Citation Impact
Citing Papers
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2008
Tlr‐4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat
2008
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
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Dissociating fatty liver and diabetes
2012
Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy
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Evolution of Inflammation in Nonalcoholic Fatty Liver Disease: The Multiple Parallel Hits Hypothesis
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Local Proliferation of Macrophages Contributes to Obesity-Associated Adipose Tissue Inflammation
2014
Genomic and epigenomic regulation of adipose tissue inflammation in obesity
2013
Cryo-EM structure of the protein-conducting ERAD channel Hrd1 in complex with Hrd3
2017 StandoutNatureNobel
Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
2007
Newly identified adipose tissue macrophage populations in obesity with distinct chemokine and chemokine receptor expression
2010
Roles of SIRT1 in the Acute and Restorative Phases following Induction of Inflammation
2010
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice
2011
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2008
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An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
2013
JNK1 in Hematopoietically Derived Cells Contributes to Diet-Induced Inflammation and Insulin Resistance without Affecting Obesity
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From Krebs to clinic: glutamine metabolism to cancer therapy
2016 Standout
Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner
2009 Standout
Induction of proinflammatory cytokines by long-chain saturated fatty acids in human macrophages
2008
Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
2010
Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages
2014
Functional interactions between the gut microbiota and host metabolism
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Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers That Drive Obesity-Associated Inflammation
2012
Insulin Receptor Signaling in Normal and Insulin-Resistant States
2014
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
2012
Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation
2007
The Problem of Establishing Relationships between Hepatic Steatosis and Hepatic Insulin Resistance
2012
Immunity, Inflammation, and Cancer
2010 Standout
Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action
2009
Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance
2017
NF-κB, Inflammation, and Metabolic Disease
2011 Standout
Emerging role of adipose tissue hypoxia in obesity and insulin resistance
2008
MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity
2009
An Integrated View of Immunometabolism
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Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
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TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
2008
PPARγ in the endothelium regulates metabolic responses to high-fat diet in mice
2008
Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism
2017 StandoutNobel
The cellular and signaling networks linking the immune system and metabolism in disease
2012
Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
2004
Role of interleukins in obesity: implications for metabolic disease
2014
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration
2012
Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice
2009
SOCS proteins causing trouble in insulin action
2007
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
2010
The immunomodulating role of exercise in metabolic disease
2014
Local proliferation initiates macrophage accumulation in adipose tissue during obesity
2016
Eicosanoids and cancer
2010 Standout
Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue
2008
Origin and physiological roles of inflammation
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A Subpopulation of Macrophages Infiltrates Hypertrophic Adipose Tissue and Is Activated by Free Fatty Acids via Toll-like Receptors 2 and 4 and JNK-dependent Pathways
2007
Fatty acid‐induced induction of Toll‐like receptor‐4/nuclear factor‐κB pathway in adipocytes links nutritional signalling with innate immunity
2008
Sterile inflammation: sensing and reacting to damage
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Calcium Homeostasis and Organelle Function in the Pathogenesis of Obesity and Diabetes
2015
C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
2007
Mechanisms of fatty acid-induced inhibition of glucose uptake.
