Standout Papers
Citation Impact
Citing Papers
Photolyase and Cryptochrome Blue-Light Photoreceptors
2004 StandoutNobel
Notch signalling controls pancreatic cell differentiation
1999 StandoutNatureNobel
CRY, a Drosophila Clock and Light-Regulated Cryptochrome, Is a Major Contributor to Circadian Rhythm Resetting and Photosensitivity
1998 StandoutNobel
Structure and Function of Photolyase and in Vivo Enzymology: 50th Anniversary
2008 StandoutNobel
Molecular Analysis of Mammalian Circadian Rhythms
2001
CONTRASTING STRUCTURAL IMPACTS INDUCED BY cis‐syn CYCLOBUTANE DIMER AND (6–4) ADDUCT IN DNA DUPLEX DECAMERS: IMPLICATION IN MUTAGENESIS AND REPAIR ACTIVITY
1995
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
1993 Nature
The cryb Mutation Identifies Cryptochrome as a Circadian Photoreceptor in Drosophila
1998 StandoutNobel
Drosophila CRY Is a Deep Brain Circadian Photoreceptor
2000 StandoutNobel
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
The torso receptor protein-tyrosine kinase signaling pathway: An endless story
1993
Recognition sequence of a highly conserved DNA binding protein RBP-Jx
1994
Torso receptor activity is regulated by a diffusible ligand produced at the extracellular terminal regions of the Drosophila egg
1992 StandoutNobel
A new role for cryptochrome in a Drosophila circadian oscillator
2001 StandoutNatureNobel
Pathways of Electron Transfer in Escherichia coli DNA Photolyase:Trp306 to FADH
1999
Role of ERas in promoting tumour-like properties in mouse embryonic stem cells
2003 StandoutNatureNobel
Sex, stress and integrity: the importance of MAP kinases in yeast
1994
Functional diversity of the DNA photolyase/blue light receptor family
1999
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
1995 Standout
PHOTOREPAIR OF NONADJACENT PYRIMIDINE DIMERS BY DNA PHOTOLYASE
1995 StandoutNobel
MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
1994
Cyclobutylpyrimidine Dimer Base Flipping by DNA Photolyase
2002
Characterization of photolyase/blue-light receptor homologs in mouse and human cells
1998
Localized requirement for torso-like expression in follicle cells for development of terminal anlagen of the Drosophila embryo
1990 StandoutNatureNobel
Photochemistry and Photobiology of Cryptochrome Blue‐light Photopigments: The Search for a Photocycle
2005 StandoutNobel
Evidence for Dinucleotide Flipping by DNA Photolyase
1998
Cryptochromes: sensory reception, transduction, and clock functions subserving circadian systems
2000
Purification and Partial Characterization of (6‐4) Photoproduct DNA Photolyase from Xenopus laevis
1996 StandoutNobel
Flavin adenine dinucleotide as a chromophore of the Xenopus (6-4)photolyase
1997
Binding and Catalytic Properties of Xenopus (6-4) Photolyase
1997
Characterization of a human homolog of (6-4)photolyase
1997
The threonine residues in MAP kinase kinase 1 phosphorylated by MAP kinase in vitro are also phosphorylated in nerve growth factor‐stimulated rat phaeochromocytoma (PC12) cells
1994
Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana
1998
The origin of pattern and polarity in the Drosophila embryo
1992 StandoutNobel
Induction of Cyclobutane Pyrimidine Dimer Photolyase in Cultured Fish Cells by UVA and Blue Light
1996
Structure and Function of Animal Cryptochromes
2007 StandoutNobel
Raf functions downstream of Rasl in the Sevenless signal transduction pathway
1992 Nature
Circadian Photoreception in Humans and Mice
2002
Activin signalling and response to a morphogen gradient
1994 StandoutNatureNobel
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells
1994 Standout
Genetics of signal transduction in invertebrates
1994
Novel ATP‐binding and autophosphorylation activity associated with Arabidopsis and human cryptochrome‐1
2003
Photolyase/cryptochrome blue-light photoreceptors use photon energy to repair DNA and reset the circadian clock
2002 StandoutNobel
Requirement of the Drosophila raf homologue for torso function
1989 Nature
The Circadian Clock of Fruit Flies Is Blind after Elimination of All Known Photoreceptors
2001 StandoutNobel
A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
1994
The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily
1990 StandoutNobel
The immune response of Drosophila
2003 StandoutNatureNobel
The mechanism of action of DNA photolyases
2001
Role of Two Histidines in the (6-4) Photolyase Reaction
2001
Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates
1992
Electron Nuclear Double Resonance Differentiates Complementary Roles for Active Site Histidines in (6-4) Photolyase
2006
The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development
1992 StandoutNobel
Dynamics and mechanism of repair of ultraviolet-induced (6–4) photoproduct by photolyase
2010 StandoutNatureNobel
Nuclear localization of the Arabidopsis blue light receptor cryptochrome 2
1999
Rapid Blue Light Regulation of a Trichoderma harzianum Photolyase Gene
1999
The C Termini of Arabidopsis Cryptochromes Mediate a Constitutive Light Response
2000
The Drosophila gene torso encodes a putative receptor tyrosine kinase
1989 StandoutNatureNobel
The cryptochromes.
