Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
The Alzheimer's disease–protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool
2017
Oxidized BAL fluid proteins in patients with interstitial lung diseases
1996
Degradation in vivo of articular cartilage in rheumatoid arthritis and juvenile chronic arthritis by cathepsin G and elastase from polymorphonuclear leukocytes
1987
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.
1987
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
GcGlobulin Functions as a Cochemotaxin in the Lower Respiratory Tract: A Potential Mechanism for Lung Neutrophil Recruitment in Cigarette Smokers
1991
Nucleotides released by apoptotic cells act as a find-me signal to promote phagocytic clearance
2009 StandoutNature
Circulating mitochondrial DAMPs cause inflammatory responses to injury
2010 StandoutNature
Aortic dissection in pregnancy: analysis of risk factors and outcome
2003
α1-antitrypsin deficiency
2005
Oxidants in Cigarette Smoke Radicals, Hydrogen Peroxide, Peroxynitrate, and Peroxynitritea
1993 Standout
Phagocytes and oxidative stress
2000
Necroptosis and its role in inflammation
2015 StandoutNature
Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease
2010 Standout
Uterocalin: A mouse acute phase protein expressed in the uterus around birth
1997
Systemic inflammation in chronic obstructive pulmonary disease
2003
Smoke Extract Stimulates Lung Epithelial Cells to Release Neutrophil and Monocyte Chemotactic Activity
1998
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
Aqueous cigarette tar extracts damage human alpha-1-proteinase inhibitor
1991
Animal models of chronic obstructive pulmonary disease
2008
The Body-Mass Index, Airflow Obstruction, Dyspnea, and Exercise Capacity Index in Chronic Obstructive Pulmonary Disease
2004 Standout
Genetic Ablation of the Aryl Hydrocarbon Receptor Causes Cigarette Smoke-induced Mitochondrial Dysfunction and Apoptosis
2011
The N-formyl peptide receptor: A model for the study of chemoattractant receptor structure and function
1997
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
1993 Standout
Hallmarks of aging: An expanding universe
2023 Standout
Percutaneous Repair or Surgery for Mitral Regurgitation
2011 Standout
Molecular basis of human hypertension: Role of angiotensinogen
1992 Standout
Tissue Destruction by Neutrophils
1989 Standout
Nicotine prevents a reduction in neutrophil filterability induced by cigarette smoke exposure.
1994
Ascorbic acid neutralizes reactive oxidants released by hyperactive phagocytes from cigarette smokers
1988
Oxidative Stress in Pathogenesis of Chronic Obstructive Pulmonary Disease: Cellular and Molecular Mechanisms
2005
Current smoking of elderly men reduces antioxidants in alveolar macrophages.
1994
Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.
1988
Nonresolving Inflammation
2010 Standout
Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase.
1987
Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis
2001 Standout
A Role of Mixed‐Function Oxidation Reactions in the Accumulation of Altered Enzyme Forms During Aging
1987
N-Formyl Peptide Receptors Internalize but Do Not Recycle in the Absence of Arrestins
2003 StandoutNobel
Constitutive Protease-activated Receptor-2-mediated Migration of MDA MB-231 Breast Cancer Cells Requires Both β-Arrestin-1 and -2
2004 StandoutNobel
Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation
2009 Standout
Cigarette smoke elicits leukocyte adhesion to endothelium in hamsters: Inhibition by CuZn-SOD
1993
Human platelets exhibit chemotaxis using functional N-formyl peptide receptors
2005
How dying cells alert the immune system to danger
2008
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
2003 Standout
Mediators of Chronic Obstructive Pulmonary Disease
2004
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron
2004 StandoutNature
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
2004 Standout
Mitochondria in the Regulation of Innate and Adaptive Immunity
2015
Chronic Obstructive Pulmonary Disease: Risk Factors, Pathophysiology and Pathogenesis
1989
Atherosclerosis — An Inflammatory Disease
1999 Standout
Origin and physiological roles of inflammation
2008 StandoutNature
Emerging role of damage-associated molecular patterns derived from mitochondria in inflammation
2011
The Role of Oxidative Stress in the Pathogenesis??of COPD
2005
Cigarette smoke inhibits lung fibroblast proliferation and chemotaxis.
