Citation Impact
Citing Papers
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809
2011
Structure of the human epithelial sodium channel by cryo-electron microscopy
2018
Leu85 in the β1-β2 Linker of ASIC1 Slows Activation and Decreases the Apparent Proton Affinity by Stabilizing a Closed Conformation
2010
Contribution of Residues in Second Transmembrane Domain of ASIC1a Protein to Ion Selectivity
2012
Hallmarks of Cancer: The Next Generation
2011 Standout
Purification and Characterization of Recombinant Cystic Fibrosis Transmembrane Conductance Regulator from Chinese Hamster Ovary and Insect Cells
1995
Purification and functional reconstitution of the cystic fibrosis transmembrane conductance regulator (CFTR)
1992
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
Reversal of acid‐induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2
2010
A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel
2010
Epithelial Sodium Channel Pore Region
2001
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Lumacaftor–Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508delCFTR
2015 Standout
The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior
2009
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel
2014 StandoutNobel
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
2007 StandoutNatureNobel
A family of candidate taste receptors in human and mouse
2000 StandoutNatureNobel
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Acid-sensing Ion Channels in Sensory Perception
2007
Capsaicin, protons and heat: new excitement about nociceptors
1999
Generation and characterization of a ΔF508 cystic fibrosis mouse model
1995 StandoutNobel
Effects of the ?F508 mutation on the structure, function, and folding of the first nucleotide-binding domain of CFTR
1993
Neuropeptide FF and FMRFamide Potentiate Acid-Evoked Currents from Sensory Neurons and Proton-Gated DEG/ENaC Channels
2000
Rescue of ΔF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules
2006
The Interaction between Two Extracellular Linker Regions Controls Sustained Opening of Acid-sensing Ion Channel 1
2011
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
A Modulatory Subunit of Acid Sensing Ion Channels in Brain and Dorsal Root Ganglion Cells
1997
Asn415 in the β11-β12 Linker Decreases Proton-dependent Desensitization of ASIC1
2010
Acid-Sensing Ion Channels (ASICs): Pharmacology and implication in pain
2010
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
1992 Nature
Mutations in the Epithelial Na+ Channel ENaC Outer Pore Disrupt Amiloride Block by Increasing Its Dissociation Rate
2003
Regulation of Caenorhabditis elegans degenerin proteins by a putative extracellular domain
1995 StandoutNobel
A Pore Segment in DEG/ENaC Na+ Channels
1999
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
1998 StandoutNobel
The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation
2009
An Intracellular Trafficking Defect in Type I Cystinuria rBAT Mutants M467T and M467K
1997
Characterization of Acid-sensing Ion Channels in Dorsal Horn Neurons of Rat Spinal Cord
2004
Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
1994 StandoutNatureNobel
Black mamba venom peptides target acid-sensing ion channels to abolish pain
2012 Nature
Receptor-targeting mechanisms of pain-causing toxins: How ow?
