Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2
2009 StandoutNobel
The Loss of PTEN Allows TCR αβ Lineage Thymocytes to Bypass IL-7 and Pre-TCR–mediated Signaling
2004
A novel human autoimmune syndrome caused by combined hypomorphic and activating mutations in ZAP-70
2016
Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130
2002 StandoutNobel
Clinical heterogeneity can hamper the diagnosis of patients with ZAP70 deficiency
2008
Cloning and expression of odorant receptors
1993 Nature
Protein tyrosine kinases in the initiation of antigen receptor signaling
1995
Temperature-sensitive ZAP70 Mutants Degrading through a Proteasome-independent Pathway
1999
Genetic effects on gene expression across human tissues
2017 StandoutNature
Oncogenic kinase signalling
2001 StandoutNature
TCR Activation of ZAP70 Is Impaired in CD4+CD8+ Thymocytes as a Consequence of Intrathymic Interactions that Diminish Available p56lck
1996
National Institutes of Health Center for Human Immunology Conference, September 2009
2010
Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment
2011 StandoutNobel
Angiotensin II Induces Transactivation of Two Different Populations of the Platelet-derived Growth Factor β Receptor
2000
αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases
1996
Constitutive Activation of Stat3 Signaling Confers Resistance to Apoptosis in Human U266 Myeloma Cells
1999 Standout
An Indirect Effect of Stat5a in IL-2–Induced Proliferation: A Critical Role for Stat5a in IL-2–Mediated IL-2 Receptor α Chain Induction
1997
Combinatorial Receptor Codes for Odors
1999 StandoutNobel
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis
2016 StandoutNobel
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
2015
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Eph receptor signalling casts a wide net on cell behaviour
2005
The language of covalent histone modifications
2000 StandoutNature
Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades
2001 Nature
CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells
2009
Opposing Functions of the T Cell Receptor Kinase ZAP-70 in Immunity and Tolerance Differentially Titrate in Response to Nucleotide Substitutions
2007
Genomic organization of human JAK2 and mutation analysis of its JH2-domain in leukemia
1999
Essential role for ZAP-70 in both positive and negative selection of thymocytes
1995 Nature
Janus Kinase 2, an Early Target of α7 Nicotinic Acetylcholine Receptor-mediated Neuroprotection against Aβ-(1–42) Amyloid
2002
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
2006 StandoutNobel
Localization of a Type 1 Diabetes Locus in the IL2RA/CD25 Region by Use of Tag Single-Nucleotide Polymorphisms
2005
T cell antigen receptor signal transduction
1997
Evolving concepts of rheumatoid arthritis
2003 StandoutNature
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Specific immunoglobulin E responses in ZAP‐70‐deficient patients are mediated by Syk‐dependent T‐cell receptor signalling
2001
Genetic susceptibility to systemic lupus erythematosus in the genomic era
2010
Novel mouse mutants with primary cellular immunodeficiencies generated by genome-wide mutagenesis
2007
STATs in oncogenesis
2000 Standout
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
1999 StandoutNature
A zonal organization of odorant receptor gene expression in the olfactory epithelium
1993 StandoutNobel
Protein modules and signalling networks
1995 StandoutNature
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway
2005 Standout
Alternative Antigen Receptor (TCR) Signaling in T Cells Derived from ZAP-70-deficient Patients Expressing High Levels of Syk
2000
Radically altered T cell receptor signaling in glycopeptide-specific T cell hybridoma induced by antigen with minimal differences in the glycan group
2001 StandoutNobel
Signals involved in thymocyte positive and negative selection
1999
ZAP70: a master regulator of adaptive immunity
2010
Role of PTPN22 in type 1 diabetes and other autoimmune diseases
2006
Hypomorphic mutation of ZAP70 in human results in a late onset immunodeficiency and no autoimmunity
2009
Stat5 Is Essential for the Myelo- and Lymphoproliferative Disease Induced by TEL/JAK2
2000
A Spontaneously Arising Mutation in the DLAARN Motif of Murine ZAP-70 Abrogates Kinase Activity and Arrests Thymocyte Development
1997
Prediction of the structure of human Janus kinase 2 (JAK2) comprising the two carboxy-terminal domains reveals a mechanism for autoregulation
2001
Progress and challenges in translating the biology of atherosclerosis
2011 StandoutNature
A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes
2004
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
2001
The Interferon Regulatory Transcription Factor IRF-1 Controls Positive and Negative Selection of CD8+ Thymocytes
1997
The Src-like Adaptor Protein Downregulates the T Cell Receptor on CD4+CD8+ Thymocytes and Regulates Positive Selection
2001
Three-dimensional segregation of supramolecular activation clusters in T cells
1998 StandoutNature
The Primary Immunodeficiencies
1995
Endocrinological late complications after hematopoietic SCT in children
2008
ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells
1994
PTPN22: Setting thresholds for autoimmunity
2006
