Citation Impact
Citing Papers
Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching
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2013
Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance
1996
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2011 Standout
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1997
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2009
p53 induction, cell cycle checkpoints, and apoptosis in DNAPK- deficient scid mice
1996
A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci
2004
Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
2000
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
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1998
Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells
1997 Nature
The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase
1998
The Mechanism of V(D)J Joining: Lessons from Molecular, Immunological, and Comparative Analyses
1994
Repair and Recombination: How to make ends meet
1995 StandoutNobel
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2005
L1 retrotransposition in human neural progenitor cells
2009 Nature
The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching
1996
Mechanism and Regulation of Immunoglobulin Isotype Switching
1993
Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair
1996
Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection
2015
Nomenclature of human genes involved in ionizing radiation sensitivity
1995
IgH Class Switch Recombination to IgG1 in DNA-PKcs-Deficient B Cells
2002
Interaction of the Ku heterodimer with the DNA ligase IV/Xrcc4 complex and its regulation by DNA-PK
2007
A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination
1998
A means to a DNA end: the many roles of Ku
2004
Mammalian mutants defective in the response to ionizing radiation-induced DNA damage
1995
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
1997 Standout
The Mechanism and Regulation of Chromosomal V(D)J Recombination
2002
XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining
2006
Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway
1997
Reduced X-Ray Resistance and Homologous Recombination Frequencies in a RAD54 Mutant of the Chicken DT40 Cell Line
1997
Unrepaired DNA Breaks in p53-Deficient Cells Lead to Oncogenic Gene Amplification Subsequent to Translocations
2002
Identification of a PKB/Akt Hydrophobic Motif Ser-473 Kinase as DNA-dependent Protein Kinase
2004
Function of DNA-Protein Kinase Catalytic Subunit During the Early Meiotic Prophase Without Ku70 and Ku861
2003
The ubiquitin-proteasome proteolytic pathway
1994 StandoutNobel
Organoid Models and Applications in Biomedical Research
2015 Standout
Ku80 is required for immunoglobulin isotype switching
1998
ATM Is Activated in Response toN-Methyl-N′-nitro- N-nitrosoguanidine-induced DNA Alkylation
2002
DNA binding of Xrcc4 protein is associated with V(D)Jrecombination but not with stimulation of DNA ligase IV activity
1999
DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
1995
When Checkpoints Fail
1997 StandoutNobel
AID Is Required for c-myc/IgH Chromosome Translocations In Vivo
2004 StandoutNobel
Mechanism and regulation of human non-homologous DNA end-joining
2003
L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells
2006
Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV
1997
Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo
2006
The AID enzyme induces class switch recombination in fibroblasts
2002 StandoutNatureNobel
Database of mouse strains carrying targeted mutations in genes affecting cellular responses to DNA damage. Version 4
2000
The human set and transposase domain protein Metnase interacts with DNA Ligase IV and enhances the efficiency and accuracy of non-homologous end-joining
2008
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates
1996
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Yeast DNA ligase IV mediates non-homologous DNA end joining
1997 Nature
DNA-dependent protein kinase
1997
A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining
2008
DNA-dependent protein kinase acts upstream of p53 in response to DNA damage
1998 Nature
Short Telomeres, even in the Presence of Telomerase, Limit Tissue Renewal Capacity
2005 StandoutNobel
DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining
2000
Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies
1997
Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases
2013
Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family
2011 StandoutNobel
Telomeres, chromosome instability and cancer
2006
A class switch control region at the 3′ end of the immunoglobulin heavy chain locus
1994
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
2005 Nature
Requirement for Ku80 in growth and immunoglobulin V(D)J recombination
1996 Nature
Apoptosis induced by γ-irradiation, but not CD4 ligation, of peripheral T lymphocytesin vivo is p53-dependent
1997
Protection of mammalian telomeres
2002
Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining
2015
Electron Crystal Structure of the Transcription Factor and DNA Repair Complex, Core TFIIH
2000 StandoutNobel
Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer
1997
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
A human RNA polymerase II complex associated with SRB and DNA-repair proteins
1996 Nature
Cdk1-Dependent Phosphorylation of Cdc13 Coordinates Telomere Elongation during Cell-Cycle Progression
2009 StandoutNobel
Evidence that mammalian cells possess homologous recombinational repair pathways
1996
The outs and ins of transposition: from Mu to Kangaroo
2003
Variation in DNA repair is a factor in cancer susceptibility: a paradigm for the promises and perils of individual and population risk estimation?
