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Citing Papers
MHC-Restricted Cytotoxic T Cells: Studies on the Biological Role of Polymorphic Major Transplantation Antigens Determining T-Cell Restriction-Specificity, Function, and Responsiveness
1979 StandoutNobel
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
1992 StandoutNatureNobel
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage
1988 Nature
Positive selection of CD4-CD8+ T cells in the thymus of normal mice
1989 Nature
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
1989 Nature
The T cell receptor Vβ6 domain imparts reactivity to the Mls-1a antigen
1989
HLA frequencies in Black Zimbabweans
1990
Molecular and Cellular Events of T Cell Development
1989
A superantigen encoded in the open reading frame of the 3′ long terminal repeat of mouse mammary tumour virus
1991 Nature
An endogenous retrovirus mediating deletion of αβ T cells?
1991 Nature
The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens
1988 Nature
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
1992
Common West African HLA antigens are associated with protection from severe malaria
1991 StandoutNature
Deletion of self-reactive T cells before entry into the thymus medulla
1988 Nature
Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo
1989
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
1995 StandoutNatureNobel
Phenotypic differences between αβ versus β T-cell receptor transgenic mice undergoing negative selection
1989 Nature
Intrathymic deletion of self-reactive cells prevented by neonatal anti-CD4 antibody treatment
1988 Nature
Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells
1988 Nature
A maternally inherited superantigen encoded by a mammary tumour virus
1991 Nature
Does T-cell tolerance require a dedicated antigen-presenting cell?
1989 Nature
Thymic cortical epithelial cells lack full capacity for antigen presentation
1989 Nature
High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR
1989 Nature
Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35
1991
Self-tolerance alters T-cell receptor expression in an antigen-specific MHC restricted immune response
1988 Nature
bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
1991
Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic β cells
1988 Nature
Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex
1988 Nature
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
2003 StandoutNatureNobel
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes
1988 Nature
Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
1990
Positive and negative selection of an antigen receptor on T cells in transgenic mice
1988 Nature
Antigen-induced apoptosis in developing t cells: a mechanism for negative selection of the t cell receptor repertoire*
1989
The complexity of DRw6 and DR5 haplotypes in American blacks demonstrated by serology, cellular typing, and restriction fragment length polymorphism analysis
1990
Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes
1989 Nature
Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
1988 Nature
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice
1988 Nature
T-cell antigen receptor genes and T-cell recognition
1988 StandoutNature
Interleukin-2 production by tumor cells bypasses T helper function in the generation of an antitumor response
1990
Preferential expression of the T-cell receptor Vβ3 gene by Mlsc reactive T cells
1988 Nature
Crystal structure of an HIV-binding recombinant fragment of human CD4
1990 StandoutNatureNobel
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
1993 StandoutNatureNobel
Vβ-Specific Stimulation of Human T Cells by Staphylococcal Toxins
1989 Science
HLA-DR-DQ haplotypes defined by restriction fragment analysis
1987
Virus-induced autoantibody response to a transgenic viral antigen
1990 StandoutNatureNobel
Idiotypic Regulation of T Cells in Graft‐Versus‐Host Disease and Autoimmunity
1989
Induction of self-tolerance in mature peripheral B lymphocytes
1989 Nature
Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
1989
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
1992 StandoutNatureNobel
Spinning molecular immunology into successful immunotherapy
2002
T-Cell Recognition of Minor Lymphocyte Stimulating (MLS) Gene Products
1989
Towards an integrated view of thymopoiesis
1991
HLA‐A, B, C, DR and DQ polymorphisms in three South African population groups: South African Negroes, Cape Coloureds and South African Caucasoids
1988
Distinct antigen receptor repertoires of two classes of murine epithelium-associated T cells
1989 StandoutNatureNobel
Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities
1990 Nature
HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
1987 StandoutNature
Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs
1990
The Vβ-specific superantigen staphylococcal enterotoxin B: Stimulation of mature T cells and clonal deletion in neonatal mice
1989
Genes encoding ligands for deletion of Vβ11 T cells cosegregate with mammary tumour virus genomes
1991 Nature
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
1991 Nature
Mls and Tolerance
1989
Extrathymic positive selection of αβ T-cell precursors in nude mice
1992 StandoutNatureNobel
Deletion of Mls‐reactive T cells in H‐2‐compatible but Mls‐incompatible bone marrow chimeras
1989
Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures
1989 Nature
T‐Cell Responses to Mls and to Bacterial Proteins that Mimic its Behavior#
1989
T‐Cell Responses and Tolerance to Mlsa Determinants
1989
Clonal anergy induced in mature Vβ6+ T lymphocytes on immunizing Mls-1b mice with Mls-1a expressing cells
1989 Nature
Virus-specific CD8+ T-cell memory determined by clonal burst size
1994 StandoutNatureNobel
Hybrid H-2 histocompatibility gene products assign domains recognized by alloreactive T cells.