1995
Expression of the CD11/CD18 Cell Surface Adhesion Glycoprotein Family on Alveolar Macrophages in Smokers and Nonsmokers
1991
Dietary Vitamin C Intake and Concentrations in the Body Fluids and Cells of Male Smokers and Nonsmokers
1992
Effect of subchronic administration of antioxidants against cigarette smoke exposure in rats
1993
Acute effects of cigarette smoke on inflammation and oxidative stress: a review
2004
Points of control in inflammation
2002 StandoutNature
Glutathione in bronchoalveolar lavage fluid from smokers is related to humoral markers of inflammatory cell activity
1989
The Nature of Small-Airway Obstruction in Chronic Obstructive Pulmonary Disease
2004 Standout
Conversion of Proepithelin to Epithelins
2002
The Role of Oxidative Stress in Chronic Obstructive Pulmonary Disease
2004
Cigarette Smoking and Oxidative Damage in the Lunga
1993
Neutrophils and the Pathogenesis of COPD
2002
Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells.
1997
Degradation of a Mutant Secretory Protein, α1-Antitrypsin Z, in the Endoplasmic Reticulum Requires Proteasome Activity
1996 StandoutNobel
Role of oxidants/antioxidants in smoking-induced lung diseases
1996
Homocysteine and Atherothrombosis
1998 Standout
The inhibitory effect of extracts of cigarette tar on electron transport of mitochondria and submitochondrial particles
1992
Nicotine prolongs neutrophil survival by suppressing apoptosis
1996
Inactivation of α 1 -Proteinase Inhibitor by Alveolar Inflammatory Cells from Smoking Patients with or without Emphysema
1993
Human mitochondria-derivedN-formylated peptides are novel agonists equally active on FPR and FPRL1, whileListeria monocytogenes-derived peptides preferentially activate FPR
2005
Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
1997
Chronic obstructive pulmonary disease: molecular and cellularmechanisms
2003
Evaluation of Elastase and Antielastase Balance in Patients with Chronic Bronchitis and Pulmonary Emphysema
1990
Immunogenic cell death and DAMPs in cancer therapy
2012 Standout
Oxidative Stress in Chronic Obstructive Pulmonary Disease
1997 Standout
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease
2012 Standout
Oxidants, antioxidants, and the degenerative diseases of aging.
1993 Standout
Oxidative inactivation of leukotriene C 4 by stimulated human polymorphonuclear leukocytes
1982 StandoutNobel
Protein Oxidation and Aging
1992 StandoutScience
Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.
1983
In vivo damage of rat lungs by oxygen metabolites.
1981
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Lower levels of vitamin C and carotenes in plasma of cigarette smokers.
1986
Erythrocytes prevent inactivation of alpha 1-antitrypsin by cigarette smoke
1991
Replacement Therapy for Alpha1-Antitrypsin Deficiency Associated with Emphysema
1987
Tissue injury in inflammation. Oxidants, proteinases, and cationic proteins.
1987
Proteolytic cleavage and inactivation of alpha 2-plasmin inhibitor and C1 inactivator by human polymorphonuclear leukocyte elastase.
1982
Shock and Tissue Injury Induced by Recombinant Human Cachectin
1986 StandoutScienceNobel
Free Radicals as Mediators of Tissue Injury
1991
Mitochondria—Striking a balance between host and endosymbiont
2019 Science
Neutrophils in Human Diseases
1987
Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties.
1988 StandoutNobel
Chemotactic Factor Inactivation by the Myeloperoxidase-Hydrogen Peroxide-Halide System
1979
Functional α 1 -Protease Inhibitor in the Lower Respiratory Tract of Cigarette Smokers Is Not Decreased
1983 Science
Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation.
1983 Standout
The inactivation of α-1-proteinase inhibitor by gas-phase cigarette smoke: Protection by antioxidants and reducing species
1986
Immune and inflammatory function in cigarette smokers.
1987
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2
1997 StandoutNobel
Effects of the myeloperoxidase system on fluorescent probes of granulocyte membrane potential.
1981
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response.
