Citation Impact
Citing Papers
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Activation of Drosophila Toll During Fungal Infection by a Blood Serine Protease
2002 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis
1999
The Trimerization Domain of Nemo Is Composed of the Interacting C-terminal CC2 and LZ Coiled-coil Subdomains
2004
IKK-γ is an essential regulatory subunit of the IκB kinase complex
1998 Nature
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
2006
TNF-Induced Recruitment and Activation of the IKK Complex Require Cdc37 and Hsp90
2002
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
2002
Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain
1999
The I B Kinase: A Master Regulator of NF- B, Innate Immunity, and Epidermal Differentiation
1999
Disruption of Hsp90 Function Results in Degradation of the Death Domain Kinase, Receptor-interacting Protein (RIP), and Blockage of Tumor Necrosis Factor-induced Nuclear Factor-κB Activation
2000
A Drosophila IκB kinase complex required for Relish cleavage and antibacterial immunity
2000
Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO
2006
Characterization of the IκB-kinase NEMO Binding Domain
2002
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
The IKK complex: an integrator of all signals that activate NF-κB?
2000
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
The Pleckstrin Homology Domain Mediates Transformation by Oncogenic Dbl through Specific Intracellular Targeting
1996
Type I Phosphatidylinositol-4-phosphate 5-Kinases
1998
Mammalian phosphoinositide kinases and phosphatases
2009 StandoutNobel
Dual Detection of Fungal Infections in Drosophila via Recognition of Glucans and Sensing of Virulence Factors
2006 StandoutNobel
Regulation of NF-κB Signaling by Pin1-Dependent Prolyl Isomerization and Ubiquitin-Mediated Proteolysis of p65/RelA
2003
Critical Roles of TRAF2 and TRAF5 in Tumor Necrosis Factor-induced NF-κB Activation and Protection from Cell Death
2001
IKK1-deficient mice exhibit abnormal development of skin and skeleton
1999
Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation
1999
IKKε Is Part of a Novel PMA-Inducible IκB Kinase Complex
2000
Shared Principles in NF-κB Signaling
2008 Standout
Role of the adaptor protein CIKS in the activation of the IKK complex
2003
The IκB Kinase (IKK) Complex Is Tripartite and Contains IKKγ but Not IKAP as a Regular Component
2000
Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos
1997 StandoutNobel
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
β-TrCP Mediates the Signal-induced Ubiquitination of IκBβ
1999
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription
2000
Regulation of IκB Kinase (IKK) Complex by IKKγ-dependent Phosphorylation of the T-loop and C Terminus of IKKβ
2006
Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
2003 StandoutNatureNobel
Inducible Degradation of IκBα by the Proteasome Requires Interaction with the F-box Protein h-βTrCP
1999
The Hallmarks of Cancer
2000 Standout
Lessons from Hereditary Colorectal Cancer
1996 Standout
IKKα controls formation of the epidermis independently of NF-κB
2001 Nature
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
2010
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways
2002
Role of Drosophila IKKγ in a Toll-independent antibacterial immune response
2000 StandoutNobel
NEMO Trimerizes through Its Coiled-coil C-terminal Domain
2002
Tumor Necrosis Factor-α-induced IKK Phosphorylation of NF-κB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway
2003
Lfc and Lsc Oncoproteins Represent Two New Guanine Nucleotide Exchange Factors for the Rho GTP-binding Protein
1996
NF-κB signaling pathways in mammalian and insect innate immunity
2001
JNK2 and IKKβ Are Required for Activating the Innate Response to Viral Infection
1999
Signal Responsiveness of IκB Kinases Is Determined by Cdc37-assisted Transient Interaction with Hsp90
2007
A Novel PDZ Domain Containing Guanine Nucleotide Exchange Factor Links Heterotrimeric G Proteins to Rho
1999
Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of IκBα
1999 StandoutNobel
Bcl10 and MALT1, Independent Targets of Chromosomal Translocation in MALT Lymphoma, Cooperate in a Novel NF-κB Signaling Pathway
2001
The Dbl family of oncogenes
1996
Missing Pieces in the NF-κB Puzzle
2002 Standout
Bcl10 activates the NF-κB pathway through ubiquitination of NEMO
2003 Nature
Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling
2006
Identification of a Novel Guanine Nucleotide Exchange Factor for the Rho GTPase
1996
Retrovirus cDNA expression library screening for oncogenes
2001
Toll-like Receptor-2 Mediates Treponema Glycolipid and Lipoteichoic Acid-induced NF-κB Translocation
2001
The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro
1999
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
1999
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
TAK1 is Critical for IκB Kinase-mediated Activation of the NF-κB Pathway
2003
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
CD36 is a sensor of diacylglycerides
2005 StandoutNatureNobel
Regulating Rap small G-proteins in time and space
2011
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Differential Phosphorylation of the Signal-responsive Domain of IκBα and IκBβ by IκB Kinases
2003
IRAK-mediated Translocation of TRAF6 and TAB2 in the Interleukin-1-induced Activation of NFκB
