Citation Impact
Citing Papers
A Prokaryotic Voltage-Gated Sodium Channel
2001 Science
Functional Conversion Between A-Type and Delayed Rectifier K + Channels by Membrane Lipids
2004 Science
Crystal Structure of Escherichia coli MscS, a Voltage-Modulated and Mechanosensitive Channel
2002 Science
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Voltage sensor conformations in the open and closed states in rosetta structural models of K + channels
2006 StandoutNobel
Molecular Architecture of the KvAP Voltage-Dependent K + Channel in a Lipid Bilayer
2004 Science
A Light-Actuated Nanovalve Derived from a Channel Protein
2005 StandoutScienceNobel
The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M II of the receptor subunits
1986
Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel
2017
The open pore conformation of potassium channels
2002 StandoutNatureNobel
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel
1994
Electrostatic interactions of S4 voltage sensor in shaker K+ channel
1995
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
KvLQT1 and IsK (minK) proteins associate to form the IKS cardiac potassium current
1996 Nature
Probing the outer vestibule of a sodium channel voltage sensor
1997
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Molecular force transduction by ion channels – diversity and unifying principles
2012
Voltage-Dependent Hydration and Conduction Properties of the Hydrophobic Pore of the Mechanosensitive Channel of Small Conductance
2006
Dominant forces in protein folding
1990 Standout
‘Feeling the pressure’: structural insights into a gated mechanosensitive channel
1999
Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium
1992
Crystal structure of the tetramerization domain of the Shaker potassium channel
1998 Nature
Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel
1996
Calcium-activated potassium channels expressed from cloned complementary DNAs
1992 StandoutNobel
The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels
2016
The Orientation and Molecular Movement of a K+ Channel Voltage-Sensing Domain
2003
Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel
1996
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
X-ray structure of a voltage-dependent K+ channel
2003 StandoutNatureNobel
Structure and mechanism in prokaryotic mechanosensitive channels
2003
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle
1989 StandoutNatureNobel
Dynamics of the Kv1.2 Voltage-Gated K+ Channel in a Membrane Environment
2007
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
Voltage-Sensing Arginines in a Potassium Channel Permeate and Occlude Cation-Selective Pores
2005
Ion Permeation through a Voltage- Sensitive Gating Pore in Brain Sodium Channels Having Voltage Sensor Mutations
2005
TRP channels in mechanosensation: direct or indirect activation?
2007
The Use ofXenopusOocytes for the Study of Ion Channel
1987
Open channel structure of MscL and the gating mechanism of mechanosensitive channels
2002 Nature
Evidence for voltage-dependent S4 movement in sodium channels
1995
Rationally Designed Chemical Modulators Convert a Bacterial Channel Protein into a pH‐Sensory Valve
2006 StandoutNobel
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Contribution of the S4 Segment to Gating Charge in the Shaker K+ Channel
1996 StandoutNobel
Large-Scale Movement within the Voltage-Sensor Paddle of a Potassium Channel—Support for a Helical-Screw Motion
2008
Closing In on the Resting State of the Shaker K+ Channel
2007
Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in shaker K+ channels
1991
Effects of substitution of putative transmembrane segments on nicotinic acetylcholine receptor function
1987
Blocker protection in the pore of a voltage-gated K+ channel and its structural implications
2000 Nature
Structure prediction for the down state of a potassium channel voltage sensor
2006 Nature
Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels
1996
Enhanced Toxicity and Cellular Binding of a Modified Amyloid β Peptide with a Methionine to Valine Substitution
2004
Common evolutionary origins of mechanosensitive ion channels in Archaea, Bacteria and cell‐walled Eukarya
2001
Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge
1992
Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands
2007
Depolarization Induces Intersubunit Cross-linking in a S4 Cysteine Mutant of the Shaker Potassium Channel
2002
Lipid-anchored influenza hemagglutinin promotes hemifusion, not complete fusion
1994
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
1993 Nature
Principles for designing ideal protein structures
2012 StandoutNatureNobel
Gating of the Large Mechanosensitive Channel In Situ: Estimation of the Spatial Scale of the Transition from Channel Population Responses
2004
Dynamic molecular processes mediate cellular mechanotransduction
2011 Nature
Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits
1997
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Electrophysiology in the eukaryotic model cell Saccharomyces cerevisiae
1998
Structure and function of voltage-gated ion channels
1993
Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology
2010
Mechanically Activated Ion Channels
2015 StandoutNobel
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis
2004
Molecular regulations governing TREK and TRAAK channel functions
2011
Biophysical Principles of Ion-Channel-Mediated Mechanosensory Transduction
2019
Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors
2001 Nature
The coming of age of de novo protein design
2016 StandoutNatureNobel
Novel potassium channels encoded by the Shaker locus in drosophila photoreceptors
1991
Assessment of protein models with three-dimensional profiles
1992 StandoutNature
Structure and function of voltage‐gated sodium channels at atomic resolution
2013
Gating charge differences between two voltagegated K+ channels are due to the specific charge content of their respective S4 regions
1993
Sensing voltage across lipid membranes
2008 Nature
Random mutagenesis reveals a region important for gating of the yeast K+ channel Ykc1
1997
Structure of the RCK Domain from the E. coli K+ Channel and Demonstration of Its Presence in the Human BK Channel
2001
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Voltage gating of ion channels
1994
From Ionic Currents to Molecular Mechanisms
2000 Standout
Metal Ions, pH, and Cholesterol Regulate the Interactions of Alzheimer's Disease Amyloid-β Peptide with Membrane Lipid
2003
Interactions between S4-S5 Linker and S6 Transmembrane Domain Modulate Gating of HERG K+ Channels
2002
Ligand-gated ion channels in the brain: The amino acid receptor superfamily
1990
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Protein Hydration and Function
1991
Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila
1988 Nature
Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity
1988
The twisted ion-permeation pathway of a resting voltage-sensing domain
2006 Nature
The design, synthesis, and crystallization of an alpha‐helical peptide
1986
Tuning ion channel mechanosensitivity by asymmetry of the transbilayer pressure profile
2018
Inhalational anesthetics activate two-pore-domain background K+ channels
1999
Atomic scale movement of the voltage-sensing region in a potassium channel measured via spectroscopy
1999 Nature
Three Transmembrane Conformations and Sequence-Dependent Displacement of the S4 Domain in Shaker K + Channel Gating
1998
Molecular mechanism of voltage sensor movements in a potassium channel
2004
Transmembrane Movement of the Shaker K+ Channel S4
1996
The principle of gating charge movement in a voltage-dependent K+ channel
2003 StandoutNatureNobel
Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating
2002
Expression of an inward-rectifying potassium channel by the Arabidopsis KAT1 cDNA
1992 Science
Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel
2014 NatureNobel
Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel
1999 Nature
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence
1991 Nature
A possible unifying principle for mechanosensation
2005 Nature
The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interface
2012
Water Dynamics and Dewetting Transitions in the Small Mechanosensitive Channel MscS
2004
Structural parts involved in activation and inactivation of the sodium channel
1989 Nature
Determination of the subunit stoichiometry of a voltage-activated potassium channel
1991 StandoutNatureNobel
cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition
1996
Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement
2005 Nature
A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP
1994 Nature
Structure and Function of the Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin
2006
Voltage-sensing residues in the S4 region of a mammalian K+ channel
1991 Nature
Ion channels: molecular basis of ion selectivity
1993
Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel
1993 StandoutNobel
Calcium channel characteristics conferred on the sodium channel by single mutations
1992 Nature
Merging functional studies with structures of inward-rectifier K+ channels
2003
The neuronal background K2P channels: focus on TREK1
2007
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel
2012 Nature
Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel
1996
The synaptic vesicle cycle: a cascade of protein–protein interactions
1995 StandoutNatureNobel
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Patch Clamp Studies on V-type ATPase of Vacuolar Membrane of Haploid Saccharomyces cerevisiae
1999 StandoutNobel
Hydrophobicity of amino acid subgroups in proteins
1990
A structural motif for the voltage-gated potassium channel pore.
1995
Site-directed mutagenesis and single-channel currents define the ionic channel of the nicotinic acetylcholine receptor
1989
Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system
1987
Disulfide locking a sodium channel voltage sensor reveals ion pair formation during activation
2008
A Hydrophobic Gating Mechanism for Nanopores
2001
Sequence of a Probable Potassium Channel Component Encoded at Shaker Locus of Drosophila
1987 Science
Structure of the high-affinity binding site for noncompetitive blockers of the acetylcholine receptor: serine-262 of the delta subunit is labeled by [3H]chlorpromazine.