1998
DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus
1997
Leaky Scid Phenotype Associated with Defective V(D)J Coding End Processing in Artemis-Deficient Mice
2002
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 StandoutNobel
Switching and Signaling at the Telomere
2001 StandoutNobel
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
2014
DNA double strand break repair and chromosomal translocation: Lessons from animal models
2001
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
2001 Nature
Ku acts in a unique way at the mammalian telomere to prevent end joining
2000
Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV
1998 Nature
Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line
1995 Science
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
2004
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis
1997
The DNA-Activated Protein Kinase — DNA-PK
1996
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Crystal structure of the Xrcc4 DNA repair protein and implications for end joining
2000
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 StandoutNobel
Cellular Responses to DNA Damage in the Absence of Poly(ADP-ribose) Polymerase
1998
Mechanism and Control of V(D)J Recombination versus Class Switch Recombination: Similarities and Differences
2005
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis
2020 StandoutNatureNobel
A phylogenomic study of DNA repair genes, proteins, and processes
1999
The role of short homology repeats and TdT in generation of the invariant γδ antigen receptor repertoire in the fetal thymus
1995 StandoutNobel
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development
2000 Nature
Molecular Mechanism of Immunoglobulin Class Switch Recombination
1999 StandoutNobel
Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks
1995 StandoutNobel
Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit
1997
DNA‐PK autophosphorylation facilitates Artemis endonuclease activity
2006
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene
1996 StandoutNatureNobel
Telomeres and human disease: ageing, cancer and beyond
2005
The Primary Immunodeficiencies
1995
Crystal structure of an Xrcc4-DNA ligase IV complex.
2001
Structure of DNA-dependent protein kinase: implications for its regulation by DNA
1999
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Crystallographic Analysis of the Recognition of a Nuclear Localization Signal by the Nuclear Import Factor Karyopherin α
1998 StandoutNobel
Recent Advances in Understanding V(D)J Recombination
1997
Somatic retrotransposition alters the genetic landscape of the human brain
2011 Nature
DNA Ligase IV Deficiency in Mice Leads to Defective Neurogenesis and Embryonic Lethality via the p53 Pathway
2000
Tetramerization and DNA Ligase IV Interaction of the DNA Double-strand Break Repair Protein XRCC4 are Mutually Exclusive
2003
Chapter 2 DNA-PK
2008
The impact of retrotransposons on human genome evolution
2009
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme
2000 StandoutNobel
Activation of DNA-dependent Protein Kinase by Single-stranded DNA Ends
2000
Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination
1995
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
2001 StandoutNatureNobel
Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice
1998 StandoutNobel
Identification of DNA-PK in the arthropods
2003
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G‐strand overhang
2000
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
1999 StandoutNobel
Mechanistic Constraints on Diversity in Human V(D)J Recombination
1996
The ATM homologue MEC1 is required for phosphorylation of replication protein A in yeast
1996
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
2009
Mechanisms of double-strand break repair in somatic mammalian cells
2009
Regulation of Telomerase by Telomeric Proteins
2004
Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo
1999 Standout
MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUS
2006
In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients
1997 StandoutNobel
Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells
2003
Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.
1995
Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.
1996
Telomerase maintains telomere structure in normal human cells
2006
Rad51 expression and localization in B cells carrying out class switch recombination.
1996
Quality Control by DNA Repair
1999 StandoutScienceNobel
Lack of N Regions in Antigen Receptor Variable Region Genes of TdT-Deficient Lymphocytes
1993 Science
NONCODING RNAS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
2006
Ataxia-telangiectasia and cellular responses to DNA damage.
1995
Identification of Genes Involved in Repair of DNA Double-Strand Breaks in Mammalian Cells
1998
The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments.
1993
DNA-dependent Protein Kinase Activity Is Not Required for Immunoglobulin Class Switching
2002
Response to RAG-Mediated V(D)J Cleavage by NBS1 and γ-H2AX
2000 Science
Loading of the Nonhomologous End Joining Factor, Ku, on Protein-occluded DNA Ends
2007
Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.
1994
Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
1997
Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA
1994 Science
DNA Mismatch Repair: Functions and Mechanisms
2005 StandoutNobel
The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: Replication protein A hyperphosphorylation and p53 induction
1996
Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen.
1995
Mutations in the p53 and SCID genes cooperate in tumorigenesis.
1996
Mutations in Two Ku Homologs Define a DNA End-Joining Repair Pathway in Saccharomyces cerevisiae
1996
Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination
2018
A Drosophila protein homologous to the human p70 Ku autoimmune antigen interacts with the P transposable element inverted repeats.
1994
Rearranging Views on Neurogenesis
1999
Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini
1998
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
2011
DNA-dependent protein kinase: DNA binding and activation in the absence of Ku
1998
Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation
1993 Science
Photocross-linking of an Oriented DNA Repair Complex
1999
The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway
2010 Standout
The characterization of a mammalian DNA structure-specific endonuclease.
