Guy Blanchet

Refinement of Structural Leads for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA)

2-Arylindoles as gonadotropin releasing hormone (GnRH) antagonists: optimization of the tryptamine side chain

Altered glutamatergic transmission in neurological disorders: From high extracellular glutamate to excessive synaptic efficacy

Dendritic Spine Pathology: Cause or Consequence of Neurological Disorders?

The cholinergic hypothesis of Alzheimer's disease: a review of progress

Management of acute organophosphorus pesticide poisoning

The N-methyl-d-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias

Glutamate uptake

Natural products: An evolving role in future drug discovery

Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning

New Rapid Diagnostic Tests for Neisseria meningitidis Serogroups A, W135, C, and Y

Treatment with Tertiary Oximes Prevents Seizures and Improves Survival Following Sarin Intoxication

Sequential changes in glutamate transporter protein levels during Fe3+-induced epileptogenesis

SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning

Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure

New Structural Scaffolds for Centrally Acting Oxime Reactivators of Phosphylated Cholinesterases

Molecular regulation of glutamate and GABA transporter proteins by valproic acid in rat hippocampus during epileptogenesis

Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs

In vivo cholinesterase inhibitory specificity of organophosphorus nerve agents

Acetylcholine esterase inhibitors in effluents from oil production platforms in the North Sea

[+]-Huperzine A treatment protects against N-methyl-d-aspartate-induced seizure/status epilepticus in rats

Control of nerve agent-induced seizures is critical for neuroprotection and survival☆ ☆The animals used in these studies were handled in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals, proposed by the Committee to Revise the Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council, and published by National Academy Press, 1996, and the Animal Welfare Act of 1966, as amended. The opinions or assertions contained herein are the private views of the authors, and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense.

Three-dimensional structure of acetylcholinesterase and of its complexes with anticholinesterase drugs

The oxime pro-2-PAM provides minimal protection against the CNS effects of the nerve agents sarin, cyclosarin, and VX in guinea pigs

Sarin (GB, O-isopropyl methylphosphonofluoridate) neurotoxicity: critical review

Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase

Mitochondrial Membrane Permeabilization in Cell Death

Organophosphate Poisoning: Peripheral Vascular Resistance – A Measure of Adequate Atropinization

Seizures, brain damage and brain development

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks

Behavioral Effects of NBQX, a Competitive Antagonist of the AMPA Receptors

In vivo reactivation by oximes of inhibited blood, brain and peripheral tissue cholinesterase activity following exposure to nerve agents in guinea pigs

Glutamate receptor function in learning and memory

The Effects of Fresh Frozen Plasma on Cholinesterase Levels and Outcomes in Patients with Organophosphate Poisoning

Pyridinium Oximes as Cholinesterase Reactivators. Structure-Activity Relationship and Efficacy in the Treatment of Poisoning with Organophosphorus Compounds

Descending systems contributing to locomotor recovery after mild or moderate spinal cord injury in rats: experimental evidence and a review of literature

Basso Mouse Scale for Locomotion Detects Differences in Recovery after Spinal Cord Injury in Five Common Mouse Strains

Applications of the Morris water maze in the study of learning and memory

Adverse reaction to atropine and the treatment of organophosphate intoxication.

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Acetylcholinesterase

Elements of a neurobiological theory of the hippocampus: the role of activity-dependent synaptic plasticity in memory

Myths of the Archaic State

About Sleep's Role in Memory

Imidazole Aldoximes Effective in Assisting Butyrylcholinesterase Catalysis of Organophosphate Detoxification

A larger number of L chains (Tac) enhance the association rate of interleukin 2 to the high affinity site of the interleukin 2 receptor.

Development of an Immunochromatographic Strip for Simple Detection of Penicillin-Binding Protein 2′

Myths of the archaic state: evolution of the earliest cities, states, and civilizations

Neuropathology of degenerative cell death in Caenorhabditis elegans.

Neurogenesis in Adult Mammals: Some Progress and Problems

Ischemic Cell Death in Brain Neurons

Large-Scale Applications of Transition Metal-Catalyzed Couplings for the Synthesis of Pharmaceuticals

Initial Social Complexity in Southwestern Asia

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

Neuropathology of Degenerative Cell Death inCaenorhabditis elegans

Neurotoxins and neurotoxic species implicated in neurodegeneration

Cardiovascular Consequences of Organophosphorus Poisoning and of Antidotes in Conscious Unrestrained Rats

Changes in hippocampal acetylcholine and glutamate extracellular levels during soman-induced seizures: Influence of septal cholinoceptive cells

Effects of TCP on Spatial Memory: Comparison with MK-801

Neuroprotective activity of glutamate receptor antagonists against soman-induced hippocampal damage: quantification with an ω3 site ligand

Early dendritic changes in hippocampal pyramidal neurones (field CA1) of rats subjected to acute soman intoxication: a light microscopic study

Stability study of a new antidote drug combination (Atropine–HI-6–Prodiazepam) for treatment of organophosphate poisoning

Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus

Medical management of organophosphate-induced seizures

Coadministration of atropine, NBQX and TCP against soman-induced seizures

Antiepileptic effects of NBQX against soman-induced seizures

Influence of medial septal cholinoceptive cells on c-Fos-like proteins induced by soman

Modulation of Somaninduced neuropathology with an anticonvulsant regimen

Clonal Expansion of Sequence Type (ST-)5 and Emergence of ST-7 in Serogroup A Meningococci, Africa

Le Moyen-Orient de 20 000 ans BP à 6 000 ans BP. Essai de reconstitution paléoclimatique.

Seizure-related opening of the blood-brain barrier induced by soman: possible correlation with the acute neuropathology observed in poisoned rats.

Novel benzimidazoles as ligands for the strychnine-insensitive N-methyl-d-aspartate-linked glycine receptor

Acétylcholinestérase

GABA receptors in Deiters nucleus modulate posturokinetic responses to cortical stimulation in the cat.

Activité de l'acétylcholinestérase d'érythrocyte à faible force ionique