2001
Induction of the NF-κB Cascade by Recruitment of the Scaffold Molecule NEMO to the T Cell Receptor
2003
Specific missense mutations in NEMO result in hyper-IgM syndrome with hypohydrotic ectodermal dysplasia
2001
ATM Is Required for IκB Kinase (IKK) Activation in Response to DNA Double Strand Breaks
2001
IKKγ Mediates the Interaction of Cellular IκB Kinases with the Tax Transforming Protein of Human T Cell Leukemia Virus Type 1
1999
Female Mice Heterozygous for IKKγ/NEMO Deficiencies Develop a Dermatopathy Similar to the Human X-Linked Disorder Incontinentia Pigmenti
2000
The immune response of Drosophila
2003 StandoutNatureNobel
β Phorbol Ester- and Diacylglycerol-Induced Augmentation of Transmitter Release Is Mediated by Munc13s and Not by PKCs
2002 StandoutNobel
Characterization of the Recombinant IKK1/IKK2 Heterodimer
2000
Positive Regulation of IκB Kinase Signaling by Protein Serine/Threonine Phosphatase 2A
2005
Taking dendritic cells into medicine
2007 StandoutNatureNobel
NEMO/IKKγ-Deficient Mice Model Incontinentia Pigmenti
2000
Complete Reconstitution of Human IκB Kinase (IKK) Complex in Yeast
2001
NF-kappa B p105 is a target of Ikappa B kinases and controls signal induction of Bcl-3-p50 complexes
1999
Tyrosine phosphorylation‐dependent activation of NF‐κB
2001
Protein Phosphatase 2Cβ Association with the IκB Kinase Complex Is Involved in Regulating NF-κB Activity
2004
Tumor necrosis factor signaling
2003 Standout
The adenomatous polyposis coli (APC) tumor suppressor
1997
Direct Phosphorylation of NF-κB1 p105 by the IκB Kinase Complex on Serine 927 Is Essential for Signal-induced p105 Proteolysis
2001
SWELL1, a Plasma Membrane Protein, Is an Essential Component of Volume-Regulated Anion Channel
2014 StandoutNobel
Structure of the rgRGS domain of p115RhoGEF.
2001
Two actions of frabin: direct activation of Cdc42 and indirect activation of Rac
2000
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
CSN3 interacts with IKKγ and inhibits TNF‐ but not IL‐1‐induced NF‐κB activation
2001
Nuclear IκBβ Maintains Persistent NF-κB Activation in HIV-1-infected Myeloid Cells
1999
IκB kinase complexes: gateways to NF-κB activation and transcription
2006
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003 StandoutNatureNobel
Signaling to NF-κB
2004 Standout
Activation of the IκB Kinases by RIP via IKKγ/NEMO-mediated Oligomerization
2000
NF-κB: a key role in inflammatory diseases
2001 Standout
Ras regulation and function in lymphocytes
2000
Induction of IRF‐3/‐7 kinase and NF‐κB in response to double‐stranded RNA and virus infection: common and unique pathways
2001
A Novel X-Linked Disorder of Immune Deficiency and Hypohidrotic Ectodermal Dysplasia Is Allelic to Incontinentia Pigmenti and Due to Mutations in IKK-gamma (NEMO)
2000
The NF-κB Activation Pathway:A Paradigm in Information Transfer from Membrane to Nucleus
1999
Phosphoinositide 3-OH Kinase Activates the β2Integrin Adhesion Pathway and Induces Membrane Recruitment of Cytohesin-1
1998
Inhibitor of nuclear factor ?B kinase ? is a key regulator of synovial inflammation
2001
An Induced Proximity Model for NF-κB Activation in the Nod1/RICK and RIP Signaling Pathways
2000
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
2003 Nature
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
2000 Standout
Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation
1999
Mature T Cells Depend on Signaling through the IKK Complex
2003
Functional Interactions of Transforming Growth Factor β-activated Kinase 1 with IκB Kinases to Stimulate NF-κB Activation
1999
The Toll-receptor family and control of innate immunity
1999
Embryonic Lethality, Liver Degeneration, and Impaired NF-κB Activation in IKK-β-Deficient Mice
1999
Analysis of Domains in the IKKα and IKKβ Proteins That Regulate Their Kinase Activity
2000
The Distinct Roles of TRAF2 and RIP in IKK Activation by TNF-R1
2000
Human T-cell Lymphotropic Virus Type 1 Tax Induction of Biologically Active NF-κB Requires IκB Kinase-1-mediated Phosphorylation of RelA/p65
2004
TAB2, a Novel Adaptor Protein, Mediates Activation of TAK1 MAPKKK by Linking TAK1 to TRAF6 in the IL-1 Signal Transduction Pathway
2000
Amazing chloride channels: an overview
2003
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Recruitment of the IKK Signalosome to the p55 TNF Receptor
2000
Identification of the receptor component of the IκBα–ubiquitin ligase
1998 Nature
The Faciogenital Dysplasia Gene Product FGD1 Functions as a Cdc42Hs-specific Guanine-Nucleotide Exchange Factor
1996
Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
2001 StandoutNatureNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα
2004 StandoutNobel
A mutation of Ikbkg causes immune deficiency without impairing degradation of IκBα
2010 StandoutNobel
Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation
1999 Science
Small GTP-Binding Proteins
2001 Standout
TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO–IKK supramolecular structures
2014
Regulation of RelA Subcellular Localization by a Putative Nuclear Export Signal and p50
1999
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Activation of NF-κB is required for hypertrophic growth of primary rat neonatal ventricular cardiomyocytes
2001
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice.