1994
Evidence for Replicative Repair of DNA Double-Strand Breaks Leading to Oncogenic Translocation and Gene Amplification
2002
V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.
1993
In Situ Visualization of DNA Double-Strand Break Repair in Human Fibroblasts
1998 Science
DNA end-joining: from yeast to man
1998
The absolute number of trans-rearrangements between the TCRG and TCRB loci is predictive of lymphoma risk: a severe combined immune deficiency (SCID) murine model.
1997
V(D)J recombination coding junction formation without DNA homology: processing of coding termini.
1993
Targeted Disruption of the Artemis Murine Counterpart Results in SCID and Defective V(D)J Recombination That Is Partially Corrected with Bone Marrow Transplantation
2005
Short Telomeres Result in Organismal Hypersensitivity to Ionizing Radiation in Mammals
2000
Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function.
1996
Mobile Elements: Drivers of Genome Evolution
2004 Science
DNA-Dependent Kinase (p350) as a Candidate Gene for the Murine SCID Defect
1995 Science
Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination
2019
Cell Cycle and Genetic Requirements of Two Pathways of Nonhomologous End-Joining Repair of Double-Strand Breaks in Saccharomyces cerevisiae
1996
Enhanced phosphorylation of p53 serine 18 following DNA damage in DNA-dependent protein kinase catalytic subunit-deficient cells.
1999
p53-dependent cell cycle arrests are preserved in DNA-activated protein kinase-deficient mouse fibroblasts.
1996
RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1.
1994 Nobel
Recognition and processing of damaged DNA
1995 StandoutNobel
DNA end-joining catalyzed by human cell-free extracts
1998
V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation
2002
Rejoining Kinetics of DNA Single- and Double-Strand Breaks in Normal and DNA Ligase-Deficient Cells after Exposure to Ultraviolet C and Gamma Radiation: An Evaluation of Ligating Activities Involved in Different DNA Repair Processes
1999
Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching
1998
Functional Intersection of ATM and DNA-Dependent Protein Kinase Catalytic Subunit in Coding End Joining during V(D)J Recombination
2013
Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM
2004
A DNA end-binding factor involved in double-strand break repair and V(D)J recombination.
1994
Initiation of DNA Interstrand Cross-Link Repair in Humans: the Nucleotide Excision Repair System Makes Dual Incisions 5′ to the Cross-linked Base and Removes a 22- to 28-Nucleotide-long Damage-Free Strand
1997 StandoutNobel
Human DNA Repair Genes
2001 StandoutScienceNobel
Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated.
1993
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.
1996
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
1999 StandoutNobel
Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends
2000
Biochemical and Genetic Defects in the DNA-Dependent Protein Kinase in Murine scid Lymphocytes
1996
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends
2007
Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4
1998 StandoutNobel
DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair.
1995
APLF (C2orf13) Is a Novel Human Protein Involved in the Cellular Response to Chromosomal DNA Strand Breaks
2007
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Works of Guillermo E. Taccioli being referenced
Activities Involved in V(D)J Recombination
1992
Function and Control of Recombination‐Activating Gene Activitya
1992
The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene
1996
Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity
1998
Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation
1995
Novel Localization of the DNA-PK Complex in Lipid Rafts
2003
DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage
1999 Nature
DNA repair mediated by endonuclease-independent LINE-1 retrotransposition
2002
Functional interaction between DNA-PKcs and telomerase in telomere length maintenance
2002
Identification of the Catalytic Subunit of DNA Dependent Protein Kinase as the Product of the Mouse scid Gene
1996
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination
1994 Science
Potential targets for autosomal SCID mutations
1995
Endonuclease-independent LINE-1 retrotransposition at mammalian telomeres
2007 Nature
Regulation of DNA-dependent Protein Kinase Activity by Ionizing Radiation-activated Abl Kinase Is an ATM-dependent Process
2000
Menage á trois: Double strand break repair, V(D)J recombination and DNA‐PK
1995
The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination
1995
Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.
1996
A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation.
1994
The C Terminus of Ku80 Activates the DNA-Dependent Protein Kinase Catalytic Subunit
1999
Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs
2004
A V(D)J recombinase-inducible B-cell line: role of transcriptional enhancer elements in directing V(D)J recombination.
1993
Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants
1993 Science
Role of Mammalian Rad54 in Telomere Length Maintenance
2003
Postreplicative Joining of DNA Double-Strand Breaks Causes Genomic Instability in DNA-PKcs–Deficient Mouse Embryonic Fibroblasts
2005
The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang
2001
VDJ recombination
1992