1983
Immunological Surveillance of Tumors in the Context of Major Histocompatibility Complex Restriction of T Cell Function
1984 StandoutNobel
The Staphylococcal Enterotoxins and Their Relatives
1990 StandoutScience
Genes of the Major Histocompatibility Complex in Mouse and Man
1983 Science
Expression of murine interleukin 7 in a murine glioma cell line results in reduced tumorigenicity in vivo.
1992 StandoutNobel
Peripheral Selection of the T Cell Repertoire
1991 Science
A Nondeletional Mechanism of Thymic Self Tolerance
1989 StandoutScienceNobel
Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma.
1982
Expression in transgenic mice of class I histocompatibility antigens controlled by the metallothionein promoter.
1989 StandoutNobel
Interaction of Staphylococcus aureus toxin "superantigens" with human T cells.
1989
Abrogation of metastatic properties of tumour cells by de novo expression of H–2K antigens following H–2 gene transfection
1985 Nature
A role for E2F1 in the induction of ARF, p53, and apoptosis during thymic negative selection.
1999
Immunological tolerance: new approaches using transgenic mice
1989 StandoutNobel
H‐2 associated resistance to leukaemia transplantation: Natural killing in vivo
1980
Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction.
1975
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Cell Cycle Control and Cancer
1994 StandoutScienceNobel
Programmed death of autoreactive thymocytes
1990 Nature
The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens.
1986
GENETIC CONTROL OF SURVIVAL IN EPIDEMICS
1979
Surface antigen changes occurring in short-term cultures of activated human T lymphocytes: Analysis by flow cytometry
1982
Expression of a Microinjected Porcine Class I Major Histocompatibility Complex Gene in Transgenic Mice
1985 StandoutScienceNobel
Molecular cloning of lymphadenopathy-associated virus
1984 StandoutNatureNobel
Absence of H-2 restriction in primary and secondary mixed-lymphocyte reactions to strong M1s determinants.
1980
Thymic Requirement for Clonal Deletion During T Cell Development
1989 Science
Distinct features of dendritic cells and anti-Ig activated B cells as stimulators of the primary mixed leukocyte reaction.
1989 StandoutNobel
Generation of both cross-reactive and virus-specific T-cell populations after immunization with serologically distinct influenza A viruses.
1977 StandoutNobel
Specific suppressor cells in graft–host tolerance of HLA-identical marrow transplantation
1981 StandoutNatureNobel
Serum β2-microglobulin binds to a T-cell differentiation antigen and increases its expression
1984 StandoutNatureNobel
Peripheral Clonal Elimination of Functional T Cells
1990 Science
Unusual organization and diversity of T-cell receptor a-chain genes
1985 StandoutNatureNobel
Functional expression of a microinjected Edα gene in C57BL/6 transgenic mice
1985 StandoutNatureNobel
Bacterial toxins as probes for the T-cell antigen receptor
1989
The Yin and Yang of T Cell Costimulation
1995 StandoutScienceNobel
Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes
1984 StandoutScienceNobel
Sensitization of lymphocytes against pooled allogeneic cells. I. Generation of cytotoxicity against autologous human lymphoblastoid cell lines.
1978
Normal Development of Mice Deficient in β 2 M, MCClass I Proteins, and CD8 + T Cells
1990 StandoutScienceNobel
Seppuku and Autoimmunity
1992 StandoutScienceNobel
In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression.
1994
The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.
1983
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
Maintenance of in Vivo Tolerance by Persistence of Antigen
1992 StandoutScienceNobel
Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse
1984 Nature
The Role of the T Cell Receptor in Positive and Negative Selection of Developing T Cells
1990 Science
The Involvement of Activated Specific Suppressor T Cells in Maintenance of Transplantation Tolerance
1979
The structure of a mutant H–2 gene suggests that the generation of polymorphism in H–2 genes may occur by gene conversion-like events
1983 Nature
Failure of T Cell Receptor V β Negative Selection in an Athymic Environment
1989 Science
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
Major Histocompatibility Complex Restricted Cell-Mediated Immunity
1978
Altered transcription of genes coding for class I histocompatibility antigens in murine tumor cells.
1983
T Cells with Multiple Specificities
1986
T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages.
1990
A third T-cell receptor beta-chain variable region gene encodes reactivity to Mls-1a gene products.
1989
Enhancement of Antitumor Immunity by CTLA-4 Blockade
1996 StandoutScienceNobel
Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells
1992 StandoutScienceNobel
The MIs system
1988
Intrathymic and Extrathymic T Cell Maturation
1978
Tolerance in transgenic mice expressing class II major histocompatibility complex on pancreatic acinar cells.
1989
Immunologic Tolerance: Collaboration Between Antigen and Lymphokines
1989 Science
Apoptosis in AIDS
1993 StandoutScienceNobel
Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy
1986 StandoutNature
Linkage of Mls genes to endogenous mammary tumour viruses of inbred mice
1991 Nature
Migration Inhibition of Endothelial Cells by Lymphokine-Containing Supernatants
1982 StandoutScienceNobel
Induction by Antigen of Intrathymic Apoptosis of CD4 + CD8 + TCR lo Thymocytes in Vivo
1990 StandoutScience
Contrasting evolutionary histories among tightly linked HLA loci.
