Citation Impact
Citing Papers
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
2008 Standout
The Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA
2009 StandoutScienceNobel
Activation of the cyclic AMP cascade as an ocoggenic mechanism: The thyroid example
1991
Mutations in G protein-linked receptors: Novel insights on disease
1993
Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor
1995 StandoutNatureNobel
Adenylyl cyclases
1992 StandoutNobel
Structural basis of function in heterotrimeric G proteins
2006
Tumor suppressor genes
1991 Standout
Identification of effector-activating residues of Gsα
1992
The GTPase superfamily: conserved structure and molecular mechanism
1991 StandoutNature
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis
1994 StandoutScienceNobel
Mutant α subunits of Gi2 inhibit cyclic AMP accumulation
1991 Nature
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
2008 StandoutNature
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Mitogenic Signaling via G Protein-Coupled Receptors
1996 StandoutNobel
Oncogenes and signal transduction
1991 Standout
Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases
1992 StandoutNatureNobel
Molecular themes in oncogenesis
1991 StandoutNobel
Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas
1993 Nature
Multiple intercellular signalling systems control the development of the Caenorhabditis elegans vulva
1991 StandoutNatureNobel
Structure of the nuclear transport complex karyopherin-β2–Ran˙GppNHp
1999 StandoutNatureNobel
Substitution of three amino acids switches receptor specificity of Gqα to that of Giα
1993 StandoutNatureNobel
SEC12 encodes a guanine-nucleotide-exchange factor essential for transport vesicle budding from the ER
1993 StandoutNatureNobel
β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf
2000
The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades
1998
Activation of the β1 isozyme of phospholipase C by α subunits of the Gq class of G proteins
1991 Nature
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
Ulcerative colitis and adenocarcinoma of the colon in Gαi2-deficient mice
1995
Mutations in GNA11 in Uveal Melanoma
2010 Standout
Limited Proteolysis and Amino Acid Replacements in the Effector Region ofThermus thermophilusElongation Factor Tu
1996
Activating Mutations of the Stimulatory G Protein in the McCune–Albright Syndrome
1991 Standout
Specific chromosomal abnormalities in malignant human gliomas.
1988
Cloning and expression of a widely distributed (type IV) adenylyl cyclase.
1991 StandoutNobel
G z -Mediated Hormonal Inhibition of Cyclic AMP accumulation
1992 Science
Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/neuOncogene
1987 StandoutScience
Identification of Two GTP-Binding Proteins in the Chloroplast Protein Import Machinery
1994 StandoutScienceNobel
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells.
1991
Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.
1993
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
2003 StandoutNobel
Mechanism of GTP hydrolysis by G-protein alpha subunits.
1994 StandoutNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Function of the Homeodomain Protein GHF1 in Pituitary Cell Proliferation
1991 Science
MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.
1992
The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants
1997 Science
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
1994 StandoutNobel
Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C.
1992
Activating point mutations of the gsp oncogene in human thyroid adenomas
1991
Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes.
1992
Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum
1993 StandoutScienceNobel
Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells.
1992
The Q205LGo-alpha subunit expressed in NIH-3T3 cells induces transformation
1992
A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.
1991
Ligand-independent activation of platelet-derived growth factor receptor is a necessary intermediate in lysophosphatidic, acid-stimulated mitogenic activity in L cells
1998
Targeting the Receptor-G q Interface to Inhibit in Vivo Pressure Overload Myocardial Hypertrophy
1998 StandoutScienceNobel
Gene Amplification of c- myc and N- myc in Small Cell Carcinoma of the Lung
1986 Science
G Protein Activation of a Hormone-Stimulated Phosphatase in Human Tumor Cells
1992 Science
Gi2-mediated activation of the MAP kinase cascade.
1995
Tumor Rejection After Direct Costimulation of CD8 + T Cells by B7-Transfected Melanoma Cells
1993 StandoutScienceNobel
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Growth Factors and Cancer
1991 StandoutScience
The Molecular Genetics of Cancer
1987 StandoutScienceNobel
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
2001 StandoutNobel
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.
1994
Antagonism of Catecholamine Receptor Signaling by Expression of Cytoplasmic Domains of the Receptors
1993 StandoutScienceNobel
GTPase-deficient G alpha i2 oncogene gip2 inhibits adenylylcyclase and attenuates receptor-stimulated phospholipase A2 activity
1991
Oncogene Amplification in Tumor Cells
1986
Inhibition of Adenylyl Cyclase by G iα
1993 StandoutScienceNobel
G PROTEIN MECHANISMS: Insights from Structural Analysis
1997
Myristoylation of the G alpha i2 polypeptide, a G protein alpha subunit, is required for its signaling and transformation functions.
1992
Lipid modifications of G proteins: alpha subunits are palmitoylated.
1993 StandoutNobel
Crystal Structure of the Adenylyl Cyclase Activator G s α
1997 ScienceNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
A Region of Adenylyl Cyclase 2 Critical for Regulation by G Protein βγ Subunits
1995 StandoutScienceNobel
Inverse, protean, and ligand‐selective agonism: matters of receptor conformation
2001
Activated alpha subunit of Go protein induces oocyte maturation.
1991
Separate GTP Binding and GTPase Activating Domains of a Gα Subunit
1993 Science
Diversity of G Proteins in Signal Transduction
1991 StandoutScience
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
1991 StandoutScienceNobel
Works of Griffith Harsh being referenced
Clinical Characteristics of Acromegalic Patients whose Pituitary Tumors Contain Mutant GsProtein
1990
Two G Protein Oncogenes in Human Endocrine Tumors
1990 Science
Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma.
1986