Standout Papers
Citation Impact
Citing Papers
Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization
2007 StandoutScience
The 2.6 Angstrom Crystal Structure of a Human A 2A Adenosine Receptor Bound to an Antagonist
2008 StandoutScience
Ovarian Sex Steroid-Dependent Plasticity of Nociceptin/Orphanin FQ and Opioid Modulation of Spinal Dynorphin Release
2001
Dose-Related Opposite Modulation by Nociceptin/Orphanin FQ of Substance P Nociception in the Nociceptors and Spinal Cord
1999
Identification of Neuropeptide W as the Endogenous Ligand for Orphan G-protein-coupled Receptors GPR7 and GPR8
2002
Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor
1998 Standout
Protein Kinase A and G Protein-coupled Receptor Kinase Phosphorylation Mediates β-1 Adrenergic Receptor Endocytosis through Different Pathways
2003 StandoutNobel
ADP Is the Cognate Ligand for the Orphan G Protein-coupled Receptor SP1999
2001
Modulation of Synaptic Transmission by Nociceptin/Orphanin FQ and Nocistatin in the Spinal Cord Dorsal Horn of Mutant Mice Lacking the Nociceptin/Orphanin FQ Receptor
2001
Presence of opioid receptor-like (ORL1) receptor mRNA splice variants in peripheral sensory and sympathetic neuronal ganglia
1999
Developmental Signaling in Hydra: What Does It Take to Build a “Simple” Animal?
2002
Neuropeptides and Neuropeptide Receptors in the Drosophila melanogaster Genome
2001
Nocistatin reverses nociceptin inhibition of glutamate release from rat brain slices
1998
A Study of the Involvement of Melanin-Concentrating Hormone Receptor 1 (MCHR1) in Murine Models of Depression
2006
Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more
1998
Hypothalamic regulation of sleep and circadian rhythms
2005 StandoutNature
A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera
2006
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
2002 StandoutNature
Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor
1997
Transgenic studies of pain
1998
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
2004 Standout
Central nervous system control of food intake and body weight
2006 StandoutNature
Descending control of pain
2002 Standout
Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors
2001
Prolonged Kappa Opioid Receptor Phosphorylation Mediated by G-protein Receptor Kinase Underlies Sustained Analgesic Tolerance
2004 StandoutNobel
Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-d-aspartate-evoked responses
1999
OPIOID RECEPTOR SIGNALLING MECHANISMS
1999
Nocistatin, a peptide that blocks nociceptin action in pain transmission
1998 Nature
Effects of pre-emptively administered nociceptin on the development of thermal hyperalgesia induced by two models of experimental mononeuropathy in the rat
2000
β-Arrestin-biased Agonism at the β2-Adrenergic Receptor
2007 StandoutNobel
Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone–receptor interactions
1995
Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells
2010
Neuroendocrine regulation of eating behavior
2002
Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice
2002
Functional genomics: the search for novel neurotransmitters and neuropeptides
1998
Creating a Functional Opioid Alkaloid Binding Site in the Orphanin FQ Receptor through Site-Directed Mutagenesis
1998
Effects of microinjection of OFQ into PAG on spinal dorsal horn WDR neurons in rats
2001
Blockade effects of (Nphe1)Nociceptin(1–13)-NH2 on anti-nociception induced by intrathecal administration of nociceptin in rats
2001
Inhibitory action of nociceptin on spinal dorsal horn neurones of the rat, in vivo
1996
Orphan G-protein-coupled receptors and natural ligand discovery
2001
Functional Blockade of Opioid Analgesia by Orphanin FQ/Nociceptin
1998
Pharmacology of nociceptin and its receptor: a novel therapeutic target
2000
New approaches to antidepressant drug discovery: beyond monoamines
2006
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Wnt/β-Catenin Signaling and Disease
2012 Standout
Ghrelin induces adiposity in rodents
2000 StandoutNature
The Ectodomain of the Luteinizing Hormone Receptor Interacts with Exoloop 2 to Constrain the Transmembrane Region
2002 StandoutNobel
Central nervous system control of food intake
2000 StandoutNature
Molecular Cloning, Genomic Organization, Developmental Regulation, and a Knock-out Mutant of a Novel Leu-rich Repeats-containing G Protein-coupled Receptor (DLGR-2) from Drosophila melanogaster
2000
Target validation of G-protein coupled receptors
2002
Identification of a Novel Seven-Transmembrane Receptor with Homology to Glycoprotein Receptors and Its Expression in the Adult and Developing Mouse
1999
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes
2003 StandoutNatureNobel
Inhibition of nociceptin‐induced allodynia in conscious mice by prostaglandin D2
1997
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
A role for ghrelin in the central regulation of feeding
2001 StandoutNature
The Three Subfamilies of Leucine-Rich Repeat-Containing G Protein-Coupled Receptors (LGR): Identification of LGR6 and LGR7 and the Signaling Mechanism for LGR7
2000
Models and Mechanisms of Hyperalgesia and Allodynia
2009
