Citation Impact
Citing Papers
Nuclear Accumulation of p21 Cip1 at the Onset of Mitosis: a Role at the G 2 /M-Phase Transition
1998
DDB, a Putative DNA Repair Protein, Can Function as a Transcriptional Partner of E2F1
1998
Hallmarks of Cancer: The Next Generation
2011 Standout
CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation
2008
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
The DNA-damage response in human biology and disease
2009 StandoutNature
Tumour suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
1995
From molecular to modular cell biology
1999 StandoutNatureNobel
CDK inhibitors: positive and negative regulators of G1-phase progression
1999 Standout
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
1999
p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase
1995 StandoutNobel
p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damage
2003
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
2005 StandoutNature
Osteoblastic cells regulate the haematopoietic stem cell niche
2003 StandoutNature
p16INK4a inactivation is not required to immortalize human mammary epithelial cells
2002
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 StandoutNature
p21Cip1 Promotes Cyclin D1 Nuclear Accumulation via Direct Inhibition of Nuclear Export
2002
Recognition and repair of the cyclobutane thymine dimer, a major cause of skin cancers, by the human excision nuclease
2003 StandoutNobel
Genes Expressed in Neurons of Adult Male Drosophila
1997 StandoutNobel
Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNAs encoding related sex-specific polypeptides
1989
Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein
2002
A DNA damage checkpoint response in telomere-initiated senescence
2003 StandoutNature
UV radiation-induced XPC translocation within chromatin is mediated by damaged-DNA binding protein, DDB2
2004
p16INK4a induces an age-dependent decline in islet regenerative potential
2006 Nature
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
Accumulation of senescent cells in mitotic tissue of aging primates
2006
Forging a signature of in vivo senescence
2015
Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions
2004
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
2005
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
RNA travel: Tracks from DNA to cytoplasm
1993 StandoutNobel
Caspase-mediated cleavage of p21Waf1/Cip1 converts cancer cells from growth arrest to undergoing apoptosis
1999
Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions
2001
p21 in cancer: intricate networks and multiple activities
2009 Standout
The emerging roles of forkhead box (Fox) proteins in cancer
2007
Protection of mammalian telomeres
2002
Expression Profiles of p53-, p16INK4a-, and Telomere-Regulating Genes in Replicative Senescent Primary Human, Mouse, and Chicken Fibroblast Cells
2002
Tumor suppression by p27Kip1 and p21Cip1 during chemically induced skin carcinogenesis
1999
Tumor-prone phenotype of the DDB2-deficient mice
2004
p21WAF1/Cip1: more than a break to the cell cycle?
2000
A Mouse Model of Accelerated Liver Aging Caused by a Defect in DNA Repair
2011
The essence of senescence: Figure 1.
2010 Standout
Enhanced Growth of Mice Lacking the Cyclin-Dependent Kinase Inhibitor Function of p27
1996
Potent Prostaglandin A1 Analogs That Suppress Tumor Cell Growth through Induction of p21 and Reduction of Cyclin E
1998 StandoutNobel
Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
2011
Microarray analysis of replicative senescence
1999
Historical claims and current interpretations of replicative aging
2002
Human cells deficient in p53 regulated p21waf1/cip1 expression exhibit normal nucleotide excision repair of UV-induced DNA damage
2002
Oncogenic functions of tumour suppressor p21Waf1/Cip1/Sdi1: association with cell senescence and tumour-promoting activities of stromal fibroblasts
2002
A 39 Amino Acid Fragment of the Cell Cycle Regulator p21 Is Sufficient to Bind PCNA and Partially Inhibit DNA Replication in vivo
1996
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
2002
DDB Accumulates at DNA Damage Sites Immediately after UV Irradiation and Directly Stimulates Nucleotide Excision Repair
2002 StandoutNobel
p21waf1/cip1-null human fibroblasts are deficient in nucleotide excision repair downstream the recruitment of PCNA to DNA repair sites
2001
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
1996 StandoutNobel
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Mechanism of Inhibition of Proliferating Cell Nuclear Antigen-Dependent DNA Synthesis by the Cyclin-Dependent Kinase Inhibitor p21
1995
Senescence and immortalization: role of telomeres and telomerase
2004
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
2004
Inhibitors of mammalian G1 cyclin-dependent kinases.
1995 Standout
The role of senescent cells in ageing
2014 StandoutNature
p16INK4A is a robust in vivo biomarker of cellular aging in human skin
2006
Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts
1996
The Hallmarks of Aging
2013 Standout
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
2003
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Nucleotide Excision Repair
2005 StandoutNobel
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
DNA damage response and cellular senescence in tissues of aging mice
2009
A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
2002
The Regulation of INK4/ARF in Cancer and Aging
2006
DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?
2007
Cellular senescence and cancer
1999
Feedback between p21 and reactive oxygen production is necessary for cell senescence
2010
Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1
2000 Science
Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication
1998
Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells.
