Standout Papers
Citation Impact
Citing Papers
In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution
2009
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
2007
Molecular Dissection of Formation of Senescence-Associated Heterochromatin Foci
2007
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells
2011
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
2011
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities
2003
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells
2009
SIRT3 Reverses Aging-Associated Degeneration
2013
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Secreted Frizzled-Related Protein 1 Extrinsically Regulates Cycling Activity and Maintenance of Hematopoietic Stem Cells
2009
Switchable Cas9
2017 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
In Situ trans Ligands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics
2010
The DNA-damage response in human biology and disease
2009 StandoutNature
Pan-Genotype Hepatitis E Virus Replication in Stem Cell–Derived Hepatocellular Systems
2017 StandoutNobel
Noncanonical Wnt Signaling Maintains Hematopoietic Stem Cells in the Niche
2012
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
2007
Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice
2008
Circular RNAs are a large class of animal RNAs with regulatory potency
2013 StandoutNature
Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment
2007
Epigenetic regulation of aging stem cells
2011
B‐cell homeostasis: digital survival or analog growth?
2004
Cellular senescence: when bad things happen to good cells
2007 Standout
Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
2010
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
Cellular Senescence in Cancer and Aging
2007 Standout
ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes
2011
Cellular senescence and organismal aging
2008
Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance
2012
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
2009
Expression of p16INK4a in peripheral blood T‐cells is a biomarker of human aging
2009
The Epigenomics of Cancer
2007 Standout
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
2013 Nature
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Rescue of key features of the p63‐null epithelial phenotype by inactivation of Ink4a and Arf
2009
Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration
2012
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells
2008 Nature
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies
2011
p16INK4a induces an age-dependent decline in islet regenerative potential
2006 Nature
Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk
2010
WNT signaling in bone homeostasis and disease: from human mutations to treatments
2013 Standout
Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow
2010
How stem cells age and why this makes us grow old
2007
The pre-BCR checkpoint as a cell-autonomous proliferation switch
2004
Bmi1 regulates mitochondrial function and the DNA damage response pathway
2009 Nature
Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development
2012 StandoutNobel
Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches
2012
Ferreting out stem cells from their niches
2011
mTOR: from growth signal integration to cancer, diabetes and ageing
2010 Standout
Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging
2009
Anti‐aging activity of the Ink4/Arf locus
2009
Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency
2008
Epigenetics and aging: the targets and the marks
2007
A common variant of the p16INK4a genetic region is associated with physical function in older people
2007
Integrating Physiological Regulation with Stem Cell and Tissue Homeostasis
2011
Stems Cells and the Pathways to Aging and Cancer
2008
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation
2010
The common biology of cancer and ageing
2007 Nature
Direct measurement of local oxygen concentration in the bone marrow of live animals
2014 Nature
Two faces of p53: aging and tumor suppression
2007
limma powers differential expression analyses for RNA-sequencing and microarray studies
2015 Standout
Emerging models and paradigms for stem cell ageing
2011
Evidence that senescent human prostate epithelial cells enhance tumorigenicity: Cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT
2007
Immortalization eliminates a roadblock during cellular reprogramming into iPS cells
2009 Nature
A Fresh Look at iPS Cells
2009 StandoutNobel
Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model
2012
Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs
2013
Hypoxia mediates low cell-cycle activity and increases the proportion of long-term–reconstituting hematopoietic stem cells during in vitro culture
2010
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
2010 Nature
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
Delayed ageing through damage protection by the Arf/p53 pathway
2007 Nature
Pax5 loss imposes a reversible differentiation block in B-progenitor acute lymphoblastic leukemia
2014
The Hallmarks of Aging
2013 Standout
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CDK Inhibitor p18INK4c Is a Downstream Target of GATA3 and Restrains Mammary Luminal Progenitor Cell Proliferation and Tumorigenesis
2009
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss
2007
Macrophage biology in development, homeostasis and disease
2013 StandoutNature
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
2010
DNA damage response and cellular senescence in tissues of aging mice
2009
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
2010
Ikaros in immune receptor signaling, lymphocyte differentiation, and function
2010
The Regulation of INK4/ARF in Cancer and Aging
2006
Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment
2013
Cdc42 Activity Regulates Hematopoietic Stem Cell Aging and Rejuvenation
2012
Stem cell-derived polarized hepatocytes
2020 StandoutNobel
Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency
2008
Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling
2009
Mechanisms that Regulate Stem Cell Aging and Life Span
2013
Nuclear reprogramming to a pluripotent state by three approaches
2010 StandoutNatureNobel
The role of Dickkopf-1 in bone development, homeostasis, and disease
2008
Regulation of Hematopoietic Stem Cells by the Steel Factor/KIT Signaling Pathway
2008
The relationship between bone, hemopoietic stem cells, and vasculature
2011
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Loss of Cxcl12/Sdf-1 in adult mice decreases the quiescent state of hematopoietic stem/progenitor cells and alters the pattern of hematopoietic regeneration after myelosuppression
2010
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Four faces of cellular senescence
2011 Standout
TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
2008
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
2010
Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization
2010 Standout
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Regulation of Bone Marrow-Derived Vascular Progenitor Cell Mobilization and Maintenance
2010
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Myc stimulates B lymphocyte differentiation and amplifies calcium signaling
2007
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Ankyrin Repeat: A Unique Motif Mediating Protein−Protein Interactions
2006
Minireview: The Stem Cell Next Door: Skeletal and Hematopoietic Stem Cell “Niches” in Bone
2011
Diabetes Impairs Hematopoietic Stem Cell Mobilization by Altering Niche Function
2011
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Coexistence of Quiescent and Active Adult Stem Cells in Mammals
2010 StandoutScience
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
2010
The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche
2010
The Biology of Cancer Stem Cells
2007
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
2010
Chemical Glycoproteomics
2016 StandoutNobel
Works of Heather E. Fleming being referenced
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
2006 Nature
Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo
2008
Cooperation between IL-7 and the pre-B cell receptor: a key to B cell selection
2002
Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3
2008
Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche
2008 Nature
Pluripotent stem cell-derived hepatocyte-like cells
2014
Frontline: IL‐7 does not prevent pro‐B/pre‐B cell maturation to the immature/sIgM+ stage
2004
Pre-B Cell Receptor Signaling Mediates Selective Response to IL-7 at the Pro-B to Pre-B Cell Transition via an ERK/MAP Kinase-Dependent Pathway
2001
Modulation of the IL-7 Dose-Response Threshold During Pro-B Cell Differentiation Is Dependent on Pre-B Cell Receptor Expression
1998
CD45-Deficient Mice Accumulate Pro-B Cells Both In Vivo and In Vitro
2004
Development of Light‐Activated CRISPR Using Guide RNAs with Photocleavable Protectors
2016
The role of homotypic interactions in the differentiation of B cell precursors
2001