The Mesolimbic Dopamine Reward Circuit in Depression
2006 Standout
Structural and functional diversity in the leucine-rich repeat family of proteins
1996
Nociceptin/orphanin FQ into the rat periaqueductal gray decreases the withdrawal latency to heat and loading, an effect reversed by (Nphe1)nociceptin(1–13)NH2
2001
Loss of Antinociception Induced by Naloxone Benzoylhydrazone in Nociceptin Receptor-Knockout Mice
1998
Antagonism of ORL1 receptor produces an algesic effect in the rat formalin test
2001
The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance
2005
Stem Cell-derived Neural Stem/Progenitor Cell Supporting Factor Is an Autocrine/Paracrine Survival Factor for Adult Neural Stem/Progenitor Cells
2003 StandoutNobel
Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
2001
Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse
2001
Activation of the Luteinizing Hormone Receptor Following Substitution of Ser-277 with Selective Hydrophobic Residues in the Ectodomain Hinge Region
2000 StandoutNobel
Phylogenetic analysis of 277 human G-protein-coupled receptors as a tool for the prediction of orphan receptor ligands
2002
A Cellular Mechanism for the Bidirectional Pain-Modulating Actions of Orphanin FQ/Nociceptin
2000
Structural diversity of G protein-coupled receptors and significance for drug discovery
2008
Insights into social insects from the genome of the honeybee Apis mellifera
2006 StandoutNature
Distinct effect of orphanin FQ in nucleus raphe magnus and nucleus reticularis gigantocellularis on the rat tail flick reflex
2001
Effects of supraspinal orphanin FQ/nociceptin
2000
Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets
2002
Morphine Activates Opioid Receptors without Causing Their Rapid Internalization
1996
Purification and Characterization of Rat des-Gln14-Ghrelin, a Second Endogenous Ligand for the Growth Hormone Secretagogue Receptor
2000
Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations
2001
The Role of Asp578 in Maintaining the Inactive Conformation of the Human Lutropin/Choriogonadotropin Receptor
1996
Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of μ-, δ- or κ-opioid receptor knockout mice
2001
Bidirectional actions of nociceptin/orphanin FQ on Aδ-fibre-evoked responses in rat superficial spinal dorsal horn in vitro
2001
Structure of the δ-opioid receptor bound to naltrindole
2012 StandoutNatureNobel
Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice
1999
Nociceptin/orphanin FQ: role in nociceptive information processing
1999
Seven-transmembrane receptors
2002 StandoutNobel
Extracellular mRNA Induces Dendritic Cell Activation by Stimulating Tumor Necrosis Factor-α Secretion and Signaling through a Nucleotide Receptor
2002 StandoutNobel
Analgesia elicited by OFQ/nociceptin and its fragments from the amygdala in rats
2001
Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats
1999
Sequential Binding of Agonists to the β2 Adrenoceptor
2003 StandoutNobel
Ghrelin: Structure and Function
2005 Standout
Co-expression of Defective Luteinizing Hormone Receptor Fragments Partially Reconstitutes Ligand-induced Signal Generation
1997 StandoutNobel
The nociceptin/orphanin FQ receptor antagonist, [Nphe1]NC(1-13)NH2, potentiates morphine analgesia
2000
Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro
2001
The molecular neurobiology of depression
2008 StandoutNature
Morphine tolerance and dependence in nociceptin/orphanin fq transgenic knock-out mice
2001
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Intracerebroventricular administration of nocistatin reduces inflammatory hyperalgesia in rats
1999
A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep
2003
Unaltered peripheral excitatory actions of nociceptin contrast with enhanced spinal inhibitory effects after carrageenan inflammation: an electrophysiological study in the rat
2000
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
Endogenous nociceptin signaling and stress-induced analgesia
2001
Anti‐nociceptive responses produced by human putative counterpart of nocistatin
1998
ORL-1 and Mu opioid receptor antisera label different fibers in areas involved in pain processing
1998
Enhanced Morphine Analgesia in Mice Lacking β-Arrestin 2
1999 StandoutScienceNobel
Characterization of Two LGR Genes Homologous to Gonadotropin and Thyrotropin Receptors with Extracellular Leucine-Rich Repeats and a G Protein-Coupled, Seven-Transmembrane Region
1998
The Metastasis Suppressor Gene KiSS-1 Encodes Kisspeptins, the Natural Ligands of the Orphan G Protein-coupled Receptor GPR54
2001 Standout
Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor
2000
Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease
2011
A prolactin-releasing peptide in the brain
1998 Nature
Circuitry Underlying AntiOpioid Actions of Orphanin FQ in the Rostral Ventromedial Medulla
1997
Characterization of Two Fly LGR (Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor) Proteins Homologous to Vertebrate Glycoprotein Hormone Receptors: Constitutive Activation of Wild-Type Fly LGR1 But Not LGR2 in Transfected Mammalian Cells**This study was supported by NIH Grant HD-23273. The GenBank submission number for fly LGR2 is AF274591.
