Standout Papers
- Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (2014)
- Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds (2013)
- Ausdehnung des Enzym‐Universums: Zugang zu nicht‐natürlichen Reaktionen durch mechanismusgeleitete, gerichtete Evolution (2015)
- Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization (2018)
- P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions (2014)
- Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution (2015)
- Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor (2016)
- Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore (2017)
- Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (2014)
- Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes (2016)
Citation Impact
Citing Papers
Machine learning-assisted directed protein evolution with combinatorial libraries
2019 Nobel
Anti-Markovnikov alkene oxidation by metal-oxo–mediated enzyme catalysis
2017 StandoutScienceNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
De novo design of self-assembling helical protein filaments
2018 StandoutScienceNobel
A de novo peroxidase is also a promiscuous yet stereoselective carbene transferase
2020
Computational Stabilization of a Non‐Heme Iron Enzyme Enables Efficient Evolution of New Function
2024 StandoutNobel
The nature of chemical innovation: new enzymes by evolution
2015 StandoutNobel
Non-natural carbenoid and nitrenoid insertion reactions catalyzed by heme proteins
2016
Improving and repurposing biocatalysts via directed evolution
2015
Single-sequence protein structure prediction using a language model and deep learning
2022
Computational redesign of enzymes for regio- and enantioselective hydroamination
2018
Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions
2017 StandoutNobel
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Biocatalysts for the formation of three- to six-membered carbo- and heterocycles
2015
A redox-mediated Kemp eliminase
2017
Highly Diastereoselective and Enantioselective Olefin Cyclopropanation Using Engineered Myoglobin‐Based Catalysts
2014
Low-N protein engineering with data-efficient deep learning
2021
Interfacing Microbial Styrene Production with a Biocompatible Cyclopropanation Reaction
2015
Genetically programmed chiral organoborane synthesis
2017 StandoutNatureNobel
Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity
2018 StandoutNobel
The coming of age of de novo protein design
2016 StandoutNatureNobel
Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes
2020
A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
2018
Diverse Engineered Heme Proteins Enable Stereodivergent Cyclopropanation of Unactivated Alkenes
2018 StandoutNobel
Directed evolution of artificial metalloenzymes for in vivo metathesis
2016 Nature
Non‐natural Olefin Cyclopropanation Catalyzed by Diverse Cytochrome P450s and Other Hemoproteins
2014 StandoutNobel
Visual detection of cyanide ions by membrane-based nanozyme assay
2017
Evolving artificial metalloenzymes via random mutagenesis
2018
Expanding P450 catalytic reaction space through evolution and engineering
2014 StandoutNobel
Protein Engineering for Improving and Diversifying Natural Product Biosynthesis
2020
De novo protein design by deep network hallucination
2021 StandoutNatureNobel
Design and evolution of enzymes for non-natural chemistry
2017 StandoutNobel
Iron Catalysis in Organic Synthesis
2015 Standout
3d Transition Metals for C–H Activation
2018 Standout
Biocatalysis with Unnatural Amino Acids: Enzymology Meets Xenobiology
2017
Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution
2017
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
Role of Biocatalysis in Sustainable Chemistry
2017
Catalytic and Biocatalytic Iron Porphyrin Carbene Formation: Effects of Binding Mode, Carbene Substituent, Porphyrin Substituent, and Protein Axial Ligand
2015
Myoglobin-catalyzed intermolecular carbene N–H insertion with arylamine substrates
2014
Directed Evolution: Bringing New Chemistry to Life
2017 StandoutNobel
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Intermolecular carbene S–H insertion catalysed by engineered myoglobin-based catalysts
2015
Noble−Metal Substitution in Hemoproteins: An Emerging Strategy for Abiological Catalysis
2019
Orthogonal Expression of an Artificial Metalloenzyme for Abiotic Catalysis
2017
Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid
2018
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non‐Natural Reactions
2016
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase
2018 StandoutNobel
Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer
2021 Nobel
P450BM3‐Axial Mutations: A Gateway to Non‐Natural Reactivity
2014 StandoutNobel
Biocatalysis engineering: the big picture
2017
Stereoselective Cyclopropanation of Electron-Deficient Olefins with a Cofactor Redesigned Carbene Transferase Featuring Radical Reactivity
2019
P450-Mediated Non-natural Cyclopropanation of Dehydroalanine-Containing Thiopeptides
2017
Stereoselective Enzymatic Synthesis of Heteroatom-Substituted Cyclopropanes
2018 StandoutNobel
Catalytic Asymmetric Hydroalkoxylation of C–C Multiple Bonds
2021 StandoutNobel
Formation and Cleavage of C–C Bonds by Enzymatic Oxidation–Reduction Reactions
2018
Theoretical Insights into the Mechanism and Stereoselectivity of Olefin Cyclopropanation Catalyzed by Two Engineered Cytochrome P450 Enzymes
2018
Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer
2014 StandoutNobel
Capture and characterization of a reactive haem–carbenoid complex in an artificial metalloenzyme
2018
