Citation Impact
Citing Papers
Cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences
2006 Standout
Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
2013
Recognition of Cognate Transfer RNA by the 30 S Ribosomal Subunit
2001 StandoutScienceNobel
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo
2010 Standout
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
1996
HBP1: a HMG box transcriptional repressor that is targeted by the retinoblastoma family.
1997
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Retinoblastoma-binding protein 2 (RBP2) is frequently expressed in neuroendocrine tumors and promotes the neoplastic phenotype
2016
AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity
2011
Inhibition of the ω-conotoxin-sensitive calcium current by distinct G proteins
1992 StandoutNobel
Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors
2007
Role for the p53 homologue p73 in E2F-1-induced apoptosis
2000 StandoutNatureNobel
RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3
2007
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth
2007
A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F
1992
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
2008
Exogenous E2F expression is growth inhibitory before, during, and after cellular transformation
2000
Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis
2014
A structural model for monastrol inhibition of dimeric kinesin Eg5
2006
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
1994 StandoutNatureNobel
Structural basis for initiation of transcription from an RNA polymerase–promoter complex
1999 StandoutNatureNobel
The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases
2007
A Screen for New Trithorax Group Genes Identified little imaginal discs, the Drosophila melanogaster Homologue of Human Retinoblastoma Binding Protein 2
2000
The deficiency of Akt1 is sufficient to suppress tumor development in Pten +/− mice
2006
Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties
1992 StandoutNobel
A protein with similarity to the human retinoblastoma binding protein 2 acts specifically as a repressor for genes regulated by the b mating type locus in Ustilago maydis
2000
Physical interaction of the retinoblastoma protein with human D cyclins
1993
Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
1998 Nature
An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics
1991
A cyclin A-protein kinase complex possesses sequence-specific DNA binding activity: p33cdk2 is a component of the E2F-cyclin A complex
1992
Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation
1993 Standout
Crystal structure of Thermus aquaticus DNA polymerase
1995 StandoutNatureNobel
JmjC-domain-containing proteins and histone demethylation
2006
Binding of pRB to the PHD Protein RBP2 Promotes Cellular Differentiation
2005 StandoutNobel
Paving the Road for RNA Therapeutics
2020
Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
1994
Retinoblastoma protein partners
2001
The regulation of E2F by pRB-family proteins
1998 Standout
The effect Akt2 deletion on tumor development in Pten+/− mice
2011
Runaway telomere elongation caused by telomerase RNA gene mutations
1995 StandoutNatureNobel
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
The retinoblastoma protein binds E2F residues required for activation in vivo and TBP bindingin vitro
1993
Structure of Human Eg5 in Complex with a New Monastrol-based Inhibitor Bound in the R Configuration
2007
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
Structure of Taq polymerase with DNA at the polymerase active site
1996 StandoutNatureNobel
Pre-steady-state kinetic analysis of processive DNA replication including complete characterization of an exonuclease-deficient mutant
1991
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5
2010
The role of E2F in the mammalian cell cycle
1993
p73 is a human p53-related protein that can induce apoptosis
1997 StandoutNatureNobel
Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition
2009
A Catalytic Asymmetric 6 π Electrocyclization: Enantioselective Synthesis of 2‐Pyrazolines
2009 StandoutNobel
The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle
1991
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
2008
AKT/PKB Signaling: Navigating the Network
2017 Standout
Retinoblastoma-binding Protein 2 (Rbp2) Potentiates Nuclear Hormone Receptor-mediated Transcription
2001
Ionic Channels and Their Regulation by G Protein Subunits
1990
RBP1 induces growth arrest by repression of E2F-dependent transcription
1999
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
A Novel Gene (PLU-1) Containing Highly Conserved Putative DNA/Chromatin Binding Motifs Is Specifically Up-regulated in Breast Cancer
1999
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Pausing of reverse transcriptase on retroviral RNA templates is influenced by secondary structures both 5' and 3' of the catalytic site
1998
Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template
2004 StandoutNatureNobel
The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest
1994
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Fluorine in medicinal chemistry
2007 Standout
A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity
2005 StandoutNobel
Heterodimerization of the transcription factors E2F-1 and DP-1 is required for binding to the adenovirus E4 (ORF6/7) protein
1994
Differential Specificity for Binding of Retinoblastoma Binding Protein 2 to RB, pl07, and TATA-Binding Protein
1994
Association of the human papillomavirus type 16 E7 protein with the S-phase-specific E2F-cyclin A complex.
