Citation Impact
Citing Papers
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
2007 Standout
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
2010 StandoutScience
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
2004 Standout
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
2005 StandoutScience
Construction and Characterization of a Retroviral Vector Demonstrating Efficient Expression of Cloned cDNA Sequences
1988
Superparamagnetic PLGA–iron oxide microspheres as contrast agents for dual-imaging and the enhancement of the effects of high-intensity focused ultrasound ablation on liver tissue
2015
The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism
2013 Standout
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX‐68
2003
A Role for AMP-Activated Protein Kinase in Contraction- and Hypoxia-Regulated Glucose Transport in Skeletal Muscle
2001
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
2006
A3adenosine receptor activation decreases mortality and renal and hepatic injury in murine septic peritonitis
2006
Adenosine A2 Receptor Occupancy Regulates Stimulated Neutrophil Function via Activation of a Serine/Threonine Protein Phosphatase
1996
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
1995 Standout
Role of AMP-activated protein kinase in mechanism of metformin action
2001 Standout
Adenosine: an endogenous regulator of innate immunity
2003
Small-Vessel Vasculitis
1997 Standout
Methotrexate modulates the kinetics of adenosine in humans in vivo
2005
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 StandoutNature
5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
1995
Chronic Venous Disease
2006 Standout
Nucleotide signalling during inflammation
2014 StandoutNature
Extracellular adenosine triphosphate and adenosine in cancer
2010
Role of Uncoupling Protein-2 Up-Regulation and Triglyceride Accumulation in Impaired Glucose-Stimulated Insulin Secretion in a β-Cell Lipotoxicity Model Overexpressing Sterol Regulatory Element-Binding Protein-1c
2004
The biology and management of non-small cell lung cancer
2018 StandoutNature
Case 38-2012
2012
Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer
2009
Activation of AMP-Activated Protein Kinase Leads to the Phosphorylation of Elongation Factor 2 and an Inhibition of Protein Synthesis
2002
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
1993
Hypoxia and Inflammation
2011 Standout
A1adenosine receptor knockout mice exhibit increased mortality, renal dysfunction, and hepatic injury in murine septic peritonitis
2005
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine
1995
The mechanisms of action of metformin
2017 Standout
Nonresolving Inflammation
2010 Standout
Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: Evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis
2000
The AMP‐Activated Protein Kinase
1997
The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto‐5′‐nucleotidase: Findings in a study of ecto‐5′‐nucleotidase gene–deficient mice
2007
Mitochondria: In Sickness and in Health
2012 Standout
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
2003 Standout
Suppression of inflammation by low-dose methotrexate is mediated by adenosine A2A receptor but not A3receptor activation in thioglycollate-induced peritonitis
2006
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
2014 StandoutNature
Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides.
1998
Adenosine in Bronchoalveolar Lavage Fluid in Asthma
1993
Cellular Distribution and Functions of P2 Receptor Subtypes in Different Systems
2004
Disruption of Fnip1 Reveals a Metabolic Checkpoint Controlling B Lymphocyte Development
2012 StandoutNobel
Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.
1998
Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer
2013
Type 2 diabetes
2017 Standout
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
2010 StandoutNature
Adenosine A2A receptors in diffuse dermal fibrosis: Pathogenic role in human dermal fibroblasts and in a murine model of scleroderma
2006
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Synergistic Inhibition of HIV-1 in Activated and Resting Peripheral Blood Mononuclear Cells, Monocyte-Derived Macrophages, and Selected Drug-Resistant Isolates With Nucleoside Analogues Combined With a Natural Product, Resveratrol
2000
Mice Lacking Adiponectin Show Decreased Hepatic Insulin Sensitivity and Reduced Responsiveness to Peroxisome Proliferator-activated Receptor γ Agonists
2005
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
2010
Memory of Extracellular Adenosine A2A Purinergic Receptor-mediated Signaling in Murine T Cells
1997 StandoutNobel
Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
1998
Adenosine receptors: therapeutic aspects for inflammatory and immune diseases
2008 Standout
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
2001 Nature
AMP-Activated Protein Kinase is Highly Expressed in Neurons in the Developing Rat Brain and Promotes Neuronal Survival Following Glucose Deprivation
2001
Leukocyte activation in patients with venous insufficiency
1999
IgG4-related disease
2014 Standout
What We Talk About When We Talk About Fat
2014 Standout
The role of autophagy during the early neonatal starvation period
2004 StandoutNatureNobel
Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential
1992
Points of control in inflammation
2002 StandoutNature
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
Suppression of macrophage inflammatory protein (MIP)‐1α production and collagen‐induced arthritis by adenosine receptor agonists
1998
A2AAdenosine Receptor Activation Improves Survival in Mouse Models of Endotoxemia and Sepsis
2004
Metformin—mode of action and clinical implications for diabetes and cancer
2014
Effect of caffeine consumption on efficacy of methotrexate in rheumatoid arthritis
2003
Position-independent, high-level expression of the human β-globin gene in transgenic mice
1987 Standout
Inhibition of Glucocorticoid-Induced Apoptosis with 5-Aminoimidazole-4-carboxamide Ribonucleoside, a Cell-Permeable Activator of AMP-Activated Protein Kinase
1998
AMP‐activated protein kinase – development of the energy sensor concept
2006
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
1988 StandoutScienceNobel
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
2007
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
2000
Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury
2013
THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?