2012 StandoutNobel
Sensory Functions for Degenerin/Epithelial Sodium Channels (DEG/ENaC)
2011
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Necrotic death as a cell fate
2006
Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis
1993
A novel mechanosensitive channel identified in sensory neurons
2006
A mutated acetylcholine receptor subunit causes neuronal degeneration in C. elegans
1995 StandoutNobel
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice
2006
The mammalian sodium channel BNC1 is required for normal touch sensation
2000 Nature
Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels
2013
Mislocalization of ΔF508 CFTR in cystic fibrosis sweat gland
1992
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits
1994 StandoutNature
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
The cystic fibrosis mutation (ΔF508) does not influence the chloride channel activity of CFTR
1993
Tarantulas: eight-legged pharmacists and combinatorial chemists
2004
The Nematode Degenerin UNC-105 Forms Ion Channels that Are Activated by Degeneration- or Hypercontraction-Causing Mutations
1998
Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH
2007 Nature
Neuroprotection in Ischemia
2004
Salmonella typhi uses CFTR to enter intestinal epithelial cells
1998 StandoutNatureNobel
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
The DRASIC Cation Channel Contributes to the Detection of Cutaneous Touch and Acid Stimuli in Mice
2001
Molecular basis of infrared detection by snakes
2010 StandoutNatureNobel
pH Dependency and Desensitization Kinetics of Heterologously Expressed Combinations of Acid-sensing Ion Channel Subunits
2004
Conformational and Temperature-sensitive Stability Defects of the ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator in Post-endoplasmic Reticulum Compartments
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
The receptors and cells for mammalian taste
2006 StandoutNature
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
2002 StandoutNatureNobel
Exploration of the pore structure of a peptide-gated Na+ channel
2001
Sensory Nerves in Lung and Airways
2014
Mechanosensation and pain
2004
Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes
2012 Nature
MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
2002 StandoutNatureNobel
unc-8, a DEG/ENaC Family Member, Encodes a Subunit of a Candidate Mechanically Gated Channel That Modulates C. elegans Locomotion
1997
Acid-sensing ion channels: advances, questions and therapeutic opportunities
2006
Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury
2006
Characterization of the Selectivity Filter of the Epithelial Sodium Channel
2000
Expression cloning of an epithelial amiloride‐sensitive Na+ channel
1993
Cystic fibrosis: molecular biology and therapeutic implications
1992 StandoutScience
Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
2009 Nature
Epithelial Na+ channels and stomatin are expressed in rat trigeminal mechanosensory neurons
2000
The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
2002
The menthol receptor TRPM8 is the principal detector of environmental cold
2007 StandoutNatureNobel
Stomatin, a MEC-2 Like Protein, Is Expressed by Mammalian Sensory Neurons
1999
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid‐sensitive channel in sensory neurons
2004
Epithelial Na Channels: Function and Diversity
1992
Enhanced Locomotion Caused by Loss of the Drosophila DEG/ENaC Protein Pickpocket1
2003
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Spider toxins activate the capsaicin receptor to produce inflammatory pain
2006 StandoutNatureNobel
Degradation of CFTR by the ubiquitin-proteasome pathway
1995 Standout
Paradoxical Stimulation of a DEG/ENaC Channel by Amiloride
1999
Acid‐sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones
2004
The receptor site of the spider toxin PcTx1 on the proton‐gated cation channel ASIC1a
2005
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
The changing sensitivity in the life of the nociceptor
1999
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
2000 StandoutNature
A mouse model for the delta F508 allele of cystic fibrosis.
1995 StandoutNobel
Cloning and Expression of a Novel Human Brain Na+ Channel
1996
The spectrum of cystic fibrosis mutations
1992
Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy
1993 StandoutNatureNobel
Nonproton Ligand Sensing Domain Is Required for Paradoxical Stimulation of Acid-sensing Ion Channel 3 (ASIC3) Channels by Amiloride
2011
Differential Localization of the Cystic Fibrosis Transmembrane Conductance Regulator in Normal and Cystic Fibrosis Airway Epithelium
1992
An Animal Model for Cystic Fibrosis Made by Gene Targeting
1992 StandoutScienceNobel
A Conformation Change in the Extracellular Domain that Accompanies Desensitization of Acid-sensing Ion Channel (ASIC) 3
2007
The Tarantula Toxin Psalmotoxin 1 Inhibits Acid-sensing Ion Channel (ASIC) 1a by Increasing Its Apparent H+ Affinity
2005
Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel
1995
Permeability Properties of Enac Selectivity Filter Mutants
2001
Eukaryotic Mechanosensitive Channels
2010 Nobel
Molecular determinants of desensitization in an ENaC/degenerin channel
2013
Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia.
1992
Structure and activity of the acid-sensing ion channels
2012
Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system
2002
The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.
1993
Potentiator ivacaftor abrogates pharmacological correction of ΔF508 CFTR in cystic fibrosis
2014
Interaction of Acid-sensing Ion Channel (ASIC) 1 with the Tarantula Toxin Psalmotoxin 1 is State Dependent
2006
DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
2001
Capsaicin Binds to the Intracellular Domain of the Capsaicin-Activated Ion Channel
1999
Transport and Localization of the DEG/ENaC Ion Channel BNaC1α to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
2001
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a.
