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Citing Papers
Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells
2002 StandoutScienceNobel
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2008
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2001 StandoutScienceNobel
Sequence of late molecular events in the activation of rhodopsin
2007
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
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Atomic-Level Characterization of the Structural Dynamics of Proteins
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Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
Structural elements of Gα subunits that interact with Gβγ, receptors, and effectors
1993
Caveolin-1 Is a Negative Regulator of Caveolae-mediated Endocytosis to the Endoplasmic Reticulum
2002
The structural basis of agonist-induced activation in constitutively active rhodopsin
2011 Nature
EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins
1996 StandoutNobel
G Protein-Coupled Receptor Kinase Function Is Essential for Chemosensation in C. elegans
2004 StandoutNobel
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor
1997 StandoutNobel
Proximal Events in Signaling by Plasma Membrane Estrogen Receptors
2003
Crystal structure of squid rhodopsin
2008 Nature
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3
1997 Standout
Antagonism between Goalpha and Gqalpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for Goalpha signaling and regulates Gqalpha activity
1999
Fluorescent BODIPY-GTP Analogs: Real-Time Measurement of Nucleotide Binding to G Proteins
2001
Dynamics of receptor/G protein coupling in living cells
2005
Real-time monitoring of receptor and G-protein interactions in living cells
2005
Two conformations of the integrin A-domain (I-domain): a pathway for activation?
1995
Regulated portals of entry into the cell
2003 StandoutNature
The molecular acrobatics of arrestin activation
2004
Rhodopsin Mutants Discriminate Sites Important for the Activation of Rhodopsin Kinase and G
1995
Novel roles for arrestins in the post-endocytic trafficking of G protein-coupled receptors
2004
Protease-activating Receptor-4 Induces Full Platelet Spreading on a Fibrinogen Matrix
2007
The GTPase superfamily: conserved structure and molecular mechanism
1991 StandoutNature
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Rhodopsin structure, dynamics, and activation: A perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking
2003
Receptor-Mediated Activation of Heterotrimeric G-Proteins: Current Structural Insights
2007
Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296
1992
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
The ATP-gated P2X1 Receptor Plays a Pivotal Role in Activation of Aspirin-treated Platelets by Thrombin and Epinephrine
2008 StandoutNobel
Modulation of the GTPase Activity of Transducin. Kinetic Studies of Reconstituted Systems
1994
The adenylyl and guanylyl cyclase superfamily
1998
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase
1998 Nobel
Roles of lipid rafts in membrane transport
2001
A novel multigene family may encode odorant receptors: A molecular basis for odor recognition
1991 StandoutNobel
The structure of the G protein heterotrimer Giα1β1γ2
1995 Nobel
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Phosducin induces a structural change in transducin βγ
1998
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Identification of Proteins Containing Cysteine Residues That Are Sensitive to Oxidation by Hydrogen Peroxide at Neutral pH
2000
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes
1993
Crystal structure of opsin in its G-protein-interacting conformation
2008 Nature
Conformations of the Active and Inactive States of Opsin
2001
Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade
1997 Standout
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Functional Analysis of a Dominant Negative Mutant of Gαi2
1995
Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits
1995 Nobel
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
Heterotrimeric C proteins: Organizers of transmembrane signals
1995
Molecular tinkering of G protein-coupled receptors: an evolutionary success
1999
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Crystal Structure at 2.4 Å Resolution of the Complex of Transducin βγ and Its Regulator, Phosducin
1996
Quantitative reactivity profiling predicts functional cysteines in proteomes
2010 StandoutNatureNobel
The Gα Protein ODR-3 Mediates Olfactory and Nociceptive Function and Controls Cilium Morphogenesis in C. elegans Olfactory Neurons
1998
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
Cell adhesion in vascular biology. New insights into integrin-ligand interaction.
1997
Endocytosis Via Caveolae
2002
Ionic Channels and Their Regulation by G Protein Subunits
1990
Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation
2005
Stable Interaction between β-Arrestin 2 and Angiotensin Type 1A Receptor Is Required for β-Arrestin 2-mediated Activation of Extracellular Signal-regulated Kinases 1 and 2
2004 StandoutNobel
X-ray structure of the mammalian GIRK2–βγ G-protein complex
2013 NatureNobel
Structure of Bovine Rhodopsin in a Trigonal Crystal Form
2004
ras p21 and GAP inhibit coupling of muscarinic receptors to atrial K+ channels
1990
Integrins
2002 Standout
GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits
1996 Nobel
Mutational Analysis of Gβγ and Phospholipid Interaction with G Protein-coupled Receptor Kinase 2
2000
Mutations in GNA11 in Uveal Melanoma
2010 Standout
Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis
1997 Nobel
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
1994 StandoutNatureNobel
Crystal Structure of β-Arrestin at 1.9 Å
2001
Differential G protein—mediated coupling of neurotransmitter receptors to Ca2+ channels in rat dorsal root ganglion neurons in vitro
1989
THE ROLE OF RECEPTOR KINASES AND ARRESTINS IN G PROTEIN–COUPLED RECEPTOR REGULATION
1998
Dendrimers Derived from 1 → 3 Branching Motifs
2010
Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception
2000 StandoutNobel
PLANT DISEASE RESISTANCE GENES
1997 Standout
Sites of interaction in the complex between beta- and gamma-subunits of transducin.
