septum, hypothalamus and in adrenergic brain stem nuclei of adult rat brain and is increased by osmotic stimulation in the paraventricular nucleus
1995
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
1994 Nature
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor
1991
Cell-specific modulation of basal and seizure-induced neurotrophin expression by adrenalectomy
1995
Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons
1992
Cloning and expression of a cDNA encoding an endothelin receptor
1990 StandoutNature
The Emerging Concept of Relaxn as a Centrally Actng Peptide Hormone with Hemodynamic Actions
1995
Zebrafish TrkC1 and TrkC2 Receptors Define Two Different Cell Populations in the Nervous System during the Period of Axonogenesis
1998
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
2004 Standout
Malignant astrocytic glioma: genetics, biology, and paths to treatment
2007 Standout
Lipid Rafts Mediate the Synaptic Localization of α-Synuclein
2004
Defects in enteric innervation and kidney development in mice lacking GDNF
1996 StandoutNature
Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions
1996
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
1990 StandoutNature
Regionally specific and rapid increases in brain-derived neurotrophic factor messenger RNA in the adult rat brain following seizures induced by systemic administration of kainic acid
1992
Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis
1999
Alpha-synuclein and transgenic mouse models
2004
Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia
1998 StandoutNobel
Oncoprotein Networks
1997
Paclitaxel–Carboplatin Alone or with Bevacizumab for Non–Small-Cell Lung Cancer
2006 Standout
Localization of Glial Cell Line‐derived Neurotrophic Factor (GDNF) mRNA in Embryonic Rat by In Situ Hybridization
1996
Angiostatin induces and sustains dormancy of human primary tumors in mice
1996
VEGF mRNA is Reversibly Stabilized by Hypoxia and Persistently Stabilized in VEGF-Overexpressing Human Tumor Cell Lines
1995
In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons
1995 Nature
Genetic Animal Models of Parkinson's Disease
2010
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
Role of α-synuclein in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in mice
2003 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Pathogenesis of retinopathy of prematurity
2003
The biology of VEGF and its receptors
2003 Standout
Neurotrophic factors and their receptors
1995
VEGF/VPF: The angiogenesis factor found?
1993
Levels of vascular endothelial growth factor, hepatocyte growth factor/scatter factor and basic fibroblast growth factor in human gliomas and their relation to angiogenesis
1999
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Limited impact of prognostic factors in patients with recurrent glioblastoma multiforme treated with a bevacizumab-based regimen
2013
Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis
1998
Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth
1997 Standout
Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma
2014 Standout
Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened
2000
Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells
1995
Characterization of Nerve Growth Factor (NGF) Release from Hippocampal Neurons: Evidence for a Constitutive and an Unconventional Sodium‐dependent Regulated Pathway
1995
Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy
2010
What causes cell death in Parkinson's disease?
2009
Ten years of anti-vascular endothelial growth factor therapy
2016
Oncogenes as inducers of tumor angiogenesis
1995
Proteolysis That Is Inhibited by Hedgehog Targets Cubitus interruptus Protein to the Nucleus and Converts It to a Repressor
1997
Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant
1994 Nature
BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF
1991
THE ROLE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN OCULAR HEALTH AND DISEASE
2005
Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
1995 Nature
Mechanisms of Disease: genetic predictors of response to treatment in brain tumors
2007
SOX10 mutation disrupts neural crest development in Dom Hirschsprung mouse model
1998
A frequent activated smoothened mutation in sporadic basal cell carcinomas
1999
The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency
1996
Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine
1997
Vascular Endothelial Growth Factor: Molecular and Biological Aspects
1999
Mice lacking brain-derived neurotrophic factor develop with sensory deficits
1994 Nature
Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment
1992
Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
1995 Nature
Inhibition of Vascular Endothelial Growth Factor (VEGF)-induced Endothelial Cell Proliferation by a Peptide Corresponding to the Exon 7-Encoded Domain of VEGF165
1997
Vascular endothelial growth factor and its receptors
1996
Spatio-temporal expression of a novel neuron-derived neurotrophic factor (NDNF) in mouse brains during development
2010
Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
1995
Neurotrophin expression in rat hippocampal slices: A stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs
1992
Relaxin signalling links tyrosine phosphorylation to phosphodiesterase and adenylyl cyclase activity
2001
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Severe Sensory Deficits but Normal CNS Development in Newborn Mice Lacking TrkB and TrkC Tyrosine Protein Kinase Receptors
1997
Invasion as limitation to anti-angiogenic glioma therapy
2003
Vascular Endothelial Growth Factor in Ocular Fluid of Patients with Diabetic Retinopathy and Other Retinal Disorders
1994 Standout