1993
Functional importance of complex formation between the retinoblastoma tumor suppressor family and adenovirus E1A proteins as determined by mutational analysis of E1A conserved region 2
1994
The mechanism of action of T7 DNA polymerase
1998
Association of the Human Papillomavirus Type 16 E7 Protein with the S-Phase-Specific E2F-Cyclin A Complex
1993
Direct Transcriptional Repression by pRB and Its Reversal by Specific Cyclins
1995
The retinoblastoma protein physically associates with the human cdc2 kinase.
1992
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
1995 StandoutNobel
Binding of the von Hippel-Lindau Tumor Suppressor Protein to Elongin B and C
1995 StandoutScienceNobel
The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.
1995
Domains A and B in the Rb Pocket Interact To Form a Transcriptional Repressor Motif
1996
Molecular Cloning of Cellular Genes Encoding Retinoblastoma-Associated Proteins: Identification of a Gene with Properties of the Transcription Factor E2F
1992
A Novel Protein with Similarities to Rb Binding Protein 2 Compensates for Loss of Chk1 Function and Affects Histone Modification in Fission Yeast
2004
HIV-1 reverse transcriptase specifically interacts with the anticodon domain of its cognate primer tRNA.
1989 StandoutNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Sp-1 binds promoter elements regulated by the RB protein and Sp-1-mediated transcription is stimulated by RB coexpression.
1993
An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt
2012
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution
2001 StandoutScienceNobel
p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
1994
The retinoblastoma protein binds to a family of E2F transcription factors.
1993
Physiological roles of PKB/Akt isoforms in development and disease
2007
Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F.
1992
DAF-16 Target Genes That Control C. elegans Life-Span and Metabolism
2003 StandoutScienceNobel
RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila.
1996
STRUCTURES OF TERNARY COMPLEXES OF RAT DNA POLYMERASE BETA, A DNA TEMPLATE-PRIMER, AND DDCTP
1994
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
1991
Molecular Matchmakers
1993 StandoutScienceNobel
The Transcription Factor E2F-1 Is a Downstream Target of RB Action
1995 StandoutNobel
Kinetic mechanism of the DNA-dependent DNA polymerase activity of human immunodeficiency virus reverse transcriptase.
1993 StandoutNobel
Transcription of the E2F-1 Gene Is Rendered Cell Cycle Dependent by E2F DNA-Binding Sites within Its Promoter
1994 StandoutNobel
The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein
1993
Cloning, chromosomal location, and characterization of mouse E2F1.
1994 StandoutNobel
Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein.
1993
Adenovirus E1a prevents the retinoblastoma gene product from repressing the activity of a cellular transcription factor.
1992
A transcriptional tryst
1991 Nature
Stimulation of the processivity of the DNA polymerase of bacteriophage T4 by the polymerase accessory proteins. The role of ATP hydrolysis
1991
The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB.
1993
The retinoblastoma gene product regulates Sp1-mediated transcription.
1992
Expression of Dominant-Negative Mutant DP-1 Blocks Cell Cycle Progression in G1
1996
DNA- and RNA-dependent DNA polymerases
1993 StandoutNobel
Synthesis of a Site-Specific DNA-Binding Peptide
1987 StandoutScienceNobel
Processive proofreading is intrinsic to T4 DNA polymerase.
1992
Dual mechanisms of repression of E2F1 activity by the retinoblastoma gene product.
1996
Heterodimerization of the transcription factors E2F-1 and DP-1 leads to cooperative trans-activation.
1993
Splice Variants of the α Subunit of the G Protein G s Activate Both Adenylyl Cyclase and Calcium Channels
1989 StandoutScienceNobel
Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.
