Citation Impact
Citing Papers
A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
2002 Standout
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoei
2004 Standout
Antitumor activity and mechanism of action of the novel marine natural products mycalamide-A and -B and onnamide.
1989
Modelling of anti‐HSV activity of lactoferricin analogues using amino acid descriptors
2004
Phase I clinical study of didemnin B
1998
Mechanism Targeted Discovery of Antitumor Marine Natural Products
2004
Marine-derived anticancer agents in clinical trials
2003
Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates
1996
Phase II Trial of Didemnin B in Previously Treated Non-Hodgkin’s Lymphoma
2000
Didemnin B in favourable histology non-Hodgkin's lymphoma
1995
Permethylation and tandem mass spectrometry of oligosaccharides having free hexosamine: Analysis of the glycoinositol phospholipid anchor glycan from the scrapie prion protein
1990 StandoutNobel
Insect Immunity
1999
A phase II study of Didemnin B (NSC 325319) in advanced malignant melanoma: an Eastern Cooperative Oncology Group study (PB687)
1998
Marine natural products
1990 Standout
Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides
1999 Standout
Synthesis and Properties of Allenic Natural Products and Pharmaceuticals
2004 Standout
Life in cellulose houses: symbiotic bacterial biosynthesis of ascidian drugs and drug leads
2010
Drug development from marine natural products
2008 Standout
STRATEGIES FOR THE DISCOVERY OF SECONDARY METABOLITES FROM MARINE BACTERIA: Ecological Perspectives
1994
Effects of metalloendoprotease substrates on the human sperm acrosome reaction
1989
Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays
1999
Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver
2001 Standout
Designing antimicrobial peptides: form follows function
2011 Standout
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
2005 Standout
Mechanism of Protein Synthesis Inhibition by Didemnin B in Vitro
1995
Evidence that metalloendoproteases are involved in gamete fusion of Ciona intestinalis, ascidia
1992 StandoutNobel
Phase II trial of Didemnin B in patients with advanced renal cell carcinoma
1990
Interferons and viruses: an evolutionary arms race of molecular interactions
2015 StandoutNobel
Phase II clinical trial of didemnin B in previously treated small cell lung cancer
1994
Pharmaceutical development of anticancer agents derived from marine sources
2000
Inhibition of protein synthesis by didemnin B is not sufficient to induce apoptosis in human mammary carcinoma (MCF7) cells
1999
Didemnin B induces apoptosis in proliferating but not resting peripheral blood mononuclear cells
2002
Phase I clinical and pharmacokinetic investigation of didemnin B, a cyclic depsipeptide
1988
Selective Rearrangements of Quadruply Hydrogen‐Bonded Dimer Driven by Donor–Acceptor Interaction
2003
Modern Synthetic Methods for Fluorine‐Substituted Target Molecules
2004 Standout
Formation of Pores in Escherichia coli Cell Membranes by a Cecropin Isolated from Hemolymph of Heliothis virescens Larvae
1996
A phase i clinical trial of didemnin B
1991
Didemnins, tamandarins and related natural products
2012
Natural products as probes of cell biology: 20 years of didemnin research
2002
Synthesis and anti-HIV activity of some novel diaryl phosphate derivatives of AZT
1994
Phase I/II clinical trial of didemnin B in non-small-cell lung cancer: neuromuscular toxicity is dose-limiting
1991
Diving for drugs: tunicate anticancer compounds
2012
Nmr in drug discovery
2002 StandoutNobel
Phase II clinical and pharmacological study of didemnin B in patients with metastatic breast cancer
1992
Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies
2006 Standout
Effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro
1982 StandoutNobel
The preparation of carrier-free iodine isotope-substituted cytosine nucleotides
1974
“Head-to-Side-Chain” Cyclodepsipeptides of Marine Origin
2013
Crystal and molecular structure of didemnin B, an antiviral and cytotoxic depsipeptide.
1988
Asymmetric Synthesis via Acetal Templates. 14.1 Preparation of Enantiomerically Pure (3S,4S)- and (3S,4R)-Statine Derivatives
1987
Improved synthesis of 1,5-dinaphtho[38]crown-10
2009 StandoutNobel
Peptide Antimicrobial Agents
2006 Standout
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I
1977 StandoutNobel
Drug Discovery and Natural Products: End of an Era or an Endless Frontier?
