Citation Impact
Citing Papers
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
2013 StandoutScience
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Counting Cytokinesis Proteins Globally and Locally in Fission Yeast
2005 Science
MicroRNA-Directed Cleavage of HOXB8 mRNA
2004 Science
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells
2004
RNA interference microarrays: High-throughput loss-of-function genetics in mammalian cells
2004
CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms
2005 Standout
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Counting Low-Copy Number Proteins in a Single Cell
2007 StandoutScienceNobel
PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
2009 Standout
A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens
2004
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
2015 StandoutNatureNobel
MicroRNA targets in Drosophila
2003 Standout
Human MicroRNA Targets
2004 Standout
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
Hallmarks of Cancer: The Next Generation
2011 Standout
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Small RNA: can RNA interference be exploited for therapy?
2003
Involvement of Members of the Cadherin Superfamily in Cancer
2009
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
2005 StandoutNobel
RNAi and HTS: exploring cancer by systematic loss-of-function
2004
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility
2013
MicroRNAs
2004 Standout
Lessons from Nature: microRNA-based shRNA libraries
2006
Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening
2009 Standout
Programmed Death-1 Ligand 1 Interacts Specifically with the B7-1 Costimulatory Molecule to Inhibit T Cell Responses
2007
Large-scale de novo DNA synthesis: technologies and applications
2014
Epithelial-Mesenchymal Transitions in Development and Disease
2009 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2
2004 StandoutNature
Drosophila microRNAs Are Sorted into Functionally Distinct Argonaute Complexes after Production by Dicer-1
2007
RNA targeting with CRISPR–Cas13
2017 Nature
Molecular medicine for the brain: silencing of disease genes with RNA interference
2004
Small RNAs with Imperfect Match to Endogenous mRNA Repress Translation
2003
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
2014 StandoutNature
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens
2012
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
Glycopeptide-preferring Polypeptide GalNAc Transferase 10 (ppGalNAc T10), Involved in Mucin-type O-Glycosylation, Has a Unique GalNAc-O-Ser/Thr-binding Site in Its Catalytic Domain Not Found in ppGalNAc T1 or T2
2009 StandoutNobel
Lung Cancer
2008 Standout
Genetic knockouts and knockins in human somatic cells
2007
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
2007 StandoutNobel
Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs)
2003
Kinetic analysis of the RNAi enzyme complex
2004
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
2012 StandoutNatureNobel
Rapid creation and quantitative monitoring of high coverage shRNA libraries
2009
Restriction enzyme–generated siRNA (REGS) vectors and libraries
2004
RISC is a 5′ phosphomonoester-producing RNA endonuclease
2004
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
2016
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
2008
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 Standout
Factors Affecting Reproducibility between Genome-Scale siRNA-Based Screens
2010
Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses
2004
Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing
2009
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
2005 StandoutNature
An Optimized microRNA Backbone for Effective Single-Copy RNAi
2013
Asymmetry in the Assembly of the RNAi Enzyme Complex
2003 Standout
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
2005
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Short Hairpin Activated Gene Silencing in Mammalian Cells
2004
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
Functional siRNAs and miRNAs Exhibit Strand Bias
2003 Standout
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
2010 Standout
Bypassing cellular EGF receptor dependence through epithelial-to-mesenchymal-like transitions
2008
RNA interference against viruses: strike and counterstrike
2007
Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
2008 Nature
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
2009
Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
2011
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
2007 StandoutNature
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence
2006
A loss-of-function RNA interference screen for molecular targets in cancer
2006 Nature
Exploring genetic interactions and networks with yeast
2007
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening
2003
Generation and Analysis of Genetically Defined Liver Carcinomas Derived from Bipotential Liver Progenitors
2005
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Pooled shRNA Screenings: Experimental Approach
2012
