Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
2003 StandoutNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
The P1 family: a new class of nuclear mammalian proteins related to the yeast Mem replication proteins
1993
Exonal Elements and Factors Involved in the Depolarization-Induced Alternative Splicing of Neurexin 2
2012
Interferon-α-dependent Activation of Tyk2 Requires Phosphorylation of Positive Regulatory Tyrosines by Another Kinase
1996
The WD Motif-containing Protein Receptor for Activated Protein Kinase C (RACK1) Is Required for Recruitment and Activation of Signal Transducer and Activator of Transcription 1 through the Type I Interferon Receptor
2001
Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway
1996 Standout
Requirement of Cysteine-rich Repeats of the Fas Receptor for Binding by the Fas Ligand
1997
Interferon gamma: A master regulator of atherosclerosis
2008
GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression
1997
A 12·8 kb segment, on the right arm of chromosome II from Saccharomyces cerevisiae including part of the DUR1, 2 gene, contains five putative new genes
1993
Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes
2005
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
Acetylation-Dependent Signal Transduction for Type I Interferon Receptor
2007
JAKs, STATs and Src kinases in hematopoiesis
2002
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
2018 StandoutNobel
α-Latrotoxin and Its Receptors
2007
Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase
1995
Liprins, a Family of LAR Transmembrane Protein-tyrosine Phosphatase-interacting Proteins
1998
Presynaptic Neurexin-3 Alternative Splicing trans-Synaptically Controls Postsynaptic AMPA Receptor Trafficking
2013 StandoutNobel
Activation of Protein Kinase A Inhibits Interferon Induction of the Jak/Stat Pathway in U266 Cells
1996
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
1997
Components of a stat recognition code: Evidence for two layers of molecular selectivity
1995
Components and Dynamics of DNA Replication Complexes in S. cerevisiae: Redistribution of MCM Proteins and Cdc45p during S Phase
1997
Interferon-α Engages the Insulin Receptor Substrate-1 to Associate with the Phosphatidylinositol 3′-Kinase
1995
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
2001 StandoutNature
Properties of the nuclear P1 protein, a mammalian homologue of the yeast Mcm3 replication protein
1992
The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts
1995
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity
2006
p65cdc18 Plays a major role controlling the initiation of DNA replication in fission yeast
1995 StandoutNobel
Endonucleolytic Function of MutLα in Human Mismatch Repair
2006 StandoutNobel
Gene Ontology: tool for the unification of biology
2000 Standout
Contribution of Human Mlh1 and Pms2 ATPase Activities to DNA Mismatch Repair
2002
Activation of the MHC Class II Transactivator CIITA by Interferon-γ Requires Cooperative Interaction between Stat1 and USF-1
1998
The vav proto‐oncogene product (p95vav) interacts with the Tyk‐2 protein tyrosine kinase
1997
A Long Twentieth Century of the Cell Cycle and Beyond
2000 StandoutNobel
The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion
2001
Tissue-specific targeting of gytokine unresponsiveness in transgenic mice
1995
hCDC47, a Human Member of the MCM Family
1996
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
The Xenopus Cdc6 Protein Is Essential for the Initiation of a Single Round of DNA Replication in Cell-Free Extracts
1996
A Serpin Shapes the Extracellular Environment to Prevent Influenza A Virus Maturation
2015 StandoutNobel
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
1994 StandoutNobel
Once and only once upon a time: specifying and regulating origins of DNA replication in eukaryotic cells.
