Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Sym004: A Novel Synergistic Anti–Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
2010
Targeting of Diacylglycerol Degradation to M1 Muscarinic Receptors by ß-Arrestins
2007 StandoutScienceNobel
Computational Design of Self-Assembling Protein Nanomaterials with Atomic Level Accuracy
2012 StandoutScienceNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
2003 StandoutScienceNobel
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity
2003 StandoutScienceNobel
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
2014 Standout
Untangling the ErbB signalling network
2001 Standout
All ErbB Receptors Other Than the Epidermal Growth Factor Receptor Are Endocytosis Impaired
1996
Hallmarks of Cancer: The Next Generation
2011 Standout
A Biparatopic HER2-Targeting Antibody-Drug Conjugate Induces Tumor Regression in Primary Models Refractory to or Ineligible for HER2-Targeted Therapy
2016
Alternative Intracellular Routing of ErbB Receptors May Determine Signaling Potency
1998
Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction.
1991
Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
1990
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Derailed endocytosis: an emerging feature of cancer
2008
An Internalization Motif Is Created in the Cytoplasmic Domain of the Transferrin Receptor by Substitution of a Tyrosine at the First Position of a Predicted Tight Turn
1995
Endocytosis and signals for internalization
1991
Structure-based Analysis of GPCR Function: Evidence for a Novel Pentameric Assembly between the Dimeric Leukotriene B4 Receptor BLT1 and the G-protein
2003
Constitutive Activation of G Protein-Coupled Receptors as a Result of Selective Substitution of a Conserved Leucine Residue in Transmembrane Helix III
2000
Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization
2000
Differential endocytic routing of homo- and hetero-dimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers
1998
Association of Epidermal Growth Factor Receptors with Coated Pit Adaptins via a Tyrosine Phosphorylation-regulated Mechanism
1995
PI3K pathway alterations in cancer: variations on a theme
2008
Stoichiometric Interaction of the Epidermal Growth Factor Receptor with the Clathrin-associated Protein Complex AP-2
1995
Multifarious Determinants of Cytokine Receptor Signaling Specificity
2014
Beyond natural antibodies: the power of in vitro display technologies
2011
Signal transduction by receptors with tyrosine kinase activity
1990 Standout
Fine Epitope Mapping of anti-Epidermal Growth Factor Receptor Antibodies Through Random Mutagenesis and Yeast Surface Display
2004
Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes
2008
An improved yeast transformation method for the generation of very large human antibody libraries
2010
Developmental regulation of MHC class II transport in mouse dendritic cells
1997 StandoutNatureNobel
Biochemical evidence that Patched is the Hedgehog receptor
1996 StandoutNature
Visualizing the mechanical activation of Src
2005 StandoutNatureNobel
Saturation of the Endocytic Pathway for the Transferrin Receptor Does Not Affect the Endocytosis of the Epidermal Growth Factor Receptor
1997 StandoutNobel
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
The class III variant of the epidermal growth factor receptor (EGFRvIII): characterization and utilization as an immunotherapeutic target
1998
Isolation of plasma membrane complexes fromXenopus oocytes
1989
Degradation Process of Ligand-stimulated Platelet-derived Growth Factor β -Receptor Involves Ubiquitin-Proteasome Proteolytic Pathway
1995 StandoutNobel
Epidermal Growth Factor Receptor Interaction with Clathrin Adaptors Is Mediated by the Tyr974-containing Internalization Motif
1996
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Isolating and engineering human antibodies using yeast surface display
2006
β-Arrestin acts as a clathrin adaptor in endocytosis of the β2-adrenergic receptor
1996 Nature
Induction of self-tolerance in mature peripheral B lymphocytes
1989 Nature
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics
2017
Distinct Saturable Pathways for the Endocytosis of Different Tyrosine Motifs
1998 StandoutNobel
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
1999 Nature
EGF receptor
1999
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Structural Determinants of Interaction of Tyrosine-based Sorting Signals with the Adaptor Medium Chains
1996
Bispecific Designed Ankyrin Repeat Proteins (DARPins) Targeting Epidermal Growth Factor Receptor Inhibit A431 Cell Proliferation and Receptor Recycling
2011
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1
1999 StandoutNobel
c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor
1998
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing
1987
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
High-throughput screens and selections of enzyme-encoding genes
2005
EGFR endocytosis requires its kinase activity and N-terminal transmembrane dimerization motif
2013
Allosteric Receptors after 30 Years
1998
Fabrication of novel biomaterials through molecular self-assembly
2003 Standout
Manufacturing Immunity to Disease in a Test Tube: The Magic Bullet Realized
2006
Regulatory interactions in the recognition of endocytic sorting signals by AP-2 complexes
1997
Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin
1997
Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C.
1994
The endocytic activity of dendritic cells.
1995
Role of the Rate of Internalization of the Agonist-Receptor Complex on the Agonist-Induced Down-Regulation of the Lutropin/ Choriogonadotropin Receptor
1999
Mutations in aquaporin-1 in Phenotypically Normal Humans Without Functional CHIP Water Channels
1994 StandoutScienceNobel
Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia
1992 StandoutScienceNobel
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail.
1990
Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling
2010
Identification of a hydrophobic region in the carboxyl terminus of the platelet-derived growth factor beta-receptor which is important for ligand-mediated endocytosis.
1991
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Postsynaptic Membrane Fusion and Long-Term Potentiation
1998 StandoutScienceNobel
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
A tyrosine residue in the juxtamembrane segment of the platelet-derived growth factor beta-receptor is critical for ligand-mediated endocytosis.
1994
Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.
1983 StandoutNobel
Coat Proteins and Vesicle Budding
1996 StandoutScienceNobel
Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells
1997
Molecular basis for multimerization in the activation of the epidermal growth factor receptor
2016
Endocytosis of the ASGP receptor H1 is reduced by mutation of tyrosine-5 but still occurs via coated pits.