1981 StandoutNobel
ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
2006 Standout
Mitochondrial Transcription Factor A Serves as a Danger Signal by Augmenting Plasmacytoid Dendritic Cell Responses to DNA
2012
Increased oxidized methionine residues in BAL fluid proteins in acute or chronic bronchitis
1992
Oxidative regulation of neutrophil elastase-alpha-1-proteinase inhibitor interactions.
1986
Free-radical chemistry of cigarette smoke and its toxicological implications.
1985
Airways Obstruction and the Risk for Lung Cancer
1987
Oxygen Radicals and Human Disease
1987 Standout
Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?
1983 StandoutScienceNobel
Synthesis in E. coli of α1-antitrypsin variants of therapeutic potential for emphysema and thrombosis
1985 Nature
Neutrophils degrade subendothelial matrices in the presence of alpha-1-proteinase inhibitor. Cooperative use of lysosomal proteinases and oxygen metabolites.
1984
Cloning and characterization of a functional human homolog of Escherichia coli endonuclease III
1997 StandoutNobel
Degradation of human glomerular basement membrane by stimulated neutrophils. Activation of a metalloproteinase(s) by reactive oxygen metabolites.
1987
The Inflammatory Response to Cell Death
2008
The antioxidant action of human extracellular fluids. Effect of human serum and its protein components on the inactivation of α1-antiproteinase by hypochlorous acid and by hydrogen peroxide
1987
Human bronchial leucocyte proteinase inhibitor. Rapid isolation and kinetic analysis with human leucocyte proteinases
1985
Cigarette smoke impairs elastin resynthesis in lungs of hamsters with elastase-induced emphysema.
1985
Interactions of granulocytes with the lungs.
1984
Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization.
1988
Deficiency of vitamin E in the alveolar fluid of cigarette smokers. Influence on alveolar macrophage cytotoxicity.
1986
Inactivation of human α-1-proteinase inhibitor by gas-phase cigarette smoke
1984
Pathogenesis of the adult respiratory distress syndrome. Evidence of oxidant activity in bronchoalveolar lavage fluid.
1983
The 2.5 A X-ray crystal structure of the acid-stable proteinase inhibitor from human mucous secretions analysed in its complex with bovine alpha-chymotrypsin.
1988 StandoutNobel
2008 Focused Update Incorporated Into the ACC/AHA 2006 Guidelines for the Management of Patients With Valvular Heart Disease
2008 Standout
Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line
2001
Myeloperoxidase-catalyzed inactivation of alpha 1-protease inhibitor by human neutrophils.
1981
alpha 1-Antitrypsin: molecular pathology, leukocytes, and tissue damage.
1986
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions.
1982
Cartilage degradation by polymorphonuclear leucocytes: in vitro assessment of the pathogenic mechanisms.
1993
Mechanisms of cigarette smoke toxicity: the inactivation of human α-1-proteinase inhibitor by nitric oxide/isoprene mixtures in air
1985
Extracellular Release of Hydrogen Peroxide by Human Alveolar Macrophages: The Relationship to Cigarette Smoking and Lower Respiratory Tract Infections
1983
Works of H. Carp being referenced
Possible Mechanisms Of Emphysema in Smokers
2015
Pregnancy complicated by aortic dissection: caesarean delivery during extradural anaesthesia
1995
Lung injury induced by leukocytic proteases.
1979
Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro.
1977
Inactivation of Bronchial Mucous Proteinase Inhibitor by Cigarette Smoke and Phagocyte-Derived Oxidants
1980
Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.
1982
Mitochondrial N-formylmethionyl proteins as chemoattractants for neutrophils.
1982
In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes.
1979
Potential Mediator of Inflammation
1980
Human methionine sulfoxide-peptide reductase, an enzyme capable of reactivating oxidized alpha-1-proteinase inhibitor in vitro.
1983
The role of oxidative processes in emphysema.
1983
Proteases, antiproteases, and oxidants: pathways of tissue injury during inflammation.
1982
Cigarette Smoke Inhalation Decreases α 1 -Antitrypsin Activity in Rat Lung
1979 Science
INACTIVATION OF ALPHA1-PROTEINASE INHIBITOR AND BRONCHIAL MUCOUS PROTEINASE INHIBITOR BY CIGARETTE SMOKE IN VITRO AND IN VIVO
1981
Possible mechanisms of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidants.
1978