1986
Solvation energy in protein folding and binding
1986 StandoutNature
Isolation and sequence of cDNA clones coding for the precursor to the γ subunit of mouse muscle nicotinic acetylcholine receptor
1986
Quantification of CD4, CCR5, and CXCR4 levels on lymphocyte subsets, dendritic cells, and differentially conditioned monocyte-derived macrophages
1999 StandoutNobel
Mechanosensitive Channel MscS in the Open State: Modeling of the Transition, Explicit Simulations, and Experimental Measurements of Conductance
2008
Water as an Active Constituent in Cell Biology
2007 Standout
A Structural Mechanism for MscS Gating in Lipid Bilayers
2008 Science
Folding Pattern Diversity of Integral Membrane Proteins
1994 Science
Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.
1991
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
1991 StandoutScienceNobel
Exchange of Conduction Pathways Between Two Related K + Channels
1991 Science
Membrane-Protein Interactions in Mechanosensitive Channels
2004
Isolation of a clone coding for the alpha-subunit of a mouse acetylcholine receptor
1985
The exocytotic fusion pore.
1992
Primary structure of gamma subunit precursor of calf-muscle acetylcholine receptor deduced from the cDNA sequence
1984
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Molecular biology of the GABAA receptor: the receptor/channel superfamily
1987
A Family of AMPA-Selective Glutamate Receptors
1990 StandoutScienceNobel
Amphipathic analysis and possible formation of the ion channel in an acetylcholine receptor.
1984
Bacterial Mechanosensors
2017
The Cation−π Interaction
1997 Standout
Structural Determinants of Ion Flow Through Recombinant Glutamate Receptor Channels
1991 StandoutScienceNobel
Sodium Channel Activation Gating Is Affected by Substitutions of Voltage Sensor Positive Charges in All Four Domains
1997
Gating charge interactions with the S1 segment during activation of a Na + channel voltage sensor
2011
The structure of ion channels in membranes of excitable cells
1989
Location of functional regions of acetylcholine receptor α-subunit by site-directed mutagenesis
1985 Nature
A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties
1992 Science
Electrostatics and the Gating Pore of Shaker Potassium Channels
2001
Molecular anatomy and molecular design of channel proteins
1990
Cation-π Interactions in Chemistry and Biology: A New View of Benzene, Phe, Tyr, and Trp
1996 StandoutScience
Gating Current Noise Produced by Elementary Transitions in Shaker Potassium Channels
1994 Science
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
1998 StandoutScienceNobel
Cloning and sequence analysis of human genomic DNA encoding γ subunit precursor of muscle acetylcholine receptor
1985
Cyclic Nucleotide-Gated Ion Channels: An Extended Family With Diverse Functions
1996
Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating
1996 Science
Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL
2005
Mouse muscle nicotinic acetylcholine receptor γ subunit: cDNA sequence and gene expression
1986
Primary structure of delta subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence
1985
Structure of the VHL-ElonginC-ElonginB Complex: Implications for VHL Tumor Suppressor Function
1999 StandoutScienceNobel
The Voltage Sensor in Voltage-Dependent Ion Channels
2000
Hydrogen bonding between aromatics and cationic amino groups
1995
Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs.
1992
Role of acetylcholine receptor subunits in gating of the channel
1985 StandoutNatureNobel
Location of a δ-subunit region determining ion transport through the acetylcholine receptor channel
1986 StandoutNatureNobel
Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel
2014
Sequential formation of ion pairs during activation of a sodium channel voltage sensor
2009
Molecular Basis of Mechanotransduction in Living Cells
2001
Structure of the MscL Homolog from Mycobacterium tuberculosis : A Gated Mechanosensitive Ion Channel
1998 Science
A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K + Channels
1992 StandoutScienceNobel
Ion permeation and block of the gating pore in the voltage sensor of NaV1.4 channels with hypokalemic periodic paralysis mutations
2010
The cytoplasmic cage domain of the mechanosensitive channel MscS is a sensor of macromolecular crowding
2014
Feeling the hidden mechanical forces in lipid bilayer is an original sense
2014
Specificity of Charge-carrying Residues in the Voltage Sensor of Potassium Channels
2004
The structure of the voltage‐sensitive sodium channel
1985
A Mechanism for Ion Selectivity in Potassium Channels: Computational Studies of Cation-π Interactions
1993 Science
Gating of the Bacterial Sodium Channel, NaChBac
2004
Shaker potassium channel gating. II: Transitions in the activation pathway.