Recent advances in heme biocatalysis engineering
2019
P450-Catalyzed Regio- and Diastereoselective Steroid Hydroxylation: Efficient Directed Evolution Enabled by Mutability Landscaping
2018
Simulation-Guided Design of Cytochrome P450 for Chemo- and Regioselective Macrocyclic Oxidation
2018
Artificial Metalloenzymes: Reaction Scope and Optimization Strategies
2017
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Directed Evolution of Protein Catalysts
2018
Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450
2015 StandoutNobel
The Crucial Role of Methodology Development in Directed Evolution of Selective Enzymes
2019
Engineering of RuMb: Toward a Green Catalyst for Carbene Insertion Reactions
2017
Green and Sustainable Solvents in Chemical Processes
2018 Standout
Oxygen Activation and Radical Transformations in Heme Proteins and Metalloporphyrins
2017
Aldehyde and Ketone Synthesis by P450‐Catalyzed Oxidative Deamination of Alkyl Azides
2016
Evolutionary-scale prediction of atomic-level protein structure with a language model
2023 StandoutScience
Gram‐Scale Synthesis of Chiral Cyclopropane‐Containing Drugs and Drug Precursors with Engineered Myoglobin Catalysts Featuring Complementary Stereoselectivity
2016
Computational tools for the evaluation of laboratory-engineered biocatalysts
2016
Extending the application of biocatalysis to meet the challenges of drug development
2018
Parallel Screening for Rapid Identification of Orthogonal Bioluminescent Tools
2017
Beyond Iron: Iridium-Containing P450 Enzymes for Selective Cyclopropanations of Structurally Diverse Alkenes
2017
Reactive Oxygen Species (ROS)-Based Nanomedicine
2019 Standout
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation
2016 StandoutNobel
Enzyme‐Catalyzed Carbonyl Olefination by the E. coli Protein YfeX in the Absence of Phosphines
2016
Computation Sheds Insight into Iron Porphyrin Carbenes’ Electronic Structure, Formation, and N–H Insertion Reactivity
2016
Carbon–Carbon Bond Forming Reactions via Photogenerated Intermediates
2016
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins
2016
Discovery of a Diazo-Forming Enzyme in Cremeomycin Biosynthesis
2018
Transition Metal-Catalyzed C–H Amination: Scope, Mechanism, and Applications
2017 Standout
Asymmetric Enzymatic Synthesis of Allylic Amines: A Sigmatropic Rearrangement Strategy
2016 StandoutNobel
Metal Substitution Modulates the Reactivity and Extends the Reaction Scope of Myoglobin Carbene Transfer Catalysts
2017
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
2016
Chemistry Takes a Bath: Reactions in Aqueous Media
2018 StandoutNobel
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
2018 StandoutNobel
Biokatalyse mit nicht‐natürlichen Aminosäuren: Enzymologie trifft Xenobiologie
2017
Chemoselective N−H insertion catalyzed by a de novo carbene transferase
2020
Biocatalytic Synthesis of Allylic and Allenyl Sulfides through a Myoglobin‐Catalyzed Doyle–Kirmse Reaction
2016
Iron-catalyzed transformations of diazo compounds
2014
The Hydrophobic Effect Applied to Organic Synthesis: Recent Synthetic Chemistry “in Water”
2018
Constructing Biocatalytic Cascades: In Vitro and in Vivo Approaches to de Novo Multi-Enzyme Pathways
2016
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Myoglobin‐Catalyzed Olefination of Aldehydes
2016
Enzymatic Nitrogen Insertion into Unactivated C–H Bonds
2022 Nobel
A Practical and Catalytic Reductive Olefin Coupling
2014
Chemoselective Cyclopropanation over Carbene Y–H Insertion Catalyzed by an Engineered Carbene Transferase
2018
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Two-Phase Synthesis of (−)-Taxuyunnanine D
2014
Highly Diastereo- and Enantioselective Synthesis of Trifluoromethyl-Substituted Cyclopropanes via Myoglobin-Catalyzed Transfer of Trifluoromethylcarbene
2017
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Synergistic Rhodium(II) Carboxylate and Brønsted Acid Catalyzed Multicomponent Reactions of Enalcarbenoids: Direct Synthesis of α-Pyrrolylbenzylamines
2014
Works of Hans Renata being referenced
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Highly Stereoselective Biocatalytic Synthesis of Key Cyclopropane Intermediate to Ticagrelor
2016 StandoutNobel
Cytochrome P450-catalyzed insertion of carbenoids into N–H bonds
2013 StandoutNobel
Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
2014 StandoutNobel
Applications of Oxygenases in the Chemoenzymatic Total Synthesis of Complex Natural Products
2017
Evolution of Biocatalytic and Chemocatalytic C–H Functionalization Strategy in the Synthesis of Manzacidin C
2018
Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran
2014 StandoutNobel
Development of a Concise Synthesis of Ouabagenin and Hydroxylated Corticosteroid Analogues
2015
Titelbild: Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (Angew. Chem. 26/2014)
2014 Nobel
Identification of Mechanism-Based Inactivation in P450-Catalyzed Cyclopropanation Facilitates Engineering of Improved Enzymes
2016 StandoutNobel
Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis
2020
P450-catalyzed asymmetric cyclopropanation of electron-deficient olefins under aerobic conditions
2014 StandoutNobel
Remote C–H Hydroxylation by an α-Ketoglutarate-Dependent Dioxygenase Enables Efficient Chemoenzymatic Synthesis of Manzacidin C and Proline Analogs
2017
Ausdehnung des Enzym‐Universums: Zugang zu nicht‐natürlichen Reaktionen durch mechanismusgeleitete, gerichtete Evolution
2015 StandoutNobel
Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin, A Bioactive Cardenolide
2013 Science