2000
Selective Suppression of Inhibitory Synaptic Transmission by Nocistatin in the Rat Spinal Cord Dorsal Horn
2000
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
2000 StandoutScienceNobel
Potentiation of Opioid Analgesia in Dopamine2Receptor Knock-Out Mice: Evidence for a Tonically Active Anti-Opioid System
2001
Effect of Intrathecal Nocistatin on the Formalin-Induced Pain in Mice Versus That of Nociceptin/Orphanin FQ
2000
COI1 : An Arabidopsis Gene Required for Jasmonate-Regulated Defense and Fertility
1998 StandoutScience
THE LUTEINIZING HORMONE RECEPTOR
1998
The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins
2011 StandoutNobel
Activation of Orphan Receptors by the Hormone Relaxin
2002 StandoutScience
Tandem Facial Amphiphiles for Membrane Protein Stabilization
2010 StandoutNobel
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Autoradiographic localization of125I[Tyr14]orphanin FQ/nociceptin and125I[Tyr10]orphanin FQ/nociceptin(1-11) binding sites in rat brain
2000
Regulation of G Protein–Coupled Receptor Signaling by Scaffold Proteins
2002 StandoutNobel
Distribution of nociceptin/orphanin FQ precursor protein and receptor in brain and spinal cord: A study using in situ hybridization and X-gal histochemistry in receptor-deficient mice
2000
Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules
2006 Standout
Toll-related receptors and the control of antimicrobial peptide expression inDrosophila
2000 StandoutNobel
The Identification of Ligands at Orphan G-Protein Coupled Receptors
2004
The orphan opioid receptor and its endogenous ligand — nociceptin/orphanin FQ
1997
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
2004 StandoutNobel
Emerging Molecular Approaches to Pain Therapy
1999
The Nematode Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor (LGR) Protein Homologous to Vertebrate Gonadotropin and Thyrotropin Receptors is Constitutively Activated in Mammalian Cells
2000
Emerging Targets in Photopharmacology
2016 StandoutNobel
The Molecular and Behavioral Pharmacology of the Orphanin FQ/Nociceptin Peptide and Receptor Family
2001
Monitoring the function of membrane transport proteins in detergent-solubilized form
2007
The PDZ-binding motif of the β 2 -adrenoceptor is essential for physiologic signaling and trafficking in cardiac myocytes
2003 StandoutNobel
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
1999 StandoutNature
Gut hormone PYY3-36 physiologically inhibits food intake
2002 StandoutNature
Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells
2001
Antianalgesic Action of Nociceptin Originating in the Brain Is Mediated by Spinal Prostaglandin E2 in Mice
2001
Pronociceptive Effects of Nociceptin/Orphanin FQ (13–17) at Peripheral and Spinal Level in Mice
2001
Proteins with leucine-rich repeats
1995 Nobel
Works of Hans‐Peter Nothacker being referenced
The Carboxyl Terminus of the Prolactin-Releasing Peptide Receptor Interacts with PDZ Domain Proteins Involved in α-Amino-3-hydroxy-5-methylisoxazole-4-propionic Acid Receptor Clustering
2001
Molecular Cloning of a Novel, Putative G Protein-Coupled Receptor from Sea Anemones Structurally Related to Members of the FSH, TSH, LH/CG Receptor Family from Mammals
1993
Orphan receptors, novel neuropeptides and reverse pharmaceutical research
1999
Reverse Physiology: Discovery of the Novel Neuropeptide, Orphanin FQ/Nociceptin
1998
Molecular Cloning, Genomic Organization, and Developmental Regulation of a Novel Receptor from Drosophila melanogaster Structurally Related to Members of the Thyroid-stimulating Hormone, Follicle-stimulating Hormone, Luteinizing Hormone/Choriogonadotropin Receptor Family from Mammals
1997
Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction
1999
The orphanin FQ/nociceptin gene: structure, tissue distribution of expression and functional implications obtained from knockout mice
2000
Orphan GPCRs and their ligands
2005
Molecular Cloning and Characterization of a Second Human Cysteinyl Leukotriene Receptor: Discovery of a Subtype Selective Agonist
2000
Molecular characterization of the melanin-concentrating-hormone receptor
1999 Nature
Targeted disruption of the orphanin FQ/nociceptin gene increases stress susceptibility and impairs stress adaptation in mice
1999
Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress
1997
Primary structure and tissue distribution of the orphanin FQ precursor.
1996
Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor
1995 StandoutScience
Opioid receptor-like (ORL1) receptor distribution in the rat central nervous system: Comparison of ORL1 receptor mRNA expression with125I-[14Tyr]-orphanin FQ binding
1999
Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
1999