1998
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Activation of A3 adenosine receptors on human eosinophils elevates intracellular calcium
1996 StandoutNobel
Minireview: The AMP-Activated Protein Kinase Cascade: The Key Sensor of Cellular Energy Status
2003
AMP-Activated Protein Kinase in the Heart
2007
Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells
1986 Nature
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
1999 StandoutScience
HIV Envelope Binding by Macrophage-Expressed gp340 Promotes HIV-1 Infection
2008 StandoutNobel
UCP-3 expression in skeletal muscle: effects of exercise, hypoxia, and AMP-activated protein kinase
2000
Physiological Control of Immune Response and Inflammatory Tissue Damage by Hypoxia -Inducible Factors and Adenosine A2AReceptors
2004 Nobel
Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes
2002
WEGENER'S GRANULOMATOSIS
1995
Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation
1989 StandoutScienceNobel
Lipopolysaccharide-Induced Cytokine Cascade and Lethality in LTα/TNFα-Deficient Mice
1997
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
2001 Standout
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle
1997
Nanotechnology for Multimodal Synergistic Cancer Therapy
2017 Standout
5-Aminoimidazole-4-Carboxamide Ribonucleoside. A Specific Method for Activating AMP-Activated Protein Kinase in Intact Cells?
1995
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Serial transplantation of methotrexate-resistant bone marrow: protection of murine recipients from drug toxicity by progeny of transduced stem cells
1990
Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon
2012 StandoutNobel
Recent Advances in Zinc Enzymology
1996 Nobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Hematopoietic stem cells with controllable tEpoR transgenes have a competitive advantage in bone marrow transplantation
2000 StandoutNobel
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle
2002
Adenosine receptors in the response to sepsis: what do receptor-specific knockouts tell us?
2006
Adenosine inhibits IL‐12 and TNF‐α production via adenosine A 2a receptor‐dependent and independent mechanisms
2000
The Antidiabetic Drug Metformin Activates the AMP-Activated Protein Kinase Cascade via an Adenine Nucleotide-Independent Mechanism
2002
Mitochondrial Dysfunction and Type 2 Diabetes
2005 StandoutScience
AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target
1999
AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes
1999
Changes in Exercise-Induced Gene Expression in 5′-AMP–Activated Protein Kinase γ3–Null and γ3 R225Q Transgenic Mice
2005
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 StandoutNobel
Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase
2001
Long-Term AICAR Administration and Exercise Prevents Diabetes in ZDF Rats
2005
Oncolytic Viruses in Cancer Treatment
2016
Role of A2a Extracellular Adenosine Receptor-Mediated Signaling in Adenosine-Mediated Inhibition of T-Cell Activation and Expansion
1997 StandoutNobel
Infection of monocyte-derived macrophages with human immunodeficiency virus type 1 (HIV-1). Monocyte-tropic and lymphocyte-tropic strains of HIV-1 show distinctive patterns of replication in a panel of cell types.
1989
Chronic activation of 5′-AMP-activated protein kinase increases GLUT-4, hexokinase, and glycogen in muscle
1999
Inflammatory Cytokines Regulate Function and Expression of Adenosine A2A Receptors in Human Monocytic THP-1 Cells
2001
Prospects for the Future
2002 StandoutScienceNobel
Activation of A2A adenosine receptors inhibits expression of α4/β1 integrin (very late antigen-4) on stimulated human neutrophils
2003
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.
1992
Works of Harry E. Gruber being referenced
Alteration of purine metabolism by AICA-riboside in human B lymphoblasts
1990
Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression
2012
Rapid and reversible modulation of T4 (CD4) on monocytoid cells by phorbol myristate acetate: Effect on HIV susceptibility
1988
Hypoglycaemic effect of AICAriboside in mice
1996
Intravenous Administration of Retroviral Replicating Vector, Toca 511, Demonstrates Therapeutic Efficacy in Orthotopic Immune-Competent Mouse Glioma Model
2014
Adenosine release from stimulated mast cells.
1984
Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells.
1991
Inhibition of neutrophil adhesion by adenosine and an adenosine kinase inhibitor. The role of selectins.
1995
Selective adenosine release from human B but not T lymphoid cell line.
1990
Retroviral Vector-Mediated Gene Transfer into Human Hematopoietic Progenitor Cells
1985 Science
Protective effect of an adenosine kinase inhibitor in septic shock.
1994
Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP‐activated protein kinase
1995
Alterations of inosinate branchpoint enzymes in cultured human lymphoblasts
1985
Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes
1991
Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.
1989
Mouth and genital ulcers with inflamed cartilage: MAGIC syndrome. Five patients with features of relapsing polychondritis and behçet's disease
1985