α-Synuclein: Normal Function and Role in Neurodegenerative Diseases
2004
Malignant Gliomas in Adults
2008 Standout
The nerve growth factor family
1990
Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF
1995 Nature
α-Synuclein Is Degraded by Both Autophagy and the Proteasome
2003
VEGF and the quest for tumour angiogenesis factors
2002
Characterization of Novel Vascular Endothelial Growth Factor (VEGF) Receptors on Tumor Cells That Bind VEGF165 via Its Exon 7-encoded Domain
1996
Characterization of the G Protein-coupled Receptor Kinase GRK4
1996 StandoutNobel
Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis
1995
Transducing Hedgehog: the story so far
1998
Identification of an angiogenic mitogen selective for endocrine gland endothelium
2001 Nature
Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
1991 StandoutNature
The role of neurotrophins in the developing nervous system
1994
Expression of Vascular Endothelial Growth Factor-C in Benign and Malignant Thyroid Tumors
2003
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer
2003 Standout
Multiple promoters direct tissue-specific expression of the rat BDNF gene
1993
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
2010
Mechanisms of angiogenesis
1997 StandoutNature
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma
1994 Standout
GDNF signalling through the Ret receptor tyrosine kinase
1996 StandoutNature
GDNF is an age-specific survival factor for sensory and autonomic neurons
1995
VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix
1997
Induction of the hair growth phase in postnatal mice by localized transient expression of Sonic hedgehog
1999
Mice without a Functional Relaxin Gene Are Unable to Deliver Milk to Their Pups1
1999
Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma
1997
Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.
1992
Adrenalectomy attenuates kainic acid-elicited increases of messenger RNAs for neurotrophins and their receptors in the rat brain
1993
Predictive markers of anti-VEGF and emerging role of angiogenesis inhibitors as immunotherapeutics
2017
Clinical applications of angiogenic growth factors and their inhibitors
1999
Anti-VEGF Antibody Treatment of Glioblastoma Prolongs Survival But Results in Increased Vascular Cooption
2000
Vascular endothelial growth factor
1993
α‐Synuclein produces a long‐lasting increase in neurotransmitter release
2004
Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
1994
Regulation of Neurotrophin mRNA Expression in the Rat Brain by Glucocorticoids
1992
Angiogenesis in cancer, vascular, rheumatoid and other disease
1995 Standout
Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis
1991
Defects in Sensory and Autonomic Ganglia and Absence of Locus Coeruleus in Mice Deficient for the Homeobox Gene Phox2a
1997
A BDNF autocrine loop in adult sensory neurons prevents cell death
1995 Nature
Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis.
1995
Conformational properties of α-synuclein in its free and lipid-associated states 1 1Edited by P. E. Wright
2001
Vascular endothelial growth factor is essential for corpus luteum angiogenesis
1998
Fibroblasts in cancer
2006 Standout
Derivation of Functional Antagonists Using N-Terminal Extracellular Domain of Gonadotropin and Thyrotropin Receptors
1997 StandoutNobel
Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila
1994
Lack of Neurotrophin-3 Results in Death of Spinal Sensory Neurons and Premature Differentiation of Their Precursors
1996
Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer
2004 Standout
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
1996 StandoutNature
VEGF in Signaling and Disease: Beyond Discovery and Development
2019 Standout
Renal agenesis and the absence of enteric neurons in mice lacking GDNF
1996 StandoutNature
Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog
1998 Standout
Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors
1996
The new mutation, E46K, of α‐synuclein causes parkinson and Lewy body dementia
2003 Standout
Possible Mechanisms of Acquired Resistance to Anti-angiogenic Drugs: Implications for the Use of Combination Therapy Approaches
2001
Angiogenesis as a therapeutic target
2005 StandoutNature
Developmental and Pathological Angiogenesis
2011
VEGF‐null cells require PDGFR α signaling‐mediated stromal fibroblast recruitment for tumorigenesis
2004
VEGF and Intraocular Neovascularization: From Discovery to Therapy
2016
Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents
1994
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
2011
Specific Subtypes of Cutaneous Mechanoreceptors Require Neurotrophin-3 Following Peripheral Target Innervation
1996
Targeted disruption of the neurotrophin-3 gene with lacZ induces loss of trkC-positive neurons in sensory ganglia but not in spinal cords
1995
Parkinson's Disease
2003 Standout
Targeting the tumour vasculature: insights from physiological angiogenesis
2010
Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy
1994
2′-Fluoropyrimidine RNA-based Aptamers to the 165-Amino Acid Form of Vascular Endothelial Growth Factor (VEGF165)
1998
VEGFs, receptors and angiogenesis
1999
More Surprises in the Hedgehog Signaling Pathway
2000
A Perivascular Niche for Brain Tumor Stem Cells
2007 Standout
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
A Single Rostrocaudal Colonization of the Rodent Intestine by Enteric Neuron Precursors Is Revealed by the Expression of Phox2b, Ret, and p75 and by Explants Grown under the Kidney Capsule or in Organ Culture
1998
Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor
1998 Standout
Relaxin: A pleiotropic hormone
1997
Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells.