1994
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Isolation, Characterization, and Expression in Escherichia coli of the DNA Polymerase Gene from Thermus aquaticus
1989
Interaction of p107 with Cyclin A Independent of Complex Formation with Viral Oncoproteins
1992 Science
The RNA Component of Human Telomerase
1995 StandoutScienceNobel
Disruption of RB/E2F-1 interaction by single point mutations in E2F-1 enhances S-phase entry and apoptosis.
1996
Structural Basis for the Transition from Initiation to Elongation Transcription in T7 RNA Polymerase
2002 StandoutScienceNobel
Structures of Ternary Complexes of Rat DNA Polymerase β, a DNA Template-Primer, and ddCTP
1994 Science
Template Boundary in a Yeast Telomerase Specified by RNA Structure
2000 StandoutScienceNobel
A genetic analysis of the E2F1 gene distinguishes regulation by Rb, p107, and adenovirus E4.
1993
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Restoration of telomeres in human papillomavirus-immortalized human anogenital epithelial cells.
1994
Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1
1993
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Independent regions of adenovirus E1A are required for binding to and dissociation of E2F-protein complexes.
1993
Endomembrane PtdIns(3,4,5)P3 activates the PI3K/Akt pathway
2015
Structural Basis of Transcription: RNA Polymerase II at 2.8 Ångstrom Resolution
2001 StandoutScienceNobel
Multiple DNA elements are required for the growth regulation of the mouse E2F1 promoter.
1994
Mechanism and fidelity of HIV reverse transcriptase.
1992
Regulation of the Ets-Related Transcription Factor Elf-1 by Binding to the Retinoblastoma Protein
1993 StandoutScienceNobel
Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein.
1994
E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins
1992 Science
Distinct roles for E2F proteins in cell growth control and apoptosis
1997
Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein.
1993
RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest
2001
RBP1 Recruits Both Histone Deacetylase-Dependent and -Independent Repression Activities to Retinoblastoma Family Proteins
1999 StandoutNobel
Identification of distinct roles for separate E1A domains in disruption of E2F complexes.
1993
Recombinant αi-3 Subunit of G Protein Activates Gk-gated K+ Channels
1989
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
1991 StandoutScienceNobel
Host protein requirements for in vitro site-specific DNA inversion
1986
Works of Hans E. Huber being referenced
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
2005
An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
2010
Kinesin spindle protein (KSP) inhibitors. Part V: Discovery of 2-propylamino-2,4-diaryl-2,5-dihydropyrroles as potent, water-soluble KSP inhibitors, and modulation of their basicity by β-fluorination to overcome cellular efflux by P-glycoprotein
2007
Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product
1991 Nature
Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer
2018
Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors
2004
Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP
2005
Allosteric inhibitors of Akt1 and Akt2: A naphthyridinone with efficacy in an A2780 tumor xenograft model
2008
Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity
2008
Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences
2003
Cloning and characterization of E2F-2, a Novel Protein with the Biochemical Properties of Transcription Factor E2F
1993
Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product.
1992
Protein Domains Governing Interactions Between E2F, the Retinoblastoma Gene Product, and Human Papillomavirus type 16 E7 Protein
1993
Interaction of mutant thioredoxins of Escherichia coli with the gene 5 protein of phage T7. The redox capacity of thioredoxin is not required for stimulation of DNA polymerase activity.
1986
Escherichia coli thioredoxin stabilizes complexes of bacteriophage T7 DNA polymerase and primed templates.
1987
Human immunodeficiency virus 1 reverse transcriptase
1989
Transcription factor E2F binds DNA as a heterodimer.
1993
Site-specific DNA inversion is enhanced by a DNA sequence element in cis
1985 Nobel
Purification and characterization of a functionally homogeneous 60-kDa species of the retinoblastoma gene product.
1992
Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F.
1993
Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members
2005
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
2005
Protein domains governing interactions between E2F, the retinoblastoma gene product, and human papillomavirus type 16 E7 protein.
1993
Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7.
1987