2010
Vanilloid (Capsaicin) Receptors and Mechanisms
1999 Standout
Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activity.
1992
Acid-Evoked Currents in Cardiac Sensory Neurons
1999
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
2005 StandoutScienceNobel
Intracellular turnover of cystic fibrosis transmembrane conductance regulator. Inefficient processing and rapid degradation of wild-type and mutant proteins.
1994
Cystic ibrosis: Molecular Biology and Therapeutic Implications
1992 Science
A single point mutation in the pore region of the epithelial Na + channel changes ion selectivity by modifying molecular sieving
1999
Stoichiometry of recombinant cystic fibrosis transmembrane conductance regulator in epithelial cells and its functional reconstitution into cells in vitro.
1994
Genetically targeted cell disruption in Caenorhabditis elegans
1997 StandoutNobel
Molecular Basis of Mechanotransduction in Living Cells
2001
Neuropathology of degenerative cell death in Caenorhabditis elegans.
1997 StandoutNobel
A sensory neuron-specific, proton-gated ion channel
1998
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001 StandoutNobel
Membrane topology of the amiloride-sensitive epithelial sodium channel.
1994
Diversity of Channels Generated by Different Combinations of Epithelial Sodium Channel Subunits
1997
ION CHANNELS OF NOCICEPTION
1999
CELLULAR MECHANISMS OF TASTE TRANSDUCTION
1999
Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in Caenorhabditis elegans.
1996 StandoutNobel
Identification of Amino Acid Residues in the α, β, and γ Subunits of the Epithelial Sodium Channel (ENaC) Involved in Amiloride Block and Ion Permeation
1997
An SH3 binding region in the epithelial Na+ channel (alpha rENaC) mediates its localization at the apical membrane.
1994
Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel.
1994
Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons
1998
Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons
2000
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1
2012
MOLECULAR MODELING OF MECHANOTRANSDUCTION IN THE NEMATODE CAENORHABDITIS ELEGANS
1997
Neuropathology of Degenerative Cell Death inCaenorhabditis elegans
1997 StandoutNobel
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
1997
Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (cftr): Detection of immunologically related proteins
1995
Differential acidic pH sensitivity of delta F508 CFTR Cl- channel activity in lipid bilayers
1994
Works of Guy Champigny being referenced
Zn2+ and H+ Are Coactivators of Acid-sensing Ion Channels
2001
A proton-gated cation channel involved in acid-sensing
1997 Nature
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
1991 Nature
Functional Degenerin-containing Chimeras Identify Residues Essential for Amiloride-sensitive Na- Channel Function
1995
The Acid-sensitive Ionic Channel Subunit ASIC and the Mammalian Degenerin MDEG Form a Heteromultimeric H+-gated Na+ Channel with Novel Properties
1997
Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel
1995 Nature
Cloning and functional expression of a novel degenerin‐like Na+ channel gene in mammals
1999
Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons
1997
dGNaC1, a Gonad-specific Amiloride-sensitive Na+Channel
1998
Molecular Cloning and Functional Expression of a Novel Amiloride-sensitive Na+ Channel
1995
H+‐Gated Cation Channelsa
1999
Identification and properties of a novel type of Na+‐permeable amiloride‐sensitive channel in thyroid cells
1989
Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels
2000
Mutations Causing Neurodegeneration in Caenorhabditis elegans Drastically Alter the pH Sensitivity and Inactivation of the Mammalian H+-gated Na+ Channel MDEG1
1998
The Mammalian Degenerin MDEG, an Amiloride-sensitive Cation Channel Activated by Mutations Causing Neurodegeneration in Caenorhabditis elegans
1996
Human kidney amiloride-binding protein: cDNA structure and functional expression.
1990
A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels
1989
The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning.
1994
Different homologous subunits of the amiloride-sensitive Na+ channel are differently regulated by aldosterone.
1994
Regulation of expression of the lung amiloride-sensitive Na+ channel by steroid hormones.
1994