1995
Transmembrane Molecular Pump Activity of Niemann-Pick C1 Protein
2000 Science
Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.
2000
Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons
1995
Inhibition of tumor growth by targeting tumor endothelium using a soluble vascular endothelial growth factor receptor.
1998
Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer
2010
Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.
1995
Characterization of Two LGR Genes Homologous to Gonadotropin and Thyrotropin Receptors with Extracellular Leucine-Rich Repeats and a G Protein-Coupled, Seven-Transmembrane Region
1998
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α
2000 StandoutNobel
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Pharmacology and Pharmacodynamics of Bevacizumab as Monotherapy or in Combination with Cytotoxic Therapy in Preclinical Studies
2005
Endothelial receptor tyrosine kinases involved in angiogenesis.
1995
Stabilization of Vascular Endothelial Growth Factor mRNA by Hypoxia and Hypoglycemia and Coregulation with Other Ischemia-Induced Genes
1995
Inhibition of glioma angiogenesis and growth in vivo by systemic treatment with a monoclonal antibody against vascular endothelial growth factor receptor-2.
2001
Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
2004 Standout
Bevacizumab and chemotherapy for recurrent glioblastoma
2009
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.
1998
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
1995 Standout
Neurons Expressing the Highest Levels of γ-Synuclein Are Unaffected by Targeted Inactivation of the Gene
2003
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
1997 StandoutScience
Vascular remodeling and clinical resistance to antiangiogenic cancer therapy
2004
Molecular Predictors in Glioblastoma
2008
VEGF-Trap: A VEGF blocker with potent antitumor effects
2002
Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.
2000
Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice
1995
Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.
1995
The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin
1997
The Biology of Vascular Endothelial Growth Factor
1997 Standout
Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR.
1994
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
2012
Vasostatin, a Calreticulin Fragment, Inhibits Angiogenesis and Suppresses Tumor Growth
1998
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
2000
Activation of Orphan Receptors by the Hormone Relaxin
2002 StandoutScience
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
1999 StandoutScience
Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy
2002
Mice carrying a human GLUD2 gene recapitulate aspects of human transcriptome and metabolome development
2016 StandoutNobel
Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.
1994
Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
1998
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors.
1999
Double-knockout mice for α- and β-synucleins: Effect on synaptic functions
2004 StandoutNobel
Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma
2008
Neurotrophins and Neuronal Plasticity
1995 StandoutScience
Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.
1995
CD14, a Receptor for Complexes of Lipopolysaccharide (LPS) and LPS Binding Protein
1990 StandoutScience
Binding to the Extracellular Matrix and Proteolytic Processing: Two Key Mechanisms Regulating Vascular Endothelial Growth Factor Action
2010
Vascular endothelial growth factor and diabetes: the agonist versus antagonist paradox.
1999
Vascular Endothelial Growth Factor
2009 Standout
Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein.
1996 StandoutNobel
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
2009
Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.
1993
Alpha-synuclein: between synaptic function and dysfunction.
2003
MECHANISMS OF WNT SIGNALING IN DEVELOPMENT
1998 Standout
Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas.
1995
Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.
1992
Resistance to Anti-Angiogenic Therapy in Cancer—Alterations to Anti-VEGF Pathway
2018
Molecular Cloning of the Thyrotropin Receptor
1989 Science
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
1997 StandoutNobel
Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.