1994
Membrane Fusion
1992 Science
Amyloid β protein forms ion channels: implications for Alzheimer's disease pathophysiology
2001
Flip and Flop: A Cell-Specific Functional Switch in Glutamate-Operated Channels of the CNS
1990 StandoutScienceNobel
Asymmetric mechanosensitivity in a eukaryotic ion channel
2017
Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor α-subunit
1986 Nature
Gating prokaryotic mechanosensitive channels
2006
Assessment of Potential Stimuli for Mechano-Dependent Gating of MscL: Effects of Pressure, Tension, and Lipid Headgroups
2005
Structure and Function of Voltage-Sensitive Ion Channels
1988 Science
Primary structure of β subunit precursor of calf muscle acetylcholine receptor deduced from cDNA sequence
1984
Periodic perturbations in Shaker K + channel gating kinetics by deletions in the S3–S4 linker
2001
Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion
2015
A structural and dynamic molecular model for the sodium channel of Electrophoruselectricus
1985
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
1988 StandoutNatureNobel
Functional expression of a probable Arabidopsis thaliana potassium channel in Saccharomyces cerevisiae.
1992
Structure-based membrane dome mechanism for Piezo mechanosensitivity
2017 Nobel
Molecular biology of GABA A receptors
1990
Hydrophobicity of Amino Acid Residues in Globular Proteins
1985 Science
Cloning, sequencing and expression of cDNA for a novel subunit of acetylcholine receptor from calf muscle
1985 Nature
How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2
2015
Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels
1992 Science
Molecular distinction between fetal and adult forms of muscle acetylcholine receptor
1986 StandoutNatureNobel
Solution Structure of Methionine-Oxidized Amyloid β-Peptide (1−40). Does Oxidation Affect Conformational Switching?,
1998
Quaternary structure of the acetylcholine receptor
1985 Nature
Molecular Models of Voltage Sensing
2002
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.
1996
Structural basis for gating charge movement in the voltage sensor of a sodium channel
2011 StandoutNobel
Shaker potassium channel gating. I: Transitions near the open state.
1994
Works of H. Robert Guy being referenced
A family of putative Kir potassium channels in prokaryotes
2001
Models of the Structure and Voltage-Gating Mechanism of the Shaker K+ Channel
2004
A Model of Voltage Gating Developed Using the KvAP Channel Crystal Structure
2004
A Putative Prokaryote Voltage-Gated Ca2+ Channel with Only One 6TM Motif per Subunit
2001
Models of Voltage-Dependent Conformational Changes in NaChBac Channels
2008
Symmetry‐restrained molecular dynamics simulations improve homology models of potassium channels
2009
Models of the Structure and Gating Mechanisms of the Pore Domain of the NaChBac Ion Channel
2008
Pursuing the structure and function of voltage-gated channels
1990
Epitope Mapping of CCR5 Reveals Multiple Conformational States and Distinct but Overlapping Structures Involved in Chemokine and Coreceptor Function
1999
Theoretical models of the ion channel structure of amyloid beta-protein
1994
Structural Models of the MscL Gating Mechanism
2001
A large iris-like expansion of a mechanosensitive channel protein induced by membrane tension
2002
Structural models of TREK channels and their gating mechanism
2010
Atomic scale structure and functional models of voltage-gated potassium channels
1992
NMR structure of inactivation gates from mammalian voltage-dependent potassium channels
1997 Nature
Models of δ‐hemolysin membrane channels and crystal structures
1990
Analyzing the fusion process of influenza hemagglutinin by mutagenesis and molecular modeling
1992
Structural Models of the Transmembrane Region of Voltage-Gated and Other K+Channels in Open, Closed, and Inactivated Conformations
1998
The gating mechanism of the large mechanosensitive channel MscL
2001 Nature
Evolutionary Relationship between K+ Channels and Symporters
1999
Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1
2010
Synexin: Molecular Mechanism of Calcium‐Dependent Membrane Fusion and Voltage‐Dependent Calcium‐Channel Activity
1991
On the Conformation of the COOH-terminal Domain of the Large Mechanosensitive Channel MscL
2003
Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli.
1996
min K channels form by assembly of at least 14 subunits.
1995
The ion channel of the nicotinic acetylcholine receptor
1987
The S. cerevisiae outwardly-rectifying potassium channel (DUK1) identifies a new family of channels with duplicated pore domains.
1996
Structural models of the nicotinic acetylcholine receptor and its toxin-binding sites
1981
Molecular model of the action potential sodium channel.
1986
Amino acid side-chain partition energies and distribution of residues in soluble proteins
1985
Molecular genetics of the VDAC ion channel: Structural model and sequence analysis
1987
Similarities in Amino Acid Sequences of Drosophila eag and Cyclic Nucleotide-Gated Channels
1991 Science
A structural model of the acetylcholine receptor channel based on partition energy and helix packing calculations
1984