2003
Control of the Replicative Life Span of Human Fibroblasts by p16 and the Polycomb Protein Bmi-1
2002
Identification of a Cyclin-cdk2 Recognition Motif Present in Substrates and p21-Like Cyclin-Dependent Kinase Inhibitors
1996 StandoutNobel
Anti-cancer-prostaglandin-induced cell-cycle arrest and its modulation by an inhibitor of the ATP-dependent glutathione S-conjugate export pump (GS-X pump)
1998 StandoutNobel
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Effects of p21Waf1/Cip1/Sdi1on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases
2000
Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts
2001
p107 uses a p21CIP1-related domain to bind cyclin/cdk2 and regulate interactions with E2F.
1995
Aging, Cellular Senescence, and Cancer
2012 Standout
The Naturally Occurring Mutants of DDB Are Impaired in Stimulating Nuclear Import of the p125 Subunit and E2F1-Activated Transcription
1999
Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation
2005
Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion
2000
Cancer Cell Cycles
1996 StandoutScience
Cyclin-Binding Motifs Are Essential for the Function of p21CIP1
1996
Anchorage-Dependent Transcription of the Cyclin A Gene
1996
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
Nucleotide Excision Repair from Site-Specifically Platinum-Modified Nucleosomes
2003 StandoutNobel
The Xeroderma Pigmentosum Group E Gene Product DDB2 Activates Nucleotide Excision Repair by Regulating the Level of p21Waf1/Cip1
2007
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
1998 StandoutScience
Repression of p27kip1 Synthesis by Platelet-Derived Growth Factor in BALB/c 3T3 Cells
1996
Integrin Signaling
1999 StandoutScience
Control of skin cancer by the circadian rhythm
2011 StandoutNobel
Four faces of cellular senescence
2011 Standout
A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells.
1996
CYCLIN-DEPENDENT KINASES: Engines, Clocks, and Microprocessors
1997 Standout
Regulation of a Senescence Checkpoint Response by the E2F1 Transcription Factor and p14ARF Tumor Suppressor
2000
Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− mice
2000
cis -Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects
2008 StandoutNobel
The Accumulation of an E2F-p130 Transcriptional Repressor Distinguishes a G0 Cell State From a G1 Cell State
1996
Posttranslational Modifications of p53 in Replicative Senescence Overlapping but Distinct from Those Induced by DNA Damage
2000
The signals and pathways activating cellular senescence
2004
C/EBPα Regulates Formation of S-Phase-Specific E2F-p107 Complexes in Livers of Newborn Mice
1999
Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins
1991
p21WAF1/CIP1 Selectively Controls the Transcriptional Activity of Estrogen Receptor α
2005
Splicing precedes polyadenylation during Drosophila E74A transcription.
1990
Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.
1994 StandoutNobel
When repair meets chromatin
2002
Splicing Precedes Polyadenylation during Drosophila E74A Transcription
1990
p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex.
1996
Inactivation of G2 checkpoint function and chromosomal destabilization are linked in human fibroblasts expressing human papillomavirus type 16 E6.
1997
High rate of CAD gene amplification in human cells deficient in MLH1 or MSH6
2001 StandoutNobel
Dual roles of ATM in the cellular response to radiation and in cell growth control.
1996 Nobel
Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
2003
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Xeroderma Pigmentosum Complementation Group E Protein (XPE/DDB2): Purification of Various Complexes of XPE and Analyses of Their Damaged DNA Binding and Putative DNA Repair Properties
2005 StandoutNobel
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
2012 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
The human Rad9–Rad1–Hus1 checkpoint complex stimulates flap endonuclease 1
2004 StandoutNobel
New functional activities for the p21 family of CDK inhibitors.
1997
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
DNA damage is able to induce senescence in tumor cells in vitro and in vivo.
2002
Infection of primary cells by adeno-associated virus type 2 results in a modulation of cell cycle-regulating proteins
1997 StandoutNobel
Works of Guy R. Adami being referenced
Site-Directed Mutant p21 Proteins Defective in Both Inhibition of E2F-Regulated Transcription and Disruption of E2F-pl30-Cyclin-cdk2 Complexes
1998
Modification of the ATM/ATR directed DNA damage response state with aging and long after hepatocyte senescence induction in vivo
2008
The p48 subunit of the damaged-DNA binding protein DDB associates with the CBP/p300 family of histone acetyltransferase
2001
Increased Hepatic Forkhead Box M1B (FoxM1B) Levels in Old-aged Mice Stimulated Liver Regeneration through Diminished p27Kip1 Protein Levels and Increased Cdc25B Expression
2002
Splice site selection dominates over poly(A) site choice in RNA production from complex adenovirus transcription units.
1988
Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
1998
Identification of the active region of the DNA synthesis inhibitory gene p21Sdi1/CIP1/WAF1.
1995
The efficiency of adenovirus transformation of rodent cells is inversely related to the rate of viral E1A gene expression
1990
Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.
1995
Misregulated expression of the cyclin dependent kinase 2 protein in human fibroblasts is accompanied by the inability to maintain a G2 arrest following DNA damage.
1995
p21 Disrupts the Interaction between cdk2 and the E2F-p130 Complex
1996