2009 StandoutScience
Sites of sequence variability in Epstein-Barr virus DNA from different sources.
1979 StandoutNobel
Supramolecular Polymerization
2009 Standout
Structures of Triacetyloleandomycin and Mycalamide A Bind to the Large Ribosomal Subunit of Haloarcula marismortui
2009 StandoutNobel
Didemnolines A-D, new N9-substituted β-carbolines from the marine ascidian Didemnum sp.
1995
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Polysialic Acid, a Glycan with Highly Restricted Expression, Is Found on Human and Murine Leukocytes and Modulates Immune Responses
2008 StandoutNobel
Tamandarins A and B: New Cytotoxic Depsipeptides from a Brazilian Ascidian of the Family Didemnidae
1999
Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis
1999
GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha.
1994
Microscopic observations of the different morphological changes caused by anti-bacterial peptides onKlebsiella pneumoniae and HL-60 leukemia cells
1998
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
2020 Standout
Chem-Bioinformatics and QSAR: A Review of QSAR Lacking Positive Hydrophobic Terms
2001 Standout
Genital Herpes Simplex Virus Infections: Clinical Manifestations, Course, and Complications
1983 Standout
Ynamides: A Modern Functional Group for the New Millennium
2010 Standout
Synthese und Eigenschaften allenischer Natur‐ und Wirkstoffe
2004
Antiproliferative Bistramides from Trididemnum cyclops from Madagascar
2009
New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum
2005
Growth Inhibition by Acycloguanosine of Herpesviruses Isolated from Human Infections
1979
The Sonogashira Reaction: A Booming Methodology in Synthetic Organic Chemistry
2007 Standout
Alkylation of adenine with functionalized tert.-Propargyl carbonates. Synthesis of 3′-hydroxymethyladenallene — A new analogue of 2′-deoxyadenosine
1995
Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues
2010
Synthesis, structural aspects and cytotoxicity of the natural cyclopeptides yunnanins A, C and phakellistatins 1, 10
2003
Electrospray ionization–principles and practice
1990 StandoutNobel
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
1978 StandoutNobel
Structure−Activity Relationships of the Didemnins
1996
Genital Herpes in Guinea Pigs: Pathogenesis of the Primary Infection and Description of Recurrent Disease
1982
Bacterial Biosynthesis and Maturation of the Didemnin Anti-cancer Agents
2012
Didemnins A and B. Effectiveness against cutaneous herpes simplex virus in mice
1983
Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate
1979 StandoutNobel
The N-terminal region of the luteovirus readthrough domain determines virus binding to Buchnera GroEL and is essential for virus persistence in the aphid
1997
Synthesis of 1‐(2‐deoxy‐2‐fluoro‐β‐D‐arabinofuranosyl)‐5‐iodo [2‐14C] uracil
1985
Mass spectrometric determination of the amino acid sequence of peptides and proteins
1987
Antiviral Activity of Arabinosylthymine in Herpesviral Replication: Mechanism of Action In Vivo and In Vitro
1977
Origin and Variation of Tunicate Secondary Metabolites
2012
Synthetic studies of didemnins. II. Approaches to statine diastereomers
1987
BIOLOGY OF BACTERIOCYTE-ASSOCIATED ENDOSYMBIONTS OF PLANT SAP-SUCKING INSECTS
2005 Standout
In vitro susceptibility of varicella-zoster virus to acyclovir
1980 StandoutNobel
Pharmacological Developments Obtained from Marine Natural Products and Current Pipeline Perspective
2011
Tetrahedron report number 163
1984 Standout
Central nervous system infection and immune response in mice inoculated into the lip with herpes simplex virus type 1
1982 StandoutNobel
Impact of Natural Products on Developing New Anti-Cancer Agents
2009 Standout
Phosphodiester Amidates of Allenic Nucleoside Analogues: Anti-HIV Activity and Possible Mechanism of Action
1996
Aplidine: A Paradigm of how to Handle the Activity and Toxicity of a Novel Marine Anticancer Poison
2007
Chiral Allenes via Alkynylogous Mukaiyama Aldol Reaction
2016 StandoutNobel
Didemnin B
1986
Chemical Defense in Ascidians of the Didemnidae Family
2002
Transition Metal Catalyzed Cycloisomerizations of 1,n-Allenynes and -Allenenes
2011 Standout
Survival and Prognostic Stratification of 670 Patients With Advanced Renal Cell Carcinoma
1999 Standout
Rapamycin inhibits didemnin B‐induced apoptosis in human HL‐60 cells: Evidence for the possible involvement of FK506‐binding protein 25
1999
Differences in Neurovirulence among Isolates of Herpes Simplex Virus Types 1 and 2 in Mice using Four Routes of Infection
1981
Organocatalytic α‐Addition of Isocyanides to Aldehydes
2014 StandoutNobel
Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine
1977 StandoutNobel
Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism.