2000
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders.
1997
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Absence of Sensory Neurons before Target Innervation in Brain-Derived Neurotrophic Factor-, Neurotrophin 3-, and TrkC-Deficient Embryonic Mice
1997
Inhibition of the NT-3 Receptor TrkC, Early in Chick Embryogenesis, Results in Severe Reductions in Multiple Neuronal Subpopulations in the Dorsal Root Ganglia
1996
Cloning of Two Novel Mammalian Paralogs of Relaxin/Insulin Family Proteins and Their Expression in Testis and Kidney
1999
Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade
2017
Design and Structure−Activity Relationship of a New Class of Potent VEGF Receptor Tyrosine Kinase Inhibitors
1999
Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo.
1996
Relaxin binding in the rat heart atrium.
1992
Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection
1993
Roles for Growth Factors in Cancer Progression
2010
Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation
1992 Standout
Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression.
1995
Exogenous vascular endothelial growth factor induces malformed and hyperfused vessels during embryonic neovascularization.
1995
Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo.
1991
Angiogenesis in Endocrine Tumors
2003
Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes
1992
Sonic hedgehog Promotes G1Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors
2000
Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.
1992
Molecular Profiling Identifies Prognostic Subgroups of Pediatric Glioblastoma and Shows Increased YB-1 Expression in Tumors
2007
Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking α-Synuclein
2002
Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.
1995
Targeted deletion of all isoforms of the trkC gene suggests the use of alternate receptors by its ligand neurotrophin-3 in neuronal development and implicates trkC in normal cardiogenesis
1997
The p75 Neurotrophin Receptor Mediates Neuronal Apoptosis and Is Essential for Naturally Occurring Sympathetic Neuron Death
1998
Interplay between glutamate and gamma-aminobutyric acid transmitter systems in the physiological regulation of brain-derived neurotrophic factor and nerve growth factor synthesis in hippocampal neurons.
1991
Vascular endothelial growth factor mediates angiogenic activity during the proliferative phase of wound healing.
1998 Standout
Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons
2000
Hypoxic Induction of Endothelial Cell Growth Factors in Retinal Cells: Identification and Characterization of Vascular Endothelial Growth Factor (VEGF) as the Mitogen
1995
Randomized Phase III Trial of Capecitabine Compared With Bevacizumab Plus Capecitabine in Patients With Previously Treated Metastatic Breast Cancer
2005
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
2004 Standout
Frequent Overexpression of Vascular Endothelial Growth Factor Gene in Human Renal Cell Carcinoma.
1994
Works of Heidi Phillips being referenced
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio Trial
2015
Sensory and Motor Neuron-derived Factor. A NOVEL HEREGULIN VARIANT HIGHLY EXPRESSED IN SENSORY AND MOTOR NEURONS
1995
Vascular Endothelial Growth Factor is Expressed in Rat Corpus Luteum
1990
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
2006 Standout
TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons
1994
GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and Kidney
1998
Characterization of a multicomponent receptor for GDNF
1996 Nature
Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons
1994
Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets
1994
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease
1991
Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary.
1992
Neurotrophins promote motor neuron survival and are present in embryonic limb bud
1993 Nature
AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme
2011
Mice Lacking α-Synuclein Display Functional Deficits in the Nigrostriatal Dopamine System
2000
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog
1996 StandoutNature
Neurotrophic‐4/5 is a survival factor for embryonic midbrain dopaminergic neurons in enriched cultures
1994
Renal and neuronal abnormalities in mice lacking GDNF
1996 Nature
Expression of vascular endothelial growth factor does not promote transformation but confers a growth advantage in vivo to Chinese hamster ovary cells.
1993
Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
1993 StandoutNature
Widespread Expression of BDNF But Not NT3 by Target Areas of Basal Forebrain Cholinergic Neurons
1990 Science
Hominoid-specific enzyme GLUD2 promotes growth of IDH1 R132H glioma
2014
Lutropin-Choriogonadotropin Receptor: An Unusual Member of the G Protein-Coupled Receptor Family
1989 Science
Synchronous Onset of NGF and TrkA Survival Dependence in Developing Dorsal Root Ganglia
1996
Developmental expression of binding sites and messenger ribonucleic acid for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis.
1993
Autoradiographic localization of relaxin binding sites in rat brain.
1991
Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic Neurons
1998
GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle
1994 Science