2005
Cloning of a marsupial DNA photolyase gene and the lack of related nucleotide sequences in placental mammals
1994
Blue Light-Dependent in Vivo and in Vitro Phosphorylation of Arabidopsis Cryptochrome 1
2003
A phylogenomic study of DNA repair genes, proteins, and processes
1999
Crystal Structure of the T(6‐4)C Lesion in Complex with a (6‐4) DNA Photolyase and Repair of UV‐Induced (6‐4) and Dewar Photolesions
2009
Regulation of the Mammalian Circadian Clock by Cryptochrome
2004 StandoutNobel
Light acts directly on organs and cells in culture to set the vertebrate circadian clock
2000 Nature
DNA photolyases and cryptochromes
2000 Nobel
Reaction Mechanism of (6-4) Photolyase
1997 StandoutNobel
Drosophila cry mutation reveals two circadian clocks that drive locomotor rhythm and have different responsiveness to light
2004
Identification and Characterization of a Second Chromophore of DNA Photolyase from Thermus thermophilus HB27
2005
Site-directed mutagenesis study on DNA binding regions of the mouse homologue of Suppressor of Hairless, RBP-Jx
1994 StandoutNobel
A gene required for the novel activation of a class II DNA photolyase in Chlamydomonas
2001
A unique circadian-rhythm photoreceptor
2000 StandoutNatureNobel
Coupled oscillators control morning and evening locomotor behaviour of Drosophila
2004 StandoutNatureNobel
A role for casein kinase 2α in the Drosophila circadian clock
2002 StandoutNatureNobel
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
1999 Nature
Human Blue‐light Photoreceptor hCRY2 Specifically Interacts with Protein Serine/Threonine Phosphatase 5 and Modulates Its Activity
1997 StandoutNobel
Photoentrainment in Mammals: A Role for Cryptochrome?
1999
Genetics and molecular biology of rhythms in Drosophila and other insects
2003 StandoutNobel
PLEIOTROPIC EFFECTS OF CRYPTOCHROMES 1 AND 2 ON FREE-RUNNING AND LIGHT-ENTRAINED MURINE CIRCADIAN RHYTHMS
2002 StandoutNobel
corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso
1992
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
1994 Nature
Chromatin structure modulates DNA repair by photolyase invivo
1997
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes
2009
Role of the Carbonyl Group of the (6−4) Photoproduct in the (6−4) Photolyase Reaction
2009
MULTIPLE EFFECTS OF FLUORESCENT LIGHT ON REPAIR OF ULTRAVIOLET‐INDUCED DNA LESIONS IN CULTURED GOLDFISH CELLS
1995
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
Identification of fuz7, a Ustilago maydis MEK/MAPKK homolog required for a-locus-dependent and -independent steps in the fungal life cycle.
1994
Roles of the Two Drosophila CRYPTOCHROME Structural Domains in Circadian Photoreception
2004 StandoutScienceNobel
The Genome of Melanoplus sanguinipes Entomopoxvirus
1999
Cryptochrome: The Second Photoactive Pigment in the Eye and Its Role in Circadian Photoreception
2000 StandoutNobel
Blue-Light Photoreceptors in Higher Plants
1999
Tales from the Crypt(ochromes)
2002
Electron-Transfer Induced Repair of 6-4 Photoproducts in DNA: A Computational Study
2007
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Stopping Time: The Genetics of Fly and Mouse Circadian Clocks
2001 StandoutNobel
Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila.
1989
Characteristic Structure and Environment in FAD Cofactor of (6−4) Photolyase along Function Revealed by Resonance Raman Spectroscopy
2006
Circadian Photoreception in Drosophila: Functions of Cryptochrome in Peripheral and Central Clocks
2001
Mechanisms of DNA Excision Repair
1994 StandoutScienceNobel
A Putative Blue‐Light Receptor From Drosophila melanogaster
1999
Fowlpox Virus Encodes a Novel DNA Repair Enzyme, CPD-Photolyase, That Restores Infectivity of UV Light-Damaged Virus
2001
Characterization of (6-4) photoproduct DNA photolyase.