2003
Some Typical Advances in the Synthetic Applications of Allenes
2005 Standout
Lamellarins and Related Pyrrole-Derived Alkaloids from Marine Organisms
2007 Standout
Synthesis, transformations and biological activity of chloro enamines and ynamines derived from chloroalkenyl- and alkynyl-N-substituted purine and pyrimidine bases of nucleic acids
1994
Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities
1981 StandoutNobel
Palladium-Catalyzed Efficient Enantioselective Synthesis of Chiral Allenes: Steric and Electronic Effects of Ligands
2013
Mechanism of action of didemnin B, a depsipeptide from the sea
1984
Self-assembly of a new series of quadruply hydrogen bonded heterotrimers driven by the donor–acceptor interaction
2005
Inhibition of herpes simplex virus replication by araT
1975
“From Large-Scale Collections to the Potential Use of Genomic Techniques for Supply of Drug Candidates”
2018
Host defenses in herpes simplex infections of the nervous system: effect of antibody on disease and viral spread
1979
Methods for the synthesis of gem-difluoromethylene compounds
1996
Ineffectiveness of Topical Idoxuridine in Dimethyl Sulfoxide for Therapy for Genital Herpes
1982
Synthetic Studies of Tamandarin B Side Chain Analogues
2010
Mass spectrometric analysis of a GPI-anchored protein: The scrapie prion protein
1993 StandoutNobel
On-line liquid chromatography/fast atom bombardment mass spectrometry
1985
Synthesis of statine and its analogues by homogeneous asymmetric hydrogenation
1988 StandoutNobel
Works of Harold E. Renis being referenced
Induction of Cecropin-Like and Attacin-Like Antibacterial but Not Antiviral Activity in Heliothis virescens Larvae
1994
Unsaturated and carbocyclic nucleoside analogs: synthesis, antitumor and antiviral activity
1991
Antiviral melanization reaction of Heliothis virescens hemolymph against DNA and RNA viruses in vitro
1993
Pyrimidinones. 1. 2-Amino-5-halo-6-aryl-4(3H)-pyrimidinones. Interferon-inducing antiviral agents
1985
DEVELOPMENT OF RESISTANCE TO ANTIVIRAL DRUGS
1965
5,6-Dihydro-5-Azathymidine: In Vitro Antiviral Properties Against Human Herpesviruses
1978
Didemnins: Antiviral and Antitumor Depsipeptides from a Caribbean Tunicate
1981 Science
Pathogenesis of herpes simplex virus types 1 and 2 in mice after various routes of inoculation
1976
A Comparison of Pyrimidinone Analogue Immunomodulators for Treatment of Phlebovirus Infections in Mice
1990
Comparison of cytotoxicity and antiviral activity of 1-beta-D-arabino-furanosyl-5-iodocytosine with related compounds.
1970
Genital Infection of Female Hamsters with Herpesvirus Hominis Type 2 (HVH-2)
1975
Bilayer stabilizing peptides and the inhibition of viral infection: antimeasles activity of carbobenzoxy-Ser-Leu-amide
1987
Biologically active peptides and their mass spectra
1982
5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents
1980
Nucleic Acids. III. Antiviral Activity of Nucleotides and Dinucleoside Phosphates Containing ara-Cytidine
1967