1991
β-Arrestin 2: A Receptor-Regulated MAPK Scaffold for the Activation of JNK3
2000 StandoutScienceNobel
A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis
1990
Regulation of GPCRs by Endocytic Membrane Trafficking and Its Potential Implications
2007
Human transferrin receptor internalization is partially dependent upon an aromatic amino acid on the cytoplasmic domain.
1990
Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis
1996 Science
Characteristics of the tyrosine recognition signal for internalization of transmembrane surface glycoproteins.
1990
Protein targeting by tyrosine- and di-leucine-based signals: evidence for distinct saturable components.
1996
CLATHRIN-COATED VESICLE FORMATION AND PROTEIN SORTING: An Integrated Process
1997
Independent mechanisms account for the regulation by protein kinase C of the epidermal growth factor receptor affinity and tyrosine-protein kinase activity.
1988
Ligand-induced internalization of the epidermal growth factor receptor is mediated by multiple endocytic codes analogous to the tyrosine motif found in constitutively internalized receptors.
1993
Sequestration of the G protein βγ subunit complex inhibits receptor-mediated endocytosis
1998 Nobel
Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.
1992
Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase
1995
Kinetics of internalization and recycling of the asialoglycoprotein receptor in a hepatoma cell line.
1982
Identifying differentially expressed transcripts from RNA-seq data with biological variation
2012
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Recruitment of epidermal growth factor and transferrin receptors into coated pits in vitro: differing biochemical requirements.
1993
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals.
1992
Genetically encoded fluorescent reporters of protein tyrosine kinase activities in living cells
2001 StandoutNobel
Computational Design of Proteins Targeting the Conserved Stem Region of Influenza Hemagglutinin
2011 StandoutScienceNobel
Nucleation of COPII Vesicular Coat Complex by Endoplasmic Reticulum to Golgi Vesicle SNAREs
1998 StandoutScienceNobel
Roles for Growth Factors in Cancer Progression
2010
Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.
1993
Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor.
1991
Interaction of Activated EGF Receptors with Coated Pit Adaptins
1993 Science
In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting.
1996
Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
1994 StandoutNatureNobel
Internalization-Dependent and -Independent Requirements for Transforming Growth Factor β Receptor Signaling via the Smad Pathway
2002
Internalization and down-regulation of the human epidermal growth factor receptor are regulated by the carboxyl-terminal tyrosines
1991
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Regulation of HeLa cell transferrin receptors.
1982
Endocytosis of activated receptors and clathrin-coated pit formation: deciphering the chicken or egg relationship.
1996
Works of H Wiley being referenced
Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects.
2003
Cholesterol Dictates the Freedom of EGF Receptors and HER2 in the Plane of the Membrane
2005
Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis
1999
Altered degradation of epidermal growth factor in a diphtheria toxin‐resistant clone of KB cells
1985
Role of Intrinsic Protein Tyrosine Kinase in Function and Metabolism of the Epidermal Growth Factor Receptor
1988
Computational modeling of the EGF-receptor system: a paradigm for systems biology
2002
Endocytosis and Lysosomal Targeting of Epidermal Growth Factor Receptors Are Mediated by Distinct Sequences Independent of the Tyrosine Kinase Domain
1995
Structural Aspects of the Epidermal Growth Factor Receptor Required for Transmodulation of erbB-2/neu
1997
The Enhanced Tumorigenic Activity of a Mutant Epidermal Growth Factor Receptor Common in Human Cancers Is Mediated by Threshold Levels of Constitutive Tyrosine Phosphorylation and Unattenuated Signaling
1997
ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors
1999
Engineering dynamics of growth factors and other therapeutic ligands
1996
Implications of epidermal growth factor (EGF) induced egf receptor aggregation
1992
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library
2003
Engineering epidermal growth factor for enhanced mitogenic potency
1996
Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation
1989
Trafficking of the ErbB receptors and its influence on signaling
2003
Highly Polarized EGF Receptor Tyrosine Kinase Activity Initiates Egg Activation in Xenopus
1994
Regulation of Receptor Tyrosine Kinase Signaling by Endocytic Trafficking
2001
Epidermal growth factor rapidly induces a redistribution of transferrin receptor pools in human fibroblasts.
1984
EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation
2007
Intracellular processing of epidermal growth factor and its effect on ligand-receptor interactions.
1985
Ligand-induced endocytosis of epidermal growth factor receptors that are defective in binding adaptor proteins.
1995
The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor
1991
Functional reconstitutional of the human epidermal growth factor receptor system in Xenopus oocytes.
1990
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor
1999
Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization.
1990
The structure of vitellogenin. Multiple vitellogenins in Xenopus laevis give rise to multiple forms of the yolk proteins.
1981
Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.
1991
The endocytotic rate constant. A cellular parameter for quantitating receptor-mediated endocytosis.
1982
Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.
1990
Receptor-mediated endocytosis in Xenopus oocytes. II. Evidence for two novel mechanisms of hormonal regulation.
1987
Anomalous binding of epidermal growth factor to A431 cells is due to the effect of high receptor densities and a saturable endocytic system.
1988
Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway
2016
Specific factors are required for kinase-dependent endocytosis of insulin receptors.
1994
Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention.
1994
A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands
1981
Characterization and improvement of RNA-Seq precision in quantitative transcript expression profiling
2011
Epidermal growth factor stimulates fluid phase endocytosis in human fibroblasts through a signal generated at the cell surface
1982
Ligand-Induced Transformation by a Noninternalizing Epidermal Growth Factor Receptor
1990 Science
Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions.
1994
The Oocyte as an Endocytic Cell
1983