1990
Mechanism of GTP hydrolysis by G-protein alpha subunits.
1994 StandoutNobel
G Protein–Coupled Receptor Oligomerization
2004
Rhodopsin/transducin interactions. II. Influence of the transducin-beta gamma subunit complex on the coupling of the transducin-alpha subunit to rhodopsin.
1992
Regulator of G Protein Signaling Proteins: Novel Multifunctional Drug Targets
2001
A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood
1999 Nobel
SCF and Cullin/RING H2-Based Ubiquitin Ligases
1999
Folding of the N-terminal, ligand-binding region of integrin α-subunits into a β-propeller domain
1997
μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence
2000 StandoutNatureNobel
Caveolae Are Highly Immobile Plasma Membrane Microdomains, Which Are not Involved in Constitutive Endocytic Trafficking
2002
Clathrin
2000
β-arrestin- but not G protein-mediated signaling by the “decoy” receptor CXCR7
2009 StandoutNobel
Complexes between photoactivated rhodopsin and transducin: progress and questions
2010
The evasive nature of drug efficacy: implications for drug discovery
2007
G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins
1996
Enhanced Cell Uptake of Superparamagnetic Iron Oxide Nanoparticles Functionalized with Dendritic Guanidines
2008
Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors
2000
Purification from bovine liver membranes of a guanine nucleotide-dependent activator of phosphoinositide-specific phospholipase C. Immunologic identification as a novel G-protein alpha subunit.
1990
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
The carboxyl terminus of Scg1, the G alpha subunit involved in yeast mating, is implicated in interactions with the pheromone receptors.
1991
Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein.
1989
CHEMICAL ACTIVATORS OF SENSORY NEURONS
1997
The Solution Structure and Dynamics of the Pleckstrin Homology Domain of G Protein-coupled Receptor Kinase 2 (β-Adrenergic Receptor Kinase 1)
1998
Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.
1992
Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling
1998 StandoutNobel
Expression and analysis of Gs alpha mutants with decreased ability to activate adenylylcyclase
1991 StandoutNobel
Structure of the RGS-like Domain from PDZ-RhoGEF
2001
Circadian fluctuations of period protein immunoreactivity in the CNS and the visual system of Drosophila
1990 StandoutNobel
Molecular Dendritic Transporter Nanoparticle Vectors Provide Efficient Intracellular Delivery of Peptides
2009
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex
2009 StandoutNobel
Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine
2010 Standout
A Transmembrane Intracellular Estrogen Receptor Mediates Rapid Cell Signaling
2005 StandoutScience
Different Effects of Gsα Splice Variants on β2-Adrenoreceptor-mediated Signaling
1998 StandoutNobel
GTPase-Activating Proteins for Heterotrimeric G Proteins: Regulators of G Protein Signaling (RGS) and RGS-Like Proteins
2000
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Alternative splicing produces transcripts encoding two forms of the alpha subunit of GTP-binding protein Go.