2000
Mutant Cells That Do Not Respond to Interleukin-1 (IL-1) Reveal a Novel Role for IL-1 Receptor-Associated Kinase
1999
The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense
2003
Rbx1, a Component of the VHL Tumor Suppressor Complex and SCF Ubiquitin Ligase
1999 StandoutScienceNobel
Mixed-Lineage Kinase 3 Delivers CD3/CD28-Derived Signals into the IκB Kinase Complex
2000
Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.
1995 StandoutNobel
IκB Kinase-Independent IκBα Degradation Pathway: Functional NF-κB Activity and Implications for Cancer Therapy
2003
Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway
2001
CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-κB subunits onIL-8andBcl-xLgene promoters
2004
Posttranslational hydroxylation of ankyrin repeats in IκB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
2006 StandoutNobel
Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis
1997
A genome-wide analysis of immune responses in Drosophila
2001 StandoutNobel
PKR Stimulates NF-κB Irrespective of Its Kinase Function by Interacting with the IκB Kinase Complex
2000
Functional Isoforms of IκB Kinase α (IKKα) Lacking Leucine Zipper and Helix-Loop-Helix Domains Reveal that IKKα and IKKβ Have Different Activation Requirements
2000
Transdominant Inhibition of Bovine Viral Diarrhea Virus Entry
2007 StandoutNobel
Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation
2000
Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene
1999 Science
Dual Activation of the Drosophila Toll Pathway by Two Pattern Recognition Receptors
2003 StandoutScienceNobel
Severe liver degeneration and lack of NF-κB activation in NEMO/IKKγ-deficient mice
2000
Abnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase
1999 Science
Shared Pathways of IκB Kinase-Induced SCFβTrCP-Mediated Ubiquitination and Degradation for the NF-κB Precursor p105 and IκBα
2001
Activation of Transcription Factor NF-κB Requires ELKS, an IκB Kinase Regulatory Subunit
2004 Science
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
IκB Kinase (IKK)-Associated Protein 1, a Common Component of the Heterogeneous IKK Complex
1999
Dimerization of the IκB Kinase-Binding Domain of NEMO Is Required for Tumor Necrosis Factor Alpha-Induced NF-κB Activity
2006
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway
2000
Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation
1997
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
The Carboxyl-Terminal Region of IκB Kinase γ (IKKγ) Is Required for Full IKK Activation
2002
CIKS, a connection to IκB kinase and stress-activated protein kinase
2000
Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice
2001 Science
The α and β Subunits of IκB Kinase (IKK) Mediate TRAF2-Dependent IKK Recruitment to Tumor Necrosis Factor (TNF) Receptor 1 in Response to TNF
2001
Regulation of nuclear factor κB activation by G-protein-coupled receptors
2001
TAPping into mRNA Export
2001 StandoutScienceNobel
Structure of the RGS-like Domain from PDZ-RhoGEF
2001
Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action
2006
Pharmacology of the receptors for the phorbol ester tumor promoters
2000
MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
2000
Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis
1999
Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1
1999
The Zinc Finger Domain of NEMO Is Selectively Required for NF-κB Activation by UV Radiation and Topoisomerase Inhibitors
2002
Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation
2003
Regulation and Function of IKK and IKK-Related Kinases
2006
Recent progress in understanding apolipoprotein B.
1990
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Innate Immune Recognition
2002 Standout
Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity
2000 Standout
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β
2000
Selective Inhibition of NF-κB Activation by a Peptide That Blocks the Interaction of NEMO with the IκB Kinase Complex
2000 Science
Act1, an NF-κB-activating protein
2000
Works of Heather Kirk being referenced
G2A is an oncogenic G protein-coupled receptor
2000
Expression Cloning of lsc, a Novel Oncogene with Structural Similarities to the Dbl Family of Guanine Nucleotide Exchange Factors
1996
Apolipoprotein B gene variants are involved in the determination of serum cholesterol levels: a study in normo- and hypelipidaemic individuals
1987
Expression Cloning of lfc, a Novel Oncogene with Structural Similarities to Guanine Nucleotide Exchange Factors and to the Regulatory Region of Protein Kinase C
1995
Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation
1998
Regulation of RasGRP via a Phorbol Ester-Responsive C1 Domain
1998
Complementation of Growth Factor Receptor-Dependent Mitogenic Signaling by a Truncated Type I Phosphatidylinositol 4-Phosphate 5-Kinase
1997
Retroviral transduction and oncogenic selection of a cDNA encoding Dbs, a homolog of the Dbl guanine nucleotide exchange factor.
1995
Expression Cloning of Oncogenes by Retroviral Transfer of cDNA Libraries
1995