1996
Purification of an MCM-containing complex as a component of the DNA replication licensing system
1995 Nature
ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
1995
Two steps in the assembly of complexes at yeast replication origins in vivo
1994
Genetics and the making of Homo sapiens
2003 Nature
Distinct Domains of the Protein Tyrosine Kinase tyk2 Required for Binding of Interferon-α/β and for Signal Transduction
1995
Identification of the yeast MCM3-related protein as a component of xenopus DNA replication licensing factor
1995
Regulating S Phase: CDKs, Licensing and Proteolysis
1996 StandoutNobel
Amino-terminal Signal Transducer and Activator of Transcription (STAT) Domains Regulate Nuclear Translocation and STAT Deactivation
1998
PupasView: a visual tool for selecting suitable SNPs, with putative pathological effect in genes, for genotyping purposes
2005
Dendritic cell regulation of TH1-TH2 development
2000
IL-4 Function Can Be Transferred to the IL-2 Receptor by Tyrosine Containing Sequences Found in the IL-4 Receptor α Chain
1996
The mcm2 mutation of yeast affects replication, rather than segregation or amplification of the two micron plasmid
1992
The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression
2003
Genetic predisposition to colorectal cancer
2004
Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants
1997
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor
1994
Neuroligins and neurexins link synaptic function to cognitive disease
2008 StandoutNatureNobel
Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ
1996
Stat1 Depends on Transcriptional Synergy with Sp1
1995
Complex roles of Stat1 in regulating gene expression
2000
The Cdt1 protein is required to license DNA for replication in fission yeast
2000 StandoutNatureNobel
A weak signal for strong responses: interferon-alpha/beta revisited
2001
The fission yeast cdc18+ gene product couples S phase to START and mitosis
1993 StandoutNobel
Interaction of p59fynwith Interferon-Activated Jak Kinases
1997
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
The Receptor of the Type I Interferon Family
2007
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Intracellular signalling: Putting JAKs on the kinase MAP
1996
Biomolecular Interaction Analysis of IFNγ-Induced Signaling Events in Whole-Cell Lysates: Prevalence of Latent STAT1 in High-Molecular Weight Complexes
1998
The Human Type I Interferon Receptor
1996
Fission yeastcdc21+belongs to a family of proteins involved in an early step of chromosome replication
1992
Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1
1997
Cell cycle control of DNA synthesis in budding yeast
1992
Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α
1998 StandoutNobel
α and α Interferons and Their Receptor and Their Friends and Relations
1995
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
1996 StandoutNatureNobel
Interaction between the Origin Recognition Complex and the Replication Licensing Systemin Xenopus
1996
The roles of IFNγ in protection against tumor development and cancer immunoediting
2002
tea1 and the Microtubular Cytoskeleton Are Important for Generating Global Spatial Order within the Fission Yeast Cell
1997 StandoutNobel
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system
1992
A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication
1993
MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells
1995 Nature
Type I Interferon Receptors: Biochemistry and Biological Functions
2007
Contribution of the Box 1 and Box 2 Motifs of Cytokine Receptors to Jak1 Association and Activation
2002
The evolution of gene expression levels in mammalian organs
2011 StandoutNatureNobel
Structural basis of recognition of interferon-α receptor by tyrosine kinase 2
2014
Differences in Interferon α and β Signaling
1996
Role for a Xenopus Orc2-related protein in controlling DNA replication
1996 Nature
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
2002 StandoutNatureNobel
STATs: transcriptional control and biological impact
2002 Standout
The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression
1996
Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer
2003
Interferon-γ: an overview of signals, mechanisms and functions
2003 Standout
A Stat3-interacting protein (StIP1) regulates cytokine signal transduction
2000
Lack of Interferon γ Receptor β Chain and the Prevention of Interferon γ Signaling in T H 1 Cells
1995 Science
Interferon-gamma inhibits interferon-alpha signalling in hepatic cells: evidence for the involvement of STAT1 induction and hyperexpression of STAT1 in chronic hepatitis C
2004
The fission yeast cdc19+ gene encodes a member of the MCM family of replication proteins
1994 StandoutNobel
Functional Subdomains of STAT2 Required for Preassociation with the Alpha Interferon Receptor and for Signaling
1997
Saccharomyces cerevisiaeCTF18 and CTF4 Are Required for Sister Chromatid Cohesion
2001
Fission yeast genes nda1+ and nda4+, mutations of which lead to S-phase block, chromatin alteration and Ca2+ suppression, are members of the CDC46/MCM2 family.
1993
Lynch Syndrome Genes
2005
Ligand-Induced Association of the Type I Interferon Receptor Components
1995
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
HOW CELLS RESPOND TO INTERFERONS
1998 Standout
Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.
1996
Transcriptional neoteny in the human brain
2009 StandoutNobel
Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.
1995 StandoutNobel
The amino-terminal region of Tyk2 sustains the level of interferon α receptor 1, a component of the interferon α/β receptor
1997
Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
1995
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.
1994
Inherited Susceptibility to Colorectal Cancer
2005
Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
2016 StandoutScienceNobel
A family of RIM-binding proteins regulated by alternative splicing: Implications for the genesis of synaptic active zones
2002 StandoutNobel
Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins
1995 Science
MCM Proteins in DNA Replication
1999
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication
1996
CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences.