1994 StandoutNobel
Model Studies of the (6−4) Photoproduct Photolyase Enzyme: Laser Flash Photolysis Experiments Confirm Radical Ion Intermediates in the Sensitized Repair of Thymine Oxetane Adducts
2000
A temperature-sensitive MEK mutation demonstrates the conservation of the signaling pathways activated by receptor tyrosine kinases.
1994
Photoactivation of the flavin cofactor in Xenopus laevis (6–4) photolyase: Observation of a transient tyrosyl radical by time-resolved electron paramagnetic resonance
2002
The cryptochrome family of blue/UV-A photoreceptors
1998
Cryptochromes: Blue Light Receptors for Plants and Animals
1999 Science
Photic Signaling by Cryptochrome in the Drosophila Circadian System
2001
An Extraretinally Expressed Insect Cryptochrome with Similarity to the Blue Light Photoreceptors of Mammals and Plants
1999
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.
1993 Nobel
Crystal Structure of DNA Photolyase from Escherichia coli
1995 StandoutScienceNobel
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.
1995
Quantum Chemical Study of the Electron-Transfer-Catalyzed Splitting of Oxetane and Azetidine Intermediates Proposed in the Photoenzymatic Repair of (6−4) Photoproducts of DNA
2000
Photoenzymic Repair of the DNA 6−4 PhotoproductA Density Functional Theory and Semiempirical Study
1997
Genomic organization of mouse J kappa recombination signal binding protein (RBP-J kappa) gene.
1992 StandoutNobel
The cancer connection
2002 StandoutNatureNobel
Disruption of the mouse RBP-Jк gene results in early embryonic death
1995 StandoutNobel
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Photic Induction of mPer1 and mPer2 in Cry -Deficient Mice Lacking a Biological Clock
1999 Science
Signal transduction via the MAP kinases: proceed at your own RSK.
1993 Standout
A (6-4) Photolyase Model: Repair of DNA (6-4) Lesions Requires a Reduced and Deprotonated Flavin
2002
Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.
1993
Vitamin B 2 -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals
1998 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Cryptochrome Structure and Signal Transduction
2003
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
1995 StandoutNobel
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues.
1994
Role of Mouse Cryptochrome Blue-Light Photoreceptor in Circadian Photoresponses
1998 StandoutScienceNobel
A Third Member of the Photolyase/Blue‐light Photoreceptor Family in Drosophila: A Putative Circadian Photoreceptor
1999 StandoutNobel
Remarkable Photoreversal of a Thio Analog of the Dewar Valence Isomer of the (6−4) Photoproduct of DNA to the Parent Nucleotides
1996
Differential regulation of mammalian Period genes and circadian rhythmicity by cryptochromes 1 and 2
1999 StandoutNobel
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1.
1994
Electronic Structure of (6−4) DNA Photoproduct Repair Involving a Non-Oxetane Pathway
2009
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Circadian neuron feedback controls the Drosophila sleep–activity profile
2016 StandoutNatureNobel
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Structure and Function of DNA Photolyase and Cryptochrome Blue-Light Photoreceptors
2003 StandoutNobel
Works of Haruko Ryo being referenced
Identification of cellular factors that recognize UV-damaged DNA in Drosophila melanogaster
1992
A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila
1993
High-level expression of the photorepair gene in Drosophila ovary and its evolutionary implications
1994
Molecular Evolution of the Photolyase–Blue-Light Photoreceptor Family
1997
Purification and characterization of Drosophila melanogaster photolyase
1996 StandoutNobel
DCRY is a Drosophila photoreceptor protein implicated in light entrainment of circadian rhythm
1999
Non-mutagenic repair of (6-4)photoproducts by (6-4)photolyase purified from Drosophila melanogaster
1997
A new photoreactivating enzyme that specifically repairs ultraviolet light-induced (6-4)photoproducts
1993 Nature
The Drosophila RBP-J kappa gene encodes the binding protein for the immunoglobulin J kappa recombination signal sequence.
1991 StandoutNobel
Similarity Among the Drosophila (6-4)Photolyase, a Human Photolyase Homolog, and the DNA Photolyase-Blue-Light Photoreceptor Family
1996 Science
Proliferation of both somatic and germ cells is affected in the Drosophila mutants of raf proto-oncogene.
1988