1990
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
G proteins, effectors and GAPs: structure and mechanism
1997
RGS4 and GAIP are GTPase-activating proteins for G qα and block activation of phospholipase Cβ by γ-thio-GTP-G qα
1997 Nobel
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Crystal Structure of the Adenylyl Cyclase Activator G s α
1997 ScienceNobel
A New Approach to Producing Functional Gα Subunits Yields the Activated and Deactivated Structures of Gα12/13 Proteins
2005
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
A G protein-coupled receptor at work: the rhodopsin model
2009
Separate GTP Binding and GTPase Activating Domains of a Gα Subunit
1993 Science
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Diversity of G Proteins in Signal Transduction
1991 StandoutScience
Works of Heidi E. Hamm being referenced
Crystal structure of a GA protein βγdimer at 2.1 Å resolution
1996 Nature
Functional Selectivity of G Protein Signaling by Agonist Peptides and Thrombin for the Protease-activated Receptor-1
2005
Potent Peptide Analogues of a G Protein Receptor-binding Region Obtained with a Combinatorial Library
1996
A site on rod G protein alpha subunit that mediates effector activation
1992 Science
The 2.0 Å crystal structure of a heterotrimeric G protein
1996 Nature
Interaction of rhodopsin with the G‐protein, transducin
1993
The Many Faces of G Protein Signaling
1998
Structural Requirements for the Stabilization of Metarhodopsin II by the C Terminus of the α subunit of Transducin
2001
Closely Related G-protein-coupled Receptors Use Multiple and Distinct Domains on G-protein α-Subunits for Selective Coupling
2003
Mapping of Effector Binding Sites of Transducin α-Subunit Using Gαt/Gαil Chimeras
1996
Insights into G Protein Structure, Function, and Regulation
2003
Structural determinants for activation of the α-subunit of a heterotrimeric G protein
1994 Nature
Structural basis of function in heterotrimeric G proteins
2006
Aspartic Acid 564 in the Third Cytoplasmic Loop of the Luteinizing Hormone/Choriogonadotropin Receptor Is Crucial for Phosphorylation-independent Interaction with Arrestin2
2002
PAR4, but Not PAR1, Signals Human Platelet Aggregation via Ca2+ Mobilization and Synergistic P2Y12 Receptor Activation
2006
NMR structure of a receptor-bound G-protein peptide
1993 Nature
Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions
1997
An Effector Site That Stimulates G-protein GTPase in Photoreceptors
1995
Antagonists of the Receptor-G Protein Interface Block Gi-coupled Signal Transduction
1998
Heterotrimeric G proteins
1996
The α-Helical Domain of Gαt Determines Specific Interaction with Regulator of G Protein Signaling 9
1999
Molecular interactions between the photoreceptor G protein and rhodopsin
1991
Protease-Activated Receptors Differentially Regulate Human Platelet Activation through a Phosphatidic Acid-Dependent Pathway
2006
Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins
2006
Interaction of Transducin with Light-activated Rhodopsin Protects It from Proteolytic Digestion by Trypsin
1996
The 2.2 Å crystal structure of transducin-α complexed with GTPγS
1993 Nature
Heterotrimeric G protein activation by G-protein-coupled receptors
2007
Effect of monoclonal antibody binding on .alpha.-.beta..gamma. subunit interactions in the rod outer segment G protein, Gt
1989
Design and Use of C-Terminal Minigene Vectors for Studying Role of Heterotrimeric G Proteins
2002
GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4
1994 Nature
An Intramolecular Contact in Gα Transducin That Participates in Maintaining Its Intrinsic GDP Release Rate
2001
Conformational Changes at The Carboxyl Terminus of Gα Occur during G Protein Activation
1999
Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotide-binding protein, transducin.
1987
Structural analysis of rod GTP-binding protein, Gt. Limited proteolytic digestion pattern of Gt with four proteases defines monoclonal antibody epitope
1991
Endothelial Cell-Surface Gp60 Activates Vesicle Formation and Trafficking via Gi-Coupled Src Kinase Signaling Pathway
2000
Surfaces of interaction between Gt and rhodopsin in the GDP-bound and empty-pocket configurations.
1990
Circadian rhythms of melatonin release from individual superfused chicken pineal glands in vitro.
1980
Conformational Changes in the Amino-Terminal Helix of the G Protein αi1 Following Dissociation From Gβγ Subunit and Activation
2002
Protein complement of rod outer segments of the frog retina
1986
Synthetic peptides as probes for G protein function. Carboxyl-terminal G alpha s peptides mimic Gs and evoke high affinity agonist binding to beta-adrenergic receptors.
1994
Helix Dipole Movement and Conformational Variability Contribute to Allosteric GDP Release in GαiSubunits,
2009
Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photoreceptor guanyl nucleotide-binding protein, transducin.
1987
Structural and dynamical changes in an α-subunit of a heterotrimeric G protein along the activation pathway
2006
A Monoclonal Antibody to the α Subunit of G k Blocks Muscarinic Activation of Atrial K + Channels
1988 Science
Structural and functional relationships of heterotrimeric G‐proteins
1995
Arrestin-rhodopsin interaction. Multi-site binding delineated by peptide inhibition.
1994
Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins
2007
Site of G Protein Binding to Rhodopsin Mapped with Synthetic Peptides from the α Subunit
1988 Science
How Gsα activates adenylyl cyclase
1998
Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit
2011
Activation of Transducin Guanosine Triphosphatase by Two Proteins of the RGS Family
1997 Nobel
Molecular Basis of Regulation of Ionic Channels by G Proteins
1989
Regulation of transducin GTPase activity in bovine rod outer segments.
1994
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Dendritic Molecular Transporters Provide Control of Delivery to Intracellular Compartments
2007