Allelic inactivation regulates olfactory receptor gene expression
1994 StandoutNobel
The Molecular Architecture of Odor and Pheromone Sensing in Mammals
2000 StandoutNobel
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
2005 StandoutNature
Angiogenesis as a therapeutic target
2005 StandoutNature
Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
2006
Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis
2006 StandoutNobel
Thymocyte development is normal in CTLA-4-deficient mice
1997 StandoutNobel
The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling
1997
Existence of activated and memory CD4+ T cells in peripheral blood and their skin infiltration in CD8 deficiency
1999
Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo
2006
A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection
1995 Science
Complex Effects of Naturally Occurring Mutations in the JAK3 Pseudokinase Domain: Evidence for Interactions between the Kinase and Pseudokinase Domains
2000
Topographic organization of sensory projections to the olfactory bulb
1994 StandoutNobel
Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3 high regulatory T cells in humans
2015 StandoutNobel
Mutation in the Jak Kinase JH2 Domain Hyperactivates Drosophila and Mammalian Jak-Stat Pathways
1997
Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease
2013
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
The Protein Kinase Complement of the Human Genome
2002 StandoutScience
The amino terminus of JAK3 is necessary and sufficient for binding to the common γ chain and confers the ability to transmit interleukin 2-mediated signals
1997
JAKS AND STATS: Biological Implications
1998 Standout
A TEL-JAK2 Fusion Protein with Constitutive Kinase Activity in Human Leukemia
1997 Science
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling.
1996
Cellular Interactions in Thymocyte Development
1996
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
The Biology of Interleukin-2
2007
Integrins and Signal Transduction Pathways: the Road Taken
1995 StandoutScience
Pre-T Cell Receptor Signals Are Responsible for the Down-Regulation of Syk Protein Tyrosine Kinase Expression
1999
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997
Peripheral Expression of Jak3 Is Required to Maintain T Lymphocyte Function
1997
THE CROONIAN LECTURE 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease
1998
Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease
2014 StandoutScienceNobel
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 StandoutNobel
Fusion of TEL, the ETS-Variant Gene 6 (ETV6), to the Receptor-Associated Kinase JAK2 as a Result of t(9; 12) in a Lymphoid and t(9; 15; 12) in a Myeloid Leukemia
1997
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function
2010 StandoutNobel
Constitutive activation of STAT proteins in primary lymphoid and myeloid leukemia cells and in Epstein-Barr virus (EBV)-related lymphoma cell lines
1996
Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to Eag and cyclic nucleotide-gated channels
1997 StandoutNobel
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Distinct T Cell Developmental Consequences in Humans and Mice Expressing Identical Mutations in the DLAARN Motif of ZAP-70
2001
Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins
1997
Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the β1-adrenergic receptor
1999 StandoutNobel
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs.
1996 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Trafficking of G Protein–Coupled Receptors
2006 StandoutNobel
ζ Phosphorylation Without ZAP-70 Activation Induced by TCR Antagonists or Partial Agonists
1995 Science
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Absence of ZAP-70 prevents signaling through the antigen receptor on peripheral blood T cells but not on thymocytes.
1995
Impaired T cell receptor signaling and development of T cell–mediated autoimmune arthritis
2020 StandoutNobel
A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.
1995 StandoutNobel
Activation of Jak/STAT proteins involved in signal transduction pathway mediated by receptor for interleukin 2 in malignant T lymphocytes derived from cutaneous anaplastic large T-cell lymphoma and Sezary syndrome.
1996
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes.
1996
Works of Harjit Dadi being referenced
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
1996 Nature
Ephrin stimulation modulates T?cell chemotaxis
2002
Characterization of ζ-associated protein, 70 kd (ZAP70)–deficient human lymphocytes
2010
Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor on human thymocytes.
1993
Effect of CD3δ Deficiency on Maturation of α/β and γ/δ T-Cell Lineages in Severe Combined Immunodeficiency
2003
Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase
1994
Cloning and Characterization of the Human Homolog of Mouse Jak2
1998
Jak3 activation in human lymphocyte precursor cells
1997
Human immune disorder arising from mutation of the α chain of the interleukin-2 receptor
1997
Cloning and Characterization of a Lymphoid-Specific, Inducible Human Protein Tyrosine Phosphatase, Lyp
1999
Muscarinic cholinergic receptor of rat brain. Factors influencing migration in electrophoresis and gel filtration in sodium dodecyl sulphate
1984