1992
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
1998 Standout
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Jaks, STATs, Cytokine Signal Transduction, and Immunoregulation: Are We There Yet?
1997
Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.
1994 StandoutNobel
Jak-STAT Signaling Induced by the v- abl oncogene
1995 Science
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Differential Regulation of the Alpha/Beta Interferon-Stimulated Jak/Stat Pathway by the SH2 Domain-Containing Tyrosine Phosphatase SHPTP1
1995
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain
1996 Science
The origin recognition complex in silencing, cell cycle progression, and DNA replication.
1995
Enhancement of Antiproliferative Activity of Gamma Interferon by the Specific Inhibition of Tyrosine Dephosphorylation of Stat1
1996
Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway.
1995
Cross Talk Between Interferon-γ and -α/β Signaling Components in Caveolar Membrane Domains
2000 Science
CELLULAR RESPONSES TO INTERFERON-γ
1997 Standout
The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.
1996 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2-terminal domains stabilizes binding of two dimers to tandem DNA sites.
1996
Cell cycle-regulated nuclear import and export of Cdc47, a protein essential for initiation of DNA replication in budding yeast.
1995
Ligand-Induced Assembly and Activation of the Gamma Interferon Receptor in Intact Cells
1996
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeast
1997
BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication.
1995
IFN Unresponsiveness in LNCaP Cells Due to the Lack of JAK1 Gene Expression
2005
Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair
2008 StandoutNobel
Regulation of STAT‐dependent pathways by growth factors and cytokines
1996
A human nuclear protein with sequence homology to a family of early s phase proteins is required for entry into s phase and for cell division
1994
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.
1996
INITIATION OF DNA REPLICATION IN EUKARYOTIC CELLS
1997
Chromatin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell-cycle dependent and associated with the control of initiation of DNA replication.
1996
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein.
1994
REPLICATION PROTEIN A: A Heterotrimeric, Single-Stranded DNA-Binding Protein Required for Eukaryotic DNA Metabolism
1997
Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding.
1992
THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling
1997
DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.
1994
Fission yeast cdc21, a member of the MCM protein family, is required for onset of S phase and is located in the nucleus throughout the cell cycle.
1996
Unraveling Function in the TNF Ligand and Receptor Families
1994 StandoutScienceNobel
Works of Hai Yan being referenced
Definition of the Interferon-α Receptor-binding Domain on the TYK2 Kinase
1998
Genetic Testing-- Present and Future
2000 Science
A Conserved Serine of Heterogeneous Nuclear Ribonucleoprotein L (hnRNP L) Mediates Depolarization-regulated Alternative Splicing of Potassium Channels
2012
A Region of the β Subunit of the Interferon α Receptor Different from Box 1 Interacts with Jak1 and Is Sufficient to Activate the Jak-Stat Pathway and Induce an Antiviral State
1997
Small changes in expression affect predisposition to tumorigenesis
2001
Stat2 Binding to the Interferon-α Receptor 2 Subunit Is Not Required for Interferon-α Signaling
2002
Stat recruitment by tyrosine-phosphorylated cytokine receptors: An ordered reversible affinity-driven process
1995
The Heterogeneous Nuclear Ribonucleoprotein L Is an Essential Component in the Ca2+/Calmodulin-dependent Protein Kinase IV-regulated Alternative Splicing through Cytidine-Adenosine Repeats
2008
p135tyk2, an interferon-alpha-activated tyrosine kinase, is physically associated with an interferon-alpha receptor.
1994
Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.
1996
Direct Binding to and Tyrosine Phosphorylation of the a Subunit of the Type I Interferon Receptor by p135tyk2 Tyrosine Kinase
1994
Molecular Characterization of an Alpha Interferon Receptor 1 Subunit (IFNaR1) Domain Required for TYK2 Binding and Signal Transduction
1996
Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.
1993
Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes
2001
The role of hPMS1 and hPMS2 in predisposing to colorectal cancer.
2001
Chimeric NGF-EGF Receptors Define Domains Responsible for Neuronal Differentiation
1991 Science
Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function.
1991
An analysis of the regulation of DNA synthesis by cdk2, Cip1, and licensing factor.
1995
Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.
1994
A novel receptor tyrosine phosphatase-sigma that is highly expressed in the nervous system.
1993
The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.
1996
Disruption of cysteine-rich repeats of the p75 nerve growth factor receptor leads to loss of ligand binding
1991
Allelic Variation in Human Gene Expression
2002 Science