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The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
cJun NH2-terminal kinase 1 (JNK1): roles in metabolic regulation of insulin resistance
2010
Chronic tissue inflammation and metabolic disease
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Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
2008
Genetics and pathogenesis of inflammatory bowel disease
2011 StandoutNature
Toll-like receptor signaling links dietary fatty acids to the metabolic syndrome
2009
What We Talk About When We Talk About Fat
2014 Standout
Mechanisms for Insulin Resistance: Common Threads and Missing Links
2012 Standout
Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity
2009
Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter
2010
A Ceramide-Centric View of Insulin Resistance
2012
The unfolded protein response transducer IRE1α prevents ER stress‐induced hepatic steatosis
2011
Adipocyte differentiation from the inside out
2006 Standout
The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia
2010
Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity
2014
Lipotoxicity in macrophages: evidence from diseases associated with the metabolic syndrome
2009
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
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The Hallmarks of Aging
2013 Standout
Energy Metabolism in the Liver
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Macrophage biology in development, homeostasis and disease
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Adipose tissue remodeling and obesity
2011
Attenuation of leptin and insulin signaling by SOCS proteins
2006
Diversity, stability and resilience of the human gut microbiota
2012 StandoutNature
Kupffer cells in non-alcoholic fatty liver disease: The emerging view
2009
Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease
2008
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
2011
Role of Krüppel-like Factor 15 (KLF15) in Transcriptional Regulation of Adipogenesis
2005
Chapter 21 Interleukin‐6 and Insulin Resistance
2009
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans
2016
Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity
2008
Macrophage-mediated inflammation in metabolic disease
2011
Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle
2007
DAG tales: the multiple faces of diacylglycerol—stereochemistry, metabolism, and signaling
2015
Stearoyl-CoA Desaturase 2 Is Required for Peroxisome Proliferator-activated Receptor γ Expression and Adipogenesis in Cultured 3T3-L1 Cells
2007
Autophagy in immunity and inflammation
2011 StandoutNature
Inflammation in obesity, diabetes, and related disorders
2022 Standout
NK cells link obesity-induced adipose stress to inflammation and insulin resistance
2015
Forming functional fat: a growing understanding of adipocyte differentiation
2011
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
2010
Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis
2015
2015
Free Fatty Acids Induce a Proinflammatory Response in Islets via the Abundantly Expressed Interleukin-1 Receptor I
2009
Altered Interleukin-10 Signaling in Skeletal Muscle Regulates Obesity-Mediated Inflammation and Insulin Resistance
2016
NOD1 Activators Link Innate Immunity to Insulin Resistance
2011
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo
2013
Pro‐Inflammatory macrophages increase in skeletal muscle of high fat‐Fed mice and correlate with metabolic risk markers in humans
2013
Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle
2009
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Hepatic ATGL knockdown uncouples glucose intolerance from liver TAG accumulation
2012
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice
2008 Standout
Phenotypic Switching of Adipose Tissue Macrophages With Obesity Is Generated by Spatiotemporal Differences in Macrophage Subtypes
2008
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
2013
Toll-Like Receptor-4 Mediates Vascular Inflammation and Insulin Resistance in Diet-Induced Obesity
2007
Inflammatory mechanisms linking obesity and metabolic disease
2017
Roles of Chemokines and Chemokine Receptors in Obesity-Associated Insulin Resistance and Nonalcoholic Fatty Liver Disease
2015
Lack of Interleukin-1 Receptor I (IL-1RI) Protects Mice From High-Fat Diet–Induced Adipose Tissue Inflammation Coincident With Improved Glucose Homeostasis
2011
The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
2010 Science
Saturated Fatty Acids Do Not Directly Stimulate Toll-Like Receptor Signaling
2009
De novolipogenesis in the liver in health and disease: more than just a shunting yard for glucose
2015
Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Fat and Beyond: The Diverse Biology of PPARγ
2008 Standout
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
Downregulation ofGLS2in glioblastoma cells is related to DNA hypermethylation but not to the p53 status
2015
Chemokine Systems Link Obesity to Insulin Resistance
2013
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice
2008 StandoutNobel
Immune Regulation in Obesity-Associated Adipose Inflammation
2013
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction
2010
Toll-like receptor 4 modulates skeletal muscle substrate metabolism
2010
Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes
2009
Increase in Endoplasmic Reticulum Stress–Related Proteins and Genes in Adipose Tissue of Obese, Insulin-Resistant Individuals
2008
Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects
2014
Inflammasomes and Metabolic Disease
2013
Spermidine in health and disease
2018 StandoutScience
Regulation of Lipolysis in Adipocytes
2007
Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance
2009
Inflammation and adipose tissue macrophages in lipodystrophic mice
2009
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism
2008
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
2020
Inflammatory Mechanisms in Obesity
2011 Standout
Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet–Fed Mice
2011
A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells
2012
Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2
2015
Regulation of metabolism by the innate immune system
2015
Human Fatty Liver Disease: Old Questions and New Insights
2011 StandoutScience
Fat fuels insulin resistance through Toll-like receptors
2006
New therapeutic approaches for the treatment of obesity
2016
Role of innate and adaptive immunity in obesity-associated metabolic disease
2017
Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation
2014
Targeting Glutamine Induces Apoptosis: A Cancer Therapy Approach
2015
Host-Gut Microbiota Metabolic Interactions
2012 StandoutScience
Mechanisms Underlying the Onset of Oral Lipid–Induced Skeletal Muscle Insulin Resistance in Humans
2013
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice
2014
G-protein-coupled receptors and cancer
2007
Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells
2014
Interferon Regulatory Factor 4 Regulates Obesity-Induced Inflammation Through Regulation of Adipose Tissue Macrophage Polarization
2013
SirT1 Regulates Adipose Tissue Inflammation
2011
Macrophages, Inflammation, and Insulin Resistance
2010 Standout
Adipose Tissue Exosome-Like Vesicles Mediate Activation of Macrophage-Induced Insulin Resistance
2009
Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle
2015 StandoutNobel
Obesity-Related Upregulation of Monocyte Chemotactic Factors in Adipocytes
2008
Interactions Between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes
2010
Fast detection of liver fibrosis with collagen-binding single-nanometer iron oxide nanoparticles via T 1 -weighted MRI
2023 StandoutNobel
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
2007
Regulation and Metabolic Significance of De Novo Lipogenesis in Adipose Tissues
2018
Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?
2015
Retinol-Binding Protein 4 Inhibits Insulin Signaling in Adipocytes by Inducing Proinflammatory Cytokines in Macrophages through a c-Jun N-Terminal Kinase- and Toll-Like Receptor 4-Dependent and Retinol-Independent Mechanism
2012
Alternative Macrophage Activation and Metabolism
2011
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance
2016
Tlr2 is critical for diet‐induced metabolic syndrome in a murine model
2009
The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
2016
Liver Perilipin 5 Expression Worsens Hepatosteatosis But Not Insulin Resistance in High Fat-Fed Mice
2015
Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue
2010
Works of Hang Shi being referenced
Lipolysis in Brown Adipocytes Is Not Essential for Cold-Induced Thermogenesis in Mice
2017
Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling
2004
Macrophage CGI-58 Deficiency Activates ROS-Inflammasome Pathway to Promote Insulin Resistance in Mice
2014
Deficiency of liver Comparative Gene Identification-58 causes steatohepatitis and fibrosis in mice
2013
Loss of Abhd5 Promotes Colorectal Tumor Development and Progression by Inducing Aerobic Glycolysis and Epithelial-Mesenchymal Transition
2014
The IRE1α-XBP1 Pathway of the Unfolded Protein Response Is Required for Adipogenesis
2009
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance
2010
Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α
2016
Regulated Production of a Peroxisome Proliferator-activated Receptor-γ Ligand during an Early Phase of Adipocyte Differentiation in 3T3-L1 Adipocytes
2004
Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation
2013
TLR4 links innate immunity and fatty acid–induced insulin resistance
2006 Standout
The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation
2015
Direct control of hepatic glucose production by interleukin-13 in mice
2012
Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM
2016
The ER-Associated Degradation Adaptor Protein Sel1L Regulates LPL Secretion and Lipid Metabolism
2014
Macrophage α1 AMP-activated Protein Kinase (α1AMPK) Antagonizes Fatty Acid-induced Inflammation through SIRT1
2010
Pro-opiomelanocortin (POMC) Deficiency and Peripheral Melanocortins in Obesity
2009
Thermoneutrality decreases thermogenic program and promotes adiposity in high-fat diet-fed mice
2016
Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.
2002
Effects of dietary calcium on adipocyte lipid metabolism and body weight regulation in energy‐restricted aP2‐agouti transgenic mice
2000
Absence of CC Chemokine Ligand 2 Does Not Limit Obesity-Associated Infiltration of Macrophages Into Adipose Tissue
2007
Role of intracellular calcium in human adipocyte differentiation
2000
Regulation of adiposity by dietary calcium
2000
Overexpression of Suppressor of Cytokine Signaling 3 in Adipose Tissue Causes Local but Not Systemic Insulin Resistance
2006