1986
Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells
1983 Nature
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
1985 StandoutNatureNobel
MHC imbalance and metastatic spread in Lewis lung carcinoma clones
1983
H–2 Antigens on a murine lymphoma are associated with additional proteins
1978 StandoutNatureNobel
Differential T Cell Costimulatory Requirements in CD28-Deficient Mice
1993 Science
Expression of complete transplantation antigens by mammalian cells transformed with truncated class I genes
1983 Nature
Biological significance of alloreactivity: T cells stimulated by Sendai virus-coated syngeneic cells specifically lyse allogeneic target cells.
1978 StandoutNobel
H–2 gene expression is required for T cell-mediated lysis of virus-infected target cells
1977 StandoutNatureNobel
Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens
1994 Science
An analysis of T-cell receptor variable region gene expression in major histocompatibility complex disparate mice.
1988
Works of H. Festenstein being referenced
T CELLS DEFINE NEW ALLOANTIGENS CONTROLLED BY A GENE(S) IN THE Mls REGION ON MOUSE CHROMOSOME 1
1988
T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens
1988 Nature
BALB.D2-Mlsa-A new congenic mouse strain
1984
Soluble Mlsa antigens: Stimulatory effect in vitro versus suppressive effect in vivo
1984
4a(W4) and 4b(W6) human histocompatibility antigens are specifically associated with complement receptors
1975 Nature
Variation in MHC Antigenic Profiles of Tumor Cells and its Biological Effects
1981
STUDIES ON H‐2 SPECIFICITIES ON MOUSE TUMOUR CELLS BY A NEW MICRORADIOASSAY*
1977
Location ofMls locus on mouse chromosome 1
1977
New HLA DNA polymorphisms associated with autoimmune diseases
1986 Nature
INCOMPATIBILITY FOR OR PRE‐IMMUNIZATION AGAINST M1s DETERMINANTS DECREASES LETHAL GRAFT‐VERSUS‐HOST REACTION DEVELOPED ACROSS NON ‐ H ‐ 2 AND/OR H‐2 BARRIERS
1981
H–2-like specificities of foreign haplotypes appearing on a mouse sarcoma after vaccinia virus infection
1976 Nature
Histocompatibility effects of mls locus.
1983
Interspecies exchange of β 2-microglobulin and associated MHC and differentiation antigens
1981
DETECTION OF A GRAFT-VERSUS-HOST REACTION BETWEEN MICE COMPATIBLE AT THE H-2 LOCUS1
1973
Dominant allele-specific regulation of expression of H-2Kk gene products revealed by somatic cell hybridization
1982
Loss of H-2Kk gene product(s) from an AKR spontaneous leukaemia
1979
HLA-DR genotyping by restriction fragment length polymorphism analyses
1985
A THYMIC ORIGIN FOR SOME PERIPHERAL-BLOOD LYMPHOCYTES
1968
GENERATION OF SUPPRESSOR CELLS IN MICE IMMUNIZED WITH M LOCUS-INCOMPATIBLE LYMPHOCYTES
1977
Rejection of transplantable AKR leukaemia cells following MHC DNA-mediated cell transformation
1984 Nature
HLA polymorphisms in Nigerians
1985
Specific lymphocyte-activating determinants expressed on mouse macrophages
1975 Nature
THE GENETIC BASIS OF ANTIGENIC STRENGTH IN HEART AND SKIN ALLOGRAFTING
1975
IMMUNOGENETIC STUDIES ON METH‐A‐VACCINIA TUMOUR CELLS IN VIVO AND IN VITRO*
1977
Variation of expression of histocompatibility antigens on tumor cells: absence of H-2Kk-gene products from a gross-virus-induced leukemia in BALB.K
1981
Strong histocompatibility and cell‐mediated cytotoxic effects of a single Mls difference demonstrated using a new congenic mouse strain
1983
HLA polymorphisms in a Shanghai Chinese population
1984
ANTIGENIC STRENGTH INVESTIGATED BY MIXED CULTURES OF ALLOGENEIC MOUSE SPLEEN CELLS
1966
MOUSE PERIPHERAL-BLOOD LYMPHOCYTES IN CULTURE
1968
Further evidence for derepression of H–2 and Ia-like specificities of foreign haplotypes in mouse tumour cell lines
1976 Nature
Resistance to cell-mediated cytotoxicity is correlated with reduction of H-2K gene products in AKR leukemia
1982
Expression of marine H–2Kb histocompatibility antigen in cells transformed with cloned H–2 genes
1982 Nature
HLA-DRα, -DXα, and DRβIII gene association studies in DR3 individuals
1987
Antigenic strength investigated by cell‐mediated lympholysis in mice
1973
Emergence of Foreign H‐2‐Like Cytotoxicity and Transplantation Targets on Vaccinia and Moloney Virus‐Infected Meth. A Tumour Cells
1977
Precursor and effector phenotypes of activated human T lymphocytes
1980 Nature