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
2008 Standout
Genome-wide in situ exon capture for selective resequencing
2007
Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc
2007
Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors
2018
The blockade of immune checkpoints in cancer immunotherapy
2012 Standout
CD28 and CTLA‐4 coreceptor expression and signal transduction
2009
A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen
2006
Identification of Conserved Pathways of DNA-Damage Response and Radiation Protection by Genome-Wide RNAi
2006
Revealing the world of RNA interference
2004 StandoutNatureNobel
KLF17 is a negative regulator of epithelial–mesenchymal transition and metastasis in breast cancer
2009
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene
2005
Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing
2017
Prevalence of off-target effects in Drosophila RNA interference screens
2006 Nature
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
2006
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
2012
Lectin Domains of Polypeptide GalNAc Transferases Exhibit Glycopeptide Binding Specificity
2011 StandoutNobel
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays
2006
The functions of animal microRNAs
2004 StandoutNatureNobel
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Perspective: machines for RNAi
2005
Involvement of MINK, a Ste20 Family Kinase, in Ras Oncogene-Induced Growth Arrest in Human Ovarian Surface Epithelial Cells
2005
Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing
2004
Delivery of siRNA and siRNA Expression Constructs to Adult Mammals by Hydrodynamic Intravascular Injection
2005
The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
2008 StandoutNobel
Epithelial to mesenchymal transition predicts gefitinib resistance in cell lines of head and neck squamous cell carcinoma and non–small cell lung carcinoma
2007
Toward a Neutral Evolutionary Model of Gene Expression
2005 StandoutNobel
Proteasome-Mediated Destruction of the Cyclin A/Cyclin-Dependent Kinase 2 Complex Suppresses Tumor Cell Growth in Vitro and in Vivo
2004
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
2005 StandoutScienceNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
RNA interference rescue by bacterial artificial chromosome transgenesis in mammalian tissue culture cells
2005
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Ribo-gnome: The Big World of Small RNAs
2005 Science
A general approach for chemical labeling and rapid, spatially controlled protein inactivation
2004
Oncogenic cooperation and coamplification of developmental transcription factor genes in lung cancer
2007
Kinase requirements in human cells: III. Altered kinase requirements inVHL−/− cancer cells detected in a pilot synthetic lethal screen
2008 StandoutNobel
Recurrent Hemizygous Deletions in Cancers May Optimize Proliferative Potential
2012 Science
Molecular correlates of gefitinib responsiveness in human bladder cancer cells
2007
Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells
2013
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Cyclooxygenase-2–Dependent Regulation of E-Cadherin: Prostaglandin E2 Induces Transcriptional Repressors ZEB1 and Snail in Non–Small Cell Lung Cancer
2006
Kinase requirements in human cells: I. Comparing kinase requirements across various cell types
2008
Use and Abuse of RNAi to Study Mammalian Gene Function
2012 StandoutScienceNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression
2007
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
Modulating Hypoxia-Inducible Transcription by Disrupting the HIF-1–DNA Interface
2007
Loss of homotypic cell adhesion by epithelial-mesenchymal transition or mutation limits sensitivity to epidermal growth factor receptor inhibition
2007
The growing catalog of small RNAs and their association with distinct Argonaute/Piwi family members
2008
Targeted Investigation of the Neandertal Genome by Array-Based Sequence Capture
2010 StandoutScienceNobel
Yeast genome-wide drug-induced haploinsufficiency screen to determine drug mode of action
2004
Targeted Retrieval and Analysis of Five Neandertal mtDNA Genomes
2009 StandoutScienceNobel
Works of Guy Cavet being referenced
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
2004
Expression profiling reveals off-target gene regulation by RNAi
2003 Standout
Production of complex nucleic acid libraries using highly parallel in situ oligonucleotide synthesis
2004
Second-generation shRNA libraries covering the mouse and human genomes
2005
Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL
2007
Discovering Modes of Action for Therapeutic Compounds Using a Genome-Wide Screen of Yeast Heterozygotes
2004
Quantitation of the distribution and flux of myosin-II during cytokinesis
2002
Genetics of gene expression surveyed in maize, mouse and man
2003 Nature
Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors
2002
Epithelial versus Mesenchymal Phenotype Determines In vitro Sensitivity and Predicts Clinical Activity